Asim B. Abdel-Mageed
Tulane University Of Louisiana

Targeting Tumor-derived exRNA-containing Microvesicles by High Throughput Screening

Unraveling the underlying mechanisms of tumor growth and metastasis is critical to developing curative strategies against castration-resistant prostate cancer (CRPC). More

Neil Aronin
University of Massachusetts Medical School, Worcester

Exosome Based Therapeutics in Huntington's Disease

The goal of this UH2 and UH3 is to study how exosomes can deliver siRNAs across the blood brain barrier to enter neurons and other brain cells. The immediate target is the mutant huntingtin mRNA. More

Richard P. Kraig
University Of Chicago

Exosome RNA-therapeutics to Promote CNS Myelination

Multiple sclerosis (MS) is the most common disabling neurological disease of young adulthood. It is an incurable autoimmune disorder involving oligodendrocyte loss, demyelination, and an inability to remyelinate damaged brain. More

AC Matin
Stanford University

HER2-targeted Exosomal Delivery of Therapeutic mRNA for Enzyme Pro-drug Therapy

In response to NIH RFA: RM-12-014, it is proposed to engineer exosomes, the body’s “natural antigen delivery system,” in order to enhance their natural capacity to activate reductive prodrugs and attach to their surface ligands that specifically target HER2-positive breast cancer, many cases of which are resistant to the current therapies (e.g., trastuzumab). More

Peter J. Quesenberry
Rhode Island Hospital

Regulation of Renal and Bone Marrow Injury by Extracellular Vesicle Non-coding RNA

Recent studies indicate that cellular derived vesicles can alter the genomic phenotype of separate target cells by transfer of RNA species. Further work has indicated that mesenchymal stem cell-derived vesicles (MSC-dv) can mediate healing of injured renal and marrow tissue by transfer of microRNA. More

Thomas D. Schmittgen
Ohio State University

Targeted Delivery of MicroRNA-loaded Microvesicle for Cancer Therapy

A new therapeutic modality is to use oligonucleotides to restore the levels of tumor suppressive miRNAs to that of normal cells or tissues. Successful targeting and delivery of therapeutic oligonucleotides has been a major bottleneck in their clinical development. More

Anil K. Sood
UT MD Anderson Cancer Center

Novel Extracellular-RNA-based Combinatorial RNA Inhibition Therapy

RNA molecules are secreted in extracellular spaces (exRNAs) and act as endocrine signals altering the phenotypes of cancer cells. In this application we will focus on the class of small non-codingRNAs named microRNAs. More

Huang-ge Zhang
University Of Louisville

Fruit Exosome-like Particles for Therapeutic Delivery of Extracellular miRNAs

The overall goal of this proposal is to develop exosome-like nanoparticles as a delivery vehicle for targetable delivery of extracellular RNA (exRNA) primarily focusing on miRNAs which modulate gene expression and induce immune responses upon delivery in mouse tumor models. More