The Extracellular RNA Communication Consortium has published 800+ research articles since its inception in 2013. Articles in the category “exRNA Biology” are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.

exRNA Biology

2023

Dragomir MP et al.

Anti-miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response.

J Clin Invest (2023) 133.

    

LaPlante EL et al.

exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers.

Cell Genom (2023) 3:100303.

   

Barman B, Dawson TR & Weaver AM.

ER membrane contact sites: Key platforms for biogenesis of RNA-containing extracellular vesicles.

Contact (2022) 5.

    

Jeppesen DK et al.

Extracellular vesicles and nanoparticles: Emerging complexities.

Trends Cell Biol AOP 2023-02-01.

      

Gornalusse G et al.

Men who inject opioids exhibit altered tRNA-Gly-GCC isoforms in semen.

Mol Hum Reprod (2023) 29.

     

Costa B et al.

Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids.

Proc Natl Acad Sci U S A (2023) 120:e2216330120.

    

Castleberry M et al.

High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages.

J Lipid Res (2023) 64:100328.

  

2022

Tosar JP, Cayota A & Witwer K.

Exomeres and supermeres: Monolithic or diverse?

J Extracell Biol (2022) 1.

   

Michell DL et al.

Elucidation of physico-chemical principles of high-density lipoprotein-small RNA binding interactions.

J Biol Chem (2022) 298:101952.

  

Barman B et al.

VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites.

Dev Cell (2022) 57:974-994.e8.

    

Chen B et al.

Targeting non-coding RNAs to overcome cancer therapy resistance.

Signal Transduct Target Ther (2022) 7:121.

    

Li G et al.

Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs.

Adv Sci (2022) 9:e2200829.

     

Alsop E et al.

A novel tissue atlas and online tool for the interrogation of small RNA expression in human tissues and biofluids.

Front Cell Dev Biol (2022) 10:804164.

     

2021

Abner JJ et al.

Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m(6)A consensus sequences.

Heliyon (2021) 7:e08519.

   

Dragomir MP, Knutsen E & Calin GA.

Classical and noncanonical functions of miRNAs in cancers.

Trends Genet (2022) 38:379-394.

    

Woodruff PG

Regulation of airway immunity by epithelial miRNAs.

Immunol Rev (2021) 304:141-153.

   

Giraldez MD & Tewari M.

Phospho-RNAseq profiling of extracellular mRNAs and lncRNAs.

Methods Mol Biol (2021) 2348:257-271.

    

Blanco-Dominguez R et al.

A novel circulating microRNA for the detection of acute myocarditis.

N Engl J Med (2021) 384:2014-2027.

    

Gruner HN & McManus MT.

Examining the evidence for extracellular RNA function in mammals.

Nat Rev Genet (2021) 22:448-458.

    

Tosar JP et al.

RI-SEC-seq: Comprehensive profiling of nonvesicular extracellular RNAs with different stabilities.

Bio Protoc (2021) 11:e3918.

    

Tosar JP, Witwer K & Cayota A.

Revisiting extracellular RNA release, processing, and function.

Trends Biochem Sci (2021) 46:438-445.

    

2020

Tosar JP, Garcia-Silva MR & Cayota A.

Circulating SNORD57 rather than piR-54265 is a promising biomarker for colorectal cancer: Common pitfalls in the study of somatic piRNAs in cancer.

RNA (2021) 27:403-410.

   

Li J et al.

miR-30d regulates cardiac remodeling by intracellular and paracrine signaling.

Circ Res (2020) 128:e1-e23.

  

Koyano K, Bahn JH & Xiao X.

Extracellular microRNA 3′ end modification across diverse body fluids.

Epigenetics (2021) 16:1000-1015.

   

Zhao Z et al.

miRNA profiling of primate cervicovaginal lavage and extracellular vesicles reveals miR-186-5p as a potential antiretroviral factor in macrophages.

FEBS Open Bio (2020) 10:2021-2039.

    

Xiao Y et al.

How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger.

J Extracell Vesicles (2020) 9:1793515.

    

Fazzalari A et al.

A translational model for venous thromboembolism: microRNA expression in hibernating black bears.

J Surg Res (2021) 257:203-212.

   

Zeng A et al.

Glioblastoma-derived extracellular vesicles facilitate transformation of astrocytes via reprogramming oncogenic metabolism.

iScience (2020) 23:101420.

     

Tosar JP et al.

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome.

Nucleic Acids Res (2020) 48:12874-12888.

   

Drula R et al.

MicroRNAs from liquid biopsy derived extracellular vesicles: Recent advances in detection and characterization methods.

Cancers (Basel) (2020) 12:2009.

     

Bouchareychas L et al.

Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via microRNA cargo.

Cell Rep (2020) 32:107881.

      

Abels ER et al.

GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma.

Sci Rep (2020) 10:9898.

    

Ahn JY et al.

Release of extracellular vesicle miR-494-3p by ARPE-19 cells with impaired mitochondria.

Biochim Biophys Acta Gen Subj (2021) 1865:129598.

     

Tosar JP & Cayota A.

Extracellular tRNAs and tRNA-derived fragments.

RNA Biol (2020) 17:1149-1167.

    

Ghai V et al.

Alterations in plasma microRNA and protein levels in war veterans with chronic mild traumatic brain injury.

J Neurotrauma (2020) 37:1418-1430.

    

Meyer C et al.

The G3BP1-Family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

Mol Cell (2020) 77:1193-1205.e5.

   

2019

Gambaro F et al.

Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner.

RNA Biol (2019) 17:1168-1182.

    

De Los Santos MC, Dragomir MP & Calin GA.

The role of exosomal long non-coding RNAs in cancer drug resistance.

Cancer Drug Resist (2019) 2:1178-1192.

    

Sun L et al.

miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44.

Theranostics (2019) 9:8409-8425.

     

Lee MJ et al.

The impact of Moyamoya disease and RNF213 mutations on the spectrum of plasma protein and microRNA.

J Clin Med (2019) 8:1648.

   

Fabbri M et al.

Decrypting noncoding RNA interactions, structures, and functional networks.

Genome Res (2019) 29:1377-1388.

    

Gyuris A et al.

Physical and molecular landscapes of mouse glioma extracellular vesicles define heterogeneity.

Cell Rep (2019) 27:3972-3987.e6.

      

Das S et al.

The Extracellular RNA Communication Consortium: Establishing foundational knowledge and technologies for extracellular RNA research.

Cell (2019) 177:231-242.

    

Murillo OD et al.

exRNA Atlas analysis reveals distinct extracellular RNA Cargo types and their carriers present across human biofluids.

Cell (2019) 177:463-477.e15.

     

Bach DH, Lee SK & Sood AK.

Circular RNAs in Cancer.

Mol Ther Nucleic Acids (2019) 16:118-129.

     

2018

Godoy PM et al.

Large differences in small RNA composition between human biofluids.

Cell Rep (2018) 25:1346-1358.

     

Bei Y et al.

Circular RNAs as potential theranostics in the cardiovascular system.

Mol Ther Nucleic Acids (2018) 13:407-418.

     

Regev K et al.

Identification of MS-specific serum miRNAs in an international multicenter study.

Neurol Neuroimmunol Neuroinflamm (2018) 5:e491.

    

Raffai RL.

MicroRNA-146a and hematopoiesis: Friend or foe in atherosclerosis.

Noncoding RNA Investig (2018) 2:43.

    

Dragomir M & Calin GA.

Circular RNAs in cancer – Lessons learned from microRNAs.

Front Oncol (2018) 8:179.

     

Dluzen DF et al.

Extracellular RNA profiles with human age.

Aging Cell (2018) 17:e12785.

   

Danielson KM et al.

Plasma circulating extracellular RNAs in Left Ventricular Remodeling post-Myocardial Infarction.

EBioMedicine (2018) 32:172-181.

      

He X et al.

Human tRNA-derived small RNAs modulate host-oral microbial interactions.

J Dent Res (2018) 97:1236-1243.

   

Vujic A et al.

Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Nat Commun (2018) 9:1659.

    

Koupenova M et al.

Micro RNAs from DNA viruses are found widely in plasma in a large observational human population.

Sci Rep (2018) 8:6397.

     

2017

Bayraktar R, Van Roosbroeck K & Calin GA.

Cell-to-cell communication: microRNAs as hormones.

Mol Oncol (2017) 11:1673-1686.

    

Nguyen TA et al.

SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition.

Immunity (2017) 47:498-509.e6.

   

Shah R et al.

Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: Brief report.

Am J Physiol Heart Circ Physiol (2017) 313:H1162-H1167.

     

Yeri A et al.

Total extracellular small RNA profiles from plasma, saliva, and urine of healthy subjects.

Sci Rep (2017) 7:44061.

    

2016

Matsuda A et al.

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.

Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.

       

Paladini L et al.

Targeting microRNAs as key modulators of tumor immune response.

J Exp Clin Cancer Res (2016) 35:103.

      

Fritz JV et al.

Sources and functions of extracellular small RNAs in human circulation.

Annu Rev Nutr (2016) 36:301-36.

     

Wu SY et al.

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

Nat Commun (2016) 7:11169.

    

Rupaimoole R et al.

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.

Oncogene (2016) 35:4312-20. Related blog post

    

2015

Rupaimoole R et al.

Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis.

Cell Rep (2015) 13:2395-402.

    

Shields BB et al.

A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.

Mol Syst Biol (2015) 11:842.

  

Related Pathways: 1, 2

 

Giza DE & Calin GA

microRNA and Chronic Lymphocytic Leukemia.

Adv Exp Med Biol (2015) 889:23-40.

     

Ainsztein AM et al.

The NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27493.

       

Patton JG et al.

Biogenesis, delivery, and function of extracellular RNA.

J Extracell Vesicles (2015) 4:27494.

     

Pua HH & Ansel KM.

MicroRNA regulation of allergic inflammation and asthma.

Curr Opin Immunol (2015) 36:101-8.

    

Pichler M & Calin GA.

MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.

Br J Cancer (2015) 113:569-73.

     

Simpson LJ & Ansel KM.

MicroRNA regulation of lymphocyte tolerance and autoimmunity.

J Clin Invest (2015) 125:2242-9.

     

2014

Berindan-Neagoe I & Calin GA.

Molecular pathways: microRNAs, cancer cells, and microenvironment.

Clin Cancer Res (2014) 20:6247-53.

    

Rupaimoole R et al.

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.

Nat Commun (2014) 5:5202.

    

Krzeszinski JY et al.

MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.

Nature (2014) 512:431-5.

    

Related Pathway

 

Takahashi K et al.

Long noncoding RNA in liver diseases.

Hepatology (2014) 60:744-53.

    

Related Pathway

 

Takahashi K et al.

Modulation of hypoxia-signaling pathways by extracellular linc-RoR.

J Cell Sci (2014) 127:1585-94.

    

2013

Clancy L & Freedman JE.

New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.

J Thromb Thrombolysis (2014) 37:12-6.