The Extracellular RNA Communication Consortium has published 500+ research articles since its inception in 2013. They are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.

2021

Tosar JP et al & .

RI-SEC-seq: Comprehensive profiling of nonvesicular extracellular RNAs with different stabilities.

Bio Protoc (2021) 11:e3918.
   

Martin-Jaular L et al.

Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.

EMBO J AOP 2021-03-11.
   

Noren Hooten N et al.

Hitting the bullseye: Are extracellular vesicles on target?

J Extracell Vesicles (2020) 10:e12032.
  

Nguyen VVT et al.

Functional assays to assess the therapeutic potential of extracellular vesicles.

J Extracell Vesicles (2020) 10:e12033.
  

Yu X et al.

Ultrasensitive amyloid beta-protein quantification with high dynamic range using a hybrid graphene-gold surface-enhanced Raman spectroscopy platform.

J Raman Spectrosc (2020) 51:432-441.
 

Saheera S et al & .

Extracellular vesicle interplay in cardiovascular pathophysiology.

Am J Physiol Heart Circ Physiol AOP 2021-03-05.
   

Gorur A et al.

ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer.

Mol Ther Nucleic Acids (2021) 23:930-943.
 

Li J et al.

Angiotensin II-induced muscle atrophy via PPARgamma suppression is mediated by miR-29b.

Mol Ther Nucleic Acids (2021) 23:743-756.
 

Chen C et al.

Acoustofluidic rotational tweezing enables high-speed contactless morphological phenotyping of zebrafish larvae.

Nat Commun (2021) 12:1118.
 

Ma S et al.

Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype.

Cell Rep (2021) 34:108726.
  

Welsh JA et al.

A simple, high-throughput method of protein and label removal from extracellular vesicle samples.

Nanoscale (2021) 13:3737-3745.
 

Zhu H et al.

Acoustohydrodynamic tweezers via spatial arrangement of streaming vortices.

Sci Adv (2021) 7:eabc7885.
 

Gu Y et al.

Acoustofluidic centrifuge for nanoparticle enrichment and separation.

Sci Adv (2021) 7:eabc0467.
 

Thistlethwaite LR et al.

CTD: An information-theoretic algorithm to interpret sets of metabolomic and transcriptomic perturbations in the context of graphical models.

PLoS Comput Biol (2021) 17:e1008550.
 

Crouser ED et al.

Circulating exosomal microRNA expression patterns distinguish cardiac sarcoidosis from myocardial ischemia.

PLoS ONE (2021) 16:e0246083.
 

Palace SG et al.

Yersinia pestis escapes entrapment in thrombi by targeting platelet function.

J Thromb Haemost (2020) 18:3236-3248.
 

2020

Silverman DA et al.

Cancer-associated neurogenesis and nerve-cancer cross-talk.

Cancer Res (2021) 81:1431-1440.
   

Morales-Kastresana A, Welsh JA & Jones JC.

Detection and sorting of extracellular vesicles and viruses using nanoFACS.

Curr Protoc Cytom (2020) 95:e81.
 

Guo C et al.

The D614G mutation enhances the lysosomal trafficking of SARS-CoV-2 spike.

bioRxiv AOP 2020-12-09.
 

Kunert-Graf J, Sakhanenko N & Galas D.

Partial information decomposition and the information delta: A geometric unification disentangling non-pairwise information.

Entropy (Basel) (2020) 22:1333.
 

Xie Y et al.

Microfluidic isolation and enrichment of nanoparticles.

ACS Nano (2020) 14:16220–16240.
  

Nieland L et al.

Extracellular vesicle-mediated bilateral communication between glioblastoma and astrocytes.

Trends Neurosci (2021) 44:215-226.
   

Burnie J et al.

Flow virometry quantification of host proteins on the surface of HIV-1 pseudovirus particles.

Viruses (2020) 12:1296.
 

Hao N et al.

Acoustofluidics-assisted fluorescence-SERS bimodal biosensors.

Small (2020) 16:e2005179.
 

Su Y et al.

Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19.

Cell (2020) 183:1479-1495.e20.
 

Zhang P et al.

Deterministic droplet coding via acoustofluidics.

Lab Chip (2020) 20:4466-4473.
 

Li J et al.

miR-30d regulates cardiac remodeling by intracellular and paracrine signaling.

Circ Res (2020) 128:e1-e23.
  

Anfossi S & Calin GA.

Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy.

Cancer Drug Resist (2020) 3:356-370.
   

Welsh JA et al.

Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration.

J Extracell Vesicles (2020) 9:1816641.
 

Muralidharan K et al.

TERT promoter mutation analysis for blood-based diagnosis and monitoring of gliomas.

Clin Cancer Res (2021) 27:169-178.
  

Zhang Q et al.

Angiotensin-converting Enzyme 2-containing small extracellular vesicles and exomeres bind the Severe Acute Respiratory Syndrome Coronavirus 2 spike protein.

Gastroenterology (2021) 160:958-961.e3.
  

Zhao Z et al.

miRNA profiling of primate cervicovaginal lavage and extracellular vesicles reveals miR-186-5p as a potential antiretroviral factor in macrophages.

FEBS Open Bio (2020) 10:2021-2039.
  

Kaczor-Urbanowicz KE et al.

Reviews on current liquid biopsy for detection and management of pancreatic cancers.

Pancreas (2020) 49:1141-1152.
  

Sandau US et al.

Performance of validated microRNA biomarkers for Alzheimer's disease in mild cognitive impairment.

J Alzheimers Dis (2020) 78:245-263.
 

Huang Y et al.

Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles.

J Extracell Vesicles (2020) 9:1785746.
 

Welsh JA & Jones JC.

Small particle fluorescence and light scatter calibration using FCMPASS software.

Curr Protoc Cytom (2020) 94:e79.
 

Tian Z et al.

Generating multifunctional acoustic tweezers in Petri dishes for contactless, precise manipulation of bioparticles.

Sci Adv (2020) 6:eabb0494.
 

Srinivasan S et al.

Discovery and verification of extracellular miRNA biomarkers for non-invasive prediction of pre-eclampsia in asymptomatic women.

Cell Rep Med (2020) 1:100013.
 

Fazzalari A et al.

A translational model for venous thromboembolism: microRNA expression in hibernating black bears.

J Surg Res (2021) 257:203-212.
  

Royo F et al.

Methods for separation and characterization of extracellular vesicles: Results of a worldwide survey performed by the ISEV Rigor and Standardization subcommittee.

Cells (2020) 9:1955.
 

Suea-Ngam A et al.

Enzyme-assisted nucleic acid detection for infectious disease diagnostics: Moving toward the point-of-care.

ACS Sens (2020) 5:2701-2723.
  

Zhong Z et al.

Hardware design and fault-tolerant synthesis for digital acoustofluidic biochips.

IEEE Trans Biomed Circuits Syst (2020) 14:1065-1078.
 

Charest A.

Experimental and biological insights from proteomic analyses of extracellular vesicle cargos in normalcy and disease.

Adv Biosyst (2020) 4:e2000069.
   

Vaze A et al.

Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study.

PLoS ONE (2020) 15:e0236960.
 

Chen B et al.

The long noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling.

Gastroenterology (2020) 159:2146-2162.e33.
 

Tosar JP et al.

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome.

Nucleic Acids Res (2020) 48:12874-12888.
  

Liu P et al.

Acoustofluidic multi-well plates for enrichment of micro/nano particles and cells.

Lab Chip (2020) 20:3399-3409.
 

Meabon JS et al.

Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure.

J Neurol Sci (2020) 417:117049.
  

Li F et al.

Ultra-short circulating tumor DNA (usctDNA) in plasma and saliva of Non-Small Cell Lung Cancer (NSCLC) patients.

Cancers (Basel) (2020) 12:2041.
  

Drula R et al.

MicroRNAs from liquid biopsy derived extracellular vesicles: Recent advances in detection and characterization methods.

Cancers (Basel) (2020) 12:2009.
    

Bouchareychas L et al.

Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via microRNA cargo.

Cell Rep (2020) 32:107881.
    

Chiu LS et al.

The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study.

Liver Int (2020) 40:2445-2454.
 

Lurie E et al.

Histoepigenetic analysis of the mesothelin network within pancreatic ductal adenocarcinoma cells reveals regulation of retinoic acid receptor gamma and AKT by mesothelin.

Oncogenesis (2020) 9:62.
  

Koupenova M & Freedman JE.

Platelets and immunity: Going viral.

Arterioscler Thromb Vasc Biol (2020) 40:1605-1607.
   

Zhang P et al.

Acoustic streaming vortices enable contactless, digital control of droplets.

Sci Adv (2020) 6:eaba0606.
 

Jin G et al.

Acoustofluidic scanning nanoscope with high resolution and large field of view.

ACS Nano (2020) 14:8624-8633.
 

Gu Y et al.

Acoustofluidic holography for micro- to nanoscale particle manipulation.

ACS Nano (2020) 14:14635-14645.
 

Shukuya T et al.

Circulating microRNAs and extracellular vesicle-containing microRNAs as response biomarkers of Anti-programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC.

J Thorac Oncol (2020) 15:1773-1781.
 

Abels ER et al.

GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma.

Sci Rep (2020) 10:9898.
   

Zhang P et al.

Acoustic microfluidics.

Annu Rev Anal Chem (Palo Alto Calif) (2020) 13:17-43.
  

Yekula A et al.

Liquid biopsy strategies to distinguish progression from pseudoprogression and radiation necrosis in glioblastomas.

Adv Biosyst (2020) 4:e2000029.
  

O'Brien K et al.

RNA delivery by extracellular vesicles in mammalian cells and its applications.

Nat Rev Mol Cell Biol (2020) 21:585-606.
  

Chen F et al.

Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in Acute Myeloid Leukaemia: Therapeutic implications.

J Cell Mol Med (2020) 24:7378-7392.
  

Sung BH et al.

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells.

Nat Commun (2020) 11:2092.
   

Hao N et al.

Acoustofluidics-assisted engineering of multifunctional three-dimensional zinc oxide nanoarrays.

ACS Nano (2020) 14:6150-6163.
  

Maas SLN et al.

Glioblastoma hijacks microglial gene expression to support tumor growth.

J Neuroinflammation (2020) 17:120.
  

Hunter-Zinck H et al.

Genotyping array design and data quality control in the Million Veteran Program.

Am J Hum Genet (2020) 106:535-548.
 

Tran AM et al.

A new world of biomarkers and therapeutics for female reproductive system and breast cancers: Circular RNAs.

Front Cell Dev Biol (2020) 8:50.
   

Zhao S et al.

A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers.

Lab Chip (2020) 20:1298-1308.
 

Wang C, Senapati S & Chang HC.

Liquid biopsy technologies based on membrane microfluidics: High-yield purification and selective quantification of biomarkers in nanocarriers.

Electrophoresis (2020) 41:1878-1892.
  

Bachman H et al.

Low-frequency flexural wave based microparticle manipulation.

Lab Chip (2020) 20:1281-1289.
 

Welsh JA et al.

MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments.

J Extracell Vesicles (2020) 9:1713526.
 

Zhang L et al.

A cell-phone-based acoustofluidic platform for quantitative point-of-care testing.

ACS Nano (2020) 14:3159-3169.
 

Bachman H et al.

An acoustofluidic device for efficient mixing over a wide range of flow rates.

Lab Chip (2020) 20:1238-1248.
 

Lucero R et al.

Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells.

Cell Rep (2020) 30:2065-2074.e4.
 

Tosar JP & Cayota A.

Extracellular tRNAs and tRNA-derived fragments.

RNA Biol (2020) 17:1149-1167.
   

Yekula A et al.

From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers.

Methods (2020) 177:58-66.
 

Rao SL et al.

Altered level of salivary placental growth factor is associated with preeclampsia.

Placenta (2020) 90:118-120.
 

Wei S et al.

A rapid and simple bead-bashing-based method for genomic DNA extraction from mammalian tissue.

Biotechniques (2020) 68:240-244.
 

Yekula A et al.

Extracellular vesicles in glioblastoma tumor microenvironment.

Front Immunol (2019) 10:3137.
   

Ghai V et al.

Alterations in plasma microRNA and protein levels in war veterans with chronic mild traumatic brain injury.

J Neurotrauma (2020) 37:1418-1430.
   

Kang P et al.

Acoustic tweezers based on circular, slanted-finger interdigital transducers for dynamic manipulation of micro-objects.

Lab Chip (2020) 20:987-994.
 

Xie Y et al.

Acoustic cell separation based on biophysical properties.

J Biomech Eng (2020) 142:0310051-9.
 

Perez PS et al.

Extracellular vesicles and chronic inflammation during HIV infection.

J Extracell Vesicles (2019) 8:1687275.
  

Pichler M et al.

Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.

Gut (2020) 69:1818-1831.
 

Meyer C et al.

The G3BP1-Family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

Mol Cell (2020) 77:1193-1205.e5.
  

Silverman MG et al.

Circulating miRNAs and risk of sudden death in patients with coronary heart disease.

JACC Clin Electrophysiol (2020) 6:70-79.
  

Oliveira GP Jr et al.

Detection of extracellular vesicle RNA using molecular beacons.

iScience (2020) 23:100782.
 

Xiong C et al.

Targeting forward and reverse EphB4/EFNB2 signaling by a peptide with dual functions.

Sci Rep (2020) 10:520.
 

Forterre AV et al.

Extracellular vesicle-mediated in vitro transcribed mRNA delivery for treatment of HER2(+) breast cancer xenografts in mice by prodrug CB1954 without general toxicity.

Mol Cancer Ther (2020) 19:858-867.
 

Rima XY et al & .

Surface engineering within a microchannel for hydrodynamic and self-assembled cell patterning.

Biomicrofluidics (2020) 14:014104.
 

El-Arabey AA et al.

GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma.

Cell Signal (2020) 68:109539.
 

2019

Gambaro F et al.

Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner.

RNA Biol (2019) 17:1168-1182.
   

Parashar D et al.

miRNA551b-3p activates an oncostatin signaling module for the progression of triple-negative breast cancer.

Cell Rep (2019) 29:4389-4406.e10.
 

De Los Santos MC, Dragomir MP & Calin GA.

The role of exosomal long non-coding RNAs in cancer drug resistance.

Cancer Drug Resist (2019) 2:1178-1192.
   

Godoy PM et al.

Comparison of reproducibility, accuracy, sensitivity, and specificity of miRNA quantification platforms.

Cell Rep (2019) 29:4212-4222.e5.
 

Yang Z et al.

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.

Nat Biomed Eng (2020) 4:69-83.
  

Wang Z et al.

Acoustofluidic salivary exosome isolation: a liquid biopsy compatible approach for human papillomavirus-associated oropharyngeal cancer detection.

J Mol Diagn (2020) 22:50-59.
 

Kalra H et al.

Extracellular vesicles containing oncogenic mutant beta-catenin activate Wnt signalling pathway in the recipient cells.

J Extracell Vesicles (2019) 8:1690217.
  

Yokoi A et al.

Mechanisms of nuclear content loading to exosomes.

Sci Adv (2019) 5:eaax8849.
  

Weaver AM & Patton JG.

Argonautes in extracellular vesicles: Artifact or selected cargo?

Cancer Res (2020) 80:379-381.
  

Russell AE et al.

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop.

J Extracell Vesicles (2019) 8:1684862.
  

Ding EY et al.

Accuracy and usability of a novel algorithm for detection of irregular pulse using a smartwatch among older adults: Observational study.

JMIR Cardio (2019) 3:e13850.
 

Zaborowski MP et al.

Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles.

Sci Rep (2019) 9:17387.
   

Darling CE et al.

Bioimpedance-based heart failure deterioration prediction using a prototype fluid accumulation vest-mobile phone dyad: an observational study.

JMIR Cardio (2017) 1:e1.
 

Sun L et al.

miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44.

Theranostics (2019) 9:8409-8425.
    

Sundaram K et al.

Plant-derived exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis.

iScience (2019) 21:308-327.
   

Lee MJ et al.

The impact of Moyamoya disease and RNF213 mutations on the spectrum of plasma protein and microRNA.

J Clin Med (2019) 8:1648.
  

Spartano NL et al.

Comparison of on-site versus remote mobile device support in the Framingham Heart Study using the health eHeart study for digital follow-up: Randomized pilot study set within an observational study design.

JMIR Mhealth Uhealth (2019) 7:e13238.
 

Pusic KM et al.

IFNgamma-stimulated dendritic cell exosomes for treatment of migraine modeled using spreading depression.

Front Neurosci (2019) 13:942.
   

Dias MM et al.

GLS2 is protumorigenic in breast cancers.

Oncogene (2020) 39:690-702.
 

Abels ER et al.

Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21.

Cell Rep (2019) 28:3105-3119.e7.
 

Ishiguro K, Yan IK & Patel T.

Isolation of tissue extracellular vesicles from the liver.

J Vis Exp (2019) 150:e58649.
 

Kanada M et al.

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy.

Mol Cancer Ther (2019) 18:2331-2342.
  

Yoneshiro T et al.

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.

Nature (2019) 572:614-619.
 

Fabbri M et al.

Decrypting noncoding RNA interactions, structures, and functional networks.

Genome Res (2019) 29:1377-1388.
  

Batki J et al.

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.

Nat Struct Mol Biol (2019) 26:720-731.
 

Bach DH, Zhang W & Sood AK.

Chromosomal instability in tumor initiation and development.

Cancer Res (2019) 79:3995-4002.
 

Chen X et al.

Identifying and targeting angiogenesis-related microRNAs in ovarian cancer.

Oncogene (2019) 38:6095-6108.
 

Lee MY et al.

Distinct profiles of cell-free microRNAs in plasma of veterans with Post-Traumatic Stress Disorder.

J Clin Med (2019) 8:963.
  

Morales-Kastresana A et al.

High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer.

J Extracell Vesicles (2019) 8:1597603.
 

Gyuris A et al.

Physical and molecular landscapes of mouse glioma extracellular vesicles define heterogeneity.

Cell Rep (2019) 27:3972-3987.e6.
     

Pegtel DM & Gould SJ.

Exosomes.

Annu Rev Biochem (2019) 88:487-514.
   

Haraszti RA et al.

Serum deprivation of Mesenchymal Stem Cells improves exosome activity and alters lipid and protein composition.

iScience (2019) 16:230-241.
   

Divakaran S et al.

Diagnostic accuracy of advanced imaging in cardiac sarcoidosis.

Circ Cardiovasc Imaging (2019) 12:e008975.
 

Kaczor-Urbanowicz KE et al.

Clinical validity of saliva and novel technology for cancer detection.

Biochim Biophys Acta Rev Cancer (2019) 1872:49-59.
  

Petrescu GED et al.

MicroRNA based theranostics for brain cancer: Basic principles.

J Exp Clin Cancer Res (2019) 38:231.
   

Xie W et al.

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.

Proc Natl Acad Sci U S A (2019) 116:11946-11955.
 

Bayraktar R, Bertilaccio MTS & Calin GA.

The interaction between two worlds: microRNAs and Toll-Like Receptors.

Front Immunol (2019) 10:1053.
 

Tapparo M et al.

Renal regenerative potential of extracellular vesicles derived from miRNA-engineered Mesenchymal Stromal Cells.

Int J Mol Sci (2019) 20:2381.
  

Wiklander OPB et al.

Advances in therapeutic applications of extracellular vesicles.

Sci Transl Med (2019) 11:eaav8521.
  

Bruno S et al.

Role of extracellular vesicles in stem cell biology.

Am J Physiol Cell Physiol (2019) 317:C303-C313.
   

Lee MY et al.

A biological function based biomarker panel optimization process.

Sci Rep (2019) 9:7365.
 

Zheng L et al.

Hatchet ribozyme structure and implications for cleavage mechanism.

Proc Natl Acad Sci U S A (2019) 116:10783-10791.
 

Ghai V et al.

Extracellular vesicle encapsulated microRNAs in patients with Type 2 Diabetes are affected by metformin treatment.

J Clin Med (2019) 8:617.
  

Wei Z et al.

Co-cultures of glioma stem cells and primary neurons, astrocytes, microglia, and endothelial cells for investigation of intercellular communication in the brain.

Front Neurosci (2019) 13:361.
  

Giraldez MD et al.

Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma.

EMBO J (2019) 38:e101695.
  

Watts JK, Brown RH & Khvorova A.

Nucleic acid therapeutics for neurological diseases.

Neurotherapeutics (2019) 16:245-247.
  

Zelniker TA et al.

Biomarker of collagen turnover (C-terminal telopeptide) and prognosis in patients with non-ST-elevation acute coronary syndromes.

J Am Heart Assoc (2019) 8:e011444.
 

Koupenova M et al.

The role of platelets in mediating a response to human influenza infection.

Nat Commun (2019) 10:1780.
 

Duong P et al.

Cushioned-Density Gradient Ultracentrifugation (C-DGUC) improves the isolation efficiency of extracellular vesicles.

PLoS One (2019) 14:e0215324.
 

Akat KM et al.

Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis.

JCI Insight (2019) 5:9.
 

Rozowsky J et al.

exceRpt: A comprehensive analytic platform for extracellular RNA profiling.

Cell Syst (2019) 8:352-357.e3.
  

Zhang Q et al.

Transfer of functional cargo in exomeres.

Cell Rep (2019) 27:940-954.e6.
   

Poggio M et al.

Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory.

Cell (2019) 177:414-427.e13.
   

Jeppesen DK et al.

Reassessment of exosome composition.

Cell (2019) 177:428-445.e18.
   

Das S et al.

The Extracellular RNA Communication Consortium: Establishing foundational knowledge and technologies for extracellular RNA research.

Cell (2019) 177:231-242.
    

Srinivasan S et al.

Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation.

Cell (2019) 177:446-462.e16.
  

Murillo OD et al.

exRNA Atlas analysis reveals distinct extracellular RNA Cargo types and their carriers present across human biofluids.

Cell (2019) 177:463-477.e15.
     

Zaborowski MP et al.

Methods for systematic identification of membrane proteins for specific capture of cancer-derived extracellular vesicles.

Cell Rep (2019) 27:255-268.e6.
  

Schmittgen TD.

Exosomal miRNA cargo as mediator of immune escape mechanisms in neuroblastoma.

Cancer Res (2019) 79:1293-1294.
 

Ma S et al.

GnRH-R-targeted lytic peptide sensitizes BRCA wild-type ovarian cancer to PARP inhibition.

Mol Cancer Ther (2019) 18:969-979.
 

Gonzalez-Villasana V et al.

Presence of circulating miR-145, miR-155, and miR-382 in exosomes isolated from serum of breast cancer patients and healthy donors.

Dis Markers (2019) 2019:6852917.
 

Roy S et al.

Navigating the landscape of tumor extracellular vesicle heterogeneity.

Int J Mol Sci (2019) 20:6.
  

Shah R, Murthy V & Freedman JE.

Nuts, cardiovascular health, and diabetes.

Circ Res (2019) 124:825-826.
 

Bach DH, Lee SK & Sood AK.

Circular RNAs in Cancer.

Mol Ther Nucleic Acids (2019) 16:118-129.
    

Roh JD et al.

Activin type II receptor signaling in cardiac aging and heart failure.

Sci Transl Med (2019) 11:482.
 

Ko D et al.

Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study.

J Am Heart Assoc (2019) 8:e010976.
 

Mazzu YZ et al.

miR-193b regulates tumorigenesis in liposarcoma cells via PDGFR, TGFbeta, and Wnt signaling.

Sci Rep (2019) 9:3197.
 

Grani C et al.

Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis.

J Cardiovasc Magn Reson (2019) 21:14.
 

Liu B et al.

Interplay between miRNAs and host genes and their role in cancer.

Brief Funct Genomics (2018) 18:255-266.
  

Belair CD et al.

High-throughput, efficient, and unbiased capture of small RNAs from low-input samples for sequencing.

Sci Rep (2019) 9:2262.
 

Dawes C & Wong DTW.

Role of saliva and salivary diagnostics in the advancement of oral health.

J Dent Res (2019) 98:133-141.
 

Bei Y et al.

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.

BMC Med (2019) 17:42.
 

Ghai V et al.

Circulating RNAs as predictive markers for the progression of type 2 diabetes.

J Cell Mol Med (2019) 23:2753-2768.
 

Wiedrick JT et al.

Validation of microRNA biomarkers for Alzheimer's Disease in human cerebrospinal fluid.

J Alzheimers Dis (2019) 67:875-891.
 

Pua HH et al.

Increased hematopoietic extracellular RNAs and vesicles in the lung during allergic airway responses.

Cell Rep (2019) 26:933-944.e4.
   

Carrero I et al.

Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments.

Oncogene (2019) 38:3551-3568.
 

Krichevsky AM & Uhlmann EJ.

Oligonucleotide therapeutics as a new class of drugs for malignant brain tumors: Targeting mRNAs, regulatory RNAs, mutations, combinations, and beyond.

Neurotherapeutics (2019) 16:319-347.
  

Varkaris A et al.

Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer.

Br J Cancer (2019) 120:340-345.
 

Thery C, Witwer KW, et al.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

J Extracell Vesicles (2018) 7:1535750.
 

Gulei D et al.

CRISPR-based RNA editing: Diagnostic applications and therapeutic options.

Expert Rev Mol Diagn (2019) 19:83-88.
   

Usmani SM et al.

HIV-1 balances the fitness costs and benefits of disrupting the host cell actin cytoskeleton early after mucosal transmission.

Cell Host Microbe (2019) 25:73-86.e5.
 

LaFargue CJ et al.

Exploring and comparing adverse events between PARP inhibitors.

Lancet Oncol (2019) 20:e15-e28.
  

Jimenez L et al.

Quantitative proteomic analysis of small and large extracellular vesicles (EVs) reveals enrichment of adhesion proteins in small EVs.

J Proteome Res (2019) 18:947-959.
  

2018

Yu H et al.

beRBP: binding estimation for human RNA-binding proteins.

Nucleic Acids Res (2019) 47:e26.
 

Shah RV et al.

Proteins altered by surgical weight loss highlight biomarkers of insulin resistance in the community.

Arterioscler Thromb Vasc Biol (2019) 39:107-115.
 

Cortez MA et al.

Role of miRNAs in immune responses and immunotherapy in cancer.

Genes Chromosomes Cancer (2019) 58:244-253.
 
Related Pathway

 

Chiou NT, Kageyama R & Ansel KM.

Selective export into extracellular vesicles and function of tRNa fragments during T cell activation.

Cell Rep (2018) 25:3356-3370.e4.
  

Jia N et al.

Type III-A CRISPR-Cas Csm complexes: Assembly, periodic RNA cleavage, DNase activity regulation, and autoimmunity.

Mol Cell (2019) 73:264-277.e5.
 

Ge XA & Hunter CP.

Efficient homologous recombination in mice using long single stranded DNA and CRISPR Cas9 nickase.

G3 (2019) 9:281-286.
 

Chen B et al.

Efficient labeling and imaging of protein-coding genes in living cells using CRISPR-Tag.

Nat Commun (2018) 9:5065.
 

Kanlikilicer P et al.

Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer.

EBioMedicine (2018) 38:100-112.
   

Shah R, Patel T & Freedman JE.

Circulating extracellular vesicles in human disease.

N Engl J Med (2018) 379:2180-2181.
  

Zhou S et al.

Chronic Platelet-derived Growth Factor Receptor signaling exerts control over initiation of protein translation in glioma.

Life Sci Alliance (2018) 1:e201800029.
 
Related Pathway

 

Teng Y et al.

Plant-derived exosomal microRNAs shape the gut microbiota.

Cell Host Microbe (2018) 24:637-652.e8.
   

Vita T et al.

Comparing CMR mapping methods and myocardial patterns toward heart failure outcomes in nonischemic dilated cardiomyopathy.

JACC Cardiovasc Imaging (2019) 12:1659-1669.
 

Wang QL et al.

Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways.

Theranostics (2018) 8:4912-4924.
  

Lusardi TA et al.

Analytics of Cerebrospinal Fluid microRNA quantitative PCR studies.

Mol Neurobiol (2019) 56:4988-4999.
 

Villar-Prados A et al.

Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4.

Mol Cancer Ther (2019) 18:421-436.
 

Van Roosbroeck K et al.

The involvement of microRNA in the pathogenesis of Richter syndrome.

Haematologica (2019) 104:1004-1015.

Suryawanshi H et al.

A single-cell survey of the human first-trimester placenta and decidua.

Sci Adv (2018) 4:eaau4788.
 

Smith EMD et al.

A Markov Multi-State model of lupus nephritis urine biomarker panel dynamics in children: Predicting changes in disease activity.

Clin Immunol (2019) 198:71-78.
 

Godoy PM et al.

Large differences in small RNA composition between human biofluids.

Cell Rep (2018) 25:1346-1358.
   

Bei Y et al.

Circular RNAs as potential theranostics in the cardiovascular system.

Mol Ther Nucleic Acids (2018) 13:407-418.
    

Haraszti RA et al.

Exosomes produced from 3D Cultures of MSCs by Tangential Flow Filtration show higher yield and improved activity.

Mol Ther (2018) 26:2838-2847.
   

Hinger SA et al.

Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells.

Cell Rep (2018) 25:715-725.e4.
   

Wei S et al.

Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer.

Fertil Steril (2018) 110:910-916.e2.
 

Wei F et al.

Electric field-induced release and measurement liquid biopsy for noninvasive early lung cancer assessment.

J Mol Diagn (2018) 20:738-742.
  

Hisamatsu T et al.

PRKRA/PACT expression promotes chemoresistance of mucinous ovarian cancer.

Mol Cancer Ther (2019) 18:162-172.
 

Gustafsson G et al.

Secretion and uptake of alpha-synuclein via extracellular vesicles in cultured cells.

Cell Mol Neurobiol (2018) 38:1539-1550.
  

Lu Y et al.

miR-205 regulates basal cell identity and stem cell regenerative potential during mammary reconstitution.

Stem Cells (2018) 36:1875-1889.
 

Antoury L et al.

Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of Muscular Dystrophies.

Nat Commun (2018) 9:3906.
 

Shen P et al.

Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling.

Mol Oncol (2018) 12:1856-1870.
 

Malabirade A et al.

The RNA complement of Outer Membrane Vesicles from Salmonella enterica Serovar Typhimurium under distinct culture conditions.

Front Microbiol (2018) 9:2015.
 

Moirangthem A & Patel T.

Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.

Biotarget (2017) 1:12.
    

Narla V et al.

Unique circulating microRNA profiles in HIV infection.

J Acquir Immune Defic Syndr (2018) 79:644-650.
 

Regev K et al.

Identification of MS-specific serum miRNAs in an international multicenter study.

Neurol Neuroimmunol Neuroinflamm (2018) 5:e491.
   

Monroig-Bosque PDC et al.

OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers.

Sci Rep (2018) 8:13106.
 

Roy S et al.

microRNA 193a-5p regulates levels of Nucleolar- and Spindle-associated Protein 1 to suppress hepatocarcinogenesis.

Gastroenterology (2018) 155:1951-1966.e26.
 

Dragomir M, Chen B & Calin GA.

Exosomal lncRNAs as new players in cell-to-cell communication.

Transl Cancer Res (2018) 7:S243-S252.
  

Onuchic V et al.

Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci.

Science (2018) 361:1354.
 

Raffai RL.

MicroRNA-146a and hematopoiesis: Friend or foe in atherosclerosis.

Noncoding RNA Investig (2018) 2:43.
   

Li F et al.

Discovery and validation of salivary extracellular RNA biomarkers for noninvasive detection of gastric cancer.

Clin Chem (2018) 64:1513-1521.
 

Shah RV et al.

Associations of circulating extracellular RNAs with myocardial remodeling and heart failure.

JAMA Cardiol (2018) 3:871-876.
 

Jun HJ et al.

A PDGFRalpha-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.

Nat Commun (2018) 9:3116.
 
Related Pathway

 

Silva AM et al.

Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.

Theranostics (2018) 8:3902-3917.
 

Gharpure KM et al.

FABP4 as a key determinant of metastatic potential of ovarian cancer.

Nat Commun (2018) 9:2923.
 
Related Pathway

 

Giraldez MD et al.

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Nat Biotechnol (2018) 36:746-757.
 

Broekman ML et al.

Multidimensional communication in the microenvirons of glioblastoma.

Nat Rev Neurol (2018) 14:482-495.
  

Sung BH & Weaver AM.

Directed migration: Cells navigate by extracellular vesicles.

J Cell Biol (2018) 217:2613-2614.
   

Umamaheswaran S et al.

Stress, inflammation, and eicosanoids: an emerging perspective.

Cancer Metastasis Rev (2018) 37:203-211.
 

Haraszti RA et al.

Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles.

Mol Ther (2018) 26:1973-1982.
  

Zhang Q et al.

Mutant KRAS exosomes alter the metabolic state of recipient colonic epithelial cells.

Cell Mol Gastroenterol Hepatol (2018) 5:627-629.e6.
  

Moustafa AA et al.

MicroRNAs in prostate cancer: From function to biomarker discovery.

Exp Biol Med (2018) 243:817-825.
 

Dragomir M & Calin GA.

Circular RNAs in cancer - Lessons learned from microRNAs.

Front Oncol (2018) 8:179.
   

Badawi M et al.

CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128.

Oncotarget (2018) 9:26032-26045.
 

Lyons YA et al.

Immune cell profiling in cancer: Molecular approaches to cell-specific identification.

NPJ Precis Oncol (2017) 1:26.
 

Yeung TL et al.

Systematic identification of druggable epithelial-stromal crosstalk signaling networks in ovarian cancer.

J Natl Cancer Inst (2019) 111:272-282.
 

Gyorgy B et al.

CRISPR/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer's disease.

Mol Ther Nucleic Acids (2018) 11:429-440.
 

Ghai V et al.

Genome-wide profiling of urinary extracellular vesicle microRNAs associated with diabetic nephropathy in type 1 diabetes.

Kidney Int Rep (2018) 3:555-572.
 

Malge A et al.

mRNA transcript distribution bias between Borrelia burgdorferi bacteria and their outer membrane vesicles.

FEMS Microbiol Lett (2018) 365:13.

Dluzen DF et al.

Extracellular RNA profiles with human age.

Aging Cell (2018) 17:e12785.
  

Danielson KM et al.

Plasma circulating extracellular RNAs in Left Ventricular Remodeling post-Myocardial Infarction.

EBioMedicine (2018) 32:172-181.
    

Kaczor-Urbanowicz KE et al.

Salivary exRNA biomarkers to detect gingivitis and monitor disease regression.

J Clin Periodontol (2018) 45:806-817.
 

Max KEA et al.

Human plasma and serum extracellular small RNA reference profiles and their clinical utility.

Proc Natl Acad Sci USA (2018) 115 :E5334-E5343.
 

Heintz-Buschart A et al.

Small RNA profiling of low biomass samples: Identification and removal of contaminants.

BMC Biol (2018) 16:52.
 

Quinn JF.

Lost in translation? Finding our way to effective Alzheimer's Disease therapies.

J Alzheimers Dis (2018) 64:S33-S39.
 

George J, Yan IK & Patel T.

Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice.

Lab Invest (2018) 98:895-910.
 

Yeri A et al.

Evaluation of commercially available small RNASeq library preparation kits using low input RNA.

BMC Genomics (2018) 19:331.
 

Biscans A et al.

Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles.

Mol Ther (2018) 26:1520-1528.
  

He X et al.

Human tRNA-derived small RNAs modulate host-oral microbial interactions.

J Dent Res (2018) 97:1236-1243.
  

Staerk L et al.

Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: Cohort study based on longitudinal data from the Framingham Heart Study.

BMJ (2018) 361:k1453.
 

Vujic A et al.

Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Nat Commun (2018) 9:1659.
   

Koupenova M et al.

Micro RNAs from DNA viruses are found widely in plasma in a large observational human population.

Sci Rep (2018) 8:6397.
   

Li F et al.

Characterization of human salivary extracellular RNA by next-generation sequencing.

Clin Chem (2018) 64:1085-1095.
 

Marangoni F et al.

Tumor tolerance-promoting function of regulatory T cells is optimized by CD28, but strictly dependent on calcineurin.

J Immunol (2018) 200:3647-3661.
 

Haemmerle M et al.

The platelet lifeline to cancer: Challenges and opportunities.

Cancer Cell (2018) 33:965-983.
   

Smith AS et al.

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability.

Proc Natl Acad Sci USA (2018) 115:E4377-E4385.
 

Sardana M et al.

Association of left atrial function index with atrial fibrillation and cardiovascular disease: the Framingham offspring study.

J Am Heart Assoc (2018) 7:7.
 

Shah MY et al.

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.

Genome Res (2018) 28:432-447.
 

Andersen MS et al.

A novel implementation of magnetic levitation to quantify leukocyte size, morphology, and magnetic properties to identify patients with sepsis.

Shock (2019) 51:147-152.
 

Wei S, Weiss ZR & Williams Z.

Rapid multiplex small DNA sequencing on the MinION Nanopore sequencing platform.

G3 (Bethesda) (2018) 8:1649-1657.
 

Ricklefs FL et al.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Sci Adv (2018) 4:eaar2766.
  

Fallen S et al.

Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour.

J Cell Mol Med (2018) 22:2760-2773.
 

Roy S, Hochberg FH & Jones PS.

Extracellular vesicles: the growth as diagnostics and therapeutics; a survey.

J Extracell Vesicles (2018) 7:1438720.
   

Nonaka T & Wong DTW.

Liquid biopsy in head and neck cancer: Promises and challenges.

J Dent Res (2018) 97:701-708.
  

Wang JH et al.

Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation.

Mol Cancer Ther (2018) 17 :1133-1142.
 

Baecher-Allan C, Kaskow BJ & Weiner HL.

Multiple Sclerosis: Mechanisms and immunotherapy.

Neuron (2018) 97:742-768.
  

Rodriguez Cetina Biefer H et al.

Mast cells regulate CD4(+) T-cell differentiation in the absence of antigen presentation.

J Allergy Clin Immunol (2018) 142:1894-1908.e7.
 

Raheja R et al.

Correlating serum microRNAs and clinical parameters in amyotrophic lateral sclerosis.

Muscle Nerve (2018) 58:261-269.
 

Shah R et al.

MicroRNAs associated with reverse left ventricular remodeling in humans identify pathways of heart failure progression.

Circ Heart Fail (2018) 11:e004278.
 

Shukla N, Yan IK & Patel T.

Multiplexed detection and quantitation of extracellular vesicle RNA expression using NanoString.

Methods Mol Biol (2018) 1740:177-185.
 

Didiot MC et al.

Loading of extracellular vesicles with hydrophobically modified siRNAs.

Methods Mol Biol (2018) 1740:199-214.
 

Etheridge A et al.

Preparation of small RNA NGS libraries from biofluids.

Methods Mol Biol (2018) 1740:163-175.
 

Yan IK, Berdah VX & Patel T.

Isolation of extracellular RNA from bile.

Methods Mol Biol (2018) 1740:59-67.
 

Velazquez-Torres G et al.

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.

Nat Commun (2018) 9:461.
 

Matsuda A & Patel T.

Milk-derived extracellular vesicles for therapeutic delivery of small interfering RNAs.

Methods Mol Biol (2018) 1740:187-197.
  

Li K et al.

Cushioned-Density Gradient Ultracentrifugation (C-DGUC): A refined and high performance method for the isolation, characterization, and use of exosomes.

Methods Mol Biol (2018) 1740:69-83.
 

Filant J et al.

Isolation of extracellular RNA from serum/plasma.

Methods Mol Biol (2018) 1740:43-57.
 

Yan IK, Lohray R & Patel T.

Droplet digital PCR for quantitation of extracellular RNA.

Methods Mol Biol (2018) 1740:155-162.
 

Li K et al.

Isolation of plasma lipoproteins as a source of extracellular RNA.

Methods Mol Biol (2018) 1740:139-153.
 

Shao H et al.

New technologies for analysis of extracellular vesicles.

Chem Rev (2018) 118:1917-1950.
 

Viswanath P et al.

2-Hydroxyglutarate-mediated autophagy of the Endoplasmic Reticulum leads to an unusual downregulation of phospholipid biosynthesis in mutant IDH1 gliomas.

Cancer Res (2018) 78:2290-2304.
 

Koupenova M et al.

Circulating platelets as mediators of immunity, inflammation, and thrombosis.

Circ Res (2018) 122:337-351.
 
Related Pathway

 

Hulsmans M et al.

Cardiac macrophages promote diastolic dysfunction.

J Exp Med (2018) 215:423-440.
 
Related Pathway

 

Reategui E et al.

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Nat Commun (2018) 9:175.
 

Lankford KL et al.

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.

PLoS ONE (2018) 13:e0190358.
   

2017

McKenzie JA et al.

The effect of topoisomerase I inhibitors on the efficacy of T-cell-based cancer immunotherapy.

J Natl Cancer Inst (2018) 110:777-786.
 

Kanlikilicer P et al.

Therapeutic targeting of AXL receptor tyrosine kinase inhibits tumor growth and intraperitoneal metastasis in ovarian cancer models.

Mol Ther Nucleic Acids (2017) 9:251-262.
 

Soni A et al.

Study protocol for Smartphone Monitoring for Atrial fibrillation in Real-Time in India (SMART-India): a community-based screening and referral programme.

BMJ Open (2017) 7:e017668.
 

Boussiotis VA & Charest A.

Immunotherapies for malignant glioma.

Oncogene (2018) 37:1121-1141.
 

Chen X et al.

RNA interference-based therapy and its delivery systems.

Cancer Metastasis Rev (2018) 37:107-124.
 

Pi F et al.

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression.

Nat Nanotechnol (2018) 13:82-89.
 

Foye C et al.

Comparison of miRNA quantitation by Nanostring in serum and plasma samples.

PLoS ONE (2017) 12:e0189165.
 

Noh K et al.

Differential effects of EGFL6 on tumor versus wound angiogenesis.

Cell Rep (2017) 21:2785-2795.
 

Lu Y et al.

MYC targeted long noncoding RNA DANCR promotes cancer in part by reducing p21 levels.

Cancer Res (2018) 78:64-74.
 

Vannini I et al.

Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.

Nat Commun (2017) 8:1801.
 
Related Pathway

 

Bei Y et al.

Extracellular vesicles in cardiovascular theranostics.

Theranostics (2017) 7:4168-4182.
  
Related Pathway

 

Slenter DN et al.

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research.

Nucleic Acids Res (2018) 46:D661-D667.
  

Singh PB et al.

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

J Exp Med (2017) 214:3627-3643.
 

Ren A, Micura R & Patel DJ.

Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes.

Curr Opin Chem Biol (2017) 41:71-83.
 

Amorim MG et al.

A total transcriptome profiling method for plasma-derived extracellular vesicles: Applications for liquid biopsies.

Sci Rep (2017) 7:14395.
 

Zheng L et al.

Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.

Nat Commun (2017) 8:1180.
 

Wei Z et al.

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Nat Commun (2017) 8:1145.
  

Nolan JP & Duggan E.

Analysis of individual extracellular vesicles by flow cytometry.

Methods Mol Biol (2018) 1678:79-92.
 

Wu X et al.

sRNAnalyzer: a flexible and customizable small RNA sequencing data analysis pipeline.

Nucleic Acids Res (2017) 45:12140-12151.
 

Bhakta NR et al.

IFN-stimulated gene expression, type 2 inflammation, and endoplasmic reticulum stress in asthma.

Am J Respir Crit Care Med (2018) 197:313-324.
 

Mitamura T et al.

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).

Oncogene (2018) 37:722-731.
 
Related Pathway

 

Nonaka T & Wong DTW.

Saliva exosomics in cancer: Molecular characterization of cancer-derived exosomes in saliva.

Enzymes (2017) 42:125-151.
  

Piao X et al.

Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2'-F RNA, and LNA in the context of Phi29 pRNA 3WJ.

RNA (2018) 24:67-76.
 

Xiao J et al.

miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1.

Exp Mol Med (2017) 49:e386.
 

Gerstberger S et al.

The conserved RNA exonuclease Rexo5 is required for 3' end maturation of 28S rRNA, 5S rRNA, and snoRNAs.

Cell Rep (2017) 21:758-772.
 

Lu Y et al.

lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/beta-catenin signaling.

Nat Med (2017) 23:1331-1341.
 

Willinger CM et al.

MicroRNA signature of cigarette smoking and evidence for a putative causal role of microRNAs in smoking-related inflammation and target organ damage.

Circ Cardiovasc Genet (2017) 10:5.
 

Bayraktar R, Van Roosbroeck K & Calin GA.

Cell-to-cell communication: microRNAs as hormones.

Mol Oncol (2017) 11:1673-1686.
   

Kaczor-Urbanowicz KE et al.

Novel approaches for bioinformatic analysis of salivary RNA sequencing data for development.

Bioinformatics (2018) 34:1-8.
 

Grinberg YY, Zitzow LA & Kraig RP.

Intranasally administered IGF-1 inhibits spreading depression in vivo.

Brain Res (2017) 1677:47-57.
 

Shen P et al.

To Wnt or lose: The missing non-coding linc in colorectal cancer.

Int J Mol Sci (2017) 18:9.
 
Related Pathway

 

Shah R et al.

Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: Brief report.

Am J Physiol Heart Circ Physiol (2017) 313:H1162-H1167.
  

Nguyen TA et al.

SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition.

Immunity (2017) 47:498-509.e6.
  

Rodriguez-Aguayo C et al.

Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer.

Cell Discov (2017) 3:17029.
 

Shankar GM et al.

Liquid biopsy for brain tumors.

Expert Rev Mol Diagn (2017) 17:943-947.
  

Haraszti RA et al.

Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system.

Bio Protoc (2017) 7:20.
 

Dalton HJ et al.

Macrophages facilitate resistance to anti-VEGF therapy by altered VEGFR expression.

Clin Cancer Res (2017) 23:7034-7046.
 

Figueroa J et al.

Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587.

Cancer Res (2017) 77:5808-5819.
  

Datta A et al.

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.

Cancer Lett (2017) 408:73-81.
  
Related Pathway

 

Jones A et al.

miRNA signatures of insulin resistance in obesity.

Obesity (2017) 25:1734-1744.
 

Wu AY & Lai CP.

Tracking extracellular vesicles delivery and RNA translation using multiplexed reporters.

Methods Mol Biol (2017) 1660:255-265.
 

Vasilescu C et al.

Circulating miRNAs in sepsis-A network under attack: An in-silico prediction of the potential existence of miRNA sponges in sepsis.

PLoS ONE (2017) 12:e0183334.
 

Zhang Y et al.

Salivary extracellular RNA biomarkers for insulin resistance detection in Hispanics.

Diabetes Res Clin Pract (2017) 132:85-94.
 

Wu X et al.

The many faces of long noncoding RNAs in cancer.

Antioxid Redox Signal (2018) 29:922-935.
  

Gogakos T et al.

Characterizing expression and processing of precursor and mature human tRNAs by hydro-tRNAseq and PAR-CLIP.

Cell Rep (2017) 20:1463-1475.
 

Fleming ND et al.

Phase II trial of bevacizumab with dose-dense paclitaxel as first-line treatment in patients with advanced ovarian cancer.

Gynecol Oncol (2017) 147:41-46.
 

August P & Suthanthiran M.

Sex and kidney transplantation: Why can't a woman be more like a man?

J Am Soc Nephrol (2017) 28:2829-2831.
 

Sardana M et al.

Clinical and echocardiographic correlates of Left Atrial Function Index: the Framingham offspring study.

J Am Soc Echocardiogr (2017) 30:904-912.e2.
 

Fabris L & Calin GA.

Understanding the genomic ultraconservations: T-UCRs and cancer.

Int Rev Cell Mol Biol (2017) 333:159-172.
 

Denizli M et al.

Chitosan nanoparticles for miRNA delivery.

Methods Mol Biol (2017) 1632:219-230.
 

Sutaria DS et al.

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.

J Extracell Vesicles (2017) 6:1333882.
 

Zhu X et al.

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells.

J Extracell Vesicles (2017) 6:1324730.
 

Pathan M et al.

A novel community driven software for functional enrichment analysis of extracellular vesicles data.

J Extracell Vesicles (2017) 6:1321455.
 

Saugstad JA et al.

Analysis of extracellular RNA in cerebrospinal fluid.

J Extracell Vesicles (2017) 6:1317577.
 

Sarkar S et al.

PRKCI promotes immune suppression in ovarian cancer.

Genes Dev (2017) 31:1109-1121.
 

Montoya MM et al.

A distinct inhibitory function for miR-18a in Th17 cell differentiation.

J Immunol (2017) 199:559-569.
 

Jayaram H et al.

Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: a pilot study.

Invest Ophthalmol Vis Sci (2017) 58:2884-2890.
  

Farmer DT et al.

Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.

Development (2017) 144:2517-2528.
 

Aldrugh S et al.

Atrial fibrillation, cognition and dementia: A review.

J Cardiovasc Electrophysiol (2017) 28:958-965.
 

Li J et al.

miR-29b contributes to multiple types of muscle atrophy.

Nat Commun (2017) 8:15201.
 

Rigoutsos I et al.

N-BLR, a primate-specific non-coding transcript, leads to colorectal cancer invasion and migration.

Genome Biol (2017) 18:98.
 

Bei Y et al.

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.

Basic Res Cardiol (2017) 112:38.
   

Farmer DT et al.

miR-205 is a critical regulator of lacrimal gland development.

Dev Biol (2017) 427:12-20.
 

Silva AM et al.

Dendritic cell-derived extracellular vesicles mediate mesenchymal stem/stromal cell recruitment.

Sci Rep (2017) 7:1667.
  

Bruno S et al.

Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells.

Tissue Eng Part A (2017) 23:1262-1273.
   

Fuentes-Mattei E et al.

Plasma viral miRNAs indicate a high prevalence of occult viral infections.

EBioMedicine (2017) 20:182-192.
 

Nikan M et al.

Synthesis and evaluation of parenchymal retention and efficacy of a metabolically stable O-phosphocholine-N-docosahexaenoyl-l-serine siRNA conjugate in mouse brain.

Bioconjug Chem (2017) 28:1758-1766.
 

Ochocinska MJ et al.

NIH workshop report on the trans-agency Blood-Brain Interface Workshop 2016: Exploring key challenges and opportunities associated with the blood, brain and their interface.

Fluids Barriers CNS (2017) 14:12.
  

Figueroa JM et al.

Detection of wtEGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients.

Neuro Oncol (2017) 19:1494-1502.
 

Montoya MM & Ansel KM.

Small RNA transfection in primary human Th17 cells by next generation electroporation.

J Vis Exp (2017) 122:e55546.
 

Camarda R, Williams J & Goga A.

In vivo reprogramming of cancer metabolism by MYC.

Front Cell Dev Biol (2017) 5:35.
  

Klingenberg M et al.

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

J Hepatol (2017) 67:603-618.
  
Related Pathways: 1, 2

 

Rashed MH et al.

Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.

Oncotarget (2017) 8:20145-20164.
  

Rabinowicz N et al.

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.

Oncotarget (2017) 8:27380-27392.
 

Roh J, Houstis N & Rosenzweig A.

Why don't we have proven treatments for HFpEF?

Circ Res (2017) 120:1243-1245.
 

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.

Liver Transpl (2017) 23:791-803.
   

Putman TE et al.

WikiGenomes: an open web application for community consumption and curation of gene annotation data in Wikidata.

Database (Oxford) (2017) 2017:1.
 

Soni A et al.

RAHI-SATHI Indo-U.S. collaboration: The evolution of a trainee-led twinning model in global health into a multidisciplinary collaborative program.

Glob Health Sci Pract (2017) 5:152-163.
 

Mateescu B et al.

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper.

J Extracell Vesicles (2017) 6:1286095.
   

Sutaria DS et al.

Achieving the promise of therapeutic extracellular vesicles: The devil is in details of therapeutic loading.

Pharm Res (2017) 34:1053-1066.
  

Yeri A et al.

Total extracellular small RNA profiles from plasma, saliva, and urine of healthy subjects.

Sci Rep (2017) 7:44061.
   

Mick E et al.

Stroke and circulating extracellular RNAs.

Stroke (2017) 48:828-834.
  

Deng Z et al.

Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.

Mol Ther (2017) 25:1641-1654.
    

Nolan JP & Jones JC.

Detection of platelet vesicles by flow cytometry.

Platelets (2017) 28:256-262.
  

Clancy L et al.

The role of RNA uptake in platelet heterogeneity.

Thromb Haemost (2017) 117:948-961.
  

He Y et al.

A systematic study of dysregulated microRNA in Type 2 Diabetes Mellitus.

Int J Mol Sci (2017) 18:3.
 

Wagner MJ et al.

Preclinical mammalian safety studies of EPHARNA (DOPC nanoliposomal EphA2-targeted siRNA).

Mol Cancer Ther (2017) 16:1114-1123.
 

Shi J et al.

miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury.

Theranostics (2017) 7:664-676.
 

Khvorova A & Watts JK.

The chemical evolution of oligonucleotide therapies of clinical utility.

Nat Biotechnol (2017) 35:238-248.
  

Yeo AT & Charest A.

Immune checkpoint blockade biology in mouse models of glioblastoma.

J Cell Biochem (2017) 118:2516-2527.
 

Anderton B et al.

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

EMBO Rep (2017) 18:569-585.
 

Xiao J et al.

Circulating miR-30d predicts survival in patients with acute heart failure.

Cell Physiol Biochem (2017) 41:865-874.
 

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells improve survival from lethal hepatic failure in mice.

Stem Cells Transl Med (2017) 6:1262-1272.
 

Teng Y et al.

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Nat Commun (2017) 8:14448.
  

Grossman RL et al.

Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.

Clin Pharmacol Ther (2017) 101:589-592.
  

Shah R et al.

Extracellular RNAs are associated with insulin resistance and metabolic phenotypes.

Diabetes Care (2017) 40:546-553.
 

McManus DD et al.

Messenger RNA and microRNA transcriptomic signatures of cardiometabolic risk factors.

BMC Genomics (2017) 18:139.
 

Gladek I et al.

HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies.

Genes Chromosomes Cancer (2017) 56:439-452.
 

Modi A et al.

Validation of two point-of-care tests against standard lab measures of NO in saliva and in serum.

Nitric Oxide (2017) 64:16-21.
 

Regev K et al.

Association between serum microRNAs and Magnetic Resonance Imaging measures of Multiple Sclerosis severity.

JAMA Neurol (2017) 74:275-285.
 

Ong WQ et al.

Live cell imaging of endogenous mRNA using RNA-based fluorescence "Turn-On" probe.

ACS Chem Biol (2017) 12:200-205.
 

Collino F et al.

Exosome and microvesicle-enriched fractions isolated from mesenchymal stem cells by gradient separation showed different molecular signatures and functions on renal tubular epithelial cells.

Stem Cell Rev (2017) 13:226-243.
  

Heydari B, Harris WS & Kwong RY.

Response by Heydari et al to letter regarding article, "Effect of omega-3 acid ethyl esters on left ventricular remodeling after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial".

Circulation (2017) 135:e13-e14.
 

Danielson KM et al.

High throughput sequencing of extracellular RNA from human plasma.

PLoS ONE (2017) 12:e0164644.
 

Maji S et al.

Extracellular vesicles in liver diseases.

Am J Physiol Gastrointest Liver Physiol (2017) 312:G194-G200.
   

Lee I et al.

The importance of standardization on analyzing circulating RNA.

Mol Diagn Ther (2017) 21:259-268.
  

2016

Baldwin S et al.

Analyzing the miRNA content of extracellular vesicles by fluorescence nanoparticle tracking.

Nanomedicine (2017) 13:765-770.
 

Maas SL, Breakefield XO & Weaver AM.

Extracellular vesicles: Unique intercellular delivery vehicles.

Trends Cell Biol (2017) 27:172-188.
    

Krzeszinski JY et al.

Lipid osteoclastokines regulate breast cancer bone metastasis.

Endocrinology (2017) 158:477-489.
 

Srivastava A et al.

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells.

Sci Rep (2016) 6:38541.
 

Wang X, Kaczor-Urbanowicz KE & Wong DT.

Salivary biomarkers in cancer detection.

Med Oncol (2017) 34:7.
  

Matsuda A et al.

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.

Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.
     

Majem B et al.

RNA sequencing analysis of salivary extracellular RNA.

Methods Mol Biol (2017) 1537:17-36.
 

Kaczor-Urbanowicz KE et al.

Saliva diagnostics - Current views and directions.

Exp Biol Med (Maywood) (2017) 242:459-472.
  

Van Roosbroeck K et al.

Combining anti-miR-155 with chemotherapy for the treatment of lung cancers.

Clin Cancer Res (2017) 23:2891-2904.
 

Moustafa AA et al.

Identification of microRNA signature and potential pathway targets in prostate cancer.

Exp Biol Med (Maywood) (2017) 242:536-546.
 

Katsiougiannis S et al.

Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity.

FASEB J (2017) 31:998-1010.
   

Pi F et al.

RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery.

Nanomedicine (2017) 13:1183-1193.
 

Dou Y et al.

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Sci Rep (2016) 6:37982.
 

Haraszti RA et al.

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

J Extracell Vesicles (2016) 5:32570.
  

Kaczor-Urbanowicz KE et al.

Emerging technologies for salivaomics in cancer detection.

J Cell Mol Med (2017) 21:640-647.
  

Previs RA et al.

The rise of genomic profiling in ovarian cancer.

Expert Rev Mol Diagn (2016) 16:1337-1351.
 

Yang L et al.

Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth.

Cell Metab (2016) 24:685-700.
 

Nazimek K, Bryniarski K & Askenase PW.

Functions of exosomes and microbial extracellular vesicles in allergy and contact and delayed-type hypersensitivity.

Int Arch Allergy Immunol (2016) 171:1-26.
   

Lusardi TA et al.

MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer's disease.

J Alzheimers Dis (2017) 55:1223-1233.
 

Hatakeyama H et al.

Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers.

Cell Rep (2016) 17:1621-1631.
 

Shah R, Pico AR & Freedman JE.

Translational epidemiology: Entering a brave new world of team science.

Circ Res (2016) 119:1060-1062.
 

Ohtsuka M et al.

H19 noncoding RNA, an independent prognostic factor, regulates essential Rb-E2F and CDK8-beta-catenin signaling in colorectal cancer.

EBioMedicine (2016) 13:113-124.
 

Mangala LS et al.

Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy.

JCI Insight (2016) 1:e87754.
 

Kanlikilicer P et al.

Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells.

Cancer Res (2016) 76:7194-7207.
   

Giza DE et al.

Cellular and viral microRNAs in sepsis: Mechanisms of action and clinical applications.

Cell Death Differ (2016) 23:1906-1918.
 
Related Pathway

 

Soni A et al.

High burden of unrecognized atrial fibrillation in rural india: An innovative community-based cross-sectional screening program.

JMIR Public Health Surveill (2016) 2:e159.
 

Shah MY et al.

microRNA therapeutics in cancer - an emerging concept.

EBioMedicine (2016) 12:34-42.
  

Tao L et al.

Crucial role of miR-433 in regulating cardiac fibrosis.

Theranostics (2016) 6:2068-2083.
 

Zhou J et al.

A novel compound ARN-3236 inhibits salt-inducible kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel.

Clin Cancer Res (2017) 23:1945-1954.
 

Huang Y et al.

Anti-tumor and anti-angiogenic effects of aspirin-PC in ovarian cancer.

Mol Cancer Ther (2016) 15:2894-2904.
 

Regev K et al.

Comprehensive evaluation of serum microRNAs as biomarkers in Multiple Sclerosis.

Neurol Neuroimmunol Neuroinflamm (2016) 3:e267.
 

Smith EM et al.

International validation of a urinary biomarker panel for identification of active lupus nephritis in children.

Pediatr Nephrol (2017) 32:283-295.
 

Ghai V & Wang K.

Recent progress toward the use of circulating microRNAs as clinical biomarkers.

Arch Toxicol (2016) 90:2959-2978.
  

Ciccone M & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: An old disease with new genetic insights.

MicroRNA (2016) 5:106-112.
 
Related Pathway

 

Sardana M et al.

Association of left atrial function index with late atrial fibrillation recurrence after catheter ablation.

J Cardiovasc Electrophysiol (2016) 27:1411-1419.
 

Harjes U et al.

Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4.

Oncogene (2017) 36:912-921.
 

Didiot MC et al.

Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing.

Mol Ther (2016) 24:1836-1847.
 

Wei Z et al.

Fetal bovine serum RNA interferes with the cell culture derived extracellular RNA.

Sci Rep (2016) 6:31175.
 

Walkey AJ et al.

Practice patterns and outcomes associated with use of anticoagulation among patients with atrial fibrillation during sepsis.

JAMA Cardiol (2016) 1:682-90.
 

Miranda F et al.

Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche.

Cancer Cell (2016) 30:273-289.
 

Wang JH et al.

Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.

BMC Cancer (2016) 16:524.
 

Anfossi S & Calin GA.

Hodgkin lymphoma cells have a specific long noncoding RNA expression pattern.

Am J Pathol (2016) 186:2251-3.
 

Zhao Z et al.

An arginine finger regulates the sequential action of asymmetrical hexameric ATPase in the double-stranded DNA translocation motor.

Mol Cell Biol (2016) 36:2514-23.
 

Gao P et al.

Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.

Cell Res (2016) 26:901-13.
 

Maji S et al.

In vitro toxicology studies of extracellular vesicles.

J Appl Toxicol (2017) 37:310-318.
 

Bezzerides VJ et al.

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.

JCI Insight (2016) 1:9.
 

Yan IK et al.

Circulating extracellular RNA markers of liver regeneration.

PLoS ONE (2016) 11:e0155888.
 

Wu S et al.

Circulating microRNAs and life expectancy among identical twins.

Ann Hum Genet (2016) 80:247-56.
 

Ren A et al.

Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.

Nat Chem Biol (2016) 12:702-8.
 

Parasramka MA & Patel T.

Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities.

Stem Cell Investig (2016) 3:1.
 

Paladini L et al.

Targeting microRNAs as key modulators of tumor immune response.

J Exp Clin Cancer Res (2016) 35:103.
    

Deng Z et al.

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis.

Oncogene (2017) 36:639-651.
  

Higginbotham JN et al.

Identification and characterization of EGF receptor in individual exosomes by Fluorescence-Activated Vesicle Sorting.

J Extracell Vesicles (2016) 5:29254.
 

Srivastava A et al.

Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer.

J Biomed Nanotechnol (2016) 12:1159-73.
  

Wang JQ et al.

Extracellular vesicle-mediated reversal of paclitaxel resistance in prostate cancer.

Crit Rev Oncog (2015) 20:407-17.
   

Freedman JE et al.

Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma.

Nat Commun (2016) 7:11902.
 

Henninger N et al.

Atrial fibrillation is associated with a worse 90-day outcome than other cardioembolic stroke subtypes.

Stroke (2016) 47:1486-92.
 

Fritz JV et al.

Sources and functions of extracellular small RNAs in human circulation.

Annu Rev Nutr (2016) 36:301-36.
   

Soares VY et al.

Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.

Neuro Oncol (2016) 18:1498-1507.
  

Zhang HG et al.

Isolation, identification, and characterization of novel nanovesicles.

Oncotarget (2016) 7:41346-41362.
  

Chaluvally-Raghavan P et al.

Direct upregulation of STAT3 by microRNA-551b-3p deregulates growth and metastasis of ovarian cancer.

Cell Rep (2016) 15:1493-504.
  

Wen S et al.

Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.

Leukemia (2016) 30:2221-2231.
 

Shah R et al.

Discordant expression of circulating microRNA from cellular and extracellular sources.

PLoS ONE (2016) 11:e0153691.
 

McKenzie AJ et al.

KRAS-MEK signaling controls Ago2 sorting into exosomes.

Cell Rep (2016) 15:978-87.
  

Freedman JE et al.

Diverse human extracellular RNAs are widely detected in human plasma.

Nat Commun (2016) 7:11106.
 

Cheung KH et al.

Extending gene ontology in the context of extracellular RNA and vesicle communication.

J Biomed Semantics (2016) 7:19.
 

Clarke D et al.

Identifying allosteric hotspots with dynamics: Application to inter- and intra-species conservation.

Structure (2016) 24:826-37.
 

Haemmerle M et al.

FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.

J Clin Invest (2016) 126:1885-96.
 

Akers JC et al.

Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid.

Cancer Biomark (2016) 17:125-32.
 

Abels ER & Breakefield XO.

Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.

Cell Mol Neurobiol (2016) 36:301-12.
    

Yan KK et al.

Cross-disciplinary network comparison: Matchmaking between hairballs.

Cell Syst (2016) 2:147-157.
 

Ciccone M & Calin GA.

MicroRNAs in myeloid hematological malignancies.

Curr Genomics (2015) 16:336-48.
 

Van Roosbroeck K & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?

Semin Oncol (2016) 43:209-14.
 

Wu SY et al.

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

Nat Commun (2016) 7:11169.
   

Pan Y et al.

miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.

Oncotarget (2016) 7:25930-48.
 

Zappulli V et al.

Extracellular vesicles and intercellular communication within the nervous system.

J Clin Invest (2016) 126:1198-207.
   

Teng Y et al.

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.

Oncotarget (2016) 7:25683-97.
   

Putman TE et al.

Centralizing content and distributing labor: a community model for curating the very long tail of microbial genomes.

Database (Oxford) (2016) 2016:baw028.
 

Hall J et al.

Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson's disease, glioma, and schwannoma.

Cell Mol Neurobiol (2016) 36:417-27.
  

Parasramka MA et al.

Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.

Pharmacol Ther (2016) 161:67-78.
  
Related Pathway

 

Huang J et al.

Dll4 inhibition plus aflibercept markedly reduces ovarian tumor growth.

Mol Cancer Ther (2016) 15:1344-52.
 

Byron SA et al.

Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.

Nat Rev Genet (2016) 17:257-71. Related blog post
   

Rennert RC, Hochberg FH & Carter BS.

ExRNA in biofluids as biomarkers for brain tumors.

Cell Mol Neurobiol (2016) 36:353-60.
  

Pusic KM, Pusic AD & Kraig RP.

Environmental enrichment stimulates immune cell secretion of exosomes that promote CNS myelination and may regulate inflammation.

Cell Mol Neurobiol (2016) 36:313-325.
  

Pucci F et al.

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.

Science (2016) 352:242-6.
  

Burgstaller-Muehlbacher S et al.

Wikidata as a semantic framework for the Gene Wiki initiative.

Database (Oxford) (2016) 2016:baw015.
 

Almeida MI & Calin GA.

The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.

Genome Med (2016) 8:29.
  

Tanriverdi K et al.

Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative Polymerase Chain Reaction.

Anal Biochem (2016) 501:66-74.
 

Rytelewski M et al.

Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.

Oncotarget (2016) 7:20825-39.
 

Zaborowski MP et al.

Extracellular vesicles: Composition, biological relevance, and methods of study.

Bioscience (2015) 65:783-797.
   

Zhang X et al.

Potential transfer of polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington's disease: Background and evaluation in cell culture.

Cell Mol Neurobiol (2016) 36:459-70.
   

Olivieri M et al.

Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis.

Oncotarget (2016) 7:20636-54.
 

Iavello A et al.

Role of Alix in miRNA packaging during extracellular vesicle biogenesis.

Int J Mol Med (2016) 37:958-66.
  

Xiao H et al.

Differential proteomic analysis of human saliva using Tandem Mass Tags quantification for gastric cancer detection.

Sci Rep (2016) 6:22165.
 

Akers JC et al.

Comparative analysis of technologies for quantifying extracellular vesicles (EVs) in clinical cerebrospinal fluids (CSF).

PLoS ONE (2016) 11:e0149866.
 

Mora-Castilla S et al.

Miniaturization technologies for efficient single-cell library preparation for next-generation sequencing.

J Lab Autom (2016) 21:557-67.
 

Kundu A et al.

Relation of atrial fibrillation in acute myocardial infarction to in-hospital complications and early hospital readmission.

Am J Cardiol (2016) 117:1213-8.
 

Rupaimoole R et al.

miRNA deregulation in cancer cells and the tumor microenvironment.

Cancer Discov (2016) 6:235-46.
   

Sun Y et al.

Examining plasma microRNA markers for colorectal cancer at different stages.

Oncotarget (2016) 7:11434-49.
 

Melman YF et al.

Response to letter regarding article, "Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study"

Circulation (2016) 133:e389-90.
  

Redis RS et al.

Allele-specific reprogramming of cancer metabolism by the long non-coding RNA CCAT2.

Mol Cell (2016) 61:520-34.
 

Pua HH et al.

MicroRNAs 24 and 27 suppress allergic inflammation and target a network of regulators of T Helper 2 cell-associated cytokine production.

Immunity (2016) 44:821-32.
 

Gleber-Netto FO et al.

Salivary biomarkers for detection of oral squamous cell carcinoma in a Taiwanese population.

Clin Cancer Res (2016) 22:3340-7.
 

Hansen JM, Coleman RL & Sood AK.

Targeting the tumour microenvironment in ovarian cancer.

Eur J Cancer (2016) 56:131-43.
 

Clancy L & Freedman JE.

Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.

Circ Res (2016) 118:374-6.
   

Harmanci A & Gerstein M.

Quantification of private information leakage from phenotype-genotype data: linking attacks.

Nat Methods (2016) 13:251-6.
 

Guo P et al.

Biological nanomotors with a revolution, linear, or rotation motion mechanism.

Microbiol Mol Biol Rev (2016) 80:161-86.
 

Fabris L et al.

The potential of microRNAs as prostate cancer biomarkers.

Eur Urol (2016) 70:312-22.
  

Xu T et al.

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients.

Oncotarget (2016) 7:12414-25.
 

Yuan T et al.

Plasma extracellular RNA profiles in healthy and cancer patients.

Sci Rep (2016) 6:19413.
 

Ben-Dov IZ et al.

Cell and microvesicle urine microRNA deep sequencing profiles from healthy individuals: Observations with potential impact on biomarker studies.

PLoS ONE (2016) 11:e0147249.
 

Mitamura T, Gourley C & Sood AK.

Prediction and failure of anti-angiogenesis escape.

Gynecol Oncol (2016) 141:80-5.
 

Danielson KM et al.

Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry.

PLoS ONE (2016) 11:e0144678.
 

Neophytou AM et al.

Air pollution and lung function in minority youth with asthma in the GALA II (Genes-environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) studies.

Am J Respir Crit Care Med (2016) 193:1271-80.
 

Lener T et al.

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

J Extracell Vesicles (2015) 4:30087.
   

Rupaimoole R et al.

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.

Oncogene (2016) 35:4312-20. Related blog post
   

McManus DD et al.

Reliability of predicting early hospital readmission after discharge for an acute coronary syndrome using claims-based data.

Am J Cardiol (2016) 117:501-7.
 

2015

Rupaimoole R et al.

Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis.

Cell Rep (2015) 13:2395-402.
   

Giza DE & Calin GA

microRNA and Chronic Lymphocytic Leukemia.

Adv Exp Med Biol (2015) 889:23-40.
   

Ren A et al.

Structural and dynamic basis for low-affinity, high-selectivity binding of L-glutamine by the glutamine riboswitch.

Cell Rep (2015) 13:1800-13.
 

Shields BB et al.

A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.

Mol Syst Biol (2015) 11:842.
  
Related Pathways: 1, 2

 

Askenase PW et al.

A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.

Ann N Y Acad Sci (2015) 1362:200-14.
 

Machtinger R, Laurent LC & Baccarelli AA.

Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation.

Hum Reprod Update (2016) 22:182-93.
   

Sercombe L et al.

Advances and challenges of liposome assisted drug delivery.

Front Pharmacol (2015) 6:286.
  

Mohankumar S & Patel T.

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.

Brief Funct Genomics (2016) 15:249-56.
  

Alterman JF et al.

Hydrophobically modified siRNAs silence Huntingtin mRNA in primary neurons and mouse brain.

Mol Ther Nucleic Acids (2015) 4:e266.
 

Zhuang X et al.

Ginger-derived nanoparticles protect against alcohol-induced liver damage.

J Extracell Vesicles (2015) 4:28713.
   

Kalani MY et al.

Rare variants in cardiomyopathy genes associated with stress-induced cardiomyopathy.

Neurosurgery (2016) 78:835-43.
 

Shaikh AY et al.

Addition of B-type natriuretic peptide to existing clinical risk scores enhances identification of patients at risk for atrial fibrillation recurrence after pulmonary vein isolation.

Crit Pathw Cardiol (2015) 14:157-65.
 

Silva A, Bullock M & Calin G.

The clinical relevance of long non-coding RNAs in cancer.

Cancers (2015) 7:2169-82.
 

Previs RA et al.

Dual metronomic chemotherapy with nab-paclitaxel and topotecan has potent antiangiogenic activity in ovarian cancer.

Mol Cancer Ther (2015) 14:2677-86.
 

Bucur O et al.

An updated h-index measures both the primary and total scientific output of a researcher.

Discoveries (2015) 3:3.
 

Wei S & Williams Z.

Rapid short-read sequencing and aneuploidy detection using MinION nanopore technology.

Genetics (2016) 202:37-44.
 

Pradeep S et al.

Erythropoietin stimulates tumor growth via EphB4.

Cancer Cell (2015) 28:610-22.
 

Kosutic M et al.

A mini-twister variant and impact of residues/cations on the phosphodiester cleavage of this ribozyme class.

Angew Chem Int Ed Engl (2015) 54:15128-33.
 

Yamamoto N et al.

Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: Evidence of a subpopulation of protective anti-pneumococcal B1a cells.

Immunology (2016) 147:97-113.
 

Zhuang X et al.

Grapefruit-derived nanovectors delivering therapeutic mir17 through an intranasal route inhibit brain tumor progression.

Mol Ther (2016) 24:96-105.
 

Keerthikumar S et al.

ExoCarta: A web-based compendium of exosomal cargo.

J Mol Biol (2016) 428:688-692.
  

van der Vos KE et al.

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.

Neuro Oncol (2016) 18:58-69.
  

Schwarzenbach H et al.

Data normalization strategies for microRNA quantification.

Clin Chem (2015) 61:1333-42.
 

Monroig-Bosque Pdel C, Rivera CA & Calin GA.

MicroRNAs in cancer therapeutics: "From the bench to the bedside".

Expert Opin Biol Ther (2015) 15:1381-5.
  

Chira S et al.

Progresses towards safe and efficient gene therapy vectors.

Oncotarget (2015) 6:30675-703.
 

Quesenberry PJ et al.

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming.

Stem Cell Res Ther (2015) 6:153.
  

Patton JG et al.

Biogenesis, delivery, and function of extracellular RNA.

J Extracell Vesicles (2015) 4:27494.
   

Quinn JF et al.

Extracellular RNAs: Development as biomarkers of human disease.

J Extracell Vesicles (2015) 4:27495.
  

Quesenberry PJ et al.

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27575.
  

Subramanian SL et al.

Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies.

J Extracell Vesicles (2015) 4:27497.
 

Laurent LC et al.

Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:26533.
   

Ainsztein AM et al.

The NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27493.
      

Giza DE, Vasilescu C & Calin GA.

Key principles of miRNA involvement in human diseases.

Discoveries (Craiova) (2014) 2:e34.
 

Ohtsuka M et al.

MicroRNA processing and human cancer.

J Clin Med (2015) 4:1651-67.
 

Ferrajoli A et al.

Epstein-Barr virus microRNAs are expressed in patients with chronic lymphocytic leukemia and correlate with overall survival.

EBioMedicine (2015) 2:572-82.
 

Nagaraja AS et al.

Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis.

Oncogene (2016) 35:2390-7.
 

Pua HH & Ansel KM.

MicroRNA regulation of allergic inflammation and asthma.

Curr Opin Immunol (2015) 36:101-8.
   

Matsuo K et al.

Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.

Eur J Cancer (2015) 51:1978-88.
 

Reyes-Gonzalez JM et al.

Targeting c-MYC in platinum-resistant ovarian cancer.

Mol Cancer Ther (2015) 14:2260-9.
 

Ong WQ et al.

Heavy water: a simple solution to increasing the brightness of fluorescent proteins in super-resolution imaging.

Chem Commun (Camb) (2015) 51:13451-3.
 

Gharpure KM et al.

Nanotechnology: Future of oncotherapy.

Clin Cancer Res (2015) 21:3121-30.
 

Pichler M & Calin GA.

MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.

Br J Cancer (2015) 113:569-73.
   

Li X, Mauro M & Williams Z.

Comparison of plasma extracellular RNA isolation kits reveals kit-dependent biases.

Biotechniques (2015) 59:13-7.
 

Zhang S et al.

CDK5 regulates paclitaxel sensitivity in ovarian cancer cells by modulating AKT activation, p21Cip1- and p27Kip1-mediated G1 cell cycle arrest and apoptosis.

PLoS ONE (2015) 10:e0131833.
 

Cha DJ et al.

KRAS-dependent sorting of miRNA to exosomes.

Elife (2015) 4:e07197.
  

Ren A, Rajashankar KR & Patel DJ.

Global RNA fold and molecular recognition for a pfl riboswitch bound to ZMP, a master regulator of one-carbon metabolism.

Structure (2015) 23:1375-81.
 

Aslan B et al.

The ZNF304-integrin axis protects against anoikis in cancer.

Nat Commun (2015) 6:7351.
 

Pusic AD & Kraig RP.

Phasic treatment with Interferon gamma stimulates release of exosomes that protect against spreading depression.

J Interferon Cytokine Res (2015) 35:795-807.
  

Kwong RY et al.

Characterization of cardiac amyloidosis by atrial late gadolinium enhancement using contrast-enhanced cardiac Magnetic Resonance Imaging and correlation with left atrial conduit and contractile function.

Am J Cardiol (2015) 116:622-9.
 

Szabo L et al.

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.

Genome Biol (2015) 16:126.
 

Simpson LJ & Ansel KM.

MicroRNA regulation of lymphocyte tolerance and autoimmunity.

J Clin Invest (2015) 125:2242-9.
   

Camussi G & Quesenberry PJ.

Perspectives on the potential therapeutic uses of vesicles.

Exosomes Microvesicles (2013) 1:6.
  

Boettcher M & McManus MT.

Choosing the right tool for the job: RNAi, TALEN, or CRISPR.

Mol Cell (2015) 58:575-85.
  

Lin X et al.

Noncoding RNAs in human saliva as potential disease biomarkers.

Front Genet (2015) 6:175.
  

Melman YF et al.

Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: a translational pilot study.

Circulation (2015) 131:2202-16.
 

Sung BH et al.

Directional cell movement through tissues is controlled by exosome secretion.

Nat Commun (2015) 6:7164.
   

Lai CP et al.

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.

Nat Commun (2015) 6:7029.
 

Shao H et al.

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Nat Commun (2015) 6:6999.
  

Li X et al.

Lowering the quantification limit of the QubitTM RNA HS assay using RNA spike-in.

BMC Mol Biol (2015) 16:9.
 

Bryniarski K et al.

Free extracellular miRNA functionally targets cells by transfecting exosomes from their companion cells.

PLoS ONE (2015) 10:e0122991.
  

Agarwal K et al.

Analysis of exosome release as a cellular response to MAPK pathway inhibition.

Langmuir (2015) 31:5440-8.
  

Deng Z et al.

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

Nat Commun (2015) 6:6956.
  

Li K et al.

Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-kappaB-driven inflammation and atherosclerosis.

Circ Res (2015) 117:e1-e11.
 
Related Pathway

 

Wong HK et al.

The Cancer Genome Atlas analysis predicts microRNA for targeting cancer growth and vascularization in glioblastoma.

Mol Ther (2015) 23:1234-47.
 
Related Pathway

 

Akers JC et al.

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients.

J Neurooncol (2015) 123:205-16.
 

Collino F et al.

AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs.

J Am Soc Nephrol (2015) 26:2349-60.
   

Majem B et al.

Non-coding RNAs in saliva: Emerging biomarkers for molecular diagnostics.

Int J Mol Sci (2015) 16:8676-98.
  

Wang Q et al.

Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites.

Cancer Res (2015) 75:2520-9.
 

Miyake TM et al.

XPO1/CRM1 inhibition causes antitumor effects by mitochondrial accumulation of eIF5A.

Clin Cancer Res (2015) 21:3286-97.
 
Related Pathway

 

Liu X et al.

miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.

Cell Metab (2015) 21:584-95.
 
Related Pathway

 

Schwarzenbacher D et al.

Low spinophilin expression enhances aggressive biological behavior of breast cancer.

Oncotarget (2015) 6:11191-202.
 

Gilder AS et al.

Soluble Urokinase Receptor is released selectively by glioblastoma cells that express Epidermal Growth Factor Receptor variant III and promotes tumor cell migration and invasion.

J Biol Chem (2015) 290:14798-809.
 

Thanapprapa D Sr et al.

PTEN expression as a predictor of response to focal adhesion kinase inhibition in uterine cancer.

Mol Cancer Ther (2015) 14:1466-1475.
 

Nouraee N, Mowla SJ & Calin GA.

Tracking miRNAs' footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy.

Genes Chromosomes Cancer (2015) 54:335-52.
  

Ren A et al.

Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch.

Cell Rep (2015) 11:1-12.
 

Saugstad JA.

Non-coding RNAs in stroke and neuroprotection.

Front Neurol (2015) 6:50.
   

Simonson B & Das S.

MicroRNA therapeutics: the next magic bullet?

Mini Rev Med Chem (2015) 15:467-74.
  

Ling H et al.

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.

Gut (2016) 65:977-989.
 

Neilan TG et al.

Late gadolinium enhancement among survivors of sudden cardiac arrest.

JACC Cardiovasc Imaging (2015) 8:414-423.
 

Wong DT.

Salivary extracellular noncoding RNA: Emerging biomarkers for molecular diagnostics.

Clin Ther (2015) 37:540-51.
  

Huan T et al.

Genome-wide identification of microRNA expression Quantitative Trait Loci.

Nat Commun (2015) 6:6601.
 

Xiao J et al.

A snapshot of genetic and epigenetic basis of arrhythmia and heart failure.

Front Genet (2015) 6:74.
  

Gardiner C et al.

Extracellular vesicles, tissue factor, cancer and thrombosis - Discussion themes of the ISEV 2014 Educational Day.

J Extracell Vesicles (2015) 4:26901.
   

Ho GY et al.

Differential expression of circulating microRNAs according to severity of colorectal neoplasia.

Transl Res (2015) 166:225-32.
 

Ciccone M, Calin GA & Perrotti D.

From the biology of PP2A to the PADs for therapy of hematologic malignancies.

Front Oncol (2015) 5:21.
  

Tewari M.

A functional extracellular transcriptome in animals? Implications for biology, disease and medicine.

Genome Biol (2015) 16:47.
   

Guzman N et al.

Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes "microRNA-like" tRNA Fragments.

Mol Cancer Res (2015) 13:891-901.
 

Kanada M et al.

Differential fates of biomolecules delivered to target cells via extracellular vesicles.

Proc Natl Acad Sci U S A (2015) 112:E1433-42.
  

Nick AM et al.

A framework for a personalized surgical approach to ovarian cancer.

Nat Rev Clin Oncol (2015) 12:239-45.
 

Boukouris S & Mathivanan S.

Exosomes in bodily fluids are a highly stable resource of disease biomarkers.

Proteomics Clin Appl (2015) 9:358-67.
  

Martinez GJ et al.

The transcription factor NFAT promotes exhaustion of activated CD8(+) T cells.

Immunity (2015) 42:265-78.
 

Ozcan G et al.

Preclinical and clinical development of siRNA-based therapeutics.

Adv Drug Deliv Rev (2015) 87:108-19.
 

Wei X, Liu X & Rosenzweig A.

What do we know about the cardiac benefits of exercise?

Trends Cardiovasc Med (2015) 25:529-36.
 

Koupenova M et al.

Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.

Arterioscler Thromb Vasc Biol (2015) 35:1030-7.
 

Chiang SH et al.

RNAPro*SAL: a device for rapid and standardized collection of saliva RNA and proteins.

Biotechniques (2015) 58:69-76.
 

George J & Patel T.

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.

Semin Liver Dis (2015) 35:63-74.
   

Cox JE et al.

Pan-viral-microRNA screening identifies interferon inhibition as a common function of diverse viruses.

Proc Natl Acad Sci U S A (2015) 112:1856-61.
 

Ling H et al.

Junk DNA and the long non-coding RNA Twist in cancer genetics.

Oncogene (2015) 34:5003-11.
 

Gonzalez-Villasana V et al.

Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer.

Clin Cancer Res (2015) 21:2127-37.
 
Related Pathway

 

Haga H et al.

Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth.

J Extracell Vesicles (2015) 4:24900.
  

2014

Choi HJ et al.

Anti-vascular therapies in ovarian cancer: Moving beyond anti-VEGF approaches.

Cancer Metastasis Rev (2015) 34:19-40.
 

Bodhankar S et al.

Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells.

Metab Brain Dis (2015) 30:911-924.
 

Srivastava A et al.

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.

Curr Gene Ther (2015) 15:182-92.
     

Lotvall J et al.

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles.

J Extracell Vesicles (2014) 3:26913.
  

Yao C et al.

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.

Circulation (2015) 131:536-49.
 

Berindan-Neagoe I & Calin GA.

Molecular pathways: microRNAs, cancer cells, and microenvironment.

Clin Cancer Res (2014) 20:6247-53.
   

Pusic AD et al.

Spreading depression transiently disrupts myelin via interferon-gamma signaling.

Exp Neurol (2015) 264:43-54.
 

Yang X et al.

New ways to successfully target tumor vasculature in ovarian cancer.

Curr Opin Obstet Gynecol (2015) 27:58-65.
 

Koupenova M & Freedman JE.

Platelets: the unsung hero of the immune response.

J Thromb Haemost (2015) 13:268-70.
 

Bottsford-Miller J et al.

Differential platelet levels affect response to taxane-based therapy in ovarian cancer.

Clin Cancer Res (2015) 21:602-10.
 

Bhattacharya S et al.

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.

PLoS ONE (2014) 9:e114409.
  

Melo SA et al.

Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

Cancer Cell (2014) 26:707-21.
   

Dotson AL et al.

Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke.

J Neuroimmunol (2015) 278:289-98.
 

Danielson KM & Das S.

Extracellular vesicles in heart disease: Excitement for the future?

Exosomes Microvesicles (2014) 2:1.
   
Related Pathway

 

Wen Y et al.

Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer.

Clin Cancer Res (2015) 21:448-59.
 

Fuentes L, Yakob M & Wong DT.

Emerging horizons of salivary diagnostics for periodontal disease.

Br Dent J (2014) 217:567-73.
  

Ren A et al.

In-line alignment and Mg(2)(+) coordination at the cleavage site of the env22 twister ribozyme.

Nat Commun (2014) 5:5534.
 

Rajendran L et al.

Emerging roles of extracellular vesicles in the nervous system.

J Neurosci (2014) 34:15482-9.
   

Previs RA et al.

Molecular pathways: Translational and therapeutic implications of the Notch signaling pathway in cancer.

Clin Cancer Res (2015) 21:955-61.
 

Kim DK et al.

EVpedia: a community web portal for extracellular vesicles research.

Bioinformatics (2015) 31:933-9.
 

Bahn JH et al.

The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva.

Clin Chem (2015) 61:221-30.
  

Rupaimoole R et al.

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.

Nat Commun (2014) 5:5202.
   

van den Beucken T et al.

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Nat Commun (2014) 5:5203.
 
Related Pathway

 

Sato-Kuwabara Y et al.

The fusion of two worlds: Non-coding RNAs and extracellular vesicles--Diagnostic and therapeutic implications.

Int J Oncol (2015) 46:17-27.
   

Gangoda L et al.

Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

Proteomics (2015) 15:260-71.
   
Related Pathway

 

Kawikova I & Askenase PW.

Diagnostic and therapeutic potentials of exosomes in CNS diseases.

Brain Res (2015) 1617:63-71.
    

Godlewski J et al.

Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

Neuro Oncol (2015) 17:652-62.
   

Gyorgy B et al.

Therapeutic applications of extracellular vesicles: Clinical promise and open questions.

Annu Rev Pharmacol Toxicol (2015) 55:439-64.
   

Leung CS et al.

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.

Nat Commun (2014) 5:5092.
 
Related Pathway

 

Haga H & Patel T.

Molecular diagnosis of intrahepatic cholangiocarcinoma.

J Hepatobiliary Pancreat Sci (2015) 22:114-23.
  

Kutmon M et al & .

WikiPathways app for Cytoscape: Making biological pathways amenable to network analysis and visualization.

F1000Research (2014) 3:152.
 

del C. Monroig P et al.

Small molecule compounds targeting miRNAs for cancer therapy.

Adv Drug Deliv Rev (2015) 81:104-16.
 

Braicu C et al.

Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?

Cell Death Differ (2015) 22:34-45.
   

Gonzalez-Villasana V et al.

Bisphosphonates inhibit stellate cell activity and enhance antitumor effects of nanoparticle albumin-bound paclitaxel in pancreatic ductal adenocarcinoma.

Mol Cancer Ther (2014) 13:2583-94.
 

Quesenberry PJ, Goldberg LR & Dooner MS.

Concise reviews: A stem cell apostasy: a tale of four H words.

Stem Cells (2015) 33:15-20.
 

Mata IF et al.

APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.

JAMA Neurol (2014) 71:1405-12.
 

Han C et al.

The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.

Cell Rep (2014) 8:1447-60.
 
Related Pathway

 

Maguire CA et al.

Gene therapy for the nervous system: Challenges and new strategies.

Neurotherapeutics (2014) 11:817-39.
 

Saleem SN & Abdel-Mageed AB.

Tumor-derived exosomes in oncogenic reprogramming and cancer progression.

Cell Mol Life Sci (2015) 72:1-10.
  

Berindan-Neagoe I et al.

MicroRNAome genome: a treasure for cancer diagnosis and therapy.

CA Cancer J Clin (2014) 64:311-36.
  

Ren A & Patel DJ.

c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets.

Nat Chem Biol (2014) 10:780-6.
 

Krzeszinski JY et al.

MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.

Nature (2014) 512:431-5.
   
Related Pathway

 

Pradeep S et al.

Hematogenous metastasis of ovarian cancer: Rethinking mode of spread.

Cancer Cell (2014) 26:77-91.
 

Davis AN, Afshar-Kharghan V & Sood AK.

Platelet effects on ovarian cancer.

Semin Oncol (2014) 41:378-84.
 

Akat KM et al.

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

Proc Natl Acad Sci U S A (2014) 111:11151-6.
 

Murphy SJ et al.

Sex differences in microRNA expression during development in rat cortex.

Neurochem Int (2014) 77:24-32.
 

Thomas MF, L'Etoile ND & Ansel KM.

Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.

Trends Genet (2014) 30:298-307.
  
Related Pathway

 

Takahashi K et al.

Analysis of extracellular RNA by digital PCR.

Front Oncol (2014) 4:129.
 

Wu SY et al.

RNAi therapies: Drugging the undruggable.

Sci Transl Med (2014) 6:240ps7.
 

Takahashi K et al.

Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer.

FEBS Open Bio (2014) 4:458-67.
  

Yakob M et al.

Salivary biomarkers for detection of oral squamous cell carcinoma - Current state and recent advances.

Curr Oral Health Rep (2014) 1:133-141.
  

Nery FC et al.

Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia.

J Neurosci Methods (2014) 232:181-8.
 

Takahashi K et al.

Involvement of extracellular vesicle long non-coding RNA (linc-VLDLR) in tumor cell responses to chemotherapy.

Mol Cancer Res (2014) 12:1377-87.
  

Mu J et al.

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.

Mol Nutr Food Res (2014) 58:1561-73.
  

Bauer CA et al.

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.

J Clin Invest (2014) 124:2425-40.
 

Jiang H et al.

Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.

Cancer Immunol Res (2014) 2:789-99.
 

Yang L et al.

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.

Mol Syst Biol (2014) 10:728.
 
Related Pathway

 

Redzic JS et al.

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol (2014) 28:14-23.
    

Quesenberry PJ et al.

Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.

Front Oncol (2014) 4:56.
   

Freedman JE.

Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease.

Circ Res (2014) 114:1372-3.
 

Tucker SL et al.

Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer.

Clin Cancer Res (2014) 20:3280-8.
 

Gharpure KM et al.

Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer.

Mol Cancer Ther (2014) 13:1750-7.
 

Patel T.

Extracellular vesicle noncoding RNA: New players in the diagnosis and pathogenesis of cholangiocarcinoma.

Hepatology (2014) 60:782-4.
  

Hochberg FH et al.

Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.

Expert Rev Mol Diagn (2014) 14:439-52.
  

Hu W et al.

Notch3 pathway alterations in ovarian cancer.

Cancer Res (2014) 74:3282-93.
 
Related Pathway

 

Pusic KM et al.

Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment.

Glia (2014) 62:1176-94.
 

Patel T & Harnois D.

Assessment of response to therapy in hepatocellular carcinoma.

Ann Med (2014) 46:130-7.
 

Abd Elmageed ZY et al.

Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.

Stem Cells (2014) 32:983-97.
  

Zhang H et al.

Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.

Breast Cancer Res (2014) 16:R36.
 

Cholerton BA et al.

Evaluation of mild cognitive impairment subtypes in Parkinson's disease.

Mov Disord (2014) 29:756-64.
 

Vader P, Breakefield XO & Wood MJ.

Extracellular vesicles: Emerging targets for cancer therapy.

Trends Mol Med (2014) 20:385-393.
   

Jiang H et al.

Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model.

Am J Pathol (2014) 184:1355-68.
 

Lindoso RS et al.

Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury.

Stem Cells Dev (2014) 23:1809-19.
  

Wu SY et al.

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

Nat Commun (2014) 5:3459.
 

Cho MS et al.

Autocrine effects of tumor-derived complement.

Cell Rep (2014) 6:1085-95.
 

Lusardi TA et al.

MicroRNA responses to Focal Cerebral Ischemia in male and female mouse brain.

Front Mol Neurosci (2014) 7:11.
 

Grange C et al.

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging.

Int J Mol Med (2014) 33:1055-63.
    

Quesenberry PJ et al.

Cellular phenotype and extracellular vesicles: Basic and clinical considerations.

Stem Cells Dev (2014) 23:1429-36.
   

Dalton HJ et al.

Monocyte subpopulations in angiogenesis.

Cancer Res (2014) 74:1287-93.
 

Pusic AD, Pusic KM & Kraig RP.

What are exosomes and how can they be used in Multiple Sclerosis therapy?

Expert Rev Neurother (2014) 14:353-5.
  

Morey R & Laurent LC.

Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.

Cell Stem Cell (2014) 14:131-2.
 

Takahashi K et al.

Long noncoding RNA in liver diseases.

Hepatology (2014) 60:744-53.
   
Related Pathway

 

Ben-Dov IZ et al.

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: Description of miRNA profiles at baseline.

PLoS ONE (2014) 9:e86856.
  

Takahashi K et al.

Modulation of hypoxia-signaling pathways by extracellular linc-RoR.

J Cell Sci (2014) 127:1585-94.
  

Beaulieu LM et al.

Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.

Arterioscler Thromb Vasc Biol (2014) 34:552-64.
 
Related Pathway

 

McManus DD et al.

Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study.

Heart Rhythm (2014) 11:663-9.
 

Zhaorigetu S et al.

Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue.

J Liposome Res (2014) 24:182-90.
   

Lai CP et al.

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

ACS Nano (2014) 8:483-94.
    

Ozpolat B, Sood AK & Lopez-Berestein G.

Liposomal siRNA nanocarriers for cancer therapy.

Adv Drug Deliv Rev (2014) 66:110-6.
 
Related Pathway

 

2013

Ngamruengphong S & Patel T.

Molecular evolution of genetic susceptibility to hepatocellular carcinoma.

Dig Dis Sci (2014) 59:986-91.
 

Pusic AD & Kraig RP.

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination.

Glia (2014) 62:284-99.
 

Pusic AD et al.

IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.

J Neuroimmunol (2014) 266:12-23.
 

Yao C et al.

Sex- and age-interacting eQTLs in human complex diseases.

Hum Mol Genet (2014) 23:1947-56.
 

Akers JC et al.

MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development.

PLoS ONE (2013) 8:e78115.
 

Clancy L & Freedman JE.

New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.

J Thromb Thrombolysis (2014) 37:12-6.
   

Jun HJ, Bronson RT & Charest A.

Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.

Stem Cells (2014) 32:338-48.
 

Panagopoulos K et al.

Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure.

Mol Cancer (2013) 12:118.
  

Aslan B et al.

Nanotechnology in cancer therapy.

J Drug Target (2013) 21:904-13.
 

Pecot CV et al.

Tumour angiogenesis regulation by the miR-200 family.

Nat Commun (2013) 4:2427.
  

Nishimura M et al.

Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment.

Cancer Discov (2013) 3:1302-15.
 

Chen WW et al.

BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles.

Mol Ther Nucleic Acids (2013) 2:e109.
  

Lau C et al.

Role of pancreatic cancer-derived exosomes in salivary biomarker development.

J Biol Chem (2013) 288:26888-97.
 

Aliotta JM et al.

Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.

Cardiovasc Res (2013) 100:354-62.
  

Saugstad JA.

MicroRNAs as effectors of brain function.

Stroke (2013) 44:S17-9.
 

Wang Q et al.

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.

Nat Commun (2013) 4:1867.
 

Deng ZB et al.

Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.

J Immunol (2013) 190:3579-89.
  

Akers JC et al.

Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.

J Neurooncol (2013) 113:1-11.
    

Quesenberry PJ et al.

A new stem cell biology: the continuum and microvesicles.

Trans Am Clin Climatol Assoc (2012) 123:152-66.
   

Gonda DD et al.

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.

Neurosurgery (2013) 72:501-10.