The Extracellular RNA Communication Consortium has published 500+ research articles since its inception in 2013. They are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.

2020

Hinger SA et al.

Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.

Sci Rep (2020) 10:15804.
  

Huang Y et al.

Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles.

J Extracell Vesicles (2020) 9:1785746.
 

Welsh JA & Jones JC.

Small particle fluorescence and light scatter calibration using FCMPASS software.

Curr Protoc Cytom (2020) 94:e79.
 

Tian Z et al.

Generating multifunctional acoustic tweezers in Petri dishes for contactless, precise manipulation of bioparticles.

Sci Adv (2020) 6:eabb0494.
 

Srinivasan S et al.

Discovery and verification of extracellular miRNA biomarkers for non-invasive prediction of pre-eclampsia in asymptomatic women.

Cell Rep Med (2020) 1:100013.
 

Charest A.

Experimental and biological insights from proteomic analyses of extracellular vesicle cargos in normalcy and disease.

Adv Biosyst AOP 2020-08-19.
   

Chen B et al.

The long noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling.

Gastroenterology AOP 2020-08-14.
 

Liu P et al.

Acoustofluidic multi-well plates for enrichment of micro/nano particles and cells.

Lab Chip (2020) 20:3399-3409.
 

Meabon JS et al.

Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure.

J Neurol Sci (2020) 417:117049.
  

Li F et al.

Ultra-short circulating tumor DNA (usctDNA) in plasma and saliva of Non-Small Cell Lung Cancer (NSCLC) patients.

Cancers (Basel) (2020) 12:2041.
  

Drula R et al.

MicroRNAs from liquid biopsy derived extracellular vesicles: Recent advances in detection and characterization methods.

Cancers (Basel) (2020) 12:2009.
    

Lurie E et al.

Histoepigenetic analysis of the mesothelin network within pancreatic ductal adenocarcinoma cells reveals regulation of retinoic acid receptor gamma and AKT by mesothelin.

Oncogenesis (2020) 9:62.
  

Koupenova M & Freedman JE.

Platelets and immunity: Going viral.

Arterioscler Thromb Vasc Biol (2020) 40:1605-1607.
   

Gu Y et al.

Acoustofluidic holography for micro- to nanoscale particle manipulation.

ACS Nano AOP 2020-06-23.
 

Jin G et al.

Acoustofluidic scanning nanoscope with high resolution and large field of view.

ACS Nano (2020) 14:8624-8633.
 

Zhang P et al.

Acoustic microfluidics.

Annu Rev Anal Chem (Palo Alto Calif) (2020) 13:17-43.
  

Yekula A et al.

Liquid biopsy strategies to distinguish progression from pseudoprogression and radiation necrosis in glioblastomas.

Adv Biosyst AOP 2020-06-02.
  

O'Brien K et al.

RNA delivery by extracellular vesicles in mammalian cells and its applications.

Nat Rev Mol Cell Biol (2020) 21:585-606.
  

Chen F et al.

Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in Acute Myeloid Leukaemia: Therapeutic implications.

J Cell Mol Med AOP 2020-05-25.
  

Sung BH et al.

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells.

Nat Commun (2020) 11:2092.
   

Hao N et al.

Acoustofluidics-assisted engineering of multifunctional three-dimensional zinc oxide nanoarrays.

ACS Nano (2020) 14:6150-6163.
  

Maas SLN et al.

Glioblastoma hijacks microglial gene expression to support tumor growth.

J Neuroinflammation (2020) 17:120.
  

Hunter-Zinck H et al.

Genotyping array design and data quality control in the Million Veteran Program.

Am J Hum Genet (2020) 106:535-548.
 

Tran AM et al.

A new world of biomarkers and therapeutics for female reproductive system and breast cancers: Circular RNAs.

Front Cell Dev Biol (2020) 8:50.
   

Zhao S et al.

A disposable acoustofluidic chip for nano/microparticle separation using unidirectional acoustic transducers.

Lab Chip (2020) 20:1298-1308.
 

Wang C, Senapati S & Chang HC.

Liquid biopsy technologies based on membrane microfluidics: High-yield purification and selective quantification of biomarkers in nanocarriers.

Electrophoresis AOP 2020-03-16.
  

Bachman H et al.

Low-frequency flexural wave based microparticle manipulation.

Lab Chip (2020) 20:1281-1289.
 

Zhang L et al.

A cell-phone-based acoustofluidic platform for quantitative point-of-care testing.

ACS Nano (2020) 14:3159-3169.
 

Bachman H et al.

An acoustofluidic device for efficient mixing over a wide range of flow rates.

Lab Chip (2020) 20:1238-1248.
 

Lucero R et al.

Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells.

Cell Rep (2020) 30:2065-2074.e4.
 

Yekula A et al.

From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers.

Methods (2020) 177:58-66.
 

Wei S et al.

A rapid and simple bead-bashing-based method for genomic DNA extraction from mammalian tissue.

Biotechniques (2020) 68:240-244.
 

Rao SL et al.

Altered level of salivary placental growth factor is associated with preeclampsia.

Placenta (2020) 90:118-120.
 

Yekula A et al.

Extracellular vesicles in glioblastoma tumor microenvironment.

Front Immunol (2019) 10:3137.
   

Kang P et al.

Acoustic tweezers based on circular, slanted-finger interdigital transducers for dynamic manipulation of micro-objects.

Lab Chip (2020) 20:987-994.
 

Xie Y et al.

Acoustic cell separation based on biophysical properties.

J Biomech Eng AOP 2020-02-03.
 

Perez PS et al.

Extracellular vesicles and chronic inflammation during HIV infection.

J Extracell Vesicles (2019) 8:1687275.
  

Pichler M et al.

Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.

Gut (2020) 69:1818-1831.
 

Meyer C et al.

The G3BP1-Family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

Mol Cell (2020) 77:1193-1205.e5.
  

Silverman MG et al.

Circulating miRNAs and risk of sudden death in patients with coronary heart disease.

JACC Clin Electrophysiol (2020) 6:70-79.
  

Oliveira GP Jr et al.

Detection of extracellular vesicle RNA using molecular beacons.

iScience (2020) 23:100782.
 

Xiong C et al.

Targeting forward and reverse EphB4/EFNB2 signaling by a peptide with dual functions.

Sci Rep (2020) 10:520.
 

Forterre AV et al.

Extracellular vesicle-mediated in vitro transcribed mRNA delivery for treatment of HER2(+) breast cancer xenografts in mice by prodrug CB1954 without general toxicity.

Mol Cancer Ther (2020) 19:858-867.
 

El-Arabey AA et al.

GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma.

Cell Signal (2020) 68:109539.
 

2019

Gambaro F et al.

Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner.

RNA Biol AOP 2019-12-29.
   

Parashar D et al.

miRNA551b-3p activates an oncostatin signaling module for the progression of triple-negative breast cancer.

Cell Rep (2019) 29:4389-4406.e10.
 

De Los Santos MC, Dragomir MP & Calin GA.

The role of exosomal long non-coding RNAs in cancer drug resistance.

Cancer Drug Resist (2019) 2:1178-1192.
   

Godoy PM et al.

Comparison of reproducibility, accuracy, sensitivity, and specificity of miRNA quantification platforms.

Cell Rep (2019) 29:4212-4222.e5.
 

Yang Z et al.

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.

Nat Biomed Eng (2020) 4:69-83.
  

Wang Z et al.

Acoustofluidic salivary exosome isolation: a liquid biopsy compatible approach for human papillomavirus-associated oropharyngeal cancer detection.

J Mol Diagn (2020) 22:50-59.
 

Yokoi A et al.

Mechanisms of nuclear content loading to exosomes.

Sci Adv (2019) 5:eaax8849.
  

Weaver AM & Patton JG.

Argonautes in extracellular vesicles: Artifact or selected cargo?

Cancer Res (2020) 80:379-381.
  

Russell AE et al.

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop.

J Extracell Vesicles (2019) 8:1684862.
  

Darling CE et al.

Bioimpedance-based heart failure deterioration prediction using a prototype fluid accumulation vest-mobile phone dyad: an observational study.

JMIR Cardio (2017) 1:e1.
 

Zaborowski MP et al.

Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles.

Sci Rep (2019) 9:17387.
   

Ding EY et al.

Accuracy and usability of a novel algorithm for detection of irregular pulse using a smartwatch among older adults: Observational study.

JMIR Cardio (2019) 3:e13850.
 

Sun L et al.

miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44.

Theranostics (2019) 9:8409-8425.
    

Sundaram K et al.

Plant-derived exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis.

iScience (2019) 21:308-327.
   

Lee MJ et al.

The impact of Moyamoya disease and RNF213 mutations on the spectrum of plasma protein and microRNA.

J Clin Med (2019) 8.
  

Spartano NL et al.

Comparison of on-site versus remote mobile device support in the Framingham Heart Study using the health eHeart study for digital follow-up: Randomized pilot study set within an observational study design.

JMIR Mhealth Uhealth (2019) 7:e13238.
 

Pusic KM et al.

IFNgamma-stimulated dendritic cell exosomes for treatment of migraine modeled using spreading depression.

Front Neurosci (2019) 13:942.
   

Dias MM et al.

GLS2 is protumorigenic in breast cancers.

Oncogene (2020) 39:690-702.
 

Abels ER et al.

Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21.

Cell Rep (2019) 28:3105-3119.e7.
 

Kanada M et al.

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy.

Mol Cancer Ther (2019) 18:2331-2342.
  

Fabbri M et al.

Decrypting noncoding RNA interactions, structures, and functional networks.

Genome Res (2019) 29:1377-1388.
  

Yoneshiro T et al.

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.

Nature (2019) 572:614-619.
 

Batki J et al.

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.

Nat Struct Mol Biol (2019) 26:720-731.
 

Bach DH, Zhang W & Sood AK.

Chromosomal instability in tumor initiation and development.

Cancer Res (2019) 79:3995-4002.
 

Chen X et al.

Identifying and targeting angiogenesis-related microRNAs in ovarian cancer.

Oncogene (2019) 38:6095-6108.
 

Lee MY et al.

Distinct profiles of cell-free microRNAs in plasma of veterans with Post-Traumatic Stress Disorder.

J Clin Med (2019) 8.
  

Gyuris A et al.

Physical and molecular landscapes of mouse glioma extracellular vesicles define heterogeneity.

Cell Rep (2019) 27:3972-3987.e6.
     

Pegtel DM & Gould SJ.

Exosomes.

Annu Rev Biochem (2019) 88:487-514.
   

Haraszti RA et al.

Serum deprivation of Mesenchymal Stem Cells improves exosome activity and alters lipid and protein composition.

iScience (2019) 16:230-241.
   

Divakaran S et al.

Diagnostic accuracy of advanced imaging in cardiac sarcoidosis.

Circ Cardiovasc Imaging (2019) 12:e008975.
 

Kaczor-Urbanowicz KE et al.

Clinical validity of saliva and novel technology for cancer detection.

Biochim Biophys Acta Rev Cancer (2019) 1872:49-59.
  

Xie W et al.

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.

Proc Natl Acad Sci U S A (2019) 116:11946-11955.
 

Petrescu GED et al.

MicroRNA based theranostics for brain cancer: Basic principles.

J Exp Clin Cancer Res (2019) 38:231.
   

Bayraktar R, Bertilaccio MTS & Calin GA.

The interaction between two worlds: microRNAs and Toll-Like Receptors.

Front Immunol (2019) 10:1053.
 

Tapparo M et al.

Renal regenerative potential of extracellular vesicles derived from miRNA-engineered Mesenchymal Stromal Cells.

Int J Mol Sci (2019) 20.
  

Wiklander OPB et al.

Advances in therapeutic applications of extracellular vesicles.

Sci Transl Med (2019) 11.
  

Lee MY et al.

A biological function based biomarker panel optimization process.

Sci Rep (2019) 9:7365.
 

Zheng L et al.

Hatchet ribozyme structure and implications for cleavage mechanism.

Proc Natl Acad Sci U S A (2019) 116:10783-10791.
 

Bruno S et al.

Role of extracellular vesicles in stem cell biology.

Am J Physiol Cell Physiol (2019) 317:C303-C313.
   

Ghai V et al.

Extracellular vesicle encapsulated microRNAs in patients with Type 2 Diabetes are affected by metformin treatment.

J Clin Med (2019) 8.
  

Wei Z et al.

Co-cultures of glioma stem cells and primary neurons, astrocytes, microglia, and endothelial cells for investigation of intercellular communication in the brain.

Front Neurosci (2019) 13:361.
  

Giraldez MD et al.

Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma.

EMBO J (2019) 38.
  

Watts JK, Brown RH & Khvorova A.

Nucleic acid therapeutics for neurological diseases.

Neurotherapeutics (2019) 16:245-247.
  

Zelniker TA et al.

Biomarker of collagen turnover (C-terminal telopeptide) and prognosis in patients with non-ST-elevation acute coronary syndromes.

J Am Heart Assoc (2019) 8:e011444.
 

Koupenova M et al.

The role of platelets in mediating a response to human influenza infection.

Nat Commun (2019) 10:1780.
 

Duong P et al.

Cushioned-Density Gradient Ultracentrifugation (C-DGUC) improves the isolation efficiency of extracellular vesicles.

PLoS One (2019) 14:e0215324.
 

Akat KM et al.

Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis.

JCI Insight (2019) 5.
 

Zhang Q et al.

Transfer of functional cargo in exomeres.

Cell Rep (2019) 27:940-954.e6.
   

Rozowsky J et al.

exceRpt: A comprehensive analytic platform for extracellular RNA profiling.

Cell Syst (2019) 8:352-357.e3.
  

Das S et al.

The Extracellular RNA Communication Consortium: Establishing foundational knowledge and technologies for extracellular RNA research.

Cell (2019) 177:231-242.
    

Jeppesen DK et al.

Reassessment of exosome composition.

Cell (2019) 177:428-445.e18.
   

Murillo OD et al.

exRNA Atlas analysis reveals distinct extracellular RNA Cargo types and their carriers present across human biofluids.

Cell (2019) 177:463-477.e15.
     

Poggio M et al.

Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory.

Cell (2019) 177:414-427.e13.
   

Srinivasan S et al.

Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation.

Cell (2019) 177:446-462.e16.
  

Zaborowski MP et al.

Methods for systematic identification of membrane proteins for specific capture of cancer-derived extracellular vesicles.

Cell Rep (2019) 27:255-268.e6.
  

Schmittgen TD.

Exosomal miRNA cargo as mediator of immune escape mechanisms in neuroblastoma.

Cancer Res (2019) 79:1293-1294.
 

Ma S et al.

GnRH-R-targeted lytic peptide sensitizes BRCA wild-type ovarian cancer to PARP inhibition.

Mol Cancer Ther (2019) 18:969-979.
 

Roy S et al.

Navigating the landscape of tumor extracellular vesicle heterogeneity.

Int J Mol Sci (2019) 20.
  

Gonzalez-Villasana V et al.

Presence of circulating miR-145, miR-155, and miR-382 in exosomes isolated from serum of breast cancer patients and healthy donors.

Dis Markers (2019) 2019:6852917.
 

Shah R, Murthy V & Freedman JE.

Nuts, cardiovascular health, and diabetes.

Circ Res (2019) 124:825-826.
 

Bach DH, Lee SK & Sood AK.

Circular RNAs in Cancer.

Mol Ther Nucleic Acids (2019) 16:118-129.
    

Roh JD et al.

Activin type II receptor signaling in cardiac aging and heart failure.

Sci Transl Med (2019) 11.
 

Ko D et al.

Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study.

J Am Heart Assoc (2019) 8:e010976.
 

Mazzu YZ et al.

miR-193b regulates tumorigenesis in liposarcoma cells via PDGFR, TGFbeta, and Wnt signaling.

Sci Rep (2019) 9:3197.
 

Grani C et al.

Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis.

J Cardiovasc Magn Reson (2019) 21:14.
 

Dawes C & Wong DTW.

Role of saliva and salivary diagnostics in the advancement of oral health.

J Dent Res (2019) 98:133-141.
 

Bei Y et al.

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.

BMC Med (2019) 17:42.
 

Liu B et al.

Interplay between miRNAs and host genes and their role in cancer.

Brief Funct Genomics (2018) 18:255-266.
  

Belair CD et al.

High-throughput, efficient, and unbiased capture of small RNAs from low-input samples for sequencing.

Sci Rep (2019) 9:2262.
 

Ghai V et al.

Circulating RNAs as predictive markers for the progression of type 2 diabetes.

J Cell Mol Med (2019) 23:2753-2768.
 

Wiedrick JT et al.

Validation of microRNA biomarkers for Alzheimer's Disease in human cerebrospinal fluid.

J Alzheimers Dis (2019) 67:875-891.
 

Pua HH et al.

Increased hematopoietic extracellular RNAs and vesicles in the lung during allergic airway responses.

Cell Rep (2019) 26:933-944.e4.
   

Carrero I et al.

Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments.

Oncogene (2019) 38:3551-3568.
 

Krichevsky AM & Uhlmann EJ.

Oligonucleotide therapeutics as a new class of drugs for malignant brain tumors: Targeting mRNAs, regulatory RNAs, mutations, combinations, and beyond.

Neurotherapeutics (2019) 16:319-347.
  

Thery C, Witwer KW, et al.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

J Extracell Vesicles (2018) 7:1535750.
 

Varkaris A et al.

Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer.

Br J Cancer (2019) 120:340-345.
 

Gulei D et al.

CRISPR-based RNA editing: Diagnostic applications and therapeutic options.

Expert Rev Mol Diagn (2019) 19:83-88.
   

Usmani SM et al.

HIV-1 balances the fitness costs and benefits of disrupting the host cell actin cytoskeleton early after mucosal transmission.

Cell Host Microbe (2019) 25:73-86.e5.
 

LaFargue CJ et al.

Exploring and comparing adverse events between PARP inhibitors.

Lancet Oncol (2019) 20:e15-e28.
  

Jimenez L et al.

Quantitative proteomic analysis of small and large extracellular vesicles (EVs) reveals enrichment of adhesion proteins in small EVs.

J Proteome Res (2019) 18:947-959.
  

2018

Yu H et al.

beRBP: binding estimation for human RNA-binding proteins.

Nucleic Acids Res (2019) 47:e26.
 

Shah RV et al.

Proteins altered by surgical weight loss highlight biomarkers of insulin resistance in the community.

Arterioscler Thromb Vasc Biol (2019) 39:107-115.
 

Cortez MA et al.

Role of miRNAs in immune responses and immunotherapy in cancer.

Genes Chromosomes Cancer (2019) 58:244-253.
  Related Pathway

 

Chiou NT, Kageyama R & Ansel KM.

Selective export into extracellular vesicles and function of tRNa fragments during T cell activation.

Cell Rep (2018) 25:3356-3370.e4.
  

Ge XA & Hunter CP.

Efficient homologous recombination in mice using long single stranded DNA and CRISPR Cas9 nickase.

G3 (2019) 9:281-286.
 

Jia N et al.

Type III-A CRISPR-Cas Csm complexes: Assembly, periodic RNA cleavage, DNase activity regulation, and autoimmunity.

Mol Cell (2019) 73:264-277.e5.
 

Chen B et al.

Efficient labeling and imaging of protein-coding genes in living cells using CRISPR-Tag.

Nat Commun (2018) 9:5065.
 

Kanlikilicer P et al.

Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer.

EBioMedicine (2018) 38:100-112.
   

Shah R, Patel T & Freedman JE.

Circulating extracellular vesicles in human disease.

N Engl J Med (2018) 379:2180-2181.
  

Zhou S et al.

Chronic Platelet-derived Growth Factor Receptor signaling exerts control over initiation of protein translation in glioma.

Life Sci Alliance (2018) 1:e201800029.
  Related Pathway

 

Teng Y et al.

Plant-derived exosomal microRNAs shape the gut microbiota.

Cell Host Microbe (2018) 24:637-652.e8.
   

Vita T et al.

Comparing CMR mapping methods and myocardial patterns toward heart failure outcomes in nonischemic dilated cardiomyopathy.

JACC Cardiovasc Imaging (2019) 12:1659-1669.
 

Lusardi TA et al.

Analytics of Cerebrospinal Fluid microRNA quantitative PCR studies.

Mol Neurobiol (2019) 56:4988-4999.
 

Wang QL et al.

Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways.

Theranostics (2018) 8:4912-4924.
  

Villar-Prados A et al.

Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4.

Mol Cancer Ther (2019) 18:421-436.
 

Van Roosbroeck K et al.

The involvement of microRNA in the pathogenesis of Richter syndrome.

Haematologica (2019) 104:1004-1015.

Suryawanshi H et al.

A single-cell survey of the human first-trimester placenta and decidua.

Sci Adv (2018) 4:eaau4788.
 

Smith EMD et al.

A Markov Multi-State model of lupus nephritis urine biomarker panel dynamics in children: Predicting changes in disease activity.

Clin Immunol (2019) 198:71-78.
 

Godoy PM et al.

Large differences in small RNA composition between human biofluids.

Cell Rep (2018) 25:1346-1358.
   

Bei Y et al.

Circular RNAs as potential theranostics in the cardiovascular system.

Mol Ther Nucleic Acids (2018) 13:407-418.
    

Haraszti RA et al.

Exosomes produced from 3D Cultures of MSCs by Tangential Flow Filtration show higher yield and improved activity.

Mol Ther (2018) 26:2838-2847.
   

Hinger SA et al.

Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells.

Cell Rep (2018) 25:715-725.e4.
   

Wei S et al.

Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer.

Fertil Steril (2018) 110:910-916.e2.
 

Wei F et al.

Electric field-induced release and measurement liquid biopsy for noninvasive early lung cancer assessment.

J Mol Diagn (2018) 20:738-742.
 

Hisamatsu T et al.

PRKRA/PACT expression promotes chemoresistance of mucinous ovarian cancer.

Mol Cancer Ther (2019) 18:162-172.
 

Gustafsson G et al.

Secretion and uptake of alpha-synuclein via extracellular vesicles in cultured cells.

Cell Mol Neurobiol (2018) 38:1539-1550.
  

Lu Y et al.

miR-205 regulates basal cell identity and stem cell regenerative potential during mammary reconstitution.

Stem Cells (2018) 36:1875-1889.
 

Antoury L et al.

Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of Muscular Dystrophies.

Nat Commun (2018) 9:3906.
 

Shen P et al.

Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling.

Mol Oncol (2018) 12:1856-1870.
 

Malabirade A et al.

The RNA complement of Outer Membrane Vesicles from Salmonella enterica Serovar Typhimurium under distinct culture conditions.

Front Microbiol (2018) 9:2015.
 

Moirangthem A & Patel T.

Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.

Biotarget (2017) 1:12.
    

Narla V et al.

Unique circulating microRNA profiles in HIV infection.

J Acquir Immune Defic Syndr (2018) 79:644-650.
 

Regev K et al.

Identification of MS-specific serum miRNAs in an international multicenter study.

Neurol Neuroimmunol Neuroinflamm (2018) 5:e491.
   

Monroig-Bosque PDC et al.

OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers.

Sci Rep (2018) 8:13106.
 

Roy S et al.

microRNA 193a-5p regulates levels of Nucleolar- and Spindle-associated Protein 1 to suppress hepatocarcinogenesis.

Gastroenterology (2018) 155:1951-1966.e26.
 

Dragomir M, Chen B & Calin GA.

Exosomal lncRNAs as new players in cell-to-cell communication.

Transl Cancer Res (2018) 7:S243-S252.
  

Onuchic V et al.

Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci.

Science (2018) 361:1354.
 

Raffai RL.

MicroRNA-146a and hematopoiesis: Friend or foe in atherosclerosis.

Noncoding RNA Investig (2018) 2:43.
   

Li F et al.

Discovery and validation of salivary extracellular RNA biomarkers for noninvasive detection of gastric cancer.

Clin Chem (2018) 64:1513-1521.
 

Shah RV et al.

Associations of circulating extracellular RNAs with myocardial remodeling and heart failure.

JAMA Cardiol (2018) 3:871-876.
 

Jun HJ et al.

A PDGFRalpha-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.

Nat Commun (2018) 9:3116.
  Related Pathway

 

Silva AM et al.

Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.

Theranostics (2018) 8:3902-3917.
 

Gharpure KM et al.

FABP4 as a key determinant of metastatic potential of ovarian cancer.

Nat Commun (2018) 9:2923.
  Related Pathway

 

Giraldez MD et al.

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Nat Biotechnol (2018) 36:746-757.
 

Broekman ML et al.

Multidimensional communication in the microenvirons of glioblastoma.

Nat Rev Neurol (2018) 14:482-495.
  

Sung BH & Weaver AM.

Directed migration: Cells navigate by extracellular vesicles.

J Cell Biol (2018) 217:2613-2614.
   

Umamaheswaran S et al.

Stress, inflammation, and eicosanoids: an emerging perspective.

Cancer Metastasis Rev (2018) 37:203-211.
 

Haraszti RA et al.

Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles.

Mol Ther (2018) 26:1973-1982.
  

Moustafa AA et al.

MicroRNAs in prostate cancer: From function to biomarker discovery.

Exp Biol Med (2018) 243:817-825.
 

Zhang Q et al.

Mutant KRAS exosomes alter the metabolic state of recipient colonic epithelial cells.

Cell Mol Gastroenterol Hepatol (2018) 5:627-629.e6.
  

Dragomir M & Calin GA.

Circular RNAs in cancer - Lessons learned from microRNAs.

Front Oncol (2018) 8:179.
   

Badawi M et al.

CD44 positive and sorafenib insensitive hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128.

Oncotarget (2018) 9:26032-26045.
 

Lyons YA et al.

Immune cell profiling in cancer: Molecular approaches to cell-specific identification.

NPJ Precis Oncol (2017) 1:26.
 

Yeung TL et al.

Systematic identification of druggable epithelial-stromal crosstalk signaling networks in ovarian cancer.

J Natl Cancer Inst (2019) 111:272-282.
 

Gyorgy B et al.

CRISPR/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer's disease.

Mol Ther Nucleic Acids (2018) 11:429-440.
 

Ghai V et al.

Genome-wide profiling of urinary extracellular vesicle microRNAs associated with diabetic nephropathy in type 1 diabetes.

Kidney Int Rep (2018) 3:555-572.
 

Malge A et al.

mRNA transcript distribution bias between Borrelia burgdorferi bacteria and their outer membrane vesicles.

FEMS Microbiol Lett (2018) 365.

Dluzen DF et al.

Extracellular RNA profiles with human age.

Aging Cell (2018) 17:e12785.
  

Danielson KM et al.

Plasma circulating extracellular RNAs in Left Ventricular Remodeling post-Myocardial Infarction.

EBioMedicine (2018) 32:172-181.
    

Kaczor-Urbanowicz KE et al.

Salivary exRNA biomarkers to detect gingivitis and monitor disease regression.

J Clin Periodontol (2018) 45:806-817.
 

Max KEA et al.

Human plasma and serum extracellular small RNA reference profiles and their clinical utility.

Proc Natl Acad Sci USA (2018) 115 :E5334-E5343.
 

Heintz-Buschart A et al.

Small RNA profiling of low biomass samples: Identification and removal of contaminants.

BMC Biol (2018) 16:52.
 

Quinn JF.

Lost in translation? Finding our way to effective Alzheimer's Disease therapies.

J Alzheimers Dis (2018) 64:S33-S39.
 

George J, Yan IK & Patel T.

Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice.

Lab Invest (2018) 98:895-910.
 

Yeri A et al.

Evaluation of commercially available small RNASeq library preparation kits using low input RNA.

BMC Genomics (2018) 19:331.
 

Biscans A et al.

Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles.

Mol Ther (2018) 26:1520-1528.
  

He X et al.

Human tRNA-derived small RNAs modulate host-oral microbial interactions.

J Dent Res (2018) 97:1236-1243.
  

Staerk L et al.

Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: Cohort study based on longitudinal data from the Framingham Heart Study.

BMJ (2018) 361:k1453.
 

Vujic A et al.

Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Nat Commun (2018) 9:1659.
   

Li F et al.

Characterization of human salivary extracellular RNA by next-generation sequencing.

Clin Chem (2018) 64:1085-1095.
 

Koupenova M et al.

Micro RNAs from DNA viruses are found widely in plasma in a large observational human population.

Sci Rep (2018) 8:6397.
   

Marangoni F et al.

Tumor tolerance-promoting function of regulatory T cells is optimized by CD28, but strictly dependent on calcineurin.

J Immunol (2018) 200:3647-3661.
 

Haemmerle M et al.

The platelet lifeline to cancer: Challenges and opportunities.

Cancer Cell (2018) 33:965-983.
   

Smith AS et al.

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability.

Proc Natl Acad Sci USA (2018) 115:E4377-E4385.
 

Sardana M et al.

Association of Left Atrial Function Index with Atrial Fibrillation and Cardiovascular Disease: the Framingham Offspring Study.

J Am Heart Assoc (2018) 7.
 

Shah MY et al.

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.

Genome Res (2018) 28:432-447.
 

Andersen MS et al.

A novel implementation of magnetic levitation to quantify leukocyte size, morphology, and magnetic properties to identify patients with sepsis.

Shock (2019) 51:147-152.
 

Wei S, Weiss ZR & Williams Z.

Rapid multiplex small DNA sequencing on the MinION Nanopore sequencing platform.

G3 (Bethesda) (2018) 8:1649-1657.
 

Ricklefs FL et al.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Sci Adv (2018) 4:eaar2766.
  

Fallen S et al.

Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour.

J Cell Mol Med (2018) 22:2760-2773.
 

Nonaka T & Wong DTW.

Liquid biopsy in head and neck cancer: Promises and challenges.

J Dent Res (2018) 97:701-708.
  

Wang JH et al.

Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation.

Mol Cancer Ther (2018) 17 :1133-1142.
 

Baecher-Allan C, Kaskow BJ & Weiner HL.

Multiple Sclerosis: Mechanisms and immunotherapy.

Neuron (2018) 97:742-768.
  

Rodriguez Cetina Biefer H et al.

Mast cells regulate CD4(+) T-cell differentiation in the absence of antigen presentation.

J Allergy Clin Immunol (2018) 142:1894-1908.e7.
 

Raheja R et al.

Correlating serum microRNAs and clinical parameters in amyotrophic lateral sclerosis.

Muscle Nerve (2018) 58:261-269.
 

Shah R et al.

MicroRNAs associated with reverse left ventricular remodeling in humans identify pathways of heart failure progression.

Circ Heart Fail (2018) 11:e004278.
 

Didiot MC et al.

Loading of extracellular vesicles with hydrophobically modified siRNAs.

Methods Mol Biol (2018) 1740:199-214.
 

Filant J et al.

Isolation of extracellular RNA from serum/plasma.

Methods Mol Biol (2018) 1740:43-57.
 

Shukla N, Yan IK & Patel T.

Multiplexed detection and quantitation of extracellular vesicle RNA expression using NanoString.

Methods Mol Biol (2018) 1740:177-185.
 

Velazquez-Torres G et al.

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.

Nat Commun (2018) 9:461.
 

Li K et al.

Cushioned-Density Gradient Ultracentrifugation (C-DGUC): A refined and high performance method for the isolation, characterization, and use of exosomes.

Methods Mol Biol (2018) 1740:69-83.
 

Yan IK, Berdah VX & Patel T.

Isolation of extracellular RNA from bile.

Methods Mol Biol (2018) 1740:59-67.
 

Matsuda A & Patel T.

Milk-derived extracellular vesicles for therapeutic delivery of small interfering RNAs.

Methods Mol Biol (2018) 1740:187-197.
  

Li K et al.

Isolation of plasma lipoproteins as a source of extracellular RNA.

Methods Mol Biol (2018) 1740:139-153.
 

Etheridge A et al.

Preparation of small RNA NGS libraries from biofluids.

Methods Mol Biol (2018) 1740:163-175.
 

Yan IK, Lohray R & Patel T.

Droplet digital PCR for quantitation of extracellular RNA.

Methods Mol Biol (2018) 1740:155-162.
 

Shao H et al.

New technologies for analysis of extracellular vesicles.

Chem Rev (2018) 118:1917-1950.
 

Viswanath P et al.

2-Hydroxyglutarate-mediated autophagy of the Endoplasmic Reticulum leads to an unusual downregulation of phospholipid biosynthesis in mutant IDH1 gliomas.

Cancer Res (2018) 78:2290-2304.
 

Koupenova M et al.

Circulating platelets as mediators of immunity, inflammation, and thrombosis.

Circ Res (2018) 122:337-351.
  Related Pathway

 

Hulsmans M et al.

Cardiac macrophages promote diastolic dysfunction.

J Exp Med (2018) 215:423-440.
  Related Pathway

 

Reategui E et al.

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Nat Commun (2018) 9:175.
 

Lankford KL et al.

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.

PLoS ONE (2018) 13:e0190358.
   

2017

McKenzie JA et al.

The effect of topoisomerase I inhibitors on the efficacy of T-cell-based cancer immunotherapy.

J Natl Cancer Inst (2018) 110:777-786.
 

Leung CS et al.

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.

J Clin Invest (2018) 128:589-606.
  Related Pathway

 

Soni A et al.

Study protocol for Smartphone Monitoring for Atrial fibrillation in Real-Time in India (SMART-India): a community-based screening and referral programme.

BMJ Open (2017) 7:e017668.
 

Kanlikilicer P et al.

Therapeutic targeting of AXL receptor tyrosine kinase inhibits tumor growth and intraperitoneal metastasis in ovarian cancer models.

Mol Ther Nucleic Acids (2017) 9:251-262.
 

Boussiotis VA & Charest A.

Immunotherapies for malignant glioma.

Oncogene (2018) 37:1121-1141.
 

Chen X et al.

RNA interference-based therapy and its delivery systems.

Cancer Metastasis Rev (2018) 37:107-124.
 

Pi F et al.

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression.

Nat Nanotechnol (2018) 13:82-89.
 

Noh K et al.

Differential effects of EGFL6 on tumor versus wound angiogenesis.

Cell Rep (2017) 21:2785-2795.
 

Lu Y et al.

MYC targeted long noncoding RNA DANCR promotes cancer in part by reducing p21 levels.

Cancer Res (2018) 78:64-74.
 

Vannini I et al.

Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.

Nat Commun (2017) 8:1801.
  Related Pathway

 

Bei Y et al.

Extracellular vesicles in cardiovascular theranostics.

Theranostics (2017) 7:4168-4182.
   Related Pathway

 

Slenter DN et al.

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research.

Nucleic Acids Res (2018) 46:D661-D667.
 

Singh PB et al.

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

J Exp Med (2017) 214:3627-3643.
 

Amorim MG et al.

A total transcriptome profiling method for plasma-derived extracellular vesicles: Applications for liquid biopsies.

Sci Rep (2017) 7:14395.
 

Zheng L et al.

Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.

Nat Commun (2017) 8:1180.
 

Wei Z et al.

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Nat Commun (2017) 8:1145.
  

Nolan JP & Duggan E.

Analysis of individual extracellular vesicles by flow cytometry.

Methods Mol Biol (2018) 1678:79-92.
 

Wu X et al.

sRNAnalyzer: a flexible and customizable small RNA sequencing data analysis pipeline.

Nucleic Acids Res (2017) 45:12140-12151.
 

Bhakta NR et al.

IFN-stimulated gene expression, type 2 inflammation, and endoplasmic reticulum stress in asthma.

Am J Respir Crit Care Med (2018) 197:313-324.
 

Mitamura T et al.

Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).

Oncogene (2018) 37:722-731.
  Related Pathway

 

Nonaka T & Wong DTW.

Saliva exosomics in cancer: Molecular characterization of cancer-derived exosomes in saliva.

Enzymes (2017) 42:125-151.
  

Piao X et al.

Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2'-F RNA, and LNA in the context of Phi29 pRNA 3WJ.

RNA (2018) 24:67-76.
 

Xiao J et al.

miR-31a-5p promotes postnatal cardiomyocyte proliferation by targeting RhoBTB1.

Exp Mol Med (2017) 49:e386.
 

Gerstberger S et al.

The conserved RNA exonuclease Rexo5 is required for 3' end maturation of 28S rRNA, 5S rRNA, and snoRNAs.

Cell Rep (2017) 21:758-772.
 

Lu Y et al.

lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/beta-catenin signaling.

Nat Med (2017) 23:1331-1341.
 

Willinger CM et al.

MicroRNA signature of cigarette smoking and evidence for a putative causal role of microRNAs in smoking-related inflammation and target organ damage.

Circ Cardiovasc Genet (2017) 10:5.
 

Bayraktar R, Van Roosbroeck K & Calin GA.

Cell-to-cell communication: microRNAs as hormones.

Mol Oncol (2017) 11:1673-1686.
   

Kaczor-Urbanowicz KE et al.

Novel approaches for bioinformatic analysis of salivary RNA sequencing data for development.

Bioinformatics (2018) 34:1-8.
 

Grinberg YY, Zitzow LA & Kraig RP.

Intranasally administered IGF-1 inhibits spreading depression in vivo.

Brain Res (2017) 1677:47-57.
 

Shen P et al.

To Wnt or lose: The missing non-coding linc in colorectal cancer.

Int J Mol Sci (2017) 18:9.
  Related Pathway

 

Nguyen TA et al.

SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition.

Immunity (2017) 47:498-509.e6.
  

Shah R et al.

Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: Brief report.

Am J Physiol Heart Circ Physiol (2017) 313:H1162-H1167.
  

Rodriguez-Aguayo C et al.

Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer.

Cell Discov (2017) 3:17029.
 

Shankar GM et al.

Liquid biopsy for brain tumors.

Expert Rev Mol Diagn (2017) 17:943-947.
  

Haraszti RA et al.

Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system.

Bio Protoc (2017) 7:20.
 

Dalton HJ et al.

Macrophages facilitate resistance to anti-VEGF therapy by altered VEGFR expression.

Clin Cancer Res (2017) 23:7034-7046.
 

Figueroa J et al.

Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587.

Cancer Res (2017) 77:5808-5819.
  

Datta A et al.

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.

Cancer Lett (2017) 408:73-81.
   Related Pathway

 

Jones A et al.

miRNA signatures of insulin resistance in obesity.

Obesity (2017) 25:1734-1744.
 

Wu AY & Lai CP.

Tracking extracellular vesicles delivery and RNA translation using multiplexed reporters.

Methods Mol Biol (2017) 1660:255-265.
 

Zhang Y et al.

Salivary extracellular RNA biomarkers for insulin resistance detection in Hispanics.

Diabetes Res Clin Pract (2017) 132:85-94.
 

Wu X et al.

The many faces of long noncoding RNAs in cancer.

Antioxid Redox Signal (2018) 29:922-935.
  

Gogakos T et al.

Characterizing expression and processing of precursor and mature human tRNAs by hydro-tRNAseq and PAR-CLIP.

Cell Rep (2017) 20:1463-1475.
 

Fleming ND et al.

Phase II trial of bevacizumab with dose-dense paclitaxel as first-line treatment in patients with advanced ovarian cancer.

Gynecol Oncol (2017) 147:41-46.
 

August P & Suthanthiran M.

Sex and kidney transplantation: Why can't a woman be more like a man?

J Am Soc Nephrol (2017) 28:2829-2831.
 

Sardana M et al.

Clinical and echocardiographic correlates of Left Atrial Function Index: the Framingham offspring study.

J Am Soc Echocardiogr (2017) 30:904-912.e2.
 

Denizli M et al.

Chitosan nanoparticles for miRNA delivery.

Methods Mol Biol (2017) 1632:219-230.
 

Fabris L & Calin GA.

Understanding the genomic ultraconservations: T-UCRs and cancer.

Int Rev Cell Mol Biol (2017) 333:159-172.
 

Zhu X et al.

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells.

J Extracell Vesicles (2017) 6:1324730.
 

Sutaria DS et al.

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.

J Extracell Vesicles (2017) 6:1333882.
 

Saugstad JA et al.

Analysis of extracellular RNA in cerebrospinal fluid.

J Extracell Vesicles (2017) 6:1317577.
 

Sarkar S et al.

PRKCI promotes immune suppression in ovarian cancer.

Genes Dev (2017) 31:1109-1121.
 

Montoya MM et al.

A distinct inhibitory function for miR-18a in Th17 cell differentiation.

J Immunol (2017) 199:559-569.
 

Jayaram H et al.

Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: a pilot study.

Invest Ophthalmol Vis Sci (2017) 58:2884-2890.
  

Farmer DT et al.

Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.

Development (2017) 144:2517-2528.
 

Aldrugh S et al.

Atrial fibrillation, cognition and dementia: A review.

J Cardiovasc Electrophysiol (2017) 28:958-965.
 

Li J et al.

miR-29b contributes to multiple types of muscle atrophy.

Nat Commun (2017) 8:15201.
 

Rigoutsos I et al.

N-BLR, a primate-specific non-coding transcript, leads to colorectal cancer invasion and migration.

Genome Biol (2017) 18:98.
 

Bei Y et al.

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.

Basic Res Cardiol (2017) 112:38.
   

Farmer DT et al.

miR-205 is a critical regulator of lacrimal gland development.

Dev Biol (2017) 427:12-20.
 

Silva AM et al.

Dendritic cell-derived extracellular vesicles mediate mesenchymal stem/stromal cell recruitment.

Sci Rep (2017) 7:1667.
  

Bruno S et al.

Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells.

Tissue Eng Part A (2017) 23:1262-1273.
   

Fuentes-Mattei E et al.

Plasma viral miRNAs indicate a high prevalence of occult viral infections.

EBioMedicine (2017) 20:182-192.
 

Nikan M et al.

Synthesis and evaluation of parenchymal retention and efficacy of a metabolically stable O-phosphocholine-N-docosahexaenoyl-l-serine siRNA conjugate in mouse brain.

Bioconjug Chem (2017) 28:1758-1766.
 

Ochocinska MJ et al.

NIH workshop report on the trans-agency Blood-Brain Interface Workshop 2016: Exploring key challenges and opportunities associated with the blood, brain and their interface.

Fluids Barriers CNS (2017) 14:12.
  

Figueroa JM et al.

Detection of wtEGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients.

Neuro Oncol (2017) 19:1494-1502.
 

Montoya MM & Ansel KM.

Small RNA transfection in primary human Th17 cells by next generation electroporation.

J Vis Exp (2017) 122:e55546.
 

Camarda R, Williams J & Goga A.

In vivo reprogramming of cancer metabolism by MYC.

Front Cell Dev Biol (2017) 5:35.
  

Klingenberg M et al.

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

J Hepatol (2017) 67:603-618.
   Related Pathways: 1, 2

 

Rabinowicz N et al.

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.

Oncotarget (2017) 8:27380-27392.
 

Rashed MH et al.

Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.

Oncotarget (2017) 8:20145-20164.
  

Roh J, Houstis N & Rosenzweig A.

Why don't we have proven treatments for HFpEF?

Circ Res (2017) 120:1243-1245.
 

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.

Liver Transpl (2017) 23:791-803.
   

Putman TE et al.

WikiGenomes: an open web application for community consumption and curation of gene annotation data in Wikidata.

Database (Oxford) (2017) 2017:1.
 

Soni A et al.

RAHI-SATHI Indo-U.S. collaboration: The evolution of a trainee-led twinning model in global health into a multidisciplinary collaborative program.

Glob Health Sci Pract (2017) 5:152-163.
 

Mateescu B et al.

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper.

J Extracell Vesicles (2017) 6:1286095.
  

Sutaria DS et al.

Achieving the promise of therapeutic extracellular vesicles: The devil is in details of therapeutic loading.

Pharm Res (2017) 34:1053-1066.
  

Yeri A et al.

Total extracellular small RNA profiles from plasma, saliva, and urine of healthy subjects.

Sci Rep (2017) 7:44061.
   

Mick E et al.

Stroke and circulating extracellular RNAs.

Stroke (2017) 48:828-834.
  

Clancy L et al.

The role of RNA uptake in platelet heterogeneity.

Thromb Haemost (2017) 117:948-961.
  

Nolan JP & Jones JC.

Detection of platelet vesicles by flow cytometry.

Platelets (2017) 28:256-262.
  

Deng Z et al.

Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.

Mol Ther (2017) 25:1641-1654.
    

Wagner MJ et al.

Preclinical mammalian safety studies of EPHARNA (DOPC nanoliposomal EphA2-targeted siRNA).

Mol Cancer Ther (2017) 16:1114-1123.
 

He Y et al.

A systematic study of dysregulated microRNA in Type 2 Diabetes Mellitus.

Int J Mol Sci (2017) 18:3.
 

Shi J et al.

miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury.

Theranostics (2017) 7:664-676.
 

Khvorova A & Watts JK.

The chemical evolution of oligonucleotide therapies of clinical utility.

Nat Biotechnol (2017) 35:238-248.
 

Yeo AT & Charest A.

Immune checkpoint blockade biology in mouse models of glioblastoma.

J Cell Biochem (2017) 118:2516-2527.
 

Anderton B et al.

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

EMBO Rep (2017) 18:569-585.
 

Xiao J et al.

Circulating miR-30d predicts survival in patients with acute heart failure.

Cell Physiol Biochem (2017) 41:865-874.
 

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells improve survival from lethal hepatic failure in mice.

Stem Cells Transl Med (2017) 6:1262-1272.
 

Teng Y et al.

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Nat Commun (2017) 8:14448.
  

Grossman RL et al.

Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.

Clin Pharmacol Ther (2017) 101:589-592.
  

Shah R et al.

Extracellular RNAs are associated with insulin resistance and metabolic phenotypes.

Diabetes Care (2017) 40:546-553.
 

McManus DD et al.

Messenger RNA and microRNA transcriptomic signatures of cardiometabolic risk factors.

BMC Genomics (2017) 18:139.
 

Gladek I et al.

HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies.

Genes Chromosomes Cancer (2017) 56:439-452.
 

Modi A et al.

Validation of two point-of-care tests against standard lab measures of NO in saliva and in serum.

Nitric Oxide (2017) 64:16-21.
 

Regev K et al.

Association between serum microRNAs and Magnetic Resonance Imaging measures of Multiple Sclerosis severity.

JAMA Neurol (2017) 74:275-285.
 

Ong WQ et al.

Live cell imaging of endogenous mRNA using RNA-based fluorescence "Turn-On" probe.

ACS Chem Biol (2017) 12:200-205.
 

Collino F et al.

Exosome and microvesicle-enriched fractions isolated from mesenchymal stem cells by gradient separation showed different molecular signatures and functions on renal tubular epithelial cells.

Stem Cell Rev (2017) 13:226-243.
  

Heydari B, Harris WS & Kwong RY.

Response by Heydari et al to letter regarding article, "Effect of omega-3 acid ethyl esters on left ventricular remodeling after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial".

Circulation (2017) 135:e13-e14.
 

Danielson KM et al.

High throughput sequencing of extracellular RNA from human plasma.

PLoS ONE (2017) 12:e0164644.
 

Lee I et al.

The importance of standardization on analyzing circulating RNA.

Mol Diagn Ther (2017) 21:259-268.
  

Maji S et al.

Extracellular vesicles in liver diseases.

Am J Physiol Gastrointest Liver Physiol (2017) 312:G194-G200.
   

2016

Baldwin S et al.

Analyzing the miRNA content of extracellular vesicles by fluorescence nanoparticle tracking.

Nanomedicine (2017) 13:765-770.
 

Maas SL, Breakefield XO & Weaver AM.

Extracellular vesicles: Unique intercellular delivery vehicles.

Trends Cell Biol (2017) 27:172-188.
    

Krzeszinski JY et al.

Lipid osteoclastokines regulate breast cancer bone metastasis.

Endocrinology (2017) 158:477-489.
 

Wang X, Kaczor-Urbanowicz KE & Wong DT.

Salivary biomarkers in cancer detection.

Med Oncol (2017) 34:7.
  

Srivastava A et al.

Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells.

Sci Rep (2016) 6:38541.
 

Matsuda A et al.

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.

Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.
     

Majem B et al.

RNA sequencing analysis of salivary extracellular RNA.

Methods Mol Biol (2017) 1537:17-36.
 

Moustafa AA et al.

Identification of microRNA signature and potential pathway targets in prostate cancer.

Exp Biol Med (Maywood) (2017) 242:536-546.
 

Kaczor-Urbanowicz KE et al.

Saliva diagnostics - Current views and directions.

Exp Biol Med (Maywood) (2017) 242:459-472.
  

Van Roosbroeck K et al.

Combining anti-miR-155 with chemotherapy for the treatment of lung cancers.

Clin Cancer Res (2017) 23:2891-2904.
 

Katsiougiannis S et al.

Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity.

FASEB J (2017) 31:998-1010.
   

Pi F et al.

RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery.

Nanomedicine (2017) 13:1183-1193.
 

Dou Y et al.

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.

Sci Rep (2016) 6:37982.
 

Haraszti RA et al.

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

J Extracell Vesicles (2016) 5:32570.
  

Kaczor-Urbanowicz KE et al.

Emerging technologies for salivaomics in cancer detection.

J Cell Mol Med (2017) 21:640-647.
  

Yang L et al.

Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth.

Cell Metab (2016) 24:685-700.
 

Previs RA et al.

The rise of genomic profiling in ovarian cancer.

Expert Rev Mol Diagn (2016) 16:1337-1351.
 

Nazimek K, Bryniarski K & Askenase PW.

Functions of exosomes and microbial extracellular vesicles in allergy and contact and delayed-type hypersensitivity.

Int Arch Allergy Immunol (2016) 171:1-26.
   

Lusardi TA et al.

MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer's disease.

J Alzheimers Dis (2017) 55:1223-1233.
 

Hatakeyama H et al.

Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers.

Cell Rep (2016) 17:1621-1631.
 

Shah R, Pico AR & Freedman JE.

Translational epidemiology: Entering a brave new world of team science.

Circ Res (2016) 119:1060-1062.
 

Ohtsuka M et al.

H19 noncoding RNA, an independent prognostic factor, regulates essential Rb-E2F and CDK8-beta-catenin signaling in colorectal cancer.

EBioMedicine (2016) 13:113-124.
 

Mangala LS et al.

Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy.

JCI Insight (2016) 1:e87754.
 

Kanlikilicer P et al.

Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells.

Cancer Res (2016) 76:7194-7207.
   

Giza DE et al.

Cellular and viral microRNAs in sepsis: Mechanisms of action and clinical applications.

Cell Death Differ (2016) 23:1906-1918.
  Related Pathway

 

Soni A et al.

High burden of unrecognized atrial fibrillation in rural india: An innovative community-based cross-sectional screening program.

JMIR Public Health Surveill (2016) 2:e159.
 

Shah MY et al.

microRNA therapeutics in cancer - an emerging concept.

EBioMedicine (2016) 12:34-42.
  

Tao L et al.

Crucial role of miR-433 in regulating cardiac fibrosis.

Theranostics (2016) 6:2068-2083.
 

Zhou J et al.

A novel compound ARN-3236 inhibits salt-inducible kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel.

Clin Cancer Res (2017) 23:1945-1954.
 

Huang Y et al.

Anti-tumor and anti-angiogenic effects of aspirin-PC in ovarian cancer.

Mol Cancer Ther (2016) 15:2894-2904.
 

Regev K et al.

Comprehensive evaluation of serum microRNAs as biomarkers in Multiple Sclerosis.

Neurol Neuroimmunol Neuroinflamm (2016) 3:e267.
 

Smith EM et al.

International validation of a urinary biomarker panel for identification of active lupus nephritis in children.

Pediatr Nephrol (2017) 32:283-295.
 

Ghai V & Wang K.

Recent progress toward the use of circulating microRNAs as clinical biomarkers.

Arch Toxicol (2016) 90:2959-2978.
  

Sardana M et al.

Association of left atrial function index with late atrial fibrillation recurrence after catheter ablation.

J Cardiovasc Electrophysiol (2016) 27:1411-1419.
 

Ciccone M & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: An old disease with new genetic insights.

MicroRNA (2016) 5:106-112.
  Related Pathway

 

Harjes U et al.

Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4.

Oncogene (2017) 36:912-921.
 

Didiot MC et al.

Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing.

Mol Ther (2016) 24:1836-1847.
 

Wei Z et al.

Fetal bovine serum RNA interferes with the cell culture derived extracellular RNA.

Sci Rep (2016) 6:31175.
 

Walkey AJ et al.

Practice patterns and outcomes associated with use of anticoagulation among patients with atrial fibrillation during sepsis.

JAMA Cardiol (2016) 1:682-90.
 

Miranda F et al.

Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche.

Cancer Cell (2016) 30:273-289.
 

Anfossi S & Calin GA.

Hodgkin lymphoma cells have a specific long noncoding RNA expression pattern.

Am J Pathol (2016) 186:2251-3.
 

Zhao Z et al.

An arginine finger regulates the sequential action of asymmetrical hexameric ATPase in the double-stranded DNA translocation motor.

Mol Cell Biol (2016) 36:2514-23.
 

Wang JH et al.

Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.

BMC Cancer (2016) 16:524.
 

Gao P et al.

Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.

Cell Res (2016) 26:901-13.
 

Maji S et al.

In vitro toxicology studies of extracellular vesicles.

J Appl Toxicol (2017) 37:310-318.
 

Bezzerides VJ et al.

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.

JCI Insight (2016) 1:9.
 

Yan IK et al.

Circulating extracellular RNA markers of liver regeneration.

PLoS ONE (2016) 11:e0155888.
 

Wu S et al.

Circulating microRNAs and life expectancy among identical twins.

Ann Hum Genet (2016) 80:247-56.
 

Ren A et al.

Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.

Nat Chem Biol (2016) 12:702-8.
 

Parasramka MA & Patel T.

Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities.

Stem Cell Investig (2016) 3:1.
 

Paladini L et al.

Targeting microRNAs as key modulators of tumor immune response.

J Exp Clin Cancer Res (2016) 35:103.
    

Higginbotham JN et al.

Identification and characterization of EGF receptor in individual exosomes by Fluorescence-Activated Vesicle Sorting.

J Extracell Vesicles (2016) 5:29254.
 

Deng Z et al.

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis.

Oncogene (2017) 36:639-651.
  

Srivastava A et al.

Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer.

J Biomed Nanotechnol (2016) 12:1159-73.
  

Wang JQ et al.

Extracellular vesicle-mediated reversal of paclitaxel resistance in prostate cancer.

Crit Rev Oncog (2015) 20:407-17.
   

Freedman JE et al.

Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma.

Nat Commun (2016) 7:11902.
 

Fritz JV et al.

Sources and functions of extracellular small RNAs in human circulation.

Annu Rev Nutr (2016) 36:301-36.
   

Henninger N et al.

Atrial fibrillation is associated with a worse 90-day outcome than other cardioembolic stroke subtypes.

Stroke (2016) 47:1486-92.
 

Soares VY et al.

Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.

Neuro Oncol (2016) 18:1498-1507.
  

Zhang HG et al.

Isolation, identification, and characterization of novel nanovesicles.

Oncotarget (2016) 7:41346-41362.
  

Chaluvally-Raghavan P et al.

Direct upregulation of STAT3 by microRNA-551b-3p deregulates growth and metastasis of ovarian cancer.

Cell Rep (2016) 15:1493-504.
  

Wen S et al.

Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.

Leukemia (2016) 30:2221-2231.
 

Shah R et al.

Discordant expression of circulating microRNA from cellular and extracellular sources.

PLoS ONE (2016) 11:e0153691.
 

McKenzie AJ et al.

KRAS-MEK signaling controls Ago2 sorting into exosomes.

Cell Rep (2016) 15:978-87.
  

Freedman JE et al.

Diverse human extracellular RNAs are widely detected in human plasma.

Nat Commun (2016) 7:11106.
 

Cheung KH et al.

Extending gene ontology in the context of extracellular RNA and vesicle communication.

J Biomed Semantics (2016) 7:19.
 

Clarke D et al.

Identifying allosteric hotspots with dynamics: Application to inter- and intra-species conservation.

Structure (2016) 24:826-37.
 

Haemmerle M et al.

FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.

J Clin Invest (2016) 126:1885-96.
 

Akers JC et al.

Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid.

Cancer Biomark (2016) 17:125-32.
 

Abels ER & Breakefield XO.

Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.

Cell Mol Neurobiol (2016) 36:301-12.
   

Ciccone M & Calin GA.

MicroRNAs in myeloid hematological malignancies.

Curr Genomics (2015) 16:336-48.
 

Yan KK et al.

Cross-disciplinary network comparison: Matchmaking between hairballs.

Cell Syst (2016) 2:147-157.
 

Van Roosbroeck K & Calin GA.

MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?

Semin Oncol (2016) 43:209-14.
 

Wu SY et al.

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

Nat Commun (2016) 7:11169.
   

Pan Y et al.

miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.

Oncotarget (2016) 7:25930-48.
 

Zappulli V et al.

Extracellular vesicles and intercellular communication within the nervous system.

J Clin Invest (2016) 126:1198-207.
   

Teng Y et al.

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.

Oncotarget (2016) 7:25683-97.
   

Putman TE et al.

Centralizing content and distributing labor: a community model for curating the very long tail of microbial genomes.

Database (Oxford) (2016) 2016:baw028.
 

Hall J et al.

Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson's disease, glioma, and schwannoma.

Cell Mol Neurobiol (2016) 36:417-27.
  

Parasramka MA et al.

Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.

Pharmacol Ther (2016) 161:67-78.
   Related Pathway

 

Huang J et al.

Dll4 inhibition plus aflibercept markedly reduces ovarian tumor growth.

Mol Cancer Ther (2016) 15:1344-52.
 

Byron SA et al.

Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.

Nat Rev Genet (2016) 17:257-71. Related blog post
   

Pusic KM, Pusic AD & Kraig RP.

Environmental enrichment stimulates immune cell secretion of exosomes that promote CNS myelination and may regulate inflammation.

Cell Mol Neurobiol (2016) 36:313-325.
  

Rennert RC, Hochberg FH & Carter BS.

ExRNA in biofluids as biomarkers for brain tumors.

Cell Mol Neurobiol (2016) 36:353-60.
  

Pucci F et al.

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.

Science (2016) 352:242-6.
  

Burgstaller-Muehlbacher S et al.

Wikidata as a semantic framework for the Gene Wiki initiative.

Database (Oxford) (2016) 2016:baw015.
 

Almeida MI & Calin GA.

The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.

Genome Med (2016) 8:29.
  

Tanriverdi K et al.

Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative Polymerase Chain Reaction.

Anal Biochem (2016) 501:66-74.
 

Rytelewski M et al.

Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.

Oncotarget (2016) 7:20825-39.
 

Zaborowski MP et al.

Extracellular vesicles: Composition, biological relevance, and methods of study.

Bioscience (2015) 65:783-797.
   

Zhang X et al.

Potential transfer of polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington's disease: Background and evaluation in cell culture.

Cell Mol Neurobiol (2016) 36:459-70.
   

Olivieri M et al.

Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis.

Oncotarget (2016) 7:20636-54.
 

Iavello A et al.

Role of Alix in miRNA packaging during extracellular vesicle biogenesis.

Int J Mol Med (2016) 37:958-66.
  

Xiao H et al.

Differential proteomic analysis of human saliva using Tandem Mass Tags quantification for gastric cancer detection.

Sci Rep (2016) 6:22165.
 

Akers JC et al.

Comparative analysis of technologies for quantifying extracellular vesicles (EVs) in clinical cerebrospinal fluids (CSF).

PLoS ONE (2016) 11:e0149866.
 

Mora-Castilla S et al.

Miniaturization technologies for efficient single-cell library preparation for next-generation sequencing.

J Lab Autom (2016) 21:557-67.
 

Kundu A et al.

Relation of atrial fibrillation in acute myocardial infarction to in-hospital complications and early hospital readmission.

Am J Cardiol (2016) 117:1213-8.
 

Rupaimoole R et al.

miRNA deregulation in cancer cells and the tumor microenvironment.

Cancer Discov (2016) 6:235-46.
   

Sun Y et al.

Examining plasma microRNA markers for colorectal cancer at different stages.

Oncotarget (2016) 7:11434-49.
 

Melman YF et al.

Response to letter regarding article, "Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study"

Circulation (2016) 133:e389-90.
  

Redis RS et al.

Allele-specific reprogramming of cancer metabolism by the long non-coding RNA CCAT2.

Mol Cell (2016) 61:520-34.
 

Pua HH et al.

MicroRNAs 24 and 27 suppress allergic inflammation and target a network of regulators of T Helper 2 cell-associated cytokine production.

Immunity (2016) 44:821-32.
 

Gleber-Netto FO et al.

Salivary biomarkers for detection of oral squamous cell carcinoma in a Taiwanese population.

Clin Cancer Res (2016) 22:3340-7.
 

Clancy L & Freedman JE.

Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.

Circ Res (2016) 118:374-6.
   

Hansen JM, Coleman RL & Sood AK.

Targeting the tumour microenvironment in ovarian cancer.

Eur J Cancer (2016) 56:131-43.
 

Harmanci A & Gerstein M.

Quantification of private information leakage from phenotype-genotype data: linking attacks.

Nat Methods (2016) 13:251-6.
 

Guo P et al.

Biological nanomotors with a revolution, linear, or rotation motion mechanism.

Microbiol Mol Biol Rev (2016) 80:161-86.
 

Fabris L et al.

The potential of microRNAs as prostate cancer biomarkers.

Eur Urol (2016) 70:312-22.
  

Xu T et al.

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients.

Oncotarget (2016) 7:12414-25.
 

Yuan T et al.

Plasma extracellular RNA profiles in healthy and cancer patients.

Sci Rep (2016) 6:19413.
 

Ben-Dov IZ et al.

Cell and microvesicle urine microRNA deep sequencing profiles from healthy individuals: Observations with potential impact on biomarker studies.

PLoS ONE (2016) 11:e0147249.
 

Mitamura T, Gourley C & Sood AK.

Prediction and failure of anti-angiogenesis escape.

Gynecol Oncol (2016) 141:80-5.
 

Danielson KM et al.

Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry.

PLoS ONE (2016) 11:e0144678.
 

Neophytou AM et al.

Air pollution and lung function in minority youth with asthma in the GALA II (Genes-environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) studies.

Am J Respir Crit Care Med (2016) 193:1271-80.
 

Rupaimoole R et al.

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.

Oncogene (2016) 35:4312-20. Related blog post
   

Lener T et al.

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

J Extracell Vesicles (2015) 4:30087.
  

McManus DD et al.

Reliability of predicting early hospital readmission after discharge for an acute coronary syndrome using claims-based data.

Am J Cardiol (2016) 117:501-7.
 

2015

Rupaimoole R et al.

Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis.

Cell Rep (2015) 13:2395-402.
   

Askenase PW et al.

A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.

Ann N Y Acad Sci (2015) 1362:200-14.
 

Machtinger R, Laurent LC & Baccarelli AA.

Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation.

Hum Reprod Update (2016) 22:182-93.
   

Ren A et al.

Structural and dynamic basis for low-affinity, high-selectivity binding of L-glutamine by the glutamine riboswitch.

Cell Rep (2015) 13:1800-13.
 

Shields BB et al.

A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.

Mol Syst Biol (2015) 11:842.
   Related Pathways: 1, 2

 

Giza DE & Calin GA

microRNA and Chronic Lymphocytic Leukemia.

Adv Exp Med Biol (2015) 889:23-40.
   

Sercombe L et al.

Advances and challenges of liposome assisted drug delivery.

Front Pharmacol (2015) 6:286.
  

Mohankumar S & Patel T.

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.

Brief Funct Genomics (2016) 15:249-56.
  

Alterman JF et al.

Hydrophobically modified siRNAs silence Huntingtin mRNA in primary neurons and mouse brain.

Mol Ther Nucleic Acids (2015) 4:e266.
 

Zhuang X et al.

Ginger-derived nanoparticles protect against alcohol-induced liver damage.

J Extracell Vesicles (2015) 4:28713.
   

Kalani MY et al.

Rare variants in cardiomyopathy genes associated with stress-induced cardiomyopathy.

Neurosurgery (2016) 78:835-43.
 

Shaikh AY et al.

Addition of B-type natriuretic peptide to existing clinical risk scores enhances identification of patients at risk for atrial fibrillation recurrence after pulmonary vein isolation.

Crit Pathw Cardiol (2015) 14:157-65.
 

Silva A, Bullock M & Calin G.

The clinical relevance of long non-coding RNAs in cancer.

Cancers (2015) 7:2169-82.
 

Previs RA et al.

Dual metronomic chemotherapy with nab-paclitaxel and topotecan has potent antiangiogenic activity in ovarian cancer.

Mol Cancer Ther (2015) 14:2677-86.
 

Bucur O et al.

An updated h-index measures both the primary and total scientific output of a researcher.

Discoveries (2015) 3:3.
 

Wei S & Williams Z.

Rapid short-read sequencing and aneuploidy detection using MinION nanopore technology.

Genetics (2016) 202:37-44.
 

Pradeep S et al.

Erythropoietin stimulates tumor growth via EphB4.

Cancer Cell (2015) 28:610-22.
 

Kosutic M et al.

A mini-twister variant and impact of residues/cations on the phosphodiester cleavage of this ribozyme class.

Angew Chem Int Ed Engl (2015) 54:15128-33.
 

Yamamoto N et al.

Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: Evidence of a subpopulation of protective anti-pneumococcal B1a cells.

Immunology (2016) 147:97-113.
 

Zhuang X et al.

Grapefruit-derived nanovectors delivering therapeutic mir17 through an intranasal route inhibit brain tumor progression.

Mol Ther (2016) 24:96-105.
 

Keerthikumar S et al.

ExoCarta: A web-based compendium of exosomal cargo.

J Mol Biol (2016) 428:688-692.
  

van der Vos KE et al.

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.

Neuro Oncol (2016) 18:58-69.
  

Schwarzenbach H et al.

Data normalization strategies for microRNA quantification.

Clin Chem (2015) 61:1333-42.
 

Monroig-Bosque Pdel C, Rivera CA & Calin GA.

MicroRNAs in cancer therapeutics: "From the bench to the bedside".

Expert Opin Biol Ther (2015) 15:1381-5.
  

Chira S et al.

Progresses towards safe and efficient gene therapy vectors.

Oncotarget (2015) 6:30675-703.
 

Quesenberry PJ et al.

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming.

Stem Cell Res Ther (2015) 6:153.
  

Laurent LC et al.

Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:26533.
   

Quinn JF et al.

Extracellular RNAs: Development as biomarkers of human disease.

J Extracell Vesicles (2015) 4:27495.
  

Ainsztein AM et al.

The NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27493.
      

Subramanian SL et al.

Integration of extracellular RNA profiling data using metadata, biomedical ontologies and Linked Data technologies.

J Extracell Vesicles (2015) 4:27497.
 

Patton JG et al.

Biogenesis, delivery, and function of extracellular RNA.

J Extracell Vesicles (2015) 4:27494.
   

Quesenberry PJ et al.

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27575.
  

Giza DE, Vasilescu C & Calin GA.

Key principles of miRNA involvement in human diseases.

Discoveries (Craiova) (2014) 2:e34.
 

Ohtsuka M et al.

MicroRNA processing and human cancer.

J Clin Med (2015) 4:1651-67.
 

Ferrajoli A et al.

Epstein-Barr virus microRNAs are expressed in patients with chronic lymphocytic leukemia and correlate with overall survival.

EBioMedicine (2015) 2:572-82.
 

Nagaraja AS et al.

Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis.

Oncogene (2016) 35:2390-7.
 

Pua HH & Ansel KM.

MicroRNA regulation of allergic inflammation and asthma.

Curr Opin Immunol (2015) 36:101-8.
   

Matsuo K et al.

Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma.

Eur J Cancer (2015) 51:1978-88.
 

Reyes-Gonzalez JM et al.

Targeting c-MYC in platinum-resistant ovarian cancer.

Mol Cancer Ther (2015) 14:2260-9.
 

Ong WQ et al.

Heavy water: a simple solution to increasing the brightness of fluorescent proteins in super-resolution imaging.

Chem Commun (Camb) (2015) 51:13451-3.
 

Gharpure KM et al.

Nanotechnology: Future of oncotherapy.

Clin Cancer Res (2015) 21:3121-30.
 

Pichler M & Calin GA.

MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.

Br J Cancer (2015) 113:569-73.
   

Li X, Mauro M & Williams Z.

Comparison of plasma extracellular RNA isolation kits reveals kit-dependent biases.

Biotechniques (2015) 59:13-7.
 

Cha DJ et al.

KRAS-dependent sorting of miRNA to exosomes.

Elife (2015) 4:e07197.
  

Ren A, Rajashankar KR & Patel DJ.

Global RNA fold and molecular recognition for a pfl riboswitch bound to ZMP, a master regulator of one-carbon metabolism.

Structure (2015) 23:1375-81.
 

Aslan B et al.

The ZNF304-integrin axis protects against anoikis in cancer.

Nat Commun (2015) 6:7351.
 

Pusic AD & Kraig RP.

Phasic treatment with Interferon gamma stimulates release of exosomes that protect against spreading depression.

J Interferon Cytokine Res (2015) 35:795-807.
  

Szabo L et al.

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.

Genome Biol (2015) 16:126.
 

Kwong RY et al.

Characterization of cardiac amyloidosis by atrial late gadolinium enhancement using contrast-enhanced cardiac Magnetic Resonance Imaging and correlation with left atrial conduit and contractile function.

Am J Cardiol (2015) 116:622-9.
 

Simpson LJ & Ansel KM.

MicroRNA regulation of lymphocyte tolerance and autoimmunity.

J Clin Invest (2015) 125:2242-9.
   

Camussi G & Quesenberry PJ.

Perspectives on the potential therapeutic uses of vesicles.

Exosomes Microvesicles (2013) 1:6.
  

Boettcher M & McManus MT.

Choosing the right tool for the job: RNAi, TALEN, or CRISPR.

Mol Cell (2015) 58:575-85.
  

Lin X et al.

Noncoding RNAs in human saliva as potential disease biomarkers.

Front Genet (2015) 6:175.
  

Melman YF et al.

Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: a translational pilot study.

Circulation (2015) 131:2202-16.
 

Sung BH et al.

Directional cell movement through tissues is controlled by exosome secretion.

Nat Commun (2015) 6:7164.
   

Lai CP et al.

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.

Nat Commun (2015) 6:7029.
 

Shao H et al.

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Nat Commun (2015) 6:6999.
 

Li X et al.

Lowering the quantification limit of the QubitTM RNA HS assay using RNA spike-in.

BMC Mol Biol (2015) 16:9.
 

Bryniarski K et al.

Free extracellular miRNA functionally targets cells by transfecting exosomes from their companion cells.

PLoS ONE (2015) 10:e0122991.
  

Agarwal K et al.

Analysis of exosome release as a cellular response to MAPK pathway inhibition.

Langmuir (2015) 31:5440-8.
  

Deng Z et al.

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

Nat Commun (2015) 6:6956.
  

Akers JC et al.

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients.

J Neurooncol (2015) 123:205-16.
 

Wong HK et al.

The Cancer Genome Atlas analysis predicts microRNA for targeting cancer growth and vascularization in glioblastoma.

Mol Ther (2015) 23:1234-47.
  Related Pathway

 

Li K et al.

Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-kappaB-driven inflammation and atherosclerosis.

Circ Res (2015) 117:e1-e11.
  Related Pathway

 

Collino F et al.

AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs.

J Am Soc Nephrol (2015) 26:2349-60.
   

Majem B et al.

Non-coding RNAs in saliva: Emerging biomarkers for molecular diagnostics.

Int J Mol Sci (2015) 16:8676-98.
  

Wang Q et al.

Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites.

Cancer Res (2015) 75:2520-9.
 

Miyake TM et al.

XPO1/CRM1 inhibition causes antitumor effects by mitochondrial accumulation of eIF5A.

Clin Cancer Res (2015) 21:3286-97.
  Related Pathway

 

Liu X et al.

miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.

Cell Metab (2015) 21:584-95.
  Related Pathway

 

Schwarzenbacher D et al.

Low spinophilin expression enhances aggressive biological behavior of breast cancer.

Oncotarget (2015) 6:11191-202.
 

Gilder AS et al.

Soluble Urokinase Receptor is released selectively by glioblastoma cells that express Epidermal Growth Factor Receptor variant III and promotes tumor cell migration and invasion.

J Biol Chem (2015) 290:14798-809.
 

Thanapprapa D Sr et al.

PTEN expression as a predictor of response to focal adhesion kinase inhibition in uterine cancer.

Mol Cancer Ther (2015) 14:1466-1475.
 

Nouraee N, Mowla SJ & Calin GA.

Tracking miRNAs' footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy.

Genes Chromosomes Cancer (2015) 54:335-52.
  

Ren A et al.

Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch.

Cell Rep (2015) 11:1-12.
 

Saugstad JA.

Non-coding RNAs in stroke and neuroprotection.

Front Neurol (2015) 6:50.
   

Simonson B & Das S.

MicroRNA therapeutics: the next magic bullet?

Mini Rev Med Chem (2015) 15:467-74.
  

Ling H et al.

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.

Gut (2016) 65:977-989.
 

Neilan TG et al.

Late gadolinium enhancement among survivors of sudden cardiac arrest.

JACC Cardiovasc Imaging (2015) 8:414-423.
 

Wong DT.

Salivary extracellular noncoding RNA: Emerging biomarkers for molecular diagnostics.

Clin Ther (2015) 37:540-51.
  

Huan T et al.

Genome-wide identification of microRNA expression Quantitative Trait Loci.

Nat Commun (2015) 6:6601.
 

Xiao J et al.

A snapshot of genetic and epigenetic basis of arrhythmia and heart failure.

Front Genet (2015) 6:74.
  

Gardiner C et al.

Extracellular vesicles, tissue factor, cancer and thrombosis - Discussion themes of the ISEV 2014 Educational Day.

J Extracell Vesicles (2015) 4:26901.
   

Ho GY et al.

Differential expression of circulating microRNAs according to severity of colorectal neoplasia.

Transl Res (2015) 166:225-32.
 

Ciccone M, Calin GA & Perrotti D.

From the biology of PP2A to the PADs for therapy of hematologic malignancies.

Front Oncol (2015) 5:21.
  

Tewari M.

A functional extracellular transcriptome in animals? Implications for biology, disease and medicine.

Genome Biol (2015) 16:47.
   

Guzman N et al.

Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes "microRNA-like" tRNA Fragments.

Mol Cancer Res (2015) 13:891-901.
 

Kanada M et al.

Differential fates of biomolecules delivered to target cells via extracellular vesicles.

Proc Natl Acad Sci U S A (2015) 112:E1433-42.
   

Nick AM et al.

A framework for a personalized surgical approach to ovarian cancer.

Nat Rev Clin Oncol (2015) 12:239-45.
 

Boukouris S & Mathivanan S.

Exosomes in bodily fluids are a highly stable resource of disease biomarkers.

Proteomics Clin Appl (2015) 9:358-67.
  

Martinez GJ et al.

The transcription factor NFAT promotes exhaustion of activated CD8(+) T cells.

Immunity (2015) 42:265-78.
 

Ozcan G et al.

Preclinical and clinical development of siRNA-based therapeutics.

Adv Drug Deliv Rev (2015) 87:108-19.
 

Wei X, Liu X & Rosenzweig A.

What do we know about the cardiac benefits of exercise?

Trends Cardiovasc Med (2015) 25:529-36.
 

Koupenova M et al.

Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.

Arterioscler Thromb Vasc Biol (2015) 35:1030-7.
 

Chiang SH et al.

RNAPro*SAL: a device for rapid and standardized collection of saliva RNA and proteins.

Biotechniques (2015) 58:69-76.
 

George J & Patel T.

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.

Semin Liver Dis (2015) 35:63-74.
   

Cox JE et al.

Pan-viral-microRNA screening identifies interferon inhibition as a common function of diverse viruses.

Proc Natl Acad Sci U S A (2015) 112:1856-61.
 

Ling H et al.

Junk DNA and the long non-coding RNA Twist in cancer genetics.

Oncogene (2015) 34:5003-11.
 

Gonzalez-Villasana V et al.

Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer.

Clin Cancer Res (2015) 21:2127-37.
  Related Pathway

 

Haga H et al.

Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth.

J Extracell Vesicles (2015) 4:24900.
  

2014

Choi HJ et al.

Anti-vascular therapies in ovarian cancer: Moving beyond anti-VEGF approaches.

Cancer Metastasis Rev (2015) 34:19-40.
 

Lotvall J et al.

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles.

J Extracell Vesicles (2014) 3:26913.
  

Srivastava A et al.

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.

Curr Gene Ther (2015) 15:182-92.
     

Bodhankar S et al.

Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells.

Metab Brain Dis (2015) 30:911-924.
 

Yao C et al.

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.

Circulation (2015) 131:536-49.
 

Berindan-Neagoe I & Calin GA.

Molecular pathways: microRNAs, cancer cells, and microenvironment.

Clin Cancer Res (2014) 20:6247-53.
   

Pusic AD et al.

Spreading depression transiently disrupts myelin via interferon-gamma signaling.

Exp Neurol (2015) 264:43-54.
 

Yang X et al.

New ways to successfully target tumor vasculature in ovarian cancer.

Curr Opin Obstet Gynecol (2015) 27:58-65.
 

Koupenova M & Freedman JE.

Platelets: the unsung hero of the immune response.

J Thromb Haemost (2015) 13:268-70.
 

Bottsford-Miller J et al.

Differential platelet levels affect response to taxane-based therapy in ovarian cancer.

Clin Cancer Res (2015) 21:602-10.
 

Bhattacharya S et al.

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.

PLoS ONE (2014) 9:e114409.
  

Melo SA et al.

Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

Cancer Cell (2014) 26:707-21.
   

Dotson AL et al.

Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke.

J Neuroimmunol (2015) 278:289-98.
 

Danielson KM & Das S.

Extracellular vesicles in heart disease: Excitement for the future?

Exosomes Microvesicles (2014) 2:1.
    Related Pathway

 

Wen Y et al.

Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer.

Clin Cancer Res (2015) 21:448-59.
 

Fuentes L, Yakob M & Wong DT.

Emerging horizons of salivary diagnostics for periodontal disease.

Br Dent J (2014) 217:567-73.
  

Ren A et al.

In-line alignment and Mg(2)(+) coordination at the cleavage site of the env22 twister ribozyme.

Nat Commun (2014) 5:5534.
 

Rajendran L et al.

Emerging roles of extracellular vesicles in the nervous system.

J Neurosci (2014) 34:15482-9.
   

Previs RA et al.

Molecular pathways: Translational and therapeutic implications of the Notch signaling pathway in cancer.

Clin Cancer Res (2015) 21:955-61.
 

Kim DK et al.

EVpedia: a community web portal for extracellular vesicles research.

Bioinformatics (2015) 31:933-9.
 

Bahn JH et al.

The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva.

Clin Chem (2015) 61:221-30.
  

van den Beucken T et al.

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Nat Commun (2014) 5:5203.
  Related Pathway

 

Rupaimoole R et al.

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.

Nat Commun (2014) 5:5202.
   

Sato-Kuwabara Y et al.

The fusion of two worlds: Non-coding RNAs and extracellular vesicles--Diagnostic and therapeutic implications.

Int J Oncol (2015) 46:17-27.
   

Gangoda L et al.

Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

Proteomics (2015) 15:260-71.
    Related Pathway

 

Kawikova I & Askenase PW.

Diagnostic and therapeutic potentials of exosomes in CNS diseases.

Brain Res (2015) 1617:63-71.
    

Godlewski J et al.

Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

Neuro Oncol (2015) 17:652-62.
   

Gyorgy B et al.

Therapeutic applications of extracellular vesicles: Clinical promise and open questions.

Annu Rev Pharmacol Toxicol (2015) 55:439-64.
   

Leung CS et al.

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.

Nat Commun (2014) 5:5092.
  Related Pathway

 

Haga H & Patel T.

Molecular diagnosis of intrahepatic cholangiocarcinoma.

J Hepatobiliary Pancreat Sci (2015) 22:114-23.
  

del C. Monroig P et al.

Small molecule compounds targeting miRNAs for cancer therapy.

Adv Drug Deliv Rev (2015) 81:104-16.
 

Braicu C et al.

Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?

Cell Death Differ (2015) 22:34-45.
   

Gonzalez-Villasana V et al.

Bisphosphonates inhibit stellate cell activity and enhance antitumor effects of nanoparticle albumin-bound paclitaxel in pancreatic ductal adenocarcinoma.

Mol Cancer Ther (2014) 13:2583-94.
 

Quesenberry PJ, Goldberg LR & Dooner MS.

Concise reviews: A stem cell apostasy: a tale of four H words.

Stem Cells (2015) 33:15-20.
 

Mata IF et al.

APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.

JAMA Neurol (2014) 71:1405-12.
 

Han C et al.

The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.

Cell Rep (2014) 8:1447-60.
  Related Pathway

 

Maguire CA et al.

Gene therapy for the nervous system: Challenges and new strategies.

Neurotherapeutics (2014) 11:817-39.
 

Saleem SN & Abdel-Mageed AB.

Tumor-derived exosomes in oncogenic reprogramming and cancer progression.

Cell Mol Life Sci (2015) 72:1-10.
  

Berindan-Neagoe I et al.

MicroRNAome genome: a treasure for cancer diagnosis and therapy.

CA Cancer J Clin (2014) 64:311-36.
  

Ren A & Patel DJ.

c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets.

Nat Chem Biol (2014) 10:780-6.
 

Krzeszinski JY et al.

MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.

Nature (2014) 512:431-5.
    Related Pathway

 

Pradeep S et al.

Hematogenous metastasis of ovarian cancer: Rethinking mode of spread.

Cancer Cell (2014) 26:77-91.
 

Davis AN, Afshar-Kharghan V & Sood AK.

Platelet effects on ovarian cancer.

Semin Oncol (2014) 41:378-84.
 

Akat KM et al.

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.

Proc Natl Acad Sci U S A (2014) 111:11151-6.
 

Murphy SJ et al.

Sex differences in microRNA expression during development in rat cortex.

Neurochem Int (2014) 77:24-32.
 

Thomas MF, L'Etoile ND & Ansel KM.

Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.

Trends Genet (2014) 30:298-307.
   Related Pathway

 

Takahashi K et al.

Analysis of extracellular RNA by digital PCR.

Front Oncol (2014) 4:129.
 

Wu SY et al.

RNAi therapies: Drugging the undruggable.

Sci Transl Med (2014) 6:240ps7.
  

Takahashi K et al.

Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer.

FEBS Open Bio (2014) 4:458-67.
  

Yakob M et al.

Salivary biomarkers for detection of oral squamous cell carcinoma - Current state and recent advances.

Curr Oral Health Rep (2014) 1:133-141.
  

Nery FC et al.

Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia.

J Neurosci Methods (2014) 232:181-8.
 

Takahashi K et al.

Involvement of extracellular vesicle long non-coding RNA (linc-VLDLR) in tumor cell responses to chemotherapy.

Mol Cancer Res (2014) 12:1377-87.
  

Mu J et al.

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.

Mol Nutr Food Res (2014) 58:1561-73.
  

Bauer CA et al.

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.

J Clin Invest (2014) 124:2425-40.
 

Jiang H et al.

Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.

Cancer Immunol Res (2014) 2:789-99.
 

Yang L et al.

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.

Mol Syst Biol (2014) 10:728.
  Related Pathway

 

Redzic JS et al.

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol (2014) 28:14-23.
    

Quesenberry PJ et al.

Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.

Front Oncol (2014) 4:56.
   

Freedman JE.

Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease.

Circ Res (2014) 114:1372-3.
 

Gharpure KM et al.

Metronomic Docetaxel in PRINT Nanoparticles and EZH2 Silencing Have Synergistic Antitumor Effect in Ovarian Cancer.

Mol Cancer Ther (2014) 13:1750-7.
 

Tucker SL et al.

Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer.

Clin Cancer Res (2014) 20:3280-8.
 

Patel T.

Extracellular vesicle noncoding RNA: New players in the diagnosis and pathogenesis of cholangiocarcinoma.

Hepatology (2014) 60:782-4.
  

Hochberg FH et al.

Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.

Expert Rev Mol Diagn (2014) 14:439-52.
  

Hu W et al.

Notch3 pathway alterations in ovarian cancer.

Cancer Res (2014) 74:3282-93.
  Related Pathway

 

Pusic KM et al.

Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment.

Glia (2014) 62:1176-94.
 

Patel T & Harnois D.

Assessment of response to therapy in hepatocellular carcinoma.

Ann Med (2014) 46:130-7.
 

Abd Elmageed ZY et al.

Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.

Stem Cells (2014) 32:983-97.
  

Zhang H et al.

Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.

Breast Cancer Res (2014) 16:R36.
 

Cholerton BA et al.

Evaluation of mild cognitive impairment subtypes in Parkinson's disease.

Mov Disord (2014) 29:756-64.
 

Vader P, Breakefield XO & Wood MJ.

Extracellular vesicles: Emerging targets for cancer therapy.

Trends Mol Med (2014) 20:385-393.
   

Jiang H et al.

Quantitatively controlling expression of miR-17~92 determines colon tumor progression in a mouse tumor model.

Am J Pathol (2014) 184:1355-68.
 

Lindoso RS et al.

Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury.

Stem Cells Dev (2014) 23:1809-19.
  

Wu SY et al.

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

Nat Commun (2014) 5:3459.
 

Cho MS et al.

Autocrine effects of tumor-derived complement.

Cell Rep (2014) 6:1085-95.
 

Lusardi TA et al.

MicroRNA responses to Focal Cerebral Ischemia in male and female mouse brain.

Front Mol Neurosci (2014) 7:11.
 

Grange C et al.

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging.

Int J Mol Med (2014) 33:1055-63.
    

Quesenberry PJ et al.

Cellular phenotype and extracellular vesicles: Basic and clinical considerations.

Stem Cells Dev (2014) 23:1429-36.
   

Dalton HJ et al.

Monocyte subpopulations in angiogenesis.

Cancer Res (2014) 74:1287-93.
 

Pusic AD, Pusic KM & Kraig RP.

What are exosomes and how can they be used in Multiple Sclerosis therapy?

Expert Rev Neurother (2014) 14:353-5.
  

Morey R & Laurent LC.

Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.

Cell Stem Cell (2014) 14:131-2.
 

Takahashi K et al.

Long noncoding RNA in liver diseases.

Hepatology (2014) 60:744-53.
    Related Pathway

 

Ben-Dov IZ et al.

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: Description of miRNA profiles at baseline.

PLoS ONE (2014) 9:e86856.
  

Takahashi K et al.

Modulation of hypoxia-signaling pathways by extracellular linc-RoR.

J Cell Sci (2014) 127:1585-94.
  

Beaulieu LM et al.

Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.

Arterioscler Thromb Vasc Biol (2014) 34:552-64.
  Related Pathway

 

McManus DD et al.

Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study.

Heart Rhythm (2014) 11:663-9.
 

Zhaorigetu S et al.

Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue.

J Liposome Res (2014) 24:182-90.
   

Ozpolat B, Sood AK & Lopez-Berestein G.

Liposomal siRNA nanocarriers for cancer therapy.

Adv Drug Deliv Rev (2014) 66:110-6.
   Related Pathway

 

Lai CP et al.

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

ACS Nano (2014) 8:483-94.
    

2013

Ngamruengphong S & Patel T.

Molecular evolution of genetic susceptibility to hepatocellular carcinoma.

Dig Dis Sci (2014) 59:986-91.
 

Pusic AD & Kraig RP.

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination.

Glia (2014) 62:284-99.
 

Pusic AD et al.

IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.

J Neuroimmunol (2014) 266:12-23.
 

Yao C et al.

Sex- and age-interacting eQTLs in human complex diseases.

Hum Mol Genet (2014) 23:1947-56.
 

Akers JC et al.

MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development.

PLoS ONE (2013) 8:e78115.
 

Clancy L & Freedman JE.

New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.

J Thromb Thrombolysis (2014) 37:12-6.
   

Jun HJ, Bronson RT & Charest A.

Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.

Stem Cells (2014) 32:338-48.
 

Panagopoulos K et al.

Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure.

Mol Cancer (2013) 12:118.
  

Aslan B et al.

Nanotechnology in cancer therapy.

J Drug Target (2013) 21:904-13.
 

Pecot CV et al.

Tumour angiogenesis regulation by the miR-200 family.

Nat Commun (2013) 4:2427.
  

Nishimura M et al.

Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment.

Cancer Discov (2013) 3:1302-15.
 

Lau C et al.

Role of pancreatic cancer-derived exosomes in salivary biomarker development.

J Biol Chem (2013) 288:26888-97.
  

Chen WW et al.

BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles.

Mol Ther Nucleic Acids (2013) 2:e109.
   

Aliotta JM et al.

Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.

Cardiovasc Res (2013) 100:354-62.
  

Saugstad JA.

MicroRNAs as effectors of brain function.

Stroke (2013) 44:S17-9.
 

Wang Q et al.

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.

Nat Commun (2013) 4:1867.
 

Deng ZB et al.

Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.

J Immunol (2013) 190:3579-89.
  

Akers JC et al.

Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.

J Neurooncol (2013) 113:1-11.
    

Quesenberry PJ et al.

A new stem cell biology: the continuum and microvesicles.

Trans Am Clin Climatol Assoc (2012) 123:152-66.
   

Gonda DD et al.

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.

Neurosurgery (2013) 72:501-10.