The Extracellular RNA Communication Consortium has published 500+ research articles since its inception in 2013. Articles in the category “exRNA and EV Biology” are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.

exRNA and EV Biology

2019

Lee MY et al.

Distinct profiles of cell-free microRNAs in plasma of veterans with Post-Traumatic Stress Disorder.

J Clin Med (2019) 8.
  

Gyuris A et al.

Physical and molecular landscapes of mouse glioma extracellular vesicles define heterogeneity.

Cell Rep (2019) 27:3972-3987.e6.
     

Haraszti RA et al.

Serum deprivation of Mesenchymal Stem Cells improves exosome activity and alters lipid and protein composition.

iScience (2019) 16:230-241.
   

Tapparo M et al.

Renal regenerative potential of extracellular vesicles derived from miRNA-engineered Mesenchymal Stromal Cells.

Int J Mol Sci (2019) 20.
  

Wei Z et al.

Co-cultures of glioma stem cells and primary neurons, astrocytes, microglia, and endothelial cells for investigation of intercellular communication in the brain.

Front Neurosci (2019) 13:361.
  

Zhang Q et al.

Transfer of functional cargo in exomeres.

Cell Rep (2019) 27:940-954.e6.
   

Poggio M et al.

Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory.

Cell (2019) 177:414-427.e13.
   

Das S et al.

The Extracellular RNA Communication Consortium: Establishing foundational knowledge and technologies for extracellular RNA research.

Cell (2019) 177:231-242.
    

Murillo OD et al.

exRNA Atlas analysis reveals distinct extracellular RNA Cargo types and their carriers present across human biofluids.

Cell (2019) 177:463-477.e15.
     

Jeppesen DK et al.

Reassessment of exosome composition.

Cell (2019) 177:428-445.e18.
   

Pua HH et al.

Increased hematopoietic extracellular RNAs and vesicles in the lung during allergic airway responses.

Cell Rep (2019) 26:933-944.e4.
   

Jimenez L et al.

Quantitative proteomic analysis of small and large extracellular vesicles (EVs) reveals enrichment of adhesion proteins in small EVs.

J Proteome Res (2019) 18:947-959.
  

2018

Chiou NT, Kageyama R & Ansel KM.

Selective export into extracellular vesicles and function of tRNa fragments during T cell activation.

Cell Rep (2018) 25:3356-3370.e4.
  

Kanlikilicer P et al.

Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer.

EBioMedicine (2018) 38:100-112.
   

Teng Y et al.

Plant-derived exosomal microRNAs shape the gut microbiota.

Cell Host Microbe (2018) 24:637-652.e8.
   

Wang QL et al.

Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways.

Theranostics (2018) 8:4912-4924.
  

Bei Y et al.

Circular RNAs as potential theranostics in the cardiovascular system.

Mol Ther Nucleic Acids (2018) 13:407-418.
    

Hinger SA et al.

Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells.

Cell Rep (2018) 25:715-725.e4.
   

Gustafsson G et al.

Secretion and uptake of alpha-synuclein via extracellular vesicles in cultured cells.

Cell Mol Neurobiol (2018) 38:1539-1550.
  

Malabirade A et al.

The RNA complement of Outer Membrane Vesicles from Salmonella enterica Serovar Typhimurium under distinct culture conditions.

Front Microbiol (2018) 9:2015.
 

Moirangthem A & Patel T.

Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.

Biotarget (2017) 1:12.
    

Regev K et al.

Identification of MS-specific serum miRNAs in an international multicenter study.

Neurol Neuroimmunol Neuroinflamm (2018) 5:e491.
   

Dragomir M, Chen B & Calin GA.

Exosomal lncRNAs as new players in cell-to-cell communication.

Transl Cancer Res (2018) 7:S243-S252.
  

Raffai RL.

MicroRNA-146a and hematopoiesis: Friend or foe in atherosclerosis.

Noncoding RNA Investig (2018) 2:43.
   

Broekman ML et al.

Multidimensional communication in the microenvirons of glioblastoma.

Nat Rev Neurol (2018) 14:482-495.
  

Sung BH & Weaver AM.

Directed migration: Cells navigate by extracellular vesicles.

J Cell Biol (2018) 217:2613-2614.
   

Zhang Q et al.

Mutant KRAS exosomes alter the metabolic state of recipient colonic epithelial cells.

Cell Mol Gastroenterol Hepatol (2018) 5:627-629.e6.
  

Dragomir M & Calin GA.

Circular RNAs in cancer – Lessons learned from microRNAs.

Front Oncol (2018) 8:179.
   

Danielson KM et al.

Plasma circulating extracellular RNAs in Left Ventricular Remodeling post-Myocardial Infarction.

EBioMedicine (2018) 32:172-181.
    

He X et al.

Human tRNA-derived small RNAs modulate host-oral microbial interactions.

J Dent Res (2018) 97:1236-1243.
  

Vujic A et al.

Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Nat Commun (2018) 9:1659.
   

Haemmerle M et al.

The platelet lifeline to cancer: Challenges and opportunities.

Cancer Cell (2018) 33:965-983.
   

Ricklefs FL et al.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Sci Adv (2018) 4:eaar2766.
  

Lankford KL et al.

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.

PLoS ONE (2018) 13:e0190358.
   

2017

Nonaka T & Wong DTW.

Saliva exosomics in cancer: Molecular characterization of cancer-derived exosomes in saliva.

Enzymes (2017) 42:125-151.
  

Bayraktar R, Van Roosbroeck K & Calin GA.

Cell-to-cell communication: microRNAs as hormones.

Mol Oncol (2017) 11:1673-1686.
   

Nguyen TA et al.

SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition.

Immunity (2017) 47:498-509.e6.
  

Figueroa J et al.

Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587.

Cancer Res (2017) 77:5808-5819.
  

Datta A et al.

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.

Cancer Lett (2017) 408:73-81.
  
Related Pathway

 

Bei Y et al.

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.

Basic Res Cardiol (2017) 112:38.
   

Silva AM et al.

Dendritic cell-derived extracellular vesicles mediate mesenchymal stem/stromal cell recruitment.

Sci Rep (2017) 7:1667.
  

Bruno S et al.

Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells.

Tissue Eng Part A (2017) 23:1262-1273.
   

Rashed MH et al.

Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.

Oncotarget (2017) 8:20145-20164.
  

Haga H et al.

Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.

Liver Transpl (2017) 23:791-803.
   

Deng Z et al.

Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.

Mol Ther (2017) 25:1641-1654.
    

Clancy L et al.

The role of RNA uptake in platelet heterogeneity.

Thromb Haemost (2017) 117:948-961.
  

Teng Y et al.

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.

Nat Commun (2017) 8:14448.
  

Collino F et al.

Exosome and microvesicle-enriched fractions isolated from mesenchymal stem cells by gradient separation showed different molecular signatures and functions on renal tubular epithelial cells.

Stem Cell Rev (2017) 13:226-243.
  

Maji S et al.

Extracellular vesicles in liver diseases.

Am J Physiol Gastrointest Liver Physiol (2017) 312:G194-G200.
   

2016

Maas SL, Breakefield XO & Weaver AM.

Extracellular vesicles: Unique intercellular delivery vehicles.

Trends Cell Biol (2017) 27:172-188.
    

Matsuda A et al.

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.

Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.
     

Katsiougiannis S et al.

Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity.

FASEB J (2017) 31:998-1010.
   

Nazimek K, Bryniarski K & Askenase PW.

Functions of exosomes and microbial extracellular vesicles in allergy and contact and delayed-type hypersensitivity.

Int Arch Allergy Immunol (2016) 171:1-26.
   

Kanlikilicer P et al.

Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells.

Cancer Res (2016) 76:7194-7207.
   

Paladini L et al.

Targeting microRNAs as key modulators of tumor immune response.

J Exp Clin Cancer Res (2016) 35:103.
    

Deng Z et al.

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis.

Oncogene (2017) 36:639-651.
  

Wang JQ et al.

Extracellular vesicle-mediated reversal of paclitaxel resistance in prostate cancer.

Crit Rev Oncog (2015) 20:407-17.
   

Fritz JV et al.

Sources and functions of extracellular small RNAs in human circulation.

Annu Rev Nutr (2016) 36:301-36.
   

Soares VY et al.

Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.

Neuro Oncol (2016) 18:1498-1507.
  

McKenzie AJ et al.

KRAS-MEK signaling controls Ago2 sorting into exosomes.

Cell Rep (2016) 15:978-87.
  

Abels ER & Breakefield XO.

Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.

Cell Mol Neurobiol (2016) 36:301-12.
   

Wu SY et al.

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

Nat Commun (2016) 7:11169.
   

Zappulli V et al.

Extracellular vesicles and intercellular communication within the nervous system.

J Clin Invest (2016) 126:1198-207.
   

Teng Y et al.

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.

Oncotarget (2016) 7:25683-97.
   

Pusic KM, Pusic AD & Kraig RP.

Environmental enrichment stimulates immune cell secretion of exosomes that promote CNS myelination and may regulate inflammation.

Cell Mol Neurobiol (2016) 36:313-325.
  

Pucci F et al.

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.

Science (2016) 352:242-6.
  

Almeida MI & Calin GA.

The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.

Genome Med (2016) 8:29.
  

Zaborowski MP et al.

Extracellular vesicles: Composition, biological relevance, and methods of study.

Bioscience (2015) 65:783-797.
   

Zhang X et al.

Potential transfer of polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington’s disease: Background and evaluation in cell culture.

Cell Mol Neurobiol (2016) 36:459-70.
   

Iavello A et al.

Role of Alix in miRNA packaging during extracellular vesicle biogenesis.

Int J Mol Med (2016) 37:958-66.
  

Rupaimoole R et al.

miRNA deregulation in cancer cells and the tumor microenvironment.

Cancer Discov (2016) 6:235-46.
   

Clancy L & Freedman JE.

Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.

Circ Res (2016) 118:374-6.
   

Rupaimoole R et al.

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.

Oncogene (2016) 35:4312-20. Related blog post
   

2015

Rupaimoole R et al.

Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis.

Cell Rep (2015) 13:2395-402.
   

Machtinger R, Laurent LC & Baccarelli AA.

Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation.

Hum Reprod Update (2016) 22:182-93.
   

Giza DE & Calin GA

microRNA and Chronic Lymphocytic Leukemia.

Adv Exp Med Biol (2015) 889:23-40.
   

Zhuang X et al.

Ginger-derived nanoparticles protect against alcohol-induced liver damage.

J Extracell Vesicles (2015) 4:28713.
   

Silva A, Bullock M & Calin G.

The clinical relevance of long non-coding RNAs in cancer.

Cancers (2015) 7:2169-82.
 

van der Vos KE et al.

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.

Neuro Oncol (2016) 18:58-69.
  

Quesenberry PJ et al.

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming.

Stem Cell Res Ther (2015) 6:153.
  

Ainsztein AM et al.

The NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27493.
      

Patton JG et al.

Biogenesis, delivery, and function of extracellular RNA.

J Extracell Vesicles (2015) 4:27494.
   

Pua HH & Ansel KM.

MicroRNA regulation of allergic inflammation and asthma.

Curr Opin Immunol (2015) 36:101-8.
   

Pichler M & Calin GA.

MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.

Br J Cancer (2015) 113:569-73.
   

Cha DJ et al.

KRAS-dependent sorting of miRNA to exosomes.

Elife (2015) 4:e07197.
  

Pusic AD & Kraig RP.

Phasic treatment with Interferon gamma stimulates release of exosomes that protect against spreading depression.

J Interferon Cytokine Res (2015) 35:795-807.
  

Simpson LJ & Ansel KM.

MicroRNA regulation of lymphocyte tolerance and autoimmunity.

J Clin Invest (2015) 125:2242-9.
   

Sung BH et al.

Directional cell movement through tissues is controlled by exosome secretion.

Nat Commun (2015) 6:7164.
   

Bryniarski K et al.

Free extracellular miRNA functionally targets cells by transfecting exosomes from their companion cells.

PLoS ONE (2015) 10:e0122991.
  

Agarwal K et al.

Analysis of exosome release as a cellular response to MAPK pathway inhibition.

Langmuir (2015) 31:5440-8.
  

Deng Z et al.

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

Nat Commun (2015) 6:6956.
  

Collino F et al.

AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs.

J Am Soc Nephrol (2015) 26:2349-60.
   

Nouraee N, Mowla SJ & Calin GA.

Tracking miRNAs’ footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy.

Genes Chromosomes Cancer (2015) 54:335-52.
  

Saugstad JA.

Non-coding RNAs in stroke and neuroprotection.

Front Neurol (2015) 6:50.
   

Gardiner C et al.

Extracellular vesicles, tissue factor, cancer and thrombosis – Discussion themes of the ISEV 2014 Educational Day.

J Extracell Vesicles (2015) 4:26901.
   

Kanada M et al.

Differential fates of biomolecules delivered to target cells via extracellular vesicles.

Proc Natl Acad Sci U S A (2015) 112:E1433-42.
   

Haga H et al.

Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth.

J Extracell Vesicles (2015) 4:24900.
  

2014

Srivastava A et al.

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.

Curr Gene Ther (2015) 15:182-92.
     

Berindan-Neagoe I & Calin GA.

Molecular pathways: microRNAs, cancer cells, and microenvironment.

Clin Cancer Res (2014) 20:6247-53.
   

Bhattacharya S et al.

GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.

PLoS ONE (2014) 9:e114409.
  

Melo SA et al.

Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

Cancer Cell (2014) 26:707-21.
   

Danielson KM & Das S.

Extracellular vesicles in heart disease: Excitement for the future?

Exosomes Microvesicles (2014) 2:1.
   
Related Pathway

 

Rajendran L et al.

Emerging roles of extracellular vesicles in the nervous system.

J Neurosci (2014) 34:15482-9.
   

Rupaimoole R et al.

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.

Nat Commun (2014) 5:5202.
   

Gangoda L et al.

Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

Proteomics (2015) 15:260-71.
   
Related Pathway

 

Godlewski J et al.

Belonging to a network–microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

Neuro Oncol (2015) 17:652-62.
   

Saleem SN & Abdel-Mageed AB.

Tumor-derived exosomes in oncogenic reprogramming and cancer progression.

Cell Mol Life Sci (2015) 72:1-10.
  

Thomas MF, L’Etoile ND & Ansel KM.

Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.

Trends Genet (2014) 30:298-307.
  
Related Pathway

 

Takahashi K et al.

Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer.

FEBS Open Bio (2014) 4:458-67.
  

Takahashi K et al.

Involvement of extracellular vesicle long non-coding RNA (linc-VLDLR) in tumor cell responses to chemotherapy.

Mol Cancer Res (2014) 12:1377-87.
  

Mu J et al.

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.

Mol Nutr Food Res (2014) 58:1561-73.
  

Redzic JS et al.

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol (2014) 28:14-23.
    

Quesenberry PJ et al.

Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.

Front Oncol (2014) 4:56.
   

Abd Elmageed ZY et al.

Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.

Stem Cells (2014) 32:983-97.
  

Lindoso RS et al.

Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury.

Stem Cells Dev (2014) 23:1809-19.
  

Grange C et al.

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging.

Int J Mol Med (2014) 33:1055-63.
    

Quesenberry PJ et al.

Cellular phenotype and extracellular vesicles: Basic and clinical considerations.

Stem Cells Dev (2014) 23:1429-36.
   

Takahashi K et al.

Long noncoding RNA in liver diseases.

Hepatology (2014) 60:744-53.
   
Related Pathway

 

Takahashi K et al.

Modulation of hypoxia-signaling pathways by extracellular linc-RoR.

J Cell Sci (2014) 127:1585-94.
  

Zhaorigetu S et al.

Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue.

J Liposome Res (2014) 24:182-90.
   

Lai CP et al.

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

ACS Nano (2014) 8:483-94.
    

2013

Pusic AD & Kraig RP.

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination.

Glia (2014) 62:284-99.
 

Clancy L & Freedman JE.

New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.

J Thromb Thrombolysis (2014) 37:12-6.
   

Panagopoulos K et al.

Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure.

Mol Cancer (2013) 12:118.
  

Aliotta JM et al.

Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice.

Cardiovasc Res (2013) 100:354-62.
  

Deng ZB et al.

Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.

J Immunol (2013) 190:3579-89.
  

Akers JC et al.

Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.

J Neurooncol (2013) 113:1-11.
    

Quesenberry PJ et al.

A new stem cell biology: the continuum and microvesicles.

Trans Am Clin Climatol Assoc (2012) 123:152-66.
   

Gonda DD et al.

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.

Neurosurgery (2013) 72:501-10.