The Extracellular RNA Communication Consortium has published 800+ research articles since its inception in 2013. Articles in the category “Biomarkers” are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.
Kumar S et al.
Quantifying PON1 on HDL with nanoparticle-gated electrokinetic membrane sensor for accurate cardiovascular risk assessment.
Nat Commun (2023) 14:557.
Nguyen LTH et al.
An immunogold single extracellular vesicular RNA and protein ((Au) SERP) biochip to predict responses to immunotherapy in non-small cell lung cancer patients.
J Extracell Vesicles (2022) 11:e12258.
Lennon KM et al.
Cardiac troponin T in extracellular vesicles as a novel biomarker in human cardiovascular disease.
Clin Transl Med (2022) 12:e979.
Spanos M et al.
Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection.
iScience (2022) 25:104833.
Li G et al.
Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs.
Adv Sci (2022) 9:e2200829.
Alsop E et al.
A novel tissue atlas and online tool for the interrogation of small RNA expression in human tissues and biofluids.
Front Cell Dev Biol (2022) 10:804164.
Su Y et al.
Multiple early factors anticipate post-acute COVID-19 sequelae.
Cell (2022) 185:881-895.e20.
Max KEA et al.
Plasma microRNA interindividual variability in healthy individuals, pregnant women, and an individual with a stably altered neuroendocrine phenotype.
Clin Chem (2021) 67:1676-1688.
Hao N et al.
Acoustofluidic multimodal diagnostic system for Alzheimer’s disease.
Biosens Bioelectron (2022) 196:113730.
Wang Z et al.
Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes.
Microsyst Nanoeng (2021) 7:20.
Ma S et al.
CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.
Cell Rep (2021) 36:109549.
Satake E et al.
Comprehensive search for novel circulating miRNAs and axon guidance pathway proteins associated with risk of ESKD in diabetes.
J Am Soc Nephrol (2021) 32:2331-2351.
Blanco-Dominguez R et al.
A novel circulating microRNA for the detection of acute myocarditis.
N Engl J Med (2021) 384:2014-2027.
Muthukumar T et al.
Serum microRNA transcriptomics and acute rejection or recurrent Hepatitis C virus in human liver allograft recipients: a pilot study.
Transplantation (2022) 106:806-820.
Chen L et al.
Elliptical pipette generated large microdroplets for POC visual ddPCR quantification of low viral load.
Anal Chem (2021) 93:6456-6462.
Crouser ED et al.
Circulating exosomal microRNA expression patterns distinguish cardiac sarcoidosis from myocardial ischemia.
PLoS ONE (2021) 16:e0246083.
Muralidharan K et al.
TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas.
Clin Cancer Res (2021) 27:169-178.
Sandau US et al.
Performance of validated microRNA biomarkers for Alzheimer’s disease in mild cognitive impairment.
J Alzheimers Dis (2020) 78:245-263.
Srinivasan S et al.
Discovery and verification of extracellular miRNA biomarkers for non-invasive prediction of pre-eclampsia in asymptomatic women.
Cell Rep Med (2020) 1:100013.
Charest A.
Experimental and biological insights from proteomic analyses of extracellular vesicle cargos in normalcy and disease.
Adv Biosyst (2020) 4:e2000069.
Vaze A et al.
Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study.
PLoS ONE (2020) 15:e0236960.
Meabon JS et al.
Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure.
J Neurol Sci (2020) 417:117049.
Li F et al.
Ultra-short circulating tumor DNA (usctDNA) in plasma and saliva of Non-Small Cell Lung Cancer (NSCLC) patients.
Cancers (Basel) (2020) 12:2041.
Shukuya T et al.
Circulating microRNAs and extracellular vesicle-containing microRNAs as response biomarkers of Anti-programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC.
J Thorac Oncol (2020) 15:1773-1781.
Yekula A et al.
Liquid biopsy strategies to distinguish progression from pseudoprogression and radiation necrosis in glioblastomas.
Adv Biosyst (2020) 4:e2000029.
Hao N et al.
Acoustofluidics-assisted engineering of multifunctional three-dimensional zinc oxide nanoarrays.
ACS Nano (2020) 14:6150-6163.
Ahn JY et al.
Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria.
Biochim Biophys Acta Gen Subj (2021) 1865:129598.
Tran AM et al.
A new world of biomarkers and therapeutics for female reproductive system and breast cancers: Circular RNAs.
Front Cell Dev Biol (2020) 8:50.
Yekula A et al.
From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers.
Methods (2020) 177:58-66.
Rao SL et al.
Altered level of salivary placental growth factor is associated with preeclampsia.
Placenta (2020) 90:118-120.
Ghai V et al.
Alterations in plasma microRNA and protein levels in war veterans with chronic mild traumatic brain injury.
J Neurotrauma (2020) 37:1418-1430.
Silverman MG et al.
Circulating miRNAs and risk of sudden death in patients with coronary heart disease.
JACC Clin Electrophysiol (2020) 6:70-79.
Wang Z et al.
Acoustofluidic salivary exosome isolation: a liquid biopsy compatible approach for human papillomavirus-associated oropharyngeal cancer detection.
J Mol Diagn (2020) 22:50-59.
Sun L et al.
miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44.
Theranostics (2019) 9:8409-8425.
Jones PS et al.
Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.
EBioMedicine (2019) 48:23-35.
Lee MY et al.
Distinct profiles of cell-free microRNAs in plasma of veterans with Post-Traumatic Stress Disorder.
J Clin Med (2019) 8:963.
Kaczor-Urbanowicz KE et al.
Clinical validity of saliva and novel technology for cancer detection.
Biochim Biophys Acta Rev Cancer (2019) 1872:49-59.
Petrescu GED et al.
MicroRNA based theranostics for brain cancer: Basic principles.
J Exp Clin Cancer Res (2019) 38:231.
Lee MY et al.
A biological function based biomarker panel optimization process.
Sci Rep (2019) 9:7365.
Ghai V et al.
Extracellular vesicle encapsulated microRNAs in patients with Type 2 Diabetes are affected by metformin treatment.
J Clin Med (2019) 8:617.
Giraldez MD et al.
Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma.
EMBO J (2019) 38:e101695.
Gonzalez-Villasana V et al.
Presence of circulating miR-145, miR-155, and miR-382 in exosomes isolated from serum of breast cancer patients and healthy donors.
Dis Markers (2019) 2019:6852917.
Dawes C & Wong DTW.
Role of saliva and salivary diagnostics in the advancement of oral health.
J Dent Res (2019) 98:133-141.
Ghai V et al.
Circulating RNAs as predictive markers for the progression of type 2 diabetes.
J Cell Mol Med (2019) 23:2753-2768.
Wiedrick JT et al.
Validation of microRNA biomarkers for Alzheimer’s Disease in human cerebrospinal fluid.
J Alzheimers Dis (2019) 67:875-891.
Pua HH et al.
Increased hematopoietic extracellular RNAs and vesicles in the lung during allergic airway responses.
Cell Rep (2019) 26:933-944.e4.
Varkaris A et al.
Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer.
Br J Cancer (2019) 120:340-345.
Gulei D et al.
CRISPR-based RNA editing: Diagnostic applications and therapeutic options.
Expert Rev Mol Diagn (2019) 19:83-88.
Lusardi TA et al.
Analytics of Cerebrospinal Fluid microRNA quantitative PCR studies.
Mol Neurobiol (2019) 56:4988-4999.
Smith EMD et al.
A Markov Multi-State model of lupus nephritis urine biomarker panel dynamics in children: Predicting changes in disease activity.
Clin Immunol (2019) 198:71-78.
Bei Y et al.
Circular RNAs as potential theranostics in the cardiovascular system.
Mol Ther Nucleic Acids (2018) 13:407-418.
Hinger SA et al.
Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells.
Cell Rep (2018) 25:715-725.e4.
Wei F et al.
Electric field-induced release and measurement liquid biopsy for noninvasive early lung cancer assessment.
J Mol Diagn (2018) 20:738-742.
Antoury L et al.
Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of Muscular Dystrophies.
Nat Commun (2018) 9:3906.
Narla V et al.
Unique circulating microRNA profiles in HIV infection.
J Acquir Immune Defic Syndr (2018) 79:644-650.
Regev K et al.
Identification of MS-specific serum miRNAs in an international multicenter study.
Neurol Neuroimmunol Neuroinflamm (2018) 5:e491.
Li F et al.
Discovery and validation of salivary extracellular RNA biomarkers for noninvasive detection of gastric cancer.
Clin Chem (2018) 64:1513-1521.
Shah RV et al.
Associations of circulating extracellular RNAs with myocardial remodeling and heart failure.
JAMA Cardiol (2018) 3:871-876.
Silva AM et al.
Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.
Theranostics (2018) 8:3902-3917.
Ghai V et al.
Genome-wide profiling of urinary extracellular vesicle microRNAs associated with diabetic nephropathy in type 1 diabetes.
Kidney Int Rep (2018) 3:555-572.
Danielson KM et al.
Plasma circulating extracellular RNAs in Left Ventricular Remodeling post-Myocardial Infarction.
EBioMedicine (2018) 32:172-181.
Kaczor-Urbanowicz KE et al.
Salivary exRNA biomarkers to detect gingivitis and monitor disease regression.
J Clin Periodontol (2018) 45:806-817.
Koupenova M et al.
Micro RNAs from DNA viruses are found widely in plasma in a large observational human population.
Sci Rep (2018) 8:6397.
Fallen S et al.
Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour.
J Cell Mol Med (2018) 22:2760-2773.
Nonaka T & Wong DTW.
Liquid biopsy in head and neck cancer: Promises and challenges.
J Dent Res (2018) 97:701-708.
Baecher-Allan C, Kaskow BJ & Weiner HL.
Multiple Sclerosis: Mechanisms and immunotherapy.
Neuron (2018) 97:742-768.
Raheja R et al.
Correlating serum microRNAs and clinical parameters in amyotrophic lateral sclerosis.
Muscle Nerve (2018) 58:261-269.
Shah R et al.
MicroRNAs associated with reverse left ventricular remodeling in humans identify pathways of heart failure progression.
Circ Heart Fail (2018) 11:e004278.
Reategui E et al.
Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.
Nat Commun (2018) 9:175.
Bei Y et al.
Extracellular vesicles in cardiovascular theranostics.
Theranostics (2017) 7:4168-4182.
Wei Z et al.
Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.
Nat Commun (2017) 8:1145.
Willinger CM et al.
MicroRNA signature of cigarette smoking and evidence for a putative causal role of microRNAs in smoking-related inflammation and target organ damage.
Circ Cardiovasc Genet (2017) 10:5.
Shah R et al.
Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: Brief report.
Am J Physiol Heart Circ Physiol (2017) 313:H1162-H1167.
Vasilescu C et al.
Circulating miRNAs in sepsis-A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis.
PLoS ONE (2017) 12:e0183334.
Zhang Y et al.
Salivary extracellular RNA biomarkers for insulin resistance detection in Hispanics.
Diabetes Res Clin Pract (2017) 132:85-94.
Jayaram H et al.
Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: a pilot study.
Invest Ophthalmol Vis Sci (2017) 58:2884-2890.
Fuentes-Mattei E et al.
Plasma viral miRNAs indicate a high prevalence of occult viral infections.
EBioMedicine (2017) 20:182-192.
Figueroa JM et al.
Detection of wtEGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients.
Neuro Oncol (2017) 19:1494-1502.
Klingenberg M et al.
Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.
J Hepatol (2017) 67:603-618.
He Y et al.
A systematic study of dysregulated microRNA in Type 2 Diabetes Mellitus.
Int J Mol Sci (2017) 18:3.
Xiao J et al.
Circulating miR-30d predicts survival in patients with acute heart failure.
Cell Physiol Biochem (2017) 41:865-874.
Shah R et al.
Extracellular RNAs are associated with insulin resistance and metabolic phenotypes.
Diabetes Care (2017) 40:546-553.
McManus DD et al.
Messenger RNA and microRNA transcriptomic signatures of cardiometabolic risk factors.
BMC Genomics (2017) 18:139.
Regev K et al.
Association between serum microRNAs and Magnetic Resonance Imaging measures of Multiple Sclerosis severity.
JAMA Neurol (2017) 74:275-285.
Wang X, Kaczor-Urbanowicz KE & Wong DT.
Salivary biomarkers in cancer detection.
Med Oncol (2017) 34:7.
Matsuda A et al.
MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.
Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.
Kaczor-Urbanowicz KE et al.
Saliva diagnostics – Current views and directions.
Exp Biol Med (Maywood) (2017) 242:459-472.
Dou Y et al.
Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.
Sci Rep (2016) 6:37982.
Kaczor-Urbanowicz KE et al.
Emerging technologies for salivaomics in cancer detection.
J Cell Mol Med (2017) 21:640-647.
Lusardi TA et al.
MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer’s disease.
J Alzheimers Dis (2017) 55:1223-1233.
Kanlikilicer P et al.
Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells.
Cancer Res (2016) 76:7194-7207.
Regev K et al.
Comprehensive evaluation of serum microRNAs as biomarkers in Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm (2016) 3:e267.
Smith EM et al.
International validation of a urinary biomarker panel for identification of active lupus nephritis in children.
Pediatr Nephrol (2017) 32:283-295.
Ghai V & Wang K.
Recent progress toward the use of circulating microRNAs as clinical biomarkers.
Arch Toxicol (2016) 90:2959-2978.
Yan IK et al.
Circulating extracellular RNA markers of liver regeneration.
PLoS ONE (2016) 11:e0155888.
Wu S et al.
Circulating microRNAs and life expectancy among identical twins.
Ann Hum Genet (2016) 80:247-56.
Van Roosbroeck K & Calin GA.
MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?
Semin Oncol (2016) 43:209-14.
Byron SA et al.
Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.
Nat Rev Genet (2016) 17:257-71. Related blog post
Rennert RC, Hochberg FH & Carter BS.
ExRNA in biofluids as biomarkers for brain tumors.
Cell Mol Neurobiol (2016) 36:353-60.
Sun Y et al.
Examining plasma microRNA markers for colorectal cancer at different stages.
Oncotarget (2016) 7:11434-49.
Melman YF et al.
Response to letter regarding article, “Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study”
Circulation (2016) 133:e389-90.
Gleber-Netto FO et al.
Salivary biomarkers for detection of oral squamous cell carcinoma in a Taiwanese population.
Clin Cancer Res (2016) 22:3340-7.
Fabris L et al.
The potential of microRNAs as prostate cancer biomarkers.
Eur Urol (2016) 70:312-22.
Xu T et al.
Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients.
Oncotarget (2016) 7:12414-25.
Mohankumar S & Patel T.
Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.
Brief Funct Genomics (2016) 15:249-56.
Monroig-Bosque Pdel C, Rivera CA & Calin GA.
MicroRNAs in cancer therapeutics: “From the bench to the bedside”.
Expert Opin Biol Ther (2015) 15:1381-5.
Ainsztein AM et al.
The NIH Extracellular RNA Communication Consortium.
J Extracell Vesicles (2015) 4:27493.
Laurent LC et al.
Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.
J Extracell Vesicles (2015) 4:26533.
Quinn JF et al.
Extracellular RNAs: Development as biomarkers of human disease.
J Extracell Vesicles (2015) 4:27495.
Lin X et al.
Noncoding RNAs in human saliva as potential disease biomarkers.
Front Genet (2015) 6:175.
Melman YF et al.
Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: a translational pilot study.
Circulation (2015) 131:2202-16.
Akers JC et al.
miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients.
J Neurooncol (2015) 123:205-16.
Majem B et al.
Non-coding RNAs in saliva: Emerging biomarkers for molecular diagnostics.
Int J Mol Sci (2015) 16:8676-98.
Wong DT.
Salivary extracellular noncoding RNA: Emerging biomarkers for molecular diagnostics.
Clin Ther (2015) 37:540-51.
Ho GY et al.
Differential expression of circulating microRNAs according to severity of colorectal neoplasia.
Transl Res (2015) 166:225-32.
Guzman N et al.
Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes “microRNA-like” tRNA Fragments.
Mol Cancer Res (2015) 13:891-901.
Boukouris S & Mathivanan S.
Exosomes in bodily fluids are a highly stable resource of disease biomarkers.
Proteomics Clin Appl (2015) 9:358-67.
George J & Patel T.
Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
Semin Liver Dis (2015) 35:63-74.
Srivastava A et al.
Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.
Curr Gene Ther (2015) 15:182-92.
Fuentes L, Yakob M & Wong DT.
Emerging horizons of salivary diagnostics for periodontal disease.
Br Dent J (2014) 217:567-73.
Sato-Kuwabara Y et al.
The fusion of two worlds: Non-coding RNAs and extracellular vesicles–Diagnostic and therapeutic implications.
Int J Oncol (2015) 46:17-27.
Kawikova I & Askenase PW.
Diagnostic and therapeutic potentials of exosomes in CNS diseases.
Brain Res (2015) 1617:63-71.
Haga H & Patel T.
Molecular diagnosis of intrahepatic cholangiocarcinoma.
J Hepatobiliary Pancreat Sci (2015) 22:114-23.
Braicu C et al.
Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?
Cell Death Differ (2015) 22:34-45.
Akat KM et al.
Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.
Proc Natl Acad Sci U S A (2014) 111:11151-6.
Yakob M et al.
Salivary biomarkers for detection of oral squamous cell carcinoma – Current state and recent advances.
Curr Oral Health Rep (2014) 1:133-141.
Redzic JS et al.
Extracellular RNA mediates and marks cancer progression.
Semin Cancer Biol (2014) 28:14-23.
Patel T.
Extracellular vesicle noncoding RNA: New players in the diagnosis and pathogenesis of cholangiocarcinoma.
Hepatology (2014) 60:782-4.
Hochberg FH et al.
Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.
Expert Rev Mol Diagn (2014) 14:439-52.
Ben-Dov IZ et al.
Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: Description of miRNA profiles at baseline.
PLoS ONE (2014) 9:e86856.
McManus DD et al.
Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study.
Heart Rhythm (2014) 11:663-9.
Akers JC et al.
MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development.
PLoS ONE (2013) 8:e78115.
Chen WW et al.
BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles.
Mol Ther Nucleic Acids (2013) 2:e109.
