Grant Project Page
Kumar S et al.
Quantifying PON1 on HDL with nanoparticle-gated electrokinetic membrane sensor for accurate cardiovascular risk assessment.
Nat Commun (2023) 14:557.
Biomarkers Resources and Technology Grant CA241684 Grant CA241694
Halushka MK & Witwer KW.
Letter by Halushka and Witwer regarding article, “Circulating microRNA-122-5p is associated with a lack of improvement in left ventricular function after transcatheter aortic valve replacement and regulates viability of cardiomyocytes through extracellular vesicles”.
Circulation (2023) 147:e64-e65.
Review Grant HL126499 Grant CA241694
Gornalusse G et al.
Men who inject opioids exhibit altered tRNA-Gly-GCC isoforms in semen.
Mol Hum Reprod (2023) 29.
exRNA and EV Biology exRNA Biology EV Biology Grant HL126499 Grant CA241694
Costa B et al.
Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids.
Proc Natl Acad Sci U S A (2023) 120:e2216330120.
exRNA and EV Biology exRNA Biology Grant CA241684 Grant CA241694
Chen L et al.
A home-made pipette droplet microfluidics rapid prototyping and training kit for digital PCR, microorganism/cell encapsulation and controlled microgel synthesis.
Sci Rep (2023) 13:184.
Resources and Technology Grant CA241684 Grant CA241694
Driedonks T et al.
Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina.
J Extracell Biol (2022) 1.
exRNA and EV Biology EV Biology Therapeutics Grant CA241694
Kaczor-Urbanowicz KE & Wong DTW.
RNA sequencing analysis of saliva exRNA.
Methods Mol Biol (2023) 2588:3-11.
Resources and Technology Grant TR000923 Grant CA241694 Grant TR002978
Huang Y et al.
Relationships of APOE genotypes with small RNA and protein cargo of brain tissue extracellular vesicles from patients with late-stage AD.
Neurol Genet (2022) 8:e200026.
exRNA and EV Biology EV Biology Therapeutics Grant CA241685 Grant CA241694
Tosar JP, Cayota A & Witwer K.
Exomeres and supermeres: Monolithic or diverse?.
exRNA and EV Biology exRNA Biology Grant CA241694
Jeppesen DK et al.
Are supermeres a distinct nanoparticle?.
Review Grant CA241685 Grant CA241694
Brain tissue-derived extracellular vesicles in Alzheimer”s disease display altered key protein levels including cell type-specific markers.
J Alzheimers Dis (2022) 90:1057-1072.
Witwer KW & Wolfram J.
Extracellular vesicles versus synthetic nanoparticles for drug delivery.
Nat Rev Mater (2021) 6:103-106.
Review EV Biology Therapeutics Grant CA241694
Mateescu B et al.
Phase 2 of Extracellular RNA Communication Consortium charts next-generation approaches for extracellular RNA research.
iScience (2022) 25:104653.
Review Resources and Technology Grant CA241694
Spanos M et al.
Elevation of neural injury markers in patients with neurologic sequelae after hospitalization for SARS-CoV-2 infection.
iScience (2022) 25:104833.
Biomarkers Grant CA241694
Arifin DR, Witwer KW & Bulte JWM.
Non-invasive imaging of extracellular vesicles: Quo vaditis in vivo?.
J Extracell Vesicles (2022) 11:e12241.
Review EV Biology Resources and Technology Grant CA241685 Grant CA241694
Jin G et al.
Intelligent nanoscope for rapid nanomaterial identification and classification.
Lab Chip (2022) 22:2978-2985.
Resources and Technology Grant CA241694 Grant TR002978
Morris KV & Witwer KW.
The evolving paradigm of extracellular vesicles in intercellular signaling and delivery of therapeutic RNAs.
Mol Ther (2022) 30:2393-2394.
Review Therapeutics Grant TR000943 Grant CA241694
Rima XY et al.
Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis.
Lab Chip (2022) 22:2502-2518.
Resources and Technology Grant CA241694 Grant TR002884
Gomes DE & Witwer KW.
L1CAM-associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization.
Review exRNA and EV Biology EV Biology Resources and Technology Grant CA179564 Grant CA241694
Zhu X et al.
Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.
Neurobiol Dis (2022) 169:105734.
Witwer KW et al.
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles.
J Extracell Vesicles (2021) 10:e12182.
Resources and Technology Grant CA241685 Grant CA241694
Couch Y et al.
A brief history of nearly EV-erything – The rise and rise of extracellular vesicles.
J Extracell Vesicles (2021) 10:e12144.
Review exRNA and EV Biology EV Biology Grant CA241694
Zhang Q et al.
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.
Nat Cell Biol (2021) 23:1240-1254.
exRNA and EV Biology EV Biology Grant CA241685 Grant CA241694
Hong BV et al.
Lipid-based nutrient supplementation increases High-Density Lipoprotein (HDL) cholesterol efflux capacity and is associated with changes in the HDL glycoproteome in children.
ACS Omega (2021) 6:32022-32031.
exRNA and EV Biology Therapeutics Grant CA241694
Verweij FJ et al.
The power of imaging to understand extracellular vesicle biology in vivo.
Nat Methods (2021) 18:1013-1026.
Review exRNA and EV Biology EV Biology Resources and Technology Grant CA241694 Grant TR002978
Bouchareychas L et al.
High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.
iScience (2021) 24:102847.
exRNA and EV Biology EV Biology Grant CA241694 Grant CA241703
Zheng JJ et al.
Isolation of HDL by sequential flotation ultracentrifugation followed by size exclusion chromatography reveals size-based enrichment of HDL-associated proteins.
Sci Rep (2021) 11:16086.
exRNA and EV Biology EV Biology Grant TR000918 Grant CA241694
Gimona M et al.
Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles.
Cytotherapy (2021) 23:373-380.
Webster NJ et al.
Testicular germ cell tumors arise in the absence of sex-specific differentiation.
Development (2021) 148.
Grant CA241694 Grant DA049098
Witwer KW.
On your MARCKS, get set, deliver: Engineering extracellular vesicles.
Mol Ther (2021) 29:1664-1665.
Review exRNA and EV Biology EV Biology Grant CA241684 Grant CA241694
Arab T et al.
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single-particle analysis platforms.
J Extracell Vesicles (2021) 10:e12079.
Resources and Technology Grant CA241694
Tallon C et al.
Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.
Drug Discov Today (2021) 26:1656-1668.
Review exRNA and EV Biology EV Biology Therapeutics Grant CA241694
Andronico LA et al.
Sizing extracellular vesicles using membrane dyes and a single molecule-sensitive flow analyzer.
Anal Chem (2021) 93:5897-5905.
Resources and Technology Grant CA241694 Grant TR002874
Tosar JP et al.
RI-SEC-seq: Comprehensive profiling of nonvesicular extracellular RNAs with different stabilities.
Bio Protoc (2021) 11:e3918.
exRNA and EV Biology exRNA Biology Resources and Technology Grant CA241694
Martin-Jaular L et al.
Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.
EMBO J (2021) 40:e105492.
exRNA and EV Biology EV Biology Resources and Technology Grant CA241694
Nguyen VVT et al.
Functional assays to assess the therapeutic potential of extracellular vesicles.
J Extracell Vesicles (2020) 10:e12033.
Review Therapeutics Grant CA241694
Noren Hooten N et al.
Hitting the bullseye: Are extracellular vesicles on target?
J Extracell Vesicles (2020) 10:e12032.
Review Therapeutics Grant CA241694 Grant TR002978
Yu X et al.
Ultrasensitive amyloid beta-protein quantification with high dynamic range using a hybrid graphene-gold surface-enhanced Raman spectroscopy platform.
J Raman Spectrosc (2020) 51:432-441.
Grant CA241694 Grant TR002978
Saheera S et al.
Extracellular vesicle interplay in cardiovascular pathophysiology.
Am J Physiol Heart Circ Physiol (2021) 320:H1749-H1761.
Tosar JP, Witwer K & Cayota A.
Revisiting extracellular RNA release, processing, and function.
Trends Biochem Sci (2021) 46:438-445.
Review exRNA and EV Biology exRNA Biology Grant CA241694
Tosar JP, Garcia-Silva MR & Cayota A.
Circulating SNORD57 rather than piR-54265 is a promising biomarker for colorectal cancer: Common pitfalls in the study of somatic piRNAs in cancer.
RNA (2021) 27:403-410.
Welsh JA et al.
Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration.
J Extracell Vesicles (2020) 9:1816641.
Zhao Z et al.
miRNA profiling of primate cervicovaginal lavage and extracellular vesicles reveals miR-186-5p as a potential antiretroviral factor in macrophages.
FEBS Open Bio (2020) 10:2021-2039.
exRNA and EV Biology exRNA Biology Grant CA241694 Grant TR002978
Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles.
J Extracell Vesicles (2020) 9:1785746.
Royo F et al.
Methods for separation and characterization of extracellular vesicles: Results of a worldwide survey performed by the ISEV Rigor and Standardization subcommittee.
Cells (2020) 9:1955.
Zeng A et al.
Glioblastoma-derived extracellular vesicles facilitate transformation of astrocytes via reprogramming oncogenic metabolism.
iScience (2020) 23:101420.
exRNA and EV Biology exRNA Biology EV Biology Grant CA241685 Grant CA241694
Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome.
Nucleic Acids Res (2020) 48:12874-12888.
Hunter-Zinck H et al.
Genotyping array design and data quality control in the Million Veteran Program.
Am J Hum Genet (2020) 106:535-548.
Resources and Technology Grant HL126495 Grant CA241694
Ahn JY et al.
Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria.
Biochim Biophys Acta Gen Subj (2021) 1865:129598.
exRNA and EV Biology exRNA Biology EV Biology Biomarkers Grant CA241694
Perez PS et al.
Extracellular vesicles and chronic inflammation during HIV infection.
J Extracell Vesicles (2019) 8:1687275.
exRNA and EV Biology EV Biology Grant CA241694
Gambaro F et al.
Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner.
RNA Biol (2019) 17:1168-1182.
exRNA and EV Biology exRNA Biology EV Biology Grant CA241694
Russell AE et al.
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop.
J Extracell Vesicles (2019) 8:1684862.
