The Extracellular RNA Communication Consortium has published 800+ research articles since its inception in 2013. Articles in the category “Therapeutics” are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.
Driedonks T et al.
Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina.
J Extracell Biol (2022) 1.
Huang Y et al.
Relationships of APOE genotypes with small RNA and protein cargo of brain tissue extracellular vesicles from patients with late-stage AD.
Neurol Genet (2022) 8:e200026.
Huang Y et al.
Brain tissue-derived extracellular vesicles in Alzheimer’s disease display altered key protein levels including cell type-specific markers.
J Alzheimers Dis (2022) 90:1057-1072.
Witwer KW & Wolfram J.
Extracellular vesicles versus synthetic nanoparticles for drug delivery.
Nat Rev Mater (2021) 6:103-106.
Morris KV & Witwer KW.
The evolving paradigm of extracellular vesicles in intercellular signaling and delivery of therapeutic RNAs.
Mol Ther (2022) 30:2393-2394.
Davies MR et al.
Muscle-derived beige adipose precursors secrete promyogenic exosomes that treat rotator cuff muscle degeneration in mice and are identified in humans by single-cell RNA sequencing.
Am J Sports Med (2022) 50:2247-2257.
Zhu X et al.
Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.
Neurobiol Dis (2022) 169:105734.
Chen B et al.
Targeting non-coding RNAs to overcome cancer therapy resistance.
Signal Transduct Target Ther (2022) 7:121.
Phu TA et al.
IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity.
Mol Ther (2022) 30:2274-2297.
Hong BV et al.
Lipid-based nutrient supplementation increases High-Density Lipoprotein (HDL) cholesterol efflux capacity and is associated with changes in the HDL glycoproteome in children.
ACS Omega (2021) 6:32022-32031.
Ma S et al.
CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance.
Cell Rep (2021) 36:109549.
Pusic KM, Kraig RP & Pusic AD.
IFNgamma-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes.
PLoS ONE (2021) 16:e0255778.
Pusic KM et al.
Environmental enrichment and its benefits for migraine: Dendritic cell extracellular vesicles as an effective mimetic.
J Cell Immunol (2021) 3:215-225.
Winkle M et al.
Noncoding RNA therapeutics – challenges and potential solutions.
Nat Rev Drug Discov (2021) 20:629-651.
Gimona M et al.
Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.
Cytotherapy (2021) 23:373-380.
Tallon C et al.
Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.
Drug Discov Today (2021) 26:1656-1668.
Noren Hooten N et al.
Hitting the bullseye: Are extracellular vesicles on target?
J Extracell Vesicles (2020) 10:e12032.
Nguyen VVT et al.
Functional assays to assess the therapeutic potential of extracellular vesicles.
J Extracell Vesicles (2020) 10:e12033.
Gorur A et al.
ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer.
Mol Ther Nucleic Acids (2021) 23:930-943.
Bouchareychas L et al.
Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via microRNA cargo.
Cell Rep (2020) 32:107881.
Chen F et al.
Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in Acute Myeloid Leukaemia: Therapeutic implications.
J Cell Mol Med (2020) 24:7378-7392.
Tran AM et al.
A new world of biomarkers and therapeutics for female reproductive system and breast cancers: Circular RNAs.
Front Cell Dev Biol (2020) 8:50.
Amit M et al.
Loss of p53 drives neuron reprogramming in head and neck cancer.
Nature (2020) 578:449-454.
Pichler M et al.
Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.
Gut (2020) 69:1818-1831.
Silverman MG et al.
Circulating miRNAs and risk of sudden death in patients with coronary heart disease.
JACC Clin Electrophysiol (2020) 6:70-79.
Forterre AV et al.
Extracellular vesicle-mediated in vitro transcribed mRNA delivery for treatment of HER2(+) breast cancer xenografts in mice by prodrug CB1954 without general toxicity.
Mol Cancer Ther (2020) 19:858-867.
El-Arabey AA et al.
GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma.
Cell Signal (2020) 68:109539.
Yang Z et al.
Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.
Nat Biomed Eng (2020) 4:69-83.
Sun L et al.
miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44.
Theranostics (2019) 9:8409-8425.
Sundaram K et al.
Plant-derived exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis.
iScience (2019) 21:308-327.
Bei Y et al.
Correction to: Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.
Basic Res Cardiol (2019) 114:44.
Pusic KM et al.
IFNgamma-stimulated dendritic cell exosomes for treatment of migraine modeled using spreading depression.
Front Neurosci (2019) 13:942.
Chen X et al.
Identifying and targeting angiogenesis-related microRNAs in ovarian cancer.
Oncogene (2019) 38:6095-6108.
Petrescu GED et al.
MicroRNA based theranostics for brain cancer: Basic principles.
J Exp Clin Cancer Res (2019) 38:231.
Tapparo M et al.
Renal regenerative potential of extracellular vesicles derived from miRNA-engineered Mesenchymal Stromal Cells.
Int J Mol Sci (2019) 20:2381.
Wiklander OPB et al.
Advances in therapeutic applications of extracellular vesicles.
Sci Transl Med (2019) 11:eaav8521.
Ghai V et al.
Extracellular vesicle encapsulated microRNAs in patients with Type 2 Diabetes are affected by metformin treatment.
J Clin Med (2019) 8:617.
Watts JK, Brown RH & Khvorova A.
Nucleic acid therapeutics for neurological diseases.
Neurotherapeutics (2019) 16:245-247.
Rodriguez-Aguayo C et al.
PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis.
EBioMedicine (2019) 40:290-304.
Krichevsky AM & Uhlmann EJ.
Oligonucleotide therapeutics as a new class of drugs for malignant brain tumors: Targeting mRNAs, regulatory RNAs, mutations, combinations, and beyond.
Neurotherapeutics (2019) 16:319-347.
Gulei D et al.
CRISPR-based RNA editing: Diagnostic applications and therapeutic options.
Expert Rev Mol Diagn (2019) 19:83-88.
Kanlikilicer P et al.
Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer.
EBioMedicine (2018) 38:100-112.
Teng Y et al.
Plant-derived exosomal microRNAs shape the gut microbiota.
Cell Host Microbe (2018) 24:637-652.e8.
Wang QL et al.
Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways.
Theranostics (2018) 8:4912-4924.
Moirangthem A & Patel T.
Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.
Biotarget (2017) 1:12.
Haraszti RA et al.
Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles.
Mol Ther (2018) 26:1973-1982.
George J, Yan IK & Patel T.
Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice.
Lab Invest (2018) 98:895-910.
Biscans A et al.
Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles.
Mol Ther (2018) 26:1520-1528.
Wang JH et al.
Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation.
Mol Cancer Ther (2018) 17 :1133-1142.
Matsuda A & Patel T.
Milk-derived extracellular vesicles for therapeutic delivery of small interfering RNAs.
Methods Mol Biol (2018) 1740:187-197.
Lankford KL et al.
Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.
PLoS ONE (2018) 13:e0190358.
Chen X et al.
RNA interference-based therapy and its delivery systems.
Cancer Metastasis Rev (2018) 37:107-124.
Pi F et al.
Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression.
Nat Nanotechnol (2018) 13:82-89.
Haraszti RA et al.
Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system.
Bio Protoc (2017) 7:20.
Wu X et al.
The many faces of long noncoding RNAs in cancer.
Antioxid Redox Signal (2018) 29:922-935.
Sutaria DS et al.
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.
J Extracell Vesicles (2017) 6:1333882.
Zhu X et al.
Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells.
J Extracell Vesicles (2017) 6:1324730.
Bei Y et al.
Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury.
Basic Res Cardiol (2017) 112:38.
Bruno S et al.
Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells.
Tissue Eng Part A (2017) 23:1262-1273.
Ochocinska MJ et al.
NIH workshop report on the trans-agency Blood-Brain Interface Workshop 2016: Exploring key challenges and opportunities associated with the blood, brain and their interface.
Fluids Barriers CNS (2017) 14:12.
Haga H et al.
Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury.
Liver Transpl (2017) 23:791-803.
Sutaria DS et al.
Achieving the promise of therapeutic extracellular vesicles: The devil is in details of therapeutic loading.
Pharm Res (2017) 34:1053-1066.
Deng Z et al.
Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.
Mol Ther (2017) 25:1641-1654.
Haga H et al.
Extracellular vesicles from bone marrow-derived mesenchymal stem cells improve survival from lethal hepatic failure in mice.
Stem Cells Transl Med (2017) 6:1262-1272.
Maas SL, Breakefield XO & Weaver AM.
Extracellular vesicles: Unique intercellular delivery vehicles.
Trends Cell Biol (2017) 27:172-188.
Srivastava A et al.
Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells.
Sci Rep (2016) 6:38541.
Matsuda A et al.
MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.
Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.
Katsiougiannis S et al.
Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity.
FASEB J (2017) 31:998-1010.
Didiot MC et al.
Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing.
Mol Ther (2016) 24:1836-1847.
Maji S et al.
In vitro toxicology studies of extracellular vesicles.
J Appl Toxicol (2017) 37:310-318.
Paladini L et al.
Targeting microRNAs as key modulators of tumor immune response.
J Exp Clin Cancer Res (2016) 35:103.
Srivastava A et al.
Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer.
J Biomed Nanotechnol (2016) 12:1159-73.
Wang JQ et al.
Extracellular vesicle-mediated reversal of paclitaxel resistance in prostate cancer.
Crit Rev Oncog (2015) 20:407-17.
Chaluvally-Raghavan P et al.
Direct upregulation of STAT3 by microRNA-551b-3p deregulates growth and metastasis of ovarian cancer.
Cell Rep (2016) 15:1493-504.
Wen S et al.
Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.
Leukemia (2016) 30:2221-2231.
Wu SY et al.
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.
Nat Commun (2016) 7:11169.
Teng Y et al.
Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.
Oncotarget (2016) 7:25683-97.
Hall J et al.
Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson’s disease, glioma, and schwannoma.
Cell Mol Neurobiol (2016) 36:417-27.
Parasramka MA et al.
Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.
Pharmacol Ther (2016) 161:67-78.
Lener T et al.
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper.
J Extracell Vesicles (2015) 4:30087.
Rupaimoole R et al.
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.
Oncogene (2016) 35:4312-20. Related blog post
Rupaimoole R et al.
Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis.
Cell Rep (2015) 13:2395-402.
Shields BB et al.
A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.
Mol Syst Biol (2015) 11:842.
Sercombe L et al.
Advances and challenges of liposome assisted drug delivery.
Front Pharmacol (2015) 6:286.
Zhuang X et al.
Ginger-derived nanoparticles protect against alcohol-induced liver damage.
J Extracell Vesicles (2015) 4:28713.
Zhuang X et al.
Grapefruit-derived nanovectors delivering therapeutic mir17 through an intranasal route inhibit brain tumor progression.
Mol Ther (2016) 24:96-105.
Chira S et al.
Progresses towards safe and efficient gene therapy vectors.
Oncotarget (2015) 6:30675-703.
Ainsztein AM et al.
The NIH Extracellular RNA Communication Consortium.
J Extracell Vesicles (2015) 4:27493.
Quesenberry PJ et al.
Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.
J Extracell Vesicles (2015) 4:27575.
Camussi G & Quesenberry PJ.
Perspectives on the potential therapeutic uses of vesicles.
Exosomes Microvesicles (2013) 1:6.
Collino F et al.
AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs.
J Am Soc Nephrol (2015) 26:2349-60.
Wang Q et al.
Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites.
Cancer Res (2015) 75:2520-9.
Simonson B & Das S.
MicroRNA therapeutics: the next magic bullet?
Mini Rev Med Chem (2015) 15:467-74.
Xiao J et al.
A snapshot of genetic and epigenetic basis of arrhythmia and heart failure.
Front Genet (2015) 6:74.
Ciccone M, Calin GA & Perrotti D.
From the biology of PP2A to the PADs for therapy of hematologic malignancies.
Front Oncol (2015) 5:21.
Nick AM et al.
A framework for a personalized surgical approach to ovarian cancer.
Nat Rev Clin Oncol (2015) 12:239-45.
Ozcan G et al.
Preclinical and clinical development of siRNA-based therapeutics.
Adv Drug Deliv Rev (2015) 87:108-19.
George J & Patel T.
Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
Semin Liver Dis (2015) 35:63-74.
Gonzalez-Villasana V et al.
Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer.
Clin Cancer Res (2015) 21:2127-37.
Choi HJ et al.
Anti-vascular therapies in ovarian cancer: Moving beyond anti-VEGF approaches.
Cancer Metastasis Rev (2015) 34:19-40.
Srivastava A et al.
Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.
Curr Gene Ther (2015) 15:182-92.
Rupaimoole R et al.
Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.
Nat Commun (2014) 5:5202.
Sato-Kuwabara Y et al.
The fusion of two worlds: Non-coding RNAs and extracellular vesicles–Diagnostic and therapeutic implications.
Int J Oncol (2015) 46:17-27.
Kawikova I & Askenase PW.
Diagnostic and therapeutic potentials of exosomes in CNS diseases.
Brain Res (2015) 1617:63-71.
Gyorgy B et al.
Therapeutic applications of extracellular vesicles: Clinical promise and open questions.
Annu Rev Pharmacol Toxicol (2015) 55:439-64.
Krzeszinski JY et al.
MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.
Nature (2014) 512:431-5.
Vader P, Breakefield XO & Wood MJ.
Extracellular vesicles: Emerging targets for cancer therapy.
Trends Mol Med (2014) 20:385-393.
Grange C et al.
Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging.
Int J Mol Med (2014) 33:1055-63.
Pusic AD, Pusic KM & Kraig RP.
What are exosomes and how can they be used in Multiple Sclerosis therapy?
Expert Rev Neurother (2014) 14:353-5.
Zhaorigetu S et al.
Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue.
J Liposome Res (2014) 24:182-90.
Ozpolat B, Sood AK & Lopez-Berestein G.
Liposomal siRNA nanocarriers for cancer therapy.
Adv Drug Deliv Rev (2014) 66:110-6.
Pusic AD et al.
IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.
J Neuroimmunol (2014) 266:12-23.
