Reviews

Dragomir M & Calin GA.

Circular RNAs in cancer - Lessons learned from microRNAs.

Front Oncol (2018) 8:179.

Lyons YA et al.

Immune cell profiling in cancer: Molecular approaches to cell-specific identification.

NPJ Precis Oncol (2017) 1:26.

Haemmerle M et al.

The platelet lifeline to cancer: Challenges and opportunities.

Cancer Cell (2018) 33:965-983.

Nonaka T & Wong DTW.

Liquid biopsy in head and neck cancer: Promises and challenges.

J Dent Res (2018) 97:701-708.

Shao H et al.

New technologies for analysis of extracellular vesicles.

Chem Rev (2018) 118:1917-1950.

Koupenova M et al.

Circulating platelets as mediators of immunity, inflammation, and thrombosis.

Circ Res (2018) 122:337-351.

Boussiotis VA & Charest A.

Immunotherapies for malignant glioma.

Oncogene (2018) 37:1121-1141.

Chen X et al.

RNA interference-based therapy and its delivery systems.

Cancer Metastasis Rev (2018) 37:107-124.

Bei Y et al.

Extracellular vesicles in cardiovascular theranostics.

Theranostics (2017) 7:4168-4182. Related Pathway

 

Bayraktar R, Van Roosbroeck K & Calin GA.

Cell-to-cell communication: microRNAs as hormones.

Mol Oncol (2017) 11:1673-1686.

Shen P et al.

To Wnt or lose: The missing non-coding linc in colorectal cancer.

Int J Mol Sci (2017) 18:9. Related Pathway

 

Shankar GM et al.

Liquid biopsy for brain tumors.

Expert Rev Mol Diagn (2017) 17:943-947.

August P & Suthanthiran M.

Sex and kidney transplantation: Why can't a woman be more like a man?

J Am Soc Nephrol (2017) 28:2829-2831.

Fabris L & Calin GA.

Understanding the genomic ultraconservations: T-UCRs and cancer.

Int Rev Cell Mol Biol (2017) 333:159-172.

Aldrugh S et al.

Atrial fibrillation, cognition and dementia: A review.

J Cardiovasc Electrophysiol (2017) 28:958-965.

Rigoutsos I et al.

N-BLR, a primate-specific non-coding transcript, leads to colorectal cancer invasion and migration.

Genome Biol (2017) 18:98.

Ochocinska MJ et al.

NIH workshop report on the trans-agency Blood-Brain Interface Workshop 2016: Exploring key challenges and opportunities associated with the blood, brain and their interface.

Fluids Barriers CNS (2017) 14:12.

Klingenberg M et al.

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

J Hepatol (2017) 67:603-618. Related Pathways: 1, 2

 

Mateescu B et al.

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper.

J Extracell Vesicles (2017) 6:1286095.

Sutaria DS et al.

Achieving the promise of therapeutic extracellular vesicles: The devil is in details of therapeutic loading.

Pharm Res (2017) 34:1053-1066.

Yeo AT & Charest A.

Immune checkpoint blockade biology in mouse models of glioblastoma.

J Cell Biochem (2017) 118:2516-2527.

Grossman RL et al.

Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.

Clin Pharmacol Ther (2017) 101:589-592.

Maji S et al.

Extracellular vesicles in liver diseases.

Am J Physiol Gastrointest Liver Physiol (2017) 312:G194-G200.

Maas SL, Breakefield XO & Weaver AM.

Extracellular vesicles: Unique intercellular delivery vehicles.

Trends Cell Biol (2017) 27:172-188.

Wang X, Kaczor-Urbanowicz KE & Wong DT.

Salivary biomarkers in cancer detection.

Med Oncol (2017) 34:7.

Matsuda A et al.

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.

Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.

Kaczor-Urbanowicz KE et al.

Saliva diagnostics - Current views and directions.

Exp Biol Med (Maywood) (2017) 242:459-472.

Kaczor-Urbanowicz KE et al.

Emerging technologies for salivaomics in cancer detection.

J Cell Mol Med (2017) 21:640-647.

Previs RA et al.

The rise of genomic profiling in ovarian cancer.

Expert Rev Mol Diagn (2016) 16:1337-1351.

Nazimek K, Bryniarski K & Askenase PW.

Functions of exosomes and microbial extracellular vesicles in allergy and contact and delayed-type hypersensitivity.

Int Arch Allergy Immunol (2016) 171:1-26.

Shah R, Pico AR & Freedman JE.

Translational epidemiology: Entering a brave new world of team science.

Circ Res (2016) 119:1060-1062.

Shah MY et al.

microRNA therapeutics in cancer - an emerging concept.

EBioMedicine (2016) 12:34-42.

Ciccone M & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: An old disease with new genetic insights.

MicroRNA (2016) 5:106-112.

Parasramka MA & Patel T.

Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities.

Stem Cell Investig (2016) 3:1.

Paladini L et al.

Targeting microRNAs as key modulators of tumor immune response.

J Exp Clin Cancer Res (2016) 35:103.

Srivastava A et al.

Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer.

J Biomed Nanotechnol (2016) 12:1159-73.

Fritz JV et al.

Sources and functions of extracellular small RNAs in human circulation.

Annu Rev Nutr (2016) 36:301-36.

Abels ER & Breakefield XO.

Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.

Cell Mol Neurobiol (2016) 36:301-12.

Ciccone M & Calin GA.

MicroRNAs in myeloid hematological malignancies.

Curr Genomics (2015) 16:336-48.

Van Roosbroeck K & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?

Semin Oncol (2016) 43:209-14.

Zappulli V et al.

Extracellular vesicles and intercellular communication within the nervous system.

J Clin Invest (2016) 126:1198-207.

Hall J et al.

Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson's disease, glioma, and schwannoma.

Cell Mol Neurobiol (2016) 36:417-27.

Parasramka MA et al.

Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.

Pharmacol Ther (2016) 161:67-78. Related Pathway

 

Byron SA et al.

Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.

Nat Rev Genet (2016) 17:257-71. Related blog post

Rennert RC, Hochberg FH & Carter BS.

ExRNA in biofluids as biomarkers for brain tumors.

Cell Mol Neurobiol (2016) 36:353-60.

Almeida MI & Calin GA.

The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.

Genome Med (2016) 8:29.

Zaborowski MP et al.

Extracellular vesicles: Composition, biological relevance, and methods of study.

Bioscience (2015) 65:783-797.

Rupaimoole R et al.

miRNA deregulation in cancer cells and the tumor microenvironment.

Cancer Discov (2016) 6:235-46.

Clancy L & Freedman JE.

Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.

Circ Res (2016) 118:374-6.

Hansen JM, Coleman RL & Sood AK.

Targeting the tumour microenvironment in ovarian cancer.

Eur J Cancer (2016) 56:131-43.

Guo P et al.

Biological nanomotors with a revolution, linear, or rotation motion mechanism.

Microbiol Mol Biol Rev (2016) 80:161-86.

Fabris L et al.

The potential of microRNAs as prostate cancer biomarkers.

Eur Urol (2016) 70:312-22.

Mitamura T, Gourley C & Sood AK.

Prediction and failure of anti-angiogenesis escape.

Gynecol Oncol (2016) 141:80-5.

Hatakeyama H et al.

Assessment of in vivo siRNA delivery in cancer mouse models.

Methods Mol Biol (2016) 1402:189-97.

Giza DE & Calin GA

microRNA and Chronic Lymphocytic Leukemia.

Adv Exp Med Biol (2015) 889:23-40.

Machtinger R, Laurent LC & Baccarelli AA.

Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation.

Hum Reprod Update (2016) 22:182-93.

Sercombe L et al.

Advances and challenges of liposome assisted drug delivery.

Front Pharmacol (2015) 6:286.

Mohankumar S & Patel T.

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.

Brief Funct Genomics (2016) 15:249-56.

Silva A, Bullock M & Calin G.

The clinical relevance of long non-coding RNAs in cancer.

Cancers (2015) 7:2169-82.

Monroig-Bosque Pdel C, Rivera CA & Calin GA.

MicroRNAs in cancer therapeutics: "From the bench to the bedside".

Expert Opin Biol Ther (2015) 15:1381-5.

Chira S et al.

Progresses towards safe and efficient gene therapy vectors.

Oncotarget (2015) 6:30675-703.

Quesenberry PJ et al.

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming.

Stem Cell Res Ther (2015) 6:153.

Giza DE, Vasilescu C & Calin GA.

Key principles of miRNA involvement in human diseases.

Discoveries (Craiova) (2014) 2:e34.

Ohtsuka M et al.

MicroRNA processing and human cancer.

J Clin Med (2015) 4:1651-67.

Pua HH & Ansel KM.

MicroRNA regulation of allergic inflammation and asthma.

Curr Opin Immunol (2015) 36:101-8.

Gharpure KM et al.

Nanotechnology: Future of oncotherapy.

Clin Cancer Res (2015) 21:3121-30.

Pichler M & Calin GA.

MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.

Br J Cancer (2015) 113:569-73.

Simpson LJ & Ansel KM.

MicroRNA regulation of lymphocyte tolerance and autoimmunity.

J Clin Invest (2015) 125:2242-9.

Camussi G & Quesenberry PJ.

Perspectives on the potential therapeutic uses of vesicles.

Exosomes Microvesicles (2013) 1:6.

Boettcher M & McManus MT.

Choosing the right tool for the job: RNAi, TALEN, or CRISPR.

Mol Cell (2015) 58:575-85.

Nouraee N, Mowla SJ & Calin GA.

Tracking miRNAs' footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy.

Genes Chromosomes Cancer (2015) 54:335-52.

Saugstad JA.

Non-coding RNAs in stroke and neuroprotection.

Front Neurol (2015) 6:50.

Xiao J et al.

A snapshot of genetic and epigenetic basis of arrhythmia and heart failure.

Front Genet (2015) 6:74.

Gardiner C et al.

Extracellular vesicles, tissue factor, cancer and thrombosis - Discussion themes of the ISEV 2014 Educational Day.

J Extracell Vesicles (2015) 4:26901.

Ciccone M, Calin GA & Perrotti D.

From the biology of PP2A to the PADs for therapy of hematologic malignancies.

Front Oncol (2015) 5:21.

Tewari M.

A functional extracellular transcriptome in animals? Implications for biology, disease and medicine.

Genome Biol (2015) 16:47.

Boukouris S & Mathivanan S.

Exosomes in bodily fluids are a highly stable resource of disease biomarkers.

Proteomics Clin Appl (2015) 9:358-67.

Wei X, Liu X & Rosenzweig A.

What do we know about the cardiac benefits of exercise?

Trends Cardiovasc Med (2015) 25:529-36.

George J & Patel T.

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.

Semin Liver Dis (2015) 35:63-74.

Ling H et al.

Junk DNA and the long non-coding RNA Twist in cancer genetics.

Oncogene (2015) 34:5003-11.

Lotvall J et al.

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles.

J Extracell Vesicles (2014) 3:26913.

Srivastava A et al.

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.

Curr Gene Ther (2015) 15:182-92.

Berindan-Neagoe I & Calin GA.

Molecular pathways: microRNAs, cancer cells, and microenvironment.

Clin Cancer Res (2014) 20:6247-53.

Koupenova M & Freedman JE.

Platelets: the unsung hero of the immune response.

J Thromb Haemost (2015) 13:268-70.

Danielson KM & Das S.

Extracellular vesicles in heart disease: Excitement for the future?

Exosomes Microvesicles (2014) 2:1. Related Pathway

 

Rajendran L et al.

Emerging roles of extracellular vesicles in the nervous system.

J Neurosci (2014) 34:15482-9.

Sato-Kuwabara Y et al.

The fusion of two worlds: Non-coding RNAs and extracellular vesicles--Diagnostic and therapeutic implications.

Int J Oncol (2015) 46:17-27.

Gangoda L et al.

Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

Proteomics (2015) 15:260-71. Related Pathway

 

Kawikova I & Askenase PW.

Diagnostic and therapeutic potentials of exosomes in CNS diseases.

Brain Res (2015) 1617:63-71.

Godlewski J et al.

Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

Neuro Oncol (2015) 17:652-62.

Gyorgy B et al.

Therapeutic applications of extracellular vesicles: Clinical promise and open questions.

Annu Rev Pharmacol Toxicol (2015) 55:439-64.

Braicu C et al.

Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?

Cell Death Differ (2015) 22:34-45.

Quesenberry PJ, Goldberg LR & Dooner MS.

Concise reviews: A stem cell apostasy: a tale of four H words.

Stem Cells (2015) 33:15-20.

Maguire CA et al.

Gene therapy for the nervous system: Challenges and new strategies.

Neurotherapeutics (2014) 11:817-39.

Saleem SN & Abdel-Mageed AB.

Tumor-derived exosomes in oncogenic reprogramming and cancer progression.

Cell Mol Life Sci (2015) 72:1-10.

Berindan-Neagoe I et al.

MicroRNAome genome: a treasure for cancer diagnosis and therapy.

CA Cancer J Clin (2014) 64:311-36.

Davis AN, Afshar-Kharghan V & Sood AK.

Platelet effects on ovarian cancer.

Semin Oncol (2014) 41:378-84.

Thomas MF, L'Etoile ND & Ansel KM.

Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.

Trends Genet (2014) 30:298-307. Related Pathway

 

Wu SY et al.

RNAi therapies: Drugging the undruggable.

Sci Transl Med (2014) 6:240ps7.

Yakob M et al.

Salivary biomarkers for detection of oral squamous cell carcinoma - Current state and recent advances.

Curr Oral Health Rep (2014) 1:133-141.

Redzic JS et al.

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol (2014) 28:14-23.

Quesenberry PJ et al.

Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.

Front Oncol (2014) 4:56.

Freedman JE.

Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease.

Circ Res (2014) 114:1372-3.

Patel T.

Extracellular vesicle noncoding RNA: New players in the diagnosis and pathogenesis of cholangiocarcinoma.

Hepatology (2014) 60:782-4.

Hochberg FH et al.

Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.

Expert Rev Mol Diagn (2014) 14:439-52.

Patel T & Harnois D.

Assessment of response to therapy in hepatocellular carcinoma.

Ann Med (2014) 46:130-7.

Cholerton BA et al.

Evaluation of mild cognitive impairment subtypes in Parkinson's disease.

Mov Disord (2014) 29:756-64.

Vader P, Breakefield XO & Wood MJ.

Extracellular vesicles: Emerging targets for cancer therapy.

Trends Mol Med (2014) 20:385-393.

Quesenberry PJ et al.

Cellular phenotype and extracellular vesicles: Basic and clinical considerations.

Stem Cells Dev (2014) 23:1429-36.

Dalton HJ et al.

Monocyte subpopulations in angiogenesis.

Cancer Res (2014) 74:1287-93.

Pusic AD, Pusic KM & Kraig RP.

What are exosomes and how can they be used in Multiple Sclerosis therapy?

Expert Rev Neurother (2014) 14:353-5.

Morey R & Laurent LC.

Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.

Cell Stem Cell (2014) 14:131-2.

Takahashi K et al.

Long noncoding RNA in liver diseases.

Hepatology (2014) 60:744-53. Related Pathway

 

Clancy L & Freedman JE.

New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.

J Thromb Thrombolysis (2014) 37:12-6.

Aslan B et al.

Nanotechnology in cancer therapy.

J Drug Target (2013) 21:904-13.

Saugstad JA.

MicroRNAs as effectors of brain function.

Stroke (2013) 44:S17-9.

Akers JC et al.

Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.

J Neurooncol (2013) 113:1-11.

Gonda DD et al.

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.

Neurosurgery (2013) 72:501-10.

Lai CP & Breakefield XO.

Role of exosomes/microvesicles in the nervous system and use in emerging therapies.

Front Physiol (2012) 3:228.

Mechanisms

Jun HJ et al.

A PDGFRalpha-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.

Nat Commun (2018) 9:3116.

Silva AM et al.

Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.

Theranostics (2018) 8:3902-3917.

Gharpure KM et al.

FABP4 as a key determinant of metastatic potential of ovarian cancer.

Nat Commun (2018) 9:2923.

Sung BH & Weaver AM.

Directed migration: Cells navigate by extracellular vesicles.

J Cell Biol (2018) 217:2613-2614.

Zhang Q et al.

Mutant KRAS exosomes alter the metabolic state of recipient colonic epithelial cells.

Cell Mol Gastroenterol Hepatol (2018) 5:627-629.e6.

Dragomir M & Calin GA.

Circular RNAs in cancer - Lessons learned from microRNAs.

Front Oncol (2018) 8:179.

Dluzen DF et al.

Extracellular RNA profiles with human age.

Aging Cell AOP 2018-05-24.

Vujic A et al.

Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Nat Commun (2018) 9:1659.

Marangoni F et al.

Tumor tolerance-promoting function of regulatory T cells is optimized by CD28, but strictly dependent on calcineurin.

J Immunol (2018) 200:3647-3661.

Smith AS et al.

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability.

Proc Natl Acad Sci USA (2018) 115:E4377-E4385.

Shah MY et al.

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.

Genome Res (2018) 28:432-447.

Ricklefs FL et al.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Sci Adv (2018) 4:eaar2766.

Wang JH et al.

Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation.

Mol Cancer Ther (2018) 17 :1133-1142.

Shah R et al.

MicroRNAs associated with reverse left ventricular remodeling in humans identify pathways of heart failure progression.

Circ Heart Fail (2018) 11:e004278.

Velazquez-Torres G et al.

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.

Nat Commun (2018) 9:461.

Hulsmans M et al.

Cardiac macrophages promote diastolic dysfunction.

J Exp Med (2018) 215:423-440.

Lankford KL et al.

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.

PLoS ONE (2018) 13:e0190358.

Leung CS et al.

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.

J Clin Invest (2018) 128:589-606.

Noh K et al.

Differential effects of EGFL6 on tumor versus wound angiogenesis.

Cell Rep (2017) 21:2785-2795.

Vannini I et al.

Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.

Nat Commun (2017) 8:1801. Related Pathway

 

Singh PB et al.

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

J Exp Med (2017) 214:3627-3643.

Zheng L et al.

Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.

Nat Commun (2017) 8:1180.

Wei Z et al.

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Nat Commun (2017) 8:1145.

Bhakta NR et al.

IFN-stimulated gene expression, type 2 inflammation, and endoplasmic reticulum stress in asthma.

Am J Respir Crit Care Med (2018) 197:313-324.

Mitamura T et al.

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).

Oncogene (2018) 37:722-731.

Xiao J et al.

miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1.

Exp Mol Med (2017) 49:e386.

Gerstberger S et al.

The conserved RNA exonuclease Rexo5 is required for 3' end maturation of 28S rRNA, 5S rRNA, and snoRNAs.

Cell Rep (2017) 21:758-772.

Willinger CM et al.

MicroRNA signature of cigarette smoking and evidence for a putative causal role of microRNAs in smoking-related inflammation and target organ damage.

Circ Cardiovasc Genet (2017) 10:5.

Grinberg YY, Zitzow LA & Kraig RP.

Intranasally administered IGF-1 inhibits spreading depression in vivo.

Brain Res (2017) 1677:47-57.

Shen P et al.

To Wnt or lose: The missing non-coding linc in colorectal cancer.

Int J Mol Sci (2017) 18:9. Related Pathway

 

Nguyen TA et al.

SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition.

Immunity (2017) 47:498-509.e6.

Shah R et al.

Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: Brief report.

Am J Physiol Heart Circ Physiol (2017) 313:H1162-H1167.

Rodriguez-Aguayo C et al.

Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer.

Cell Discov (2017) 3:17029.

Dalton HJ et al.

Macrophages facilitate resistance to anti-VEGF therapy by altered VEGFR expression.

Clin Cancer Res (2017) 23:7034-7046.

Figueroa J et al.

Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587.

Cancer Res (2017) 77:5808-5819.

Datta A et al.

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.

Cancer Lett (2017) 408:73-81. Related Pathway

 

Gogakos T et al.

Characterizing expression and processing of precursor and mature human tRNAs by hydro-tRNAseq and PAR-CLIP.

Cell Rep (2017) 20:1463-1475.

Sarkar S et al.

PRKCI promotes immune suppression in ovarian cancer.

Genes Dev (2017) 31:1109-1121.

Montoya MM et al.

A distinct inhibitory function for miR-18a in Th17 cell differentiation.

J Immunol (2017) 199:559-569.

Farmer DT et al.

Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.

Development (2017) 144:2517-2528.

Li J et al.

miR-29b contributes to multiple types of muscle atrophy.

Nat Commun (2017) 8:15201.

Bei Y et al.

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.

Basic Res Cardiol (2017) 112:38.

Farmer DT et al.

miR-205 is a critical regulator of lacrimal gland development.

Dev Biol (2017) 427:12-20.

Silva AM et al.

Dendritic cell-derived extracellular vesicles mediate mesenchymal stem/stromal cell recruitment.

Sci Rep (2017) 7:1667.

Bruno S et al.

Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells.

Tissue Eng Part A (2017) 23:1262-1273.

Klingenberg M et al.

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

J Hepatol (2017) 67:603-618. Related Pathways: 1, 2

 

Rashed MH et al.

Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.

Oncotarget (2017) 8:20145-20164.

Rabinowicz N et al.

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.

Oncotarget (2017) 8:27380-27392.

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.

Liver Transpl (2017) 23:791-803.

Clancy L et al.

The role of RNA uptake in platelet heterogeneity.

Thromb Haemost (2017) 117:948-961.

Deng Z et al.

Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.

Mol Ther (2017) 25:1641-1654.

He Y et al.

A systematic study of dysregulated microRNA in Type 2 Diabetes Mellitus.

Int J Mol Sci (2017) 18:3.

Shi J et al.

miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury.

Theranostics (2017) 7:664-676.

Yeo AT & Charest A.

Immune checkpoint blockade biology in mouse models of glioblastoma.

J Cell Biochem (2017) 118:2516-2527.

Anderton B et al.

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

EMBO Rep (2017) 18:569-585.

Teng Y et al.

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Nat Commun (2017) 8:14448.

Shah R et al.

Extracellular RNAs are associated with insulin resistance and metabolic phenotypes.

Diabetes Care (2017) 40:546-553.

Collino F et al.

Exosome and microvesicle-enriched fractions isolated from mesenchymal stem cells by gradient separation showed different molecular signatures and functions on renal tubular epithelial cells.

Stem Cell Rev (2017) 13:226-243.

Krzeszinski JY et al.

Lipid osteoclastokines regulate breast cancer bone metastasis.

Endocrinology (2017) 158:477-489.

Van Roosbroeck K et al.

Combining anti-miR-155 with chemotherapy for the treatment of lung cancers.

Clin Cancer Res (2017) 23:2891-2904.

Katsiougiannis S et al.

Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity.

FASEB J (2017) 31:998-1010.

Dou Y et al.

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Sci Rep (2016) 6:37982.

Haraszti RA et al.

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

J Extracell Vesicles (2016) 5:32570.

Hatakeyama H et al.

Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers.

Cell Rep (2016) 17:1621-1631.

Ohtsuka M et al.

H19 noncoding RNA, an independent prognostic factor, regulates essential Rb-E2F and CDK8-beta-catenin signaling in colorectal cancer.

EBioMedicine (2016) 13:113-124.

Kanlikilicer P et al.

Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells.

Cancer Res (2016) 76:7194-7207.

Giza DE et al.

Cellular and viral microRNAs in sepsis: Mechanisms of action and clinical applications.

Cell Death Differ (2016) 23:1906-1918. Related Pathway

 

Tao L et al.

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Am J Cardiol (2015) 116:622-9.

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Front Genet (2015) 6:175.

Melman YF et al.

Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: a translational pilot study.

Circulation (2015) 131:2202-16.

Wong HK et al.

The Cancer Genome Atlas analysis predicts microRNA for targeting cancer growth and vascularization in glioblastoma.

Mol Ther (2015) 23:1234-47. Related Pathway

 

Akers JC et al.

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J Neurooncol (2015) 123:205-16.

Majem B et al.

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Gut (2016) 65:977-989.

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JACC Cardiovasc Imaging (2015) 8:414-423.

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Mol Cancer Res (2015) 13:891-901.

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Proteomics Clin Appl (2015) 9:358-67.

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Arterioscler Thromb Vasc Biol (2015) 35:1030-7.

Chiang SH et al.

RNAPro*SAL: a device for rapid and standardized collection of saliva RNA and proteins.

Biotechniques (2015) 58:69-76.

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Br Dent J (2014) 217:567-73.

Bahn JH et al.

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Clin Chem (2015) 61:221-30.

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Int J Oncol (2015) 46:17-27.

Haga H & Patel T.

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J Hepatobiliary Pancreat Sci (2015) 22:114-23.

Mata IF et al.

APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.

JAMA Neurol (2014) 71:1405-12.

Akat KM et al.

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

Proc Natl Acad Sci U S A (2014) 111:11151-6.

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Mol Syst Biol (2014) 10:728. Related Pathway

 

Tucker SL et al.

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Clin Cancer Res (2014) 20:3280-8.

Patel T.

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Hepatology (2014) 60:782-4.

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Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.

Expert Rev Mol Diagn (2014) 14:439-52.

Ben-Dov IZ et al.

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: Description of miRNA profiles at baseline.

PLoS ONE (2014) 9:e86856.

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Heart Rhythm (2014) 11:663-9.

Ngamruengphong S & Patel T.

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Yao C et al.

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Hum Mol Genet (2014) 23:1947-56.

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MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development.

PLoS ONE (2013) 8:e78115.

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J Biol Chem (2013) 288:26888-97.

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Therapies

Jun HJ et al.

A PDGFRalpha-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.

Nat Commun (2018) 9:3116.

Gyorgy B et al.

CRISPR/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer's disease.

Mol Ther Nucleic Acids (2018) 11:429-440.

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Mol Ther (2018) 26:1520-1528.

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A novel implementation of magnetic levitation to quantify leukocyte size, morphology, and magnetic properties to identify patients with sepsis.

Shock AOP 2018-03-20.

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Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Sci Adv (2018) 4:eaar2766.

Wang JH et al.

Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation.

Mol Cancer Ther (2018) 17 :1133-1142.

Lankford KL et al.

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.

PLoS ONE (2018) 13:e0190358.

Leung CS et al.

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J Clin Invest (2018) 128:589-606.

Kanlikilicer P et al.

Therapeutic targeting of AXL receptor tyrosine kinase inhibits tumor growth and intraperitoneal metastasis in ovarian cancer models.

Mol Ther Nucleic Acids (2017) 9:251-262.

Boussiotis VA & Charest A.

Immunotherapies for malignant glioma.

Oncogene (2018) 37:1121-1141.

Chen X et al.

RNA interference-based therapy and its delivery systems.

Cancer Metastasis Rev (2018) 37:107-124.

Pi F et al.

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Nat Nanotechnol (2018) 13:82-89.

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Cell Rep (2017) 21:2785-2795.

Bei Y et al.

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Singh PB et al.

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

J Exp Med (2017) 214:3627-3643.

Mitamura T et al.

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Oncogene (2018) 37:722-731.

Piao X et al.

Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2'-F RNA, and LNA in the context of Phi29 pRNA 3WJ.

RNA (2018) 24:67-76.

Xiao J et al.

miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1.

Exp Mol Med (2017) 49:e386.

Grinberg YY, Zitzow LA & Kraig RP.

Intranasally administered IGF-1 inhibits spreading depression in vivo.

Brain Res (2017) 1677:47-57.

Rodriguez-Aguayo C et al.

Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer.

Cell Discov (2017) 3:17029.

Shankar GM et al.

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Expert Rev Mol Diagn (2017) 17:943-947.

Dalton HJ et al.

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Clin Cancer Res (2017) 23:7034-7046.

Datta A et al.

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.

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Fleming ND et al.

Phase II trial of bevacizumab with dose-dense paclitaxel as first-line treatment in patients with advanced ovarian cancer.

Gynecol Oncol (2017) 147:41-46.

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Bei Y et al.

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Basic Res Cardiol (2017) 112:38.

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Bruno S et al.

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Tissue Eng Part A (2017) 23:1262-1273.

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Synthesis and evaluation of parenchymal retention and efficacy of a metabolically stable O-phosphocholine-N-docosahexaenoyl-l-serine siRNA conjugate in mouse brain.

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Detection of wtEGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients.

Neuro Oncol (2017) 19:1494-1502.

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Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

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Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.

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Roh J, Houstis N & Rosenzweig A.

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Circ Res (2017) 120:1243-1245.

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.

Liver Transpl (2017) 23:791-803.

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Pharm Res (2017) 34:1053-1066.

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Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.

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A systematic study of dysregulated microRNA in Type 2 Diabetes Mellitus.

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Preclinical mammalian safety studies of EPHARNA (DOPC nanoliposomal EphA2-targeted siRNA).

Mol Cancer Ther (2017) 16:1114-1123.

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miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury.

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The chemical evolution of oligonucleotide therapies of clinical utility.

Nat Biotechnol (2017) 35:238-248.

Yeo AT & Charest A.

Immune checkpoint blockade biology in mouse models of glioblastoma.

J Cell Biochem (2017) 118:2516-2527.

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells improve survival from lethal hepatic failure in mice.

Stem Cells Transl Med (2017) 6:1262-1272.

Heydari B, Harris WS & Kwong RY.

Response by Heydari et al to letter regarding article, "Effect of omega-3 acid ethyl esters on left ventricular remodeling after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial".

Circulation (2017) 135:e13-e14.

Collino F et al.

Exosome and microvesicle-enriched fractions isolated from mesenchymal stem cells by gradient separation showed different molecular signatures and functions on renal tubular epithelial cells.

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Krzeszinski JY et al.

Lipid osteoclastokines regulate breast cancer bone metastasis.

Endocrinology (2017) 158:477-489.

Srivastava A et al.

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells.

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Combining anti-miR-155 with chemotherapy for the treatment of lung cancers.

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RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery.

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Hatakeyama H et al.

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Cell Rep (2016) 17:1621-1631.

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H19 noncoding RNA, an independent prognostic factor, regulates essential Rb-E2F and CDK8-beta-catenin signaling in colorectal cancer.

EBioMedicine (2016) 13:113-124.

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Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy.

JCI Insight (2016) 1:e87754.

Kanlikilicer P et al.

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Cancer Res (2016) 76:7194-7207.

Soni A et al.

High burden of unrecognized atrial fibrillation in rural india: An innovative community-based cross-sectional screening program.

JMIR Public Health Surveill (2016) 2:e159.

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Tao L et al.

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Zhou J et al.

A novel compound ARN-3236 inhibits salt-inducible kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel.

Clin Cancer Res (2017) 23:1945-1954.

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Mol Cancer Ther (2016) 15:2894-2904.

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Oncogene (2017) 36:912-921.

Sardana M et al.

Association of left atrial function index with late atrial fibrillation recurrence after catheter ablation.

J Cardiovasc Electrophysiol (2016) 27:1411-1419.

Didiot MC et al.

Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing.

Mol Ther (2016) 24:1836-1847.

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Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche.

Cancer Cell (2016) 30:273-289.

Wang JH et al.

Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.

BMC Cancer (2016) 16:524.

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J Appl Toxicol (2017) 37:310-318.

Bezzerides VJ et al.

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.

JCI Insight (2016) 1:9.

Parasramka MA & Patel T.

Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities.

Stem Cell Investig (2016) 3:1.

Deng Z et al.

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis.

Oncogene (2017) 36:639-651.

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J Biomed Nanotechnol (2016) 12:1159-73.

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Extracellular vesicle-mediated reversal of paclitaxel resistance in prostate cancer.

Crit Rev Oncog (2015) 20:407-17.

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Atrial fibrillation is associated with a worse 90-day outcome than other cardioembolic stroke subtypes.

Stroke (2016) 47:1486-92.

Chaluvally-Raghavan P et al.

Direct upregulation of STAT3 by microRNA-551b-3p deregulates growth and metastasis of ovarian cancer.

Cell Rep (2016) 15:1493-504.

Wen S et al.

Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.

Leukemia (2016) 30:2221-2231.

Rosas LE et al.

In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes.

J Immunotoxicol (2016) 13:652-65.

Haemmerle M et al.

FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.

J Clin Invest (2016) 126:1885-96.

Ciccone M & Calin GA.

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Curr Genomics (2015) 16:336-48.

Wu SY et al.

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

Nat Commun (2016) 7:11169.

Van Roosbroeck K & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?

Semin Oncol (2016) 43:209-14.

Pan Y et al.

miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.

Oncotarget (2016) 7:25930-48.

Teng Y et al.

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.

Oncotarget (2016) 7:25683-97.

Hall J et al.

Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson's disease, glioma, and schwannoma.

Cell Mol Neurobiol (2016) 36:417-27.

Parasramka MA et al.

Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.

Pharmacol Ther (2016) 161:67-78. Related Pathway

 

Huang J et al.

Dll4 inhibition plus aflibercept markedly reduces ovarian tumor growth.

Mol Cancer Ther (2016) 15:1344-52.

Pusic KM, Pusic AD & Kraig RP.

Environmental enrichment stimulates immune cell secretion of exosomes that promote CNS myelination and may regulate inflammation.

Cell Mol Neurobiol (2016) 36:313-325.

Almeida MI & Calin GA.

The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.

Genome Med (2016) 8:29.

Rytelewski M et al.

Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.

Oncotarget (2016) 7:20825-39.

Rupaimoole R et al.

miRNA deregulation in cancer cells and the tumor microenvironment.

Cancer Discov (2016) 6:235-46.

Melman YF et al.

Response to letter regarding article, "Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study"

Circulation (2016) 133:e389-90.

Hansen JM, Coleman RL & Sood AK.

Targeting the tumour microenvironment in ovarian cancer.

Eur J Cancer (2016) 56:131-43.

Mitamura T, Gourley C & Sood AK.

Prediction and failure of anti-angiogenesis escape.

Gynecol Oncol (2016) 141:80-5.

Lener T et al.

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J Extracell Vesicles (2015) 4:30087.

Sercombe L et al.

Advances and challenges of liposome assisted drug delivery.

Front Pharmacol (2015) 6:286.

Alterman JF et al.

Hydrophobically modified siRNAs silence Huntingtin mRNA in primary neurons and mouse brain.

Mol Ther Nucleic Acids (2015) 4:e266.

Zhuang X et al.

Ginger-derived nanoparticles protect against alcohol-induced liver damage.

J Extracell Vesicles (2015) 4:28713.

Kalani MY et al.

Rare variants in cardiomyopathy genes associated with stress-induced cardiomyopathy.

Neurosurgery (2016) 78:835-43.

Previs RA et al.

Dual metronomic chemotherapy with nab-paclitaxel and topotecan has potent antiangiogenic activity in ovarian cancer.

Mol Cancer Ther (2015) 14:2677-86.

Pradeep S et al.

Erythropoietin stimulates tumor growth via EphB4.

Cancer Cell (2015) 28:610-22.

Zhuang X et al.

Grapefruit-derived nanovectors delivering therapeutic mir17 through an intranasal route inhibit brain tumor progression.

Mol Ther (2016) 24:96-105.

Monroig-Bosque Pdel C, Rivera CA & Calin GA.

MicroRNAs in cancer therapeutics: "From the bench to the bedside".

Expert Opin Biol Ther (2015) 15:1381-5.

Chira S et al.

Progresses towards safe and efficient gene therapy vectors.

Oncotarget (2015) 6:30675-703.

Quesenberry PJ et al.

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27575.

Reyes-Gonzalez JM et al.

Targeting c-MYC in platinum-resistant ovarian cancer.

Mol Cancer Ther (2015) 14:2260-9.

Pusic AD & Kraig RP.

Phasic treatment with Interferon gamma stimulates release of exosomes that protect against spreading depression.

J Interferon Cytokine Res (2015) 35:795-807.

Aslan B et al.

The ZNF304-integrin axis protects against anoikis in cancer.

Nat Commun (2015) 6:7351.

Camussi G & Quesenberry PJ.

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Exosomes Microvesicles (2013) 1:6.

Wang Q et al.

Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites.

Cancer Res (2015) 75:2520-9.

Thanapprapa D Sr et al.

PTEN expression as a predictor of response to focal adhesion kinase inhibition in uterine cancer.

Mol Cancer Ther (2015) 14:1466-1475.

Saugstad JA.

Non-coding RNAs in stroke and neuroprotection.

Front Neurol (2015) 6:50.

Simonson B & Das S.

MicroRNA therapeutics: the next magic bullet?

Mini Rev Med Chem (2015) 15:467-74.

Ciccone M, Calin GA & Perrotti D.

From the biology of PP2A to the PADs for therapy of hematologic malignancies.

Front Oncol (2015) 5:21.

Nick AM et al.

A framework for a personalized surgical approach to ovarian cancer.

Nat Rev Clin Oncol (2015) 12:239-45.

Ozcan G et al.

Preclinical and clinical development of siRNA-based therapeutics.

Adv Drug Deliv Rev (2015) 87:108-19.

George J & Patel T.

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.

Semin Liver Dis (2015) 35:63-74.

Gonzalez-Villasana V et al.

Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer.

Clin Cancer Res (2015) 21:2127-37. Related Pathway

 

Choi HJ et al.

Anti-vascular therapies in ovarian cancer: Moving beyond anti-VEGF approaches.

Cancer Metastasis Rev (2015) 34:19-40.

Bodhankar S et al.

Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells.

Metab Brain Dis (2015) 30:911-924.

Pusic AD et al.

Spreading depression transiently disrupts myelin via interferon-gamma signaling.

Exp Neurol (2015) 264:43-54.

Yang X et al.

New ways to successfully target tumor vasculature in ovarian cancer.

Curr Opin Obstet Gynecol (2015) 27:58-65.

Bottsford-Miller J et al.

Differential platelet levels affect response to taxane-based therapy in ovarian cancer.

Clin Cancer Res (2015) 21:602-10.

Bhattacharya S et al.

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.

PLoS ONE (2014) 9:e114409.

Wen Y et al.

Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer.

Clin Cancer Res (2015) 21:448-59.

Previs RA et al.

Molecular pathways: Translational and therapeutic implications of the Notch signaling pathway in cancer.

Clin Cancer Res (2015) 21:955-61.

Sato-Kuwabara Y et al.

The fusion of two worlds: Non-coding RNAs and extracellular vesicles--Diagnostic and therapeutic implications.

Int J Oncol (2015) 46:17-27.

Leung CS et al.

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.

Nat Commun (2014) 5:5092. Related Pathway

 

del C. Monroig P et al.

Small molecule compounds targeting miRNAs for cancer therapy.

Adv Drug Deliv Rev (2015) 81:104-16.

Gonzalez-Villasana V et al.

Bisphosphonates inhibit stellate cell activity and enhance antitumor effects of nanoparticle albumin-bound paclitaxel in pancreatic ductal adenocarcinoma.

Mol Cancer Ther (2014) 13:2583-94.

Wu SY et al.

RNAi therapies: Drugging the undruggable.

Sci Transl Med (2014) 6:240ps7.

Gharpure KM et al.

Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer.

Mol Cancer Ther (2014) 13:1750-7.

Patel T & Harnois D.

Assessment of response to therapy in hepatocellular carcinoma.

Ann Med (2014) 46:130-7.

Zhang H et al.

Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.

Breast Cancer Res (2014) 16:R36.

Vader P, Breakefield XO & Wood MJ.

Extracellular vesicles: Emerging targets for cancer therapy.

Trends Mol Med (2014) 20:385-393.

Jiang H et al.

Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model.

Am J Pathol (2014) 184:1355-68.

Wu SY et al.

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

Nat Commun (2014) 5:3459.

Pusic AD, Pusic KM & Kraig RP.

What are exosomes and how can they be used in Multiple Sclerosis therapy?

Expert Rev Neurother (2014) 14:353-5.

Ozpolat B, Sood AK & Lopez-Berestein G.

Liposomal siRNA nanocarriers for cancer therapy.

Adv Drug Deliv Rev (2014) 66:110-6. Related Pathway

 

Pusic AD & Kraig RP.

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination.

Glia (2014) 62:284-99.

Pusic AD et al.

IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.

J Neuroimmunol (2014) 266:12-23.

Jun HJ, Bronson RT & Charest A.

Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.

Stem Cells (2014) 32:338-48.

Pecot CV et al.

Tumour angiogenesis regulation by the miR-200 family.

Nat Commun (2013) 4:2427.

Nishimura M et al.

Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment.

Cancer Discov (2013) 3:1302-15.

Wang Q et al.

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Nat Commun (2013) 4:1867.

Methods

Giraldez MD et al.

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Nat Biotechnol (2018) 36:746-757.

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Immune cell profiling in cancer: Molecular approaches to cell-specific identification.

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Gyorgy B et al.

CRISPR/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer's disease.

Mol Ther Nucleic Acids (2018) 11:429-440.

Max KEA et al.

Human plasma and serum extracellular small RNA reference profiles and their clinical utility.

Proc Natl Acad Sci USA (2018) 115 :E5334-E5343.

Heintz-Buschart A et al.

Small RNA profiling of low biomass samples: Identification and removal of contaminants.

BMC Biol (2018) 16:52.

Yeri A et al.

Evaluation of commercially available small RNASeq library preparation kits using low input RNA.

BMC Genomics (2018) 19:331.

Andersen MS et al.

A novel implementation of magnetic levitation to quantify leukocyte size, morphology, and magnetic properties to identify patients with sepsis.

Shock AOP 2018-03-20.

Wei S, Weiss ZR & Williams Z.

Rapid multiplex small DNA sequencing on the MinION Nanopore sequencing platform.

G3 (Bethesda) (2018) 8:1649-1657.

Fallen S et al.

Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour.

J Cell Mol Med (2018) 22:2760-2773.

Wang JH et al.

Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation.

Mol Cancer Ther (2018) 17 :1133-1142.

Shah R et al.

MicroRNAs associated with reverse left ventricular remodeling in humans identify pathways of heart failure progression.

Circ Heart Fail (2018) 11:e004278.

Li K et al.

Isolation of plasma lipoproteins as a source of extracellular RNA.

Methods Mol Biol (2018) 1740:139-153.

Etheridge A et al & .

Preparation of small RNA NGS libraries from biofluids.

Methods Mol Biol (2018) 1740:163-175.

Shao H et al.

New technologies for analysis of extracellular vesicles.

Chem Rev (2018) 118:1917-1950.

Reategui E et al.

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Nat Commun (2018) 9:175.

Soni A et al.

Study protocol for Smartphone Monitoring for Atrial fibrillation in Real-Time in India (SMART-India): a community-based screening and referral programme.

BMJ Open (2017) 7:e017668.

Pi F et al.

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression.

Nat Nanotechnol (2018) 13:82-89.

Amorim MG et al.

A total transcriptome profiling method for plasma-derived extracellular vesicles: Applications for liquid biopsies.

Sci Rep (2017) 7:14395.

Wei Z et al.

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Nat Commun (2017) 8:1145.

Wu X et al.

sRNAnalyzer: a flexible and customizable small RNA sequencing data analysis pipeline.

Nucleic Acids Res (2017) 45:12140-12151.

Piao X et al.

Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2'-F RNA, and LNA in the context of Phi29 pRNA 3WJ.

RNA (2018) 24:67-76.

Alterman JF et al.

A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics.

Bio Protoc (2017) 7:16.

Kaczor-Urbanowicz KE et al.

Novel approaches for bioinformatic analysis of salivary RNA sequencing data for development.

Bioinformatics (2018) 34:1-8.

Shah R et al.

Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: Brief report.

Am J Physiol Heart Circ Physiol (2017) 313:H1162-H1167.

Haraszti RA et al.

Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system.

Bio Protoc (2017) 7:20.

Wu AY & Lai CP.

Tracking extracellular vesicles delivery and RNA translation using multiplexed reporters.

Methods Mol Biol (2017) 1660:255-265.

Gogakos T et al.

Characterizing expression and processing of precursor and mature human tRNAs by hydro-tRNAseq and PAR-CLIP.

Cell Rep (2017) 20:1463-1475.

Saugstad JA et al.

Analysis of extracellular RNA in cerebrospinal fluid.

J Extracell Vesicles (2017) 6:1317577.

Fuentes-Mattei E et al.

Plasma viral miRNAs indicate a high prevalence of occult viral infections.

EBioMedicine (2017) 20:182-192.

Nikan M et al.

Synthesis and evaluation of parenchymal retention and efficacy of a metabolically stable O-phosphocholine-N-docosahexaenoyl-l-serine siRNA conjugate in mouse brain.

Bioconjug Chem (2017) 28:1758-1766.

Montoya MM & Ansel KM.

Small RNA transfection in primary human Th17 cells by next generation electroporation.

J Vis Exp AOP 2017-04-13.

Roh J, Houstis N & Rosenzweig A.

Why don't we have proven treatments for HFpEF?

Circ Res (2017) 120:1243-1245.

Putman TE et al.

WikiGenomes: an open web application for community consumption and curation of gene annotation data in Wikidata.

Database (Oxford) (2017) 2017:1.

Soni A et al.

RAHI-SATHI Indo-U.S. collaboration: The evolution of a trainee-led twinning model in global health into a multidisciplinary collaborative program.

Glob Health Sci Pract (2017) 5:152-163.

Mateescu B et al.

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper.

J Extracell Vesicles (2017) 6:1286095.

Nolan JP & Jones JC.

Detection of platelet vesicles by flow cytometry.

Platelets (2017) 28:256-262.

Grossman RL et al.

Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.

Clin Pharmacol Ther (2017) 101:589-592.

Gladek I et al.

HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies.

Genes Chromosomes Cancer (2017) 56:439-452.

Modi A et al.

Validation of two point-of-care tests against standard lab measures of NO in saliva and in serum.

Nitric Oxide (2017) 64:16-21.

Ong WQ et al.

Live cell imaging of endogenous mRNA using RNA-based fluorescence "Turn-On" probe.

ACS Chem Biol (2017) 12:200-205.

Danielson KM et al.

High throughput sequencing of extracellular RNA from human plasma.

PLoS ONE (2017) 12:e0164644.

Lee I et al.

The importance of standardization on analyzing circulating RNA.

Mol Diagn Ther (2017) 21:259-268.

Baldwin S et al.

Analyzing the miRNA content of extracellular vesicles by fluorescence nanoparticle tracking.

Nanomedicine (2017) 13:765-770.

Majem B et al.

RNA sequencing analysis of salivary extracellular RNA.

Methods Mol Biol (2017) 1537:17-36.

Kaczor-Urbanowicz KE et al.

Saliva diagnostics - Current views and directions.

Exp Biol Med (Maywood) (2017) 242:459-472.

Pi F et al.

RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery.

Nanomedicine (2017) 13:1183-1193.

Kaczor-Urbanowicz KE et al.

Emerging technologies for salivaomics in cancer detection.

J Cell Mol Med (2017) 21:640-647.

Previs RA et al.

The rise of genomic profiling in ovarian cancer.

Expert Rev Mol Diagn (2016) 16:1337-1351.

Didiot MC et al.

Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing.

Mol Ther (2016) 24:1836-1847.

Wei Z et al.

Fetal bovine serum RNA interferes with the cell culture derived extracellular RNA.

Sci Rep (2016) 6:31175.

Walkey AJ et al.

Practice patterns and outcomes associated with use of anticoagulation among patients with atrial fibrillation during sepsis.

JAMA Cardiol (2016) 1:682-90.

Wang JH et al.

Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.

BMC Cancer (2016) 16:524.

Maji S et al.

In vitro toxicology studies of extracellular vesicles.

J Appl Toxicol (2017) 37:310-318.

Higginbotham JN et al.

Identification and characterization of EGF receptor in individual exosomes by Fluorescence-Activated Vesicle Sorting.

J Extracell Vesicles (2016) 5:29254.

Freedman JE et al.

Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma.

Nat Commun (2016) 7:11902.

Freedman JE et al.

Diverse human extracellular RNAs are widely detected in human plasma.

Nat Commun (2016) 7:11106.

Cheung KH et al.

Extending gene ontology in the context of extracellular RNA and vesicle communication.

J Biomed Semantics (2016) 7:19.

Clarke D et al.

Identifying allosteric hotspots with dynamics: Application to inter- and intra-species conservation.

Structure (2016) 24:826-37.

Akers JC et al.

Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid.

Cancer Biomark (2016) 17:125-32.

Yan KK et al.

Cross-disciplinary network comparison: Matchmaking between hairballs.

Cell Syst (2016) 2:147-157.

Putman TE et al.

Centralizing content and distributing labor: a community model for curating the very long tail of microbial genomes.

Database (Oxford) (2016) 2016:baw028.

Burgstaller-Muehlbacher S et al.

Wikidata as a semantic framework for the Gene Wiki initiative.

Database (Oxford) (2016) 2016:baw015.

Tanriverdi K et al.

Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative Polymerase Chain Reaction.

Anal Biochem (2016) 501:66-74.

Zaborowski MP et al.

Extracellular vesicles: Composition, biological relevance, and methods of study.

Bioscience (2015) 65:783-797.

Xiao H et al.

Differential proteomic analysis of human saliva using Tandem Mass Tags quantification for gastric cancer detection.

Sci Rep (2016) 6:22165.

Akers JC et al.

Comparative analysis of technologies for quantifying extracellular vesicles (EVs) in clinical cerebrospinal fluids (CSF).

PLoS ONE (2016) 11:e0149866.

Mora-Castilla S et al.

Miniaturization technologies for efficient single-cell library preparation for next-generation sequencing.

J Lab Autom (2016) 21:557-67.

Harmanci A & Gerstein M.

Quantification of private information leakage from phenotype-genotype data: linking attacks.

Nat Methods (2016) 13:251-6.

Yuan T et al.

Plasma extracellular RNA profiles in healthy and cancer patients.

Sci Rep (2016) 6:19413.

Danielson KM et al.

Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry.

PLoS ONE (2016) 11:e0144678.

Chen B et al.

Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci.

Nucleic Acids Res (2016) 44:e75.

Lener T et al.

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

J Extracell Vesicles (2015) 4:30087.

Hatakeyama H et al.

Assessment of in vivo siRNA delivery in cancer mouse models.

Methods Mol Biol (2016) 1402:189-97.

McManus DD et al.

Reliability of predicting early hospital readmission after discharge for an acute coronary syndrome using claims-based data.

Am J Cardiol (2016) 117:501-7.

Coles AH et al.

A high-throughput method for direct detection of therapeutic oligonucleotide-induced gene silencing in vivo.

Nucleic Acid Ther (2016) 26:86-92.

Bucur O et al.

An updated h-index measures both the primary and total scientific output of a researcher.

Discoveries (2015) 3:3.

Wei S & Williams Z.

Rapid short-read sequencing and aneuploidy detection using MinION nanopore technology.

Genetics (2016) 202:37-44.

Keerthikumar S et al.

ExoCarta: A web-based compendium of exosomal cargo.

J Mol Biol (2016) 428:688-692.

Schwarzenbach H et al.

Data normalization strategies for microRNA quantification.

Clin Chem (2015) 61:1333-42.

Subramanian SL et al.

Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies.

J Extracell Vesicles (2015) 4:27497.

Laurent LC et al.

Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:26533.

Ong WQ et al.

Heavy water: a simple solution to increasing the brightness of fluorescent proteins in super-resolution imaging.

Chem Commun (Camb) (2015) 51:13451-3.

Gharpure KM et al.

Nanotechnology: Future of oncotherapy.

Clin Cancer Res (2015) 21:3121-30.

Kwong RY et al.

Characterization of cardiac amyloidosis by atrial late gadolinium enhancement using contrast-enhanced cardiac Magnetic Resonance Imaging and correlation with left atrial conduit and contractile function.

Am J Cardiol (2015) 116:622-9.

Szabo L et al.

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.

Genome Biol (2015) 16:126.

Boettcher M & McManus MT.

Choosing the right tool for the job: RNAi, TALEN, or CRISPR.

Mol Cell (2015) 58:575-85.

Lai CP et al.

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.

Nat Commun (2015) 6:7029.

Shao H et al.

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Nat Commun (2015) 6:6999.

Li X et al.

Lowering the quantification limit of the QubitTM RNA HS assay using RNA spike-in.

BMC Mol Biol (2015) 16:9.

Neilan TG et al.

Late gadolinium enhancement among survivors of sudden cardiac arrest.

JACC Cardiovasc Imaging (2015) 8:414-423.

Nick AM et al.

A framework for a personalized surgical approach to ovarian cancer.

Nat Rev Clin Oncol (2015) 12:239-45.

Kim DK et al.

EVpedia: a community web portal for extracellular vesicles research.

Bioinformatics (2015) 31:933-9.

Takahashi K et al.

Analysis of extracellular RNA by digital PCR.

Front Oncol (2014) 4:129.

Nery FC et al.

Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia.

J Neurosci Methods (2014) 232:181-8.

Grange C et al.

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging.

Int J Mol Med (2014) 33:1055-63.

Lai CP et al.

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

ACS Nano (2014) 8:483-94.

Chen WW et al.

BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles.

Mol Ther Nucleic Acids (2013) 2:e109.

Protocols

Giraldez MD et al.

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Nat Biotechnol (2018) 36:746-757.

Max KEA et al.

Human plasma and serum extracellular small RNA reference profiles and their clinical utility.

Proc Natl Acad Sci USA (2018) 115 :E5334-E5343.

Fallen S et al.

Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour.

J Cell Mol Med (2018) 22:2760-2773.

Etheridge A et al & .

Preparation of small RNA NGS libraries from biofluids.

Methods Mol Biol (2018) 1740:163-175.

Reategui E et al.

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Nat Commun (2018) 9:175.

Amorim MG et al.

A total transcriptome profiling method for plasma-derived extracellular vesicles: Applications for liquid biopsies.

Sci Rep (2017) 7:14395.

Wei Z et al.

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Nat Commun (2017) 8:1145.

Alterman JF et al.

A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics.

Bio Protoc (2017) 7:16.

Kaczor-Urbanowicz KE et al.

Novel approaches for bioinformatic analysis of salivary RNA sequencing data for development.

Bioinformatics (2018) 34:1-8.

Haraszti RA et al.

Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system.

Bio Protoc (2017) 7:20.

Montoya MM & Ansel KM.

Small RNA transfection in primary human Th17 cells by next generation electroporation.

J Vis Exp AOP 2017-04-13.

Danielson KM et al.

High throughput sequencing of extracellular RNA from human plasma.

PLoS ONE (2017) 12:e0164644.

Majem B et al.

RNA sequencing analysis of salivary extracellular RNA.

Methods Mol Biol (2017) 1537:17-36.

pre-ERCC Bibliography

Papers Related to exRNA

This is not a comprehensive list, but a snapshot to serve as a guide to the published literature.  There are several other relevant published studies.   Inclusion in this list, or omission from this list of any published work does not indicate impact or significance.

Categories

  • Reviews

  • Observations/Biomarkers

  • Mechanisms & Models

  • Methods/Protocols

Reviews

Cocucci, E., Racchetti, G. & Meldolesi, J. Shedding microvesicles: artefacts no more. Trends Cell Biol 19, 43-51, doi:10.1016/J.Tcb.2008.11.003 (2009).

Etheridge, A., Gomes, Clarissa P. C., Pereira, R.W., Galas, D.J., & Wang, K. 2013. The complexity, function, and applications of RNA in circulation. Front. Genet., doi: 10.3389/fgene.2013.00115.

Fabian, M. R., Sonenberg, N. & Filipowicz, W. 2010. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem, 79, 351-79.

Gerdes, H. H. & Carvalho, R.N. 2008. Intercellular transfer mediated by tunneling nanotubes. Curr Opin Cell Biol, 20, 470-5.

Kulp, A., & Kuehn, M.J. 2010. Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles. Annual Review of Microbiology, 64(1), 163–184.

Lo, Y. M. & Chiu, R.W. 2012. Genomic analysis of fetal nucleic acids in maternal blood. Annu Rev Genomics Hum Genet, 13, 285-306.

Lotvall, J. & Valadi, H. 2007. Cell to cell signalling via exosomes through esRNA. Cell Adh Migr, 1, 156-8.

Mause, S. F. & Weber, C. Microparticles: Protagonists of a Novel Communication Network for Intercellular Information Exchange. Circ Res 107, 1047-1057, doi:10.1161/Circresaha.110.226456 (2010).

Repoila, F., & Darfeuille, F. 2009. Small regulatory non-coding RNAs in bacteria: physiology and mechanistic aspects. Biology of the Cell, 101(2), 117–131.

Shifrin, D.A., Beckler, M.D., Coffey, R.J. & Tyska, M.J. Extracellular vesicles: communication, coercion, and conditioning. Mol Biol Cell 24, 1253-1259, doi:10.1091/Mbc.E12-08-0572 (2013).

Vogel, J., & Wagner, E.G.H. 2007. Target identification of small noncoding RNAs in bacteria. Current Opinion in Microbiology, 10(3), 262–270.

Observations / Biomarkers

Arroyo, J.D., Chevillet, J.R., Kroh, E.M., Ruf, I.K., Pritchard, C.C., Gibson, D.F., Mitchell, P.S., Bennett, C.F., Pogosova-Agadjanyan, E.L., Stirewalt, D.L., Tait, J.F.& Tewari, M.2011.Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma.Proc Natl Acad Sci U S A, 108: 5003-5008.

Bala, S., Petrasek, J., Mundkur, S., Catalano, D., Levin, I., Ward, J., Alao, H., Kodys, K.& Szabo, G.2012.Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases.Hepatology, 56, 1946-57.

Cortez, M.A., Bueso-Ramos, C., Ferdin, J., Lopez-Berestein, G., Sood, A.K.& Calin, G.A.2011.MicroRNAs in body fluids--the mix of hormones and biomarkers.Nat Rev Clin Oncol, 8, 467-77.

Devaux, Y.et al.Use of Circulating MicroRNAs to Diagnose Acute Myocardial Infarction.Clin Chem 58, 559-567, doi:10.1373/Clinchem.2011.173823 (2012).

Gandhi, R.et al.Circulating MicroRNAs as biomarkers for disease staging in multiple sclerosis.Ann Neurol 73, 729-740, doi:10.1002/Ana.23880 (2013).

Hanke, M., Hoefig, K., Merz, H., Feller, A.C., Kausch, I., Jocham, D., Warnecke, J.M.& Sczakiel, G.2010.A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer.Urol Oncol, 28, 655-61.

Kohler, C., Barekati, Z., Radpour, R.& Zhong, X.Y.2011.Cell-free DNA in the circulation as a potential cancer biomarker.Anticancer Res, 31, 2623-8.

Laterza, O.F., Lim, L., Garrett-Engele, P.W., Vlasakova, K., Muniappa, N., Tanaka, W.K., Johnson, J.M., Sina, J.F., Fare, T.L., Sistare, F.D.& Glaab, W.E.2009.Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury.Clin Chem, 55, 1977-83.

Lawrie, C.H., Gal, S., Dunlop, H.M., Pushkaran, B., Liggins, A.P., Pulford, K., Banham, A.H., Pezzella, F., Boultwood, J., Wainscoat, J.S., Hatton, C.S.& Harris, A.L.2008.Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma.Br J Haematol, 141, 672-5.

Ma, Y., Zhang, P., Wang, F., Zhang, H., Yang, J., Peng, J., Liu, W.& Qin, H.2012.miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in colorectal cancer.Gut, 61, 1447-53.

Mandel, P.& Métais, P.1948.Les acides nucléiques du plasma sanguin chez l’homme.C.R.Acad.Sci.Paris, 142, 241-243.

Mitchell, P.S., Parkin, R.K., Kroh, E.M., Fritz, B.R., Wyman, S.K., Pogosova-Agadjanyan, E.L., Peterson, A., Noteboom, J., O'Briant, K.C., Allen, A., Lin, D.W., Urban, N., Drescher, C.W., Knudsen, B.S., Stirewalt, D.L., Gentleman, R., Vessella, R.L., Nelson, P.S., Martin, D.B.& Tewari, M.2008.Circulating microRNAs as stable blood-based markers for cancer detection.Proc Natl Acad Sci U S A, 105, 10513-8.

Miyamoto, M., Yanai, M., Ookubo, S., Awasaki, N., Takami, K.& Imai, R.2008.Detection of cell-free, liver-specific mRNAs in peripheral blood from rats with hepatotoxicity: a potential toxicological biomarker for safety evaluation.Toxicol Sci, 106, 538-45.

Moltzahn, F.et al.Microfluidic-Based Multiplex qRT-PCR Identifies Diagnostic and Prognostic microRNA Signatures in the Sera of Prostate Cancer Patients.Cancer Res 71, 550-560, doi:10.1158/0008-5472.Can-10-1229 (2011).

Moussay, E., Wang, K., Cho, J., Van Moer, K., Pierson, S., Paggetti, J., Nazarov, P.V., Palissot, V., Hood, L., Berchem, G., & Galas, D.J.2011.microRNA as biomarkers and regulators in B chronic lymphocytic leukemia.PNAS, 108(16):6573-6578.

Okubo, S., Miyamoto, M., Takami, K., Kanki, M., Ono, A., Nakatsu, N., Yamada, H., Ohno, Y.& Urushidani, T.2013.Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds.Toxicol Sci, 132, 21-31.

Park, N.J., Zhou, H., Elashoff, D., Henson, B.S., Kastratovic, D.A., Abemayor, E.& Wong, D.T.2009.Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection.Clin Cancer Res, 15, 5473-7.

Skog, J.et al.Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.Nat Cell Biol 10, 1470-U1209, doi:10.1038/Ncb1800 (2008).

Su, Y.W., Chen, X., Jiang, Z.Z., Wang, T., Wang, C., Zhang, Y., Wen, J., Xue, M., Zhu, D., Zhang, Y., Su, Y.J., Xing, T.Y., Zhang, C.Y.& Zhang, L.Y.2012.A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats.PLoS ONE, 7, e37395.

Sueoka, E., Sueoka, N., Iwanaga, K., Sato, A., Suga, K., Hayashi, S., Nagasawa, K.& Nakachi, K.2005.Detection of plasma hnRNP B1 mRNA, a new cancer biomarker, in lung cancer patients by quantitative real-time polymerase chain reaction.Lung Cancer, 48, 77-83.

Taylor, D.D.& Gercel-Taylor, C.2008.MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.Gynecol Oncol, 110, 13-21.

Turchinovich, A., Weiz, L., Langheinz, A.& Burwinkel, B.2011.Characterization of extracellular circulating microRNA.Nucleic Acids Res, 39, 7223-33.

Vickers, K.C., Palmisano, B.T., Shoucri, B.M., Shamburek, R.D.& Remaley, A.T.2011.MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins.Nat Cell Biol, 13, 423-33.

Wagner, J., Riwanto, M., Besler, C., Knau, A., Fichtlscherer, S., Roxe, T., Zeiher, A.M., Landmesser, U.& Dimmeler, S.2013.Characterization of Levels and Cellular Transfer of Circulating Lipoprotein-Bound MicroRNAs.Arterioscler Thromb Vasc Biol.

Wang, G.K., Zhu, J.Q., Zhang, J.T., Li, Q., Li, Y., He, J., Qin, Y.W.& Jing, Q.2010.Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans.Eur Heart J, 31, 659-66.

Wang, K., Li, H., Yuan, Y., Etheridge, A., Zhou, Y., Huang, D., Wilmes, P.& Galas, D.2012.The complex exogenous RNA spectra in human plasma: an interface with human gut biota? PLoS ONE, 7, e51009.

Wang, K.Yuan, Y., Cho, J-H., McClarty, S., Baxter, D.Galas, D.J.2012.Comparing the MicroRNA spectrum between serum and plasma.PLoS ONE, 7 (7), e41561

Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L.E.& Galas, D.J.2009.Circulating microRNAs, potential biomarkers for drug-induced liver injury.Proc Natl Acad Sci U S A, 106, 4402-7.

Weber, J.A., Baxter, D.H., Zhang, S., Huang, D.Y., Huang, K.H., Lee, M.J., Galas, D.J.& Wang, K.2010.The microRNA spectrum in 12 body fluids.Clin Chem, 56, 1733-41.

Witwer, K.W., McAlexander, M.A., Queen, S.E., and Adams R.J.2013.Real-time PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs.RNA Biology, 10:7, 1-7.

Wu, L., Zhou, H., Lin, H., Qi, J., Zhu, C., Gao, Z.& Wang, H.2012.Circulating microRNAs are elevated in plasma from severe preeclamptic pregnancies.Reproduction, 143, 389-97.

Zhang, X., Wang, C., Wang, L., Du, L., Wang, S., Zheng, G., Li, W., Zhuang, X., Zhang, X.& Dong, Z.2012b.Detection of circulating Bmi-1 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer.Int J Cancer, 131, 165-72.

Zhao, H., Shen, J., Medico, L., Wang, D., Ambrosone, C.B.& Liu, S.2010.A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer.PLoS ONE, 5, e13735.

Zhao, Z., Zhao, Q., Warrick, J., Lockwood, C.M., Woodworth, A., Moley, K.H.& Gronowski, A.M.2012.Circulating microRNA miR-323-3p as a biomarker of ectopic pregnancy.Clin Chem, 58, 896-905.

Zhong, X.Y., Holzgreve, W.& Huang, D.J.2008.Isolation of cell-free RNA from maternal plasma.Methods Mol Biol, 444, 269-73.

Mechanisms & Models

Alexopoulou, L., Holt, A.C., Medzhitov, R., & Flavell, R.A. Recognition of double-stranded RNA and activation of NF-[kappa]B by Toll-like receptor 3. Nature(2001) 413: 732–738.

Bomberger, J.M., MacEachran, D.P., Coutermarsh, B.A., Ye, S., O’Toole, G.A., & Stanton, B.A.2009.Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles.PLoS Pathog, 5(4), e1000382.

Camussi, G., Deregibus, M.C., Bruno, S., Grange, C., Fonsato, V.& Tetta, C.2011.Exosome/microvesicle-mediated epigenetic reprogramming of cells.Am J Cancer Res, 1, 98-110.

Care, A., Catalucci, D., Felicetti, F., Bonci, D., Addario, A., Gallo, P., Bang, M.L., Segnalini, P., Gu, Y., Dalton, N.D., Elia, L., Latronico, M.V., Hoydal, M., Autore, C., Russo, M.A., Dorn, G.W., 2nd, Ellingsen, O., Ruiz-Lozano, P., Peterson, K.L., Croce, C.M., Peschle, C.& Condorelli, G.2007.MicroRNA-133 controls cardiac hypertrophy.Nat Med, 13, 613-8.

Chabelskaya, S., Gaillot, O., & Felden, B.2010.A Staphylococcus aureus Small RNA Is Required for Bacterial Virulence and Regulates the Expression of an Immune-Evasion Molecule.PLoS Pathog, 6(6), e1000927.

Chendrimada, T.P., Finn, K.J., Ji, X., Baillat, D., Gregory, R.I., Liebhaber, S.A., Pasquinelli, A.E.& Shiekhattar, R.2007.MicroRNA silencing through RISC recruitment of eIF6.Nature, 447, 823-8.

Choi, D.S., Kim, D.K., Kim, Y.K.& Gho, Y.S.Proteomics, transcriptomics and lipidomics of exosomes and ectosomes.Proteomics 13, 1554-1571, doi:10.1002/Pmic.201200329 (2013).

Gong, H., Vu, G.-P., Bai, Y., Chan, E., Wu, R., Yang, E., Liu, F., et al.2011.A Salmonella Small Non-Coding RNA Facilitates Bacterial Invasion and Intracellular Replication by Modulating the Expression of Virulence Factors.PLoS Pathog, 7(9), e1002120.

Hammell, C.M., & Hannon, G.J.2012.Inducing RNAi in C.elegans by Feeding with dsRNA-expressing E.coli.Cold Spring Harbor Protocols, 2012(12), pdb.prot072348.

Hansen, D.R., Van Alfen, N.K., Gillies, K., & Powell, W.A.1985.Naked dsRNA Associated with Hypovirulence of Endothia parasitica is Packaged in Fungal Vesicles.Journal of General Virology, 66(12), 2605–2614.

Kogure, T., Lin, W.L., Yan, I.K., Braconi, C.& Patel, T.2011.Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth.Hepatology, 54, 1237-48.

Higashijima, A., Miura, K., Mishima, H., Kinoshita, A., Jo, O., Abe, S., Hasegawa, Y., Miura, S., Yamasaki, K., Yoshida, A., Yoshiura, K.& Masuzaki, H.2013.Characterization of placenta-specific microRNAs in fetal growth restriction pregnancy.Prenat Diagn, 33, 214-22.

Lee, E.-Y., Choi, D.-Y., Kim, D.-K., Kim, J.-W., Park, J.O., Kim, S., Kim, S.-H., et al.2009.Gram-positive bacteria produce membrane vesicles: Proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles.Proteomics, 9(24), 5425–5436.

Lee, S.T., Chu, K., Jung, K.H., Kim, J.H., Huh, J.Y., Yoon, H., Park, D.K., Lim, J.Y., Kim, J.M., Jeon, D., Ryu, H., Lee, S.K., Kim, M.& Roh, J.K.2012.miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model.Ann Neurol, 72, 269-77.

Liu, A.Y., Pascal, L.E., Vencio, R.Z.& Vencio, E.F.2010.Stromal-epithelial interactions in early neoplasia.Cancer biomarkers: section A of Disease markers, 9, 141-55.

Liu, H., Wang, X., Wang, H.-D., Wu, J., Ren, J., Meng, L., Wu, Q., et al.2012.Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans.Nat Commun, 3, 1073.

Mittelbrunn, M., Gutierrez-Vazquez, C., Villarroya-Beltri, C., Gonzalez, S., Sanchez-Cabo, F., Gonzalez, M.A., Bernad, A.& Sanchez-Madrid, F.2011.Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells.Nat Commun, 2, 282.

Parker, H., Chitcholtan, K., Hampton, M.B., & Keenan, J.I.2010.Uptake of Helicobacter pylori Outer Membrane Vesicles by Gastric Epithelial Cells.Infection and Immunity, 78(12), 5054–5061.

Ratajczak, J., Miekus, K., Kucia, M., Zhang, J., Reca, R., Dvorak, P.& Ratajczak, M.Z.2006.Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery.Leukemia, 20, 847-56.

Riley D.R., Sieber K.B., Robinson K.M., White J.R., Ganesan A., Nourbakhsh S., Dunning Hotopp J.C.2013.Bacteria-Human Somatic Cell Lateral Gene Transfer Is Enriched in Cancer Samples.PLoS Comput Biol, 9(6): e1003107.

Rodrigues, M.L., Franzen, A.J., Nimrichter, L., & Miranda, K.(n.d.).Vesicular mechanisms of traffic of fungal molecules to the extracellular space.Current Opinion in Microbiology, (0).doi:http://dx.doi.org/10.1016/j.mib.2013.04.002.

Schmidt, W.M., Spiel, A.O., Jilma, B., Wolzt, M.& Muller, M.2009.In vivo profile of the human leukocyte microRNA response to endotoxemia.Biochemical and biophysical research communications, 380, 437-41.

Valadi, H., Ekstrom, K., Bossios, A., Sjostrand, M., Lee, J.J.& Lotvall, J.O.2007.Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.Nat Cell Biol, 9, 654-9.

Vencio, E.F., Pascal, L.E., Page, L.S., Denyer, G., Wang, A.J., Ruohola-Baker, H., Zhang, S., Wang, K., Galas, D.J.& Liu, A.Y.2011.Embryonal carcinoma cell induction of miRNA and mRNA changes in co-cultured prostate stromal fibromuscular cells.Journal of cellular physiology, 226, 1479-88.

Wang, K., Zhang, S., Weber, J., Baxter, D., & Galas, D.J.2010a.Mammalian cells in culture actively export specific microRNAs.Nucleic Acids Research, 38(20):7248-7259.

Wang, K., Zhang, S., Weber, J., Baxter, D., & Galas, D.J.2010b.Export of microRNAs and microRNA-protective protein by mammalian cells.Nucleic Acids Res, 38, 7248-59.

Yang, M., Chen, J., Su, F., Yu, B., Lin, L., Liu, Y., Huang, J.D.& Song, E.2011.Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells.Molecular cancer, 10, 117.

Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., Yin, Y., Wang, C., Zhang, T., Zhu, D., Zhang, D., Xu, J., Chen, Q., Ba, Y., Liu, J., Wang, Q., Chen, J., Wang, J., Wang, M., Zhang, Q., Zhang, J., Zen, K.& Zhang, C.Y.2012a.Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA.Cell Res, 22, 107-26.

Methods/Protocols

Argyropoulos, C., Wang, K., McClarty, S., Huang, D., Bernardo, J., Ellis, D., Orchard, T., Galas, D., Johnson, J. 2013. Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes. PLoS ONE 8:e54662. doi: 10.1371/journal.pone.0054662.

Lee, H.-J., & Hong, S.-H. 2012. Analysis of microRNA-size, small RNAs in Streptococcus mutans by deep sequencing. FEMS Microbiology Letters, 326(2), 131–136.

Lee, L.W., Zhang, S., Etheridge, A., Ma, L., Martin, D., Galas, D. & Wang, K. 2010. Complexity of the microRNA repertoire revealed by next-generation sequencing. RNA, 16, 2170-80.

Kang, S.M., Choi, J.W., Lee, Y., Hong, S.H., & Lee, H.-J. 2013. Identification of microRNA-Size, Small RNAs in Escherichia coli. Current Microbiology, 1–5. doi:10.1007/s00284-013-0411-9.

Kogure, T., & Patel, T.  2013.   Isolation of extracellular nanovesicle microRNA from liver cancer cells in culture.  Methods Mol Biol. 2013;1024:11-8. doi: 10.1007/978-1-62703-453-1_2.

Nolte-'T hoen, E.N.M., Buermans, H.P.J., Wasdorp, M., Stoorvogel, W., Wauben, M.H.M., & 'T hoen, P.A.C., Deep sequencing of RNA from immune cell-dervived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions,  Nucl Acids Res. (2012) 40: 9272-9285.

Semenov, D.V., Baryakin, D.N., Brenner, E.V., Kurilshikov, A.M., Vasiliev, G.V., Bryzgalov, L.A., Chikova, E.D., Filippova, J.A., Kuligina, E.V. & Richter, V.A. 2012. Unbiased approach to profile the variety of small non-coding RNA of human blood plasma with massively parallel sequencing technology. Expert Opin Biol Ther, 12 Suppl 1, S43-51.

Sipova, H., Zhang, S., Dudley, A.M., Galas, D.J., Wang, K. & Homola, J. 2010. Surface Plasmon Resonance Biosensor for Rapid Label-free Detection of microRNA at Sub-femtomolar Levels. Analytical Chemistry, 82(24):10110-10115.

Turchinovich A., Weiz, L., Langheinz, A., & Burwinkel B. 2011. Characterization of extracellular circulating microRNA.  Nucleic Acids Res. 39(16):7223-33. doi: 10.1093/nar/gkr254. Epub 2011 May 24.

Wang, Q.L. et al. Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids. Nat Commun 4, 1867, doi:10.1038/Ncomms2886 (2013).

Witwer, K.W. et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Ves 2, 20360, doi:10.3402/jev.v2i0.20360 (2013).