The Extracellular RNA Communication Consortium has published 700+ research articles since its inception in 2013. Articles in the category “Biomarkers” are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.



Su Y et al.

Multiple early factors anticipate post-acute COVID-19 sequelae.

Cell (2022) 185:881-895.e20.


Max KEA et al.

Plasma microRNA interindividual variability in healthy individuals, pregnant women, and an individual with a stably altered neuroendocrine phenotype.

Clin Chem (2021) 67:1676-1688.

Hao N et al.

Acoustofluidic multimodal diagnostic system for Alzheimer’s disease.

Biosens Bioelectron (2022) 196:113730.

Ma S et al.

CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.

Cell Rep (2021) 36:109549.

Satake E et al.

Comprehensive search for novel circulating miRNAs and axon guidance pathway proteins associated with risk of ESKD in diabetes.

J Am Soc Nephrol (2021) 32:2331-2351.

Blanco-Dominguez R et al.

A novel circulating microRNA for the detection of acute myocarditis.

N Engl J Med (2021) 384:2014-2027.

Muthukumar T et al.

Serum microRNA transcriptomics and acute rejection or recurrent Hepatitis C virus in human liver allograft recipients: a pilot study.

Transplantation (2022) 106:806-820.

Chen L et al.

Elliptical pipette generated large microdroplets for POC visual ddPCR quantification of low viral load.

Anal Chem (2021) 93:6456-6462.

Crouser ED et al.

Circulating exosomal microRNA expression patterns distinguish cardiac sarcoidosis from myocardial ischemia.

PLoS ONE (2021) 16:e0246083.


Muralidharan K et al.

TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas.

Clin Cancer Res (2021) 27:169-178.

Sandau US et al.

Performance of validated microRNA biomarkers for Alzheimer’s disease in mild cognitive impairment.

J Alzheimers Dis (2020) 78:245-263.

Srinivasan S et al.

Discovery and verification of extracellular miRNA biomarkers for non-invasive prediction of pre-eclampsia in asymptomatic women.

Cell Rep Med (2020) 1:100013.

Charest A.

Experimental and biological insights from proteomic analyses of extracellular vesicle cargos in normalcy and disease.

Adv Biosyst (2020) 4:e2000069.

Vaze A et al.

Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study.

PLoS ONE (2020) 15:e0236960.

Meabon JS et al.

Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure.

J Neurol Sci (2020) 417:117049.

Li F et al.

Ultra-short circulating tumor DNA (usctDNA) in plasma and saliva of Non-Small Cell Lung Cancer (NSCLC) patients.

Cancers (Basel) (2020) 12:2041.

Shukuya T et al.

Circulating microRNAs and extracellular vesicle-containing microRNAs as response biomarkers of Anti-programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC.

J Thorac Oncol (2020) 15:1773-1781.

Yekula A et al.

Liquid biopsy strategies to distinguish progression from pseudoprogression and radiation necrosis in glioblastomas.

Adv Biosyst (2020) 4:e2000029.

Hao N et al.

Acoustofluidics-assisted engineering of multifunctional three-dimensional zinc oxide nanoarrays.

ACS Nano (2020) 14:6150-6163.

Ahn JY et al.

Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria.

Biochim Biophys Acta Gen Subj (2021) 1865:129598.

Tran AM et al.

A new world of biomarkers and therapeutics for female reproductive system and breast cancers: Circular RNAs.

Front Cell Dev Biol (2020) 8:50.

Yekula A et al.

From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers.

Methods (2020) 177:58-66.

Rao SL et al.

Altered level of salivary placental growth factor is associated with preeclampsia.

Placenta (2020) 90:118-120.

Ghai V et al.

Alterations in plasma microRNA and protein levels in war veterans with chronic mild traumatic brain injury.

J Neurotrauma (2020) 37:1418-1430.

Silverman MG et al.

Circulating miRNAs and risk of sudden death in patients with coronary heart disease.

JACC Clin Electrophysiol (2020) 6:70-79.


Wang Z et al.

Acoustofluidic salivary exosome isolation: a liquid biopsy compatible approach for human papillomavirus-associated oropharyngeal cancer detection.

J Mol Diagn (2020) 22:50-59.

Sun L et al.

miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44.

Theranostics (2019) 9:8409-8425.

Jones PS et al.

Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.

EBioMedicine (2019) 48:23-35.

Lee MY et al.

Distinct profiles of cell-free microRNAs in plasma of veterans with Post-Traumatic Stress Disorder.

J Clin Med (2019) 8:963.

Kaczor-Urbanowicz KE et al.

Clinical validity of saliva and novel technology for cancer detection.

Biochim Biophys Acta Rev Cancer (2019) 1872:49-59.

Petrescu GED et al.

MicroRNA based theranostics for brain cancer: Basic principles.

J Exp Clin Cancer Res (2019) 38:231.

Lee MY et al.

A biological function based biomarker panel optimization process.

Sci Rep (2019) 9:7365.

Ghai V et al.

Extracellular vesicle encapsulated microRNAs in patients with Type 2 Diabetes are affected by metformin treatment.

J Clin Med (2019) 8:617.

Giraldez MD et al.

Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma.

EMBO J (2019) 38:e101695.

Gonzalez-Villasana V et al.

Presence of circulating miR-145, miR-155, and miR-382 in exosomes isolated from serum of breast cancer patients and healthy donors.

Dis Markers (2019) 2019:6852917.

Bach DH, Lee SK & Sood AK.

Circular RNAs in Cancer.

Mol Ther Nucleic Acids (2019) 16:118-129.

Dawes C & Wong DTW.

Role of saliva and salivary diagnostics in the advancement of oral health.

J Dent Res (2019) 98:133-141.

Ghai V et al.

Circulating RNAs as predictive markers for the progression of type 2 diabetes.

J Cell Mol Med (2019) 23:2753-2768.

Wiedrick JT et al.

Validation of microRNA biomarkers for Alzheimer’s Disease in human cerebrospinal fluid.

J Alzheimers Dis (2019) 67:875-891.

Pua HH et al.

Increased hematopoietic extracellular RNAs and vesicles in the lung during allergic airway responses.

Cell Rep (2019) 26:933-944.e4.

Varkaris A et al.

Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer.

Br J Cancer (2019) 120:340-345.

Gulei D et al.

CRISPR-based RNA editing: Diagnostic applications and therapeutic options.

Expert Rev Mol Diagn (2019) 19:83-88.


Lusardi TA et al.

Analytics of Cerebrospinal Fluid microRNA quantitative PCR studies.

Mol Neurobiol (2019) 56:4988-4999.

Smith EMD et al.

A Markov Multi-State model of lupus nephritis urine biomarker panel dynamics in children: Predicting changes in disease activity.

Clin Immunol (2019) 198:71-78.

Bei Y et al.

Circular RNAs as potential theranostics in the cardiovascular system.

Mol Ther Nucleic Acids (2018) 13:407-418.

Hinger SA et al.

Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells.

Cell Rep (2018) 25:715-725.e4.

Wei F et al.

Electric field-induced release and measurement liquid biopsy for noninvasive early lung cancer assessment.

J Mol Diagn (2018) 20:738-742.

Antoury L et al.

Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of Muscular Dystrophies.

Nat Commun (2018) 9:3906.

Narla V et al.

Unique circulating microRNA profiles in HIV infection.

J Acquir Immune Defic Syndr (2018) 79:644-650.

Regev K et al.

Identification of MS-specific serum miRNAs in an international multicenter study.

Neurol Neuroimmunol Neuroinflamm (2018) 5:e491.

Li F et al.

Discovery and validation of salivary extracellular RNA biomarkers for noninvasive detection of gastric cancer.

Clin Chem (2018) 64:1513-1521.

Shah RV et al.

Associations of circulating extracellular RNAs with myocardial remodeling and heart failure.

JAMA Cardiol (2018) 3:871-876.

Silva AM et al.

Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.

Theranostics (2018) 8:3902-3917.

Ghai V et al.

Genome-wide profiling of urinary extracellular vesicle microRNAs associated with diabetic nephropathy in type 1 diabetes.

Kidney Int Rep (2018) 3:555-572.

Danielson KM et al.

Plasma circulating extracellular RNAs in Left Ventricular Remodeling post-Myocardial Infarction.

EBioMedicine (2018) 32:172-181.

Kaczor-Urbanowicz KE et al.

Salivary exRNA biomarkers to detect gingivitis and monitor disease regression.

J Clin Periodontol (2018) 45:806-817.

Koupenova M et al.

Micro RNAs from DNA viruses are found widely in plasma in a large observational human population.

Sci Rep (2018) 8:6397.

Fallen S et al.

Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour.

J Cell Mol Med (2018) 22:2760-2773.

Nonaka T & Wong DTW.

Liquid biopsy in head and neck cancer: Promises and challenges.

J Dent Res (2018) 97:701-708.

Baecher-Allan C, Kaskow BJ & Weiner HL.

Multiple Sclerosis: Mechanisms and immunotherapy.

Neuron (2018) 97:742-768.

Raheja R et al.

Correlating serum microRNAs and clinical parameters in amyotrophic lateral sclerosis.

Muscle Nerve (2018) 58:261-269.

Shah R et al.

MicroRNAs associated with reverse left ventricular remodeling in humans identify pathways of heart failure progression.

Circ Heart Fail (2018) 11:e004278.

Reategui E et al.

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Nat Commun (2018) 9:175.


Bei Y et al.

Extracellular vesicles in cardiovascular theranostics.

Theranostics (2017) 7:4168-4182.
Related Pathway


Wei Z et al.

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Nat Commun (2017) 8:1145.

Willinger CM et al.

MicroRNA signature of cigarette smoking and evidence for a putative causal role of microRNAs in smoking-related inflammation and target organ damage.

Circ Cardiovasc Genet (2017) 10:5.

Shah R et al.

Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: Brief report.

Am J Physiol Heart Circ Physiol (2017) 313:H1162-H1167.

Shankar GM et al.

Liquid biopsy for brain tumors.

Expert Rev Mol Diagn (2017) 17:943-947.

Jones A et al.

miRNA signatures of insulin resistance in obesity.

Obesity (2017) 25:1734-1744.

Vasilescu C et al.

Circulating miRNAs in sepsis-A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis.

PLoS ONE (2017) 12:e0183334.

Zhang Y et al.

Salivary extracellular RNA biomarkers for insulin resistance detection in Hispanics.

Diabetes Res Clin Pract (2017) 132:85-94.

Jayaram H et al.

Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: a pilot study.

Invest Ophthalmol Vis Sci (2017) 58:2884-2890.

Fuentes-Mattei E et al.

Plasma viral miRNAs indicate a high prevalence of occult viral infections.

EBioMedicine (2017) 20:182-192.

Figueroa JM et al.

Detection of wtEGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients.

Neuro Oncol (2017) 19:1494-1502.

Klingenberg M et al.

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

J Hepatol (2017) 67:603-618.
Related Pathways: 1, 2


Mick E et al.

Stroke and circulating extracellular RNAs.

Stroke (2017) 48:828-834.

He Y et al.

A systematic study of dysregulated microRNA in Type 2 Diabetes Mellitus.

Int J Mol Sci (2017) 18:3.

Xiao J et al.

Circulating miR-30d predicts survival in patients with acute heart failure.

Cell Physiol Biochem (2017) 41:865-874.

Shah R et al.

Extracellular RNAs are associated with insulin resistance and metabolic phenotypes.

Diabetes Care (2017) 40:546-553.

McManus DD et al.

Messenger RNA and microRNA transcriptomic signatures of cardiometabolic risk factors.

BMC Genomics (2017) 18:139.

Regev K et al.

Association between serum microRNAs and Magnetic Resonance Imaging measures of Multiple Sclerosis severity.

JAMA Neurol (2017) 74:275-285.


Wang X, Kaczor-Urbanowicz KE & Wong DT.

Salivary biomarkers in cancer detection.

Med Oncol (2017) 34:7.

Matsuda A et al.

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.

Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.

Kaczor-Urbanowicz KE et al.

Saliva diagnostics – Current views and directions.

Exp Biol Med (Maywood) (2017) 242:459-472.

Dou Y et al.

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Sci Rep (2016) 6:37982.

Kaczor-Urbanowicz KE et al.

Emerging technologies for salivaomics in cancer detection.

J Cell Mol Med (2017) 21:640-647.

Lusardi TA et al.

MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer’s disease.

J Alzheimers Dis (2017) 55:1223-1233.

Kanlikilicer P et al.

Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells.

Cancer Res (2016) 76:7194-7207.

Regev K et al.

Comprehensive evaluation of serum microRNAs as biomarkers in Multiple Sclerosis.

Neurol Neuroimmunol Neuroinflamm (2016) 3:e267.

Smith EM et al.

International validation of a urinary biomarker panel for identification of active lupus nephritis in children.

Pediatr Nephrol (2017) 32:283-295.

Ghai V & Wang K.

Recent progress toward the use of circulating microRNAs as clinical biomarkers.

Arch Toxicol (2016) 90:2959-2978.

Yan IK et al.

Circulating extracellular RNA markers of liver regeneration.

PLoS ONE (2016) 11:e0155888.

Wu S et al.

Circulating microRNAs and life expectancy among identical twins.

Ann Hum Genet (2016) 80:247-56.

Van Roosbroeck K & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?

Semin Oncol (2016) 43:209-14.

Byron SA et al.

Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.

Nat Rev Genet (2016) 17:257-71. Related blog post

Rennert RC, Hochberg FH & Carter BS.

ExRNA in biofluids as biomarkers for brain tumors.

Cell Mol Neurobiol (2016) 36:353-60.

Sun Y et al.

Examining plasma microRNA markers for colorectal cancer at different stages.

Oncotarget (2016) 7:11434-49.

Melman YF et al.

Response to letter regarding article, “Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study”

Circulation (2016) 133:e389-90.

Gleber-Netto FO et al.

Salivary biomarkers for detection of oral squamous cell carcinoma in a Taiwanese population.

Clin Cancer Res (2016) 22:3340-7.

Fabris L et al.

The potential of microRNAs as prostate cancer biomarkers.

Eur Urol (2016) 70:312-22.

Xu T et al.

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients.

Oncotarget (2016) 7:12414-25.


Mohankumar S & Patel T.

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.

Brief Funct Genomics (2016) 15:249-56.

Monroig-Bosque Pdel C, Rivera CA & Calin GA.

MicroRNAs in cancer therapeutics: “From the bench to the bedside”.

Expert Opin Biol Ther (2015) 15:1381-5.

Ainsztein AM et al.

The NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27493.

Laurent LC et al.

Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:26533.

Quinn JF et al.

Extracellular RNAs: Development as biomarkers of human disease.

J Extracell Vesicles (2015) 4:27495.

Lin X et al.

Noncoding RNAs in human saliva as potential disease biomarkers.

Front Genet (2015) 6:175.

Melman YF et al.

Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: a translational pilot study.

Circulation (2015) 131:2202-16.

Akers JC et al.

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients.

J Neurooncol (2015) 123:205-16.

Majem B et al.

Non-coding RNAs in saliva: Emerging biomarkers for molecular diagnostics.

Int J Mol Sci (2015) 16:8676-98.

Saugstad JA.

Non-coding RNAs in stroke and neuroprotection.

Front Neurol (2015) 6:50.

Wong DT.

Salivary extracellular noncoding RNA: Emerging biomarkers for molecular diagnostics.

Clin Ther (2015) 37:540-51.

Ho GY et al.

Differential expression of circulating microRNAs according to severity of colorectal neoplasia.

Transl Res (2015) 166:225-32.

Guzman N et al.

Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes “microRNA-like” tRNA Fragments.

Mol Cancer Res (2015) 13:891-901.

Boukouris S & Mathivanan S.

Exosomes in bodily fluids are a highly stable resource of disease biomarkers.

Proteomics Clin Appl (2015) 9:358-67.

George J & Patel T.

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.

Semin Liver Dis (2015) 35:63-74.


Srivastava A et al.

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.

Curr Gene Ther (2015) 15:182-92.

Fuentes L, Yakob M & Wong DT.

Emerging horizons of salivary diagnostics for periodontal disease.

Br Dent J (2014) 217:567-73.

Sato-Kuwabara Y et al.

The fusion of two worlds: Non-coding RNAs and extracellular vesicles–Diagnostic and therapeutic implications.

Int J Oncol (2015) 46:17-27.

Kawikova I & Askenase PW.

Diagnostic and therapeutic potentials of exosomes in CNS diseases.

Brain Res (2015) 1617:63-71.

Haga H & Patel T.

Molecular diagnosis of intrahepatic cholangiocarcinoma.

J Hepatobiliary Pancreat Sci (2015) 22:114-23.

Braicu C et al.

Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?

Cell Death Differ (2015) 22:34-45.

Akat KM et al.

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

Proc Natl Acad Sci U S A (2014) 111:11151-6.

Yakob M et al.

Salivary biomarkers for detection of oral squamous cell carcinoma – Current state and recent advances.

Curr Oral Health Rep (2014) 1:133-141.

Redzic JS et al.

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol (2014) 28:14-23.

Patel T.

Extracellular vesicle noncoding RNA: New players in the diagnosis and pathogenesis of cholangiocarcinoma.

Hepatology (2014) 60:782-4.

Hochberg FH et al.

Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.

Expert Rev Mol Diagn (2014) 14:439-52.

Ben-Dov IZ et al.

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: Description of miRNA profiles at baseline.

PLoS ONE (2014) 9:e86856.

McManus DD et al.

Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study.

Heart Rhythm (2014) 11:663-9.


Akers JC et al.

MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development.

PLoS ONE (2013) 8:e78115.

Chen WW et al.

BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles.

Mol Ther Nucleic Acids (2013) 2:e109.

Lau C et al.

Role of pancreatic cancer-derived exosomes in salivary biomarker development.

J Biol Chem (2013) 288:26888-97.

Gonda DD et al.

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.

Neurosurgery (2013) 72:501-10.