Saftics A et al.

Single Extracellular VEsicle Nanoscopy.

J Extracell Vesicles (2023) 12:e12346.

Fordjour FK et al.

Exomap1 mouse: a transgenic model for in vivo studies of exosome biology.

bioRxiv AOP 2023-05-29.

Dragomir MP et al.

Anti-miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response.

J Clin Invest (2023) 133.

Barman B, Dawson TR & Weaver AM.

ER membrane contact sites: Key platforms for biogenesis of RNA-containing extracellular vesicles.

Contact (2022) 5.

Palacio PL et al.

Emerging role of extracellular vesicles in multiple sclerosis: From cellular surrogates to pathogenic mediators and beyond.

J Neuroimmunol (2023) 377:578064.

Nieland L et al.

Engineered EVs designed to target diseases of the CNS.

J Control Release (2023) 356:493-506.

Li G et al.

Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.

J Extracell Vesicles (2023) 12:e12305.

Jeppesen DK et al.

Extracellular vesicles and nanoparticles: Emerging complexities.

Trends Cell Biol AOP 2023-02-01.

Gornalusse G et al.

Men who inject opioids exhibit altered tRNA-Gly-GCC isoforms in semen.

Mol Hum Reprod (2023) 29.

Driedonks T et al.

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina.

J Extracell Biol (2022) 1.

Zhang J et al.

A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER).

Sci Adv (2022) 8:eade0640.

Huang Y et al.

Relationships of APOE genotypes with small RNA and protein cargo of brain tissue extracellular vesicles from patients with late-stage AD.

Neurol Genet (2022) 8:e200026.

Huang Y et al.

Brain tissue-derived extracellular vesicles in Alzheimer’s disease display altered key protein levels including cell type-specific markers.

J Alzheimers Dis (2022) 90:1057-1072.

Witwer KW & Wolfram J.

Extracellular vesicles versus synthetic nanoparticles for drug delivery.

Nat Rev Mater (2021) 6:103-106.

Nguyen LTH et al.

An immunogold single extracellular vesicular RNA and protein ((Au) SERP) biochip to predict responses to immunotherapy in non-small cell lung cancer patients.

J Extracell Vesicles (2022) 11:e12258.

Fordjour FK et al.

A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes.

J Biol Chem (2022) 298:102394.

Lennon KM et al.

Cardiac troponin T in extracellular vesicles as a novel biomarker in human cardiovascular disease.

Clin Transl Med (2022) 12:e979.

Arifin DR, Witwer KW & Bulte JWM.

Non-invasive imaging of extracellular vesicles: Quo vaditis in vivo?

J Extracell Vesicles (2022) 11:e12241.

Glass SE & Coffey RJ.

Recent advances in the study of extracellular vesicles in colorectal cancer.

Gastroenterology (2022) 163:1188-1197.

Davies MR et al.

Muscle-derived beige adipose precursors secrete promyogenic exosomes that treat rotator cuff muscle degeneration in mice and are identified in humans by single-cell RNA sequencing.

Am J Sports Med (2022) 50:2247-2257.

Gomes DE & Witwer KW.

L1CAM-associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization.

J Extracell Biol (2022) 1.

Zhu X et al.

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.

Neurobiol Dis (2022) 169:105734.

Barman B et al.

VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites.

Dev Cell (2022) 57:974-994.e8.

Phu TA et al.

IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity.

Mol Ther (2022) 30:2274-2297.

Clancy JW et al.

Recruitment of DNA to tumor-derived microvesicles.

Cell Rep (2022) 38:110443.

Couch Y et al.

A brief history of nearly EV-erything – The rise and rise of extracellular vesicles.

J Extracell Vesicles (2021) 10:e12144.

Bittel M et al.

Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo.

J Extracell Vesicles (2021) 10:e12159.

Valkov N et al.

snRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.

Life Sci Alliance (2021) 4.

Ma S et al.

CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.

Cell Rep (2021) 36:109549.

Kilinc S et al.

Oncogene-regulated release of extracellular vesicles.

Dev Cell (2021) 56:1989-2006.e6.

Guo C et al.

Choice of selectable marker affects recombinant protein expression in cells and exosomes.

J Biol Chem (2021) 297:100838.

Gimona M et al.

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.

Cytotherapy (2021) 23:373-380.

Witwer KW.

On your MARCKS, get set, deliver: Engineering extracellular vesicles.

Mol Ther (2021) 29:1664-1665.

Tallon C et al.

Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.

Drug Discov Today (2021) 26:1656-1668.

Martin-Jaular L et al.

Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.

EMBO J (2021) 40:e105492.

Saheera S et al.

Extracellular vesicle interplay in cardiovascular pathophysiology.

Am J Physiol Heart Circ Physiol (2021) 320:H1749-H1761.

Ma S et al.

Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype.

Cell Rep (2021) 34:108726.

Silverman DA et al.

Cancer-associated neurogenesis and nerve-cancer cross-talk.

Cancer Res (2021) 81:1431-1440.

Nieland L et al.

Extracellular vesicle-mediated bilateral communication between glioblastoma and astrocytes.

Trends Neurosci (2021) 44:215-226.

Anfossi S & Calin GA.

Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy.

Cancer Drug Resist (2020) 3:356-370.

Zhang Q et al.

Angiotensin-converting Enzyme 2-containing small extracellular vesicles and exomeres bind the Severe Acute Respiratory Syndrome Coronavirus 2 spike protein.

Gastroenterology (2021) 160:958-961.e3.

Zeng A et al.

Glioblastoma-derived extracellular vesicles facilitate transformation of astrocytes via reprogramming oncogenic metabolism.

iScience (2020) 23:101420.

Drula R et al.

MicroRNAs from liquid biopsy derived extracellular vesicles: Recent advances in detection and characterization methods.

Cancers (Basel) (2020) 12:2009.

Bouchareychas L et al.

Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via microRNA cargo.

Cell Rep (2020) 32:107881.

Koupenova M & Freedman JE.

Platelets and immunity: Going viral.

Arterioscler Thromb Vasc Biol (2020) 40:1605-1607.

Ahn JY et al.

Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria.

Biochim Biophys Acta Gen Subj (2021) 1865:129598.

Yekula A et al.

Extracellular vesicles in glioblastoma tumor microenvironment.

Front Immunol (2019) 10:3137.

Gambaro F et al.

Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner.

RNA Biol (2019) 17:1168-1182.

Sundaram K et al.

Plant-derived exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis.

iScience (2019) 21:308-327.

Jones PS et al.

Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.

EBioMedicine (2019) 48:23-35.

Pusic KM et al.

IFNgamma-stimulated dendritic cell exosomes for treatment of migraine modeled using spreading depression.

Front Neurosci (2019) 13:942.

Kanada M et al.

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy.

Mol Cancer Ther (2019) 18:2331-2342.

Gyuris A et al.

Physical and molecular landscapes of mouse glioma extracellular vesicles define heterogeneity.

Cell Rep (2019) 27:3972-3987.e6.

Pegtel DM & Gould SJ.

Exosomes.

Annu Rev Biochem (2019) 88:487-514.

Haraszti RA et al.

Serum deprivation of Mesenchymal Stem Cells improves exosome activity and alters lipid and protein composition.

iScience (2019) 16:230-241.

Bruno S et al.

Role of extracellular vesicles in stem cell biology.

Am J Physiol Cell Physiol (2019) 317:C303-C313.

Poggio M et al.

Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory.

Cell (2019) 177:414-427.e13.

Jeppesen DK et al.

Reassessment of exosome composition.

Cell (2019) 177:428-445.e18.

Murillo OD et al.

exRNA Atlas analysis reveals distinct extracellular RNA Cargo types and their carriers present across human biofluids.

Cell (2019) 177:463-477.e15.

Roy S et al.

Navigating the landscape of tumor extracellular vesicle heterogeneity.

Int J Mol Sci (2019) 20:6.

Jimenez L et al.

Quantitative proteomic analysis of small and large extracellular vesicles (EVs) reveals enrichment of adhesion proteins in small EVs.

J Proteome Res (2019) 18:947-959.

Haraszti RA et al.

Exosomes produced from 3D Cultures of MSCs by Tangential Flow Filtration show higher yield and improved activity.

Mol Ther (2018) 26:2838-2847.

Moirangthem A & Patel T.

Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.

Biotarget (2017) 1:12.

Sung BH & Weaver AM.

Directed migration: Cells navigate by extracellular vesicles.

J Cell Biol (2018) 217:2613-2614.

Zhang Q et al.

Mutant KRAS exosomes alter the metabolic state of recipient colonic epithelial cells.

Cell Mol Gastroenterol Hepatol (2018) 5:627-629.e6.

Haemmerle M et al.

The platelet lifeline to cancer: Challenges and opportunities.

Cancer Cell (2018) 33:965-983.

Lankford KL et al.

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.

PLoS ONE (2018) 13:e0190358.

Nonaka T & Wong DTW.

Saliva exosomics in cancer: Molecular characterization of cancer-derived exosomes in saliva.

Enzymes (2017) 42:125-151.

Figueroa J et al.

Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587.

Cancer Res (2017) 77:5808-5819.

Datta A et al.

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.

Cancer Lett (2017) 408:73-81.

Bei Y et al.

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.

Basic Res Cardiol (2017) 112:38.

Silva AM et al.

Dendritic cell-derived extracellular vesicles mediate mesenchymal stem/stromal cell recruitment.

Sci Rep (2017) 7:1667.

Bruno S et al.

Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells.

Tissue Eng Part A (2017) 23:1262-1273.

Rashed MH et al.

Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.

Oncotarget (2017) 8:20145-20164.

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.

Liver Transpl (2017) 23:791-803.

Clancy L et al.

The role of RNA uptake in platelet heterogeneity.

Thromb Haemost (2017) 117:948-961.

Deng Z et al.

Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.

Mol Ther (2017) 25:1641-1654.

Teng Y et al.

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Nat Commun (2017) 8:14448.

Collino F et al.

Exosome and microvesicle-enriched fractions isolated from mesenchymal stem cells by gradient separation showed different molecular signatures and functions on renal tubular epithelial cells.

Stem Cell Rev (2017) 13:226-243.

Maji S et al.

Extracellular vesicles in liver diseases.

Am J Physiol Gastrointest Liver Physiol (2017) 312:G194-G200.

Maas SL, Breakefield XO & Weaver AM.

Extracellular vesicles: Unique intercellular delivery vehicles.

Trends Cell Biol (2017) 27:172-188.

Katsiougiannis S et al.

Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity.

FASEB J (2017) 31:998-1010.

Haraszti RA et al.

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

J Extracell Vesicles (2016) 5:32570.

Nazimek K, Bryniarski K & Askenase PW.

Functions of exosomes and microbial extracellular vesicles in allergy and contact and delayed-type hypersensitivity.

Int Arch Allergy Immunol (2016) 171:1-26.

Kanlikilicer P et al.

Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells.

Cancer Res (2016) 76:7194-7207.

Deng Z et al.

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis.

Oncogene (2017) 36:639-651.

Wang JQ et al.

Extracellular vesicle-mediated reversal of paclitaxel resistance in prostate cancer.

Crit Rev Oncog (2015) 20:407-17.

Soares VY et al.

Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.

Neuro Oncol (2016) 18:1498-1507.

Zhang HG et al.

Isolation, identification, and characterization of novel nanovesicles.

Oncotarget (2016) 7:41346-41362.

McKenzie AJ et al.

KRAS-MEK signaling controls Ago2 sorting into exosomes.

Cell Rep (2016) 15:978-87.

Abels ER & Breakefield XO.

Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.

Cell Mol Neurobiol (2016) 36:301-12.

Zappulli V et al.

Extracellular vesicles and intercellular communication within the nervous system.

J Clin Invest (2016) 126:1198-207.

Teng Y et al.

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.

Oncotarget (2016) 7:25683-97.

Pusic KM, Pusic AD & Kraig RP.

Environmental enrichment stimulates immune cell secretion of exosomes that promote CNS myelination and may regulate inflammation.

Cell Mol Neurobiol (2016) 36:313-325.

Pucci F et al.

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.

Science (2016) 352:242-6.

Zhang X et al.

Potential transfer of polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington’s disease: Background and evaluation in cell culture.

Cell Mol Neurobiol (2016) 36:459-70.

Iavello A et al.

Role of Alix in miRNA packaging during extracellular vesicle biogenesis.

Int J Mol Med (2016) 37:958-66.

Rupaimoole R et al.

miRNA deregulation in cancer cells and the tumor microenvironment.

Cancer Discov (2016) 6:235-46.

Clancy L & Freedman JE.

Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.

Circ Res (2016) 118:374-6.

Machtinger R, Laurent LC & Baccarelli AA.

Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation.

Hum Reprod Update (2016) 22:182-93.

Zhuang X et al.

Ginger-derived nanoparticles protect against alcohol-induced liver damage.

J Extracell Vesicles (2015) 4:28713.

van der Vos KE et al.

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.

Neuro Oncol (2016) 18:58-69.

Quesenberry PJ et al.

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming.

Stem Cell Res Ther (2015) 6:153.

Cha DJ et al.

KRAS-dependent sorting of miRNA to exosomes.

Elife (2015) 4:e07197.

Pusic AD & Kraig RP.

Phasic treatment with Interferon gamma stimulates release of exosomes that protect against spreading depression.

J Interferon Cytokine Res (2015) 35:795-807.

Sung BH et al.

Directional cell movement through tissues is controlled by exosome secretion.

Nat Commun (2015) 6:7164.

Bryniarski K et al.

Free extracellular miRNA functionally targets cells by transfecting exosomes from their companion cells.

PLoS ONE (2015) 10:e0122991.

Agarwal K et al.

Analysis of exosome release as a cellular response to MAPK pathway inhibition.

Langmuir (2015) 31:5440-8.

Deng Z et al.

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

Nat Commun (2015) 6:6956.

Collino F et al.

AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs.

J Am Soc Nephrol (2015) 26:2349-60.

Gardiner C et al.

Extracellular vesicles, tissue factor, cancer and thrombosis – Discussion themes of the ISEV 2014 Educational Day.

J Extracell Vesicles (2015) 4:26901.

Tewari M.

A functional extracellular transcriptome in animals? Implications for biology, disease and medicine.

Genome Biol (2015) 16:47.

Kanada M et al.

Differential fates of biomolecules delivered to target cells via extracellular vesicles.

Proc Natl Acad Sci U S A (2015) 112:E1433-42.

Haga H et al.

Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth.

J Extracell Vesicles (2015) 4:24900.

Srivastava A et al.

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.

Curr Gene Ther (2015) 15:182-92.

Bhattacharya S et al.

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.

PLoS ONE (2014) 9:e114409.

Melo SA et al.

Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

Cancer Cell (2014) 26:707-21.

Danielson KM & Das S.

Extracellular vesicles in heart disease: Excitement for the future?

Exosomes Microvesicles (2014) 2:1.

Rajendran L et al.

Emerging roles of extracellular vesicles in the nervous system.

J Neurosci (2014) 34:15482-9.

Gangoda L et al.

Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

Proteomics (2015) 15:260-71.

Kawikova I & Askenase PW.

Diagnostic and therapeutic potentials of exosomes in CNS diseases.

Brain Res (2015) 1617:63-71.

Godlewski J et al.

Belonging to a network–microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

Neuro Oncol (2015) 17:652-62.

Braicu C et al.

Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?

Cell Death Differ (2015) 22:34-45.

Saleem SN & Abdel-Mageed AB.

Tumor-derived exosomes in oncogenic reprogramming and cancer progression.

Cell Mol Life Sci (2015) 72:1-10.

Takahashi K et al.

Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer.

FEBS Open Bio (2014) 4:458-67.

Takahashi K et al.

Involvement of extracellular vesicle long non-coding RNA (linc-VLDLR) in tumor cell responses to chemotherapy.

Mol Cancer Res (2014) 12:1377-87.

Mu J et al.

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.

Mol Nutr Food Res (2014) 58:1561-73.

Redzic JS et al.

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol (2014) 28:14-23.

Quesenberry PJ et al.

Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.

Front Oncol (2014) 4:56.

Abd Elmageed ZY et al.

Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.

Stem Cells (2014) 32:983-97.

Lindoso RS et al.

Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury.

Stem Cells Dev (2014) 23:1809-19.

Grange C et al.

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging.

Int J Mol Med (2014) 33:1055-63.

Quesenberry PJ et al.

Cellular phenotype and extracellular vesicles: Basic and clinical considerations.

Stem Cells Dev (2014) 23:1429-36.

Zhaorigetu S et al.

Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue.

J Liposome Res (2014) 24:182-90.

Lai CP et al.

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

ACS Nano (2014) 8:483-94.

Panagopoulos K et al.

Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure.

Mol Cancer (2013) 12:118.

Aliotta JM et al.

Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.

Cardiovasc Res (2013) 100:354-62.

Deng ZB et al.

Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.

J Immunol (2013) 190:3579-89.

Akers JC et al.

Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.

J Neurooncol (2013) 113:1-11.

Gonda DD et al.

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.

Neurosurgery (2013) 72:501-10.