The top 20 most highly cited articles from the Extracellular RNA Communication Consortium are listed here. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles. Clicking on the “Highly Cited” tag for an article links to its entry at Google Scholar.

Highly Cited

Melo SA et al.

Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

Cancer Cell (2014) 26:707-21.

Sercombe L et al.

Advances and challenges of liposome assisted drug delivery.

Front Pharmacol (2015) 6:286.

Akers JC et al.

Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.

J Neurooncol (2013) 113:1-11.

Lener T et al.

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper.

J Extracell Vesicles (2015) 4:30087.

Keerthikumar S et al.

ExoCarta: A web-based compendium of exosomal cargo.

J Mol Biol (2016) 428:688-692.

Abels ER & Breakefield XO.

Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.

Cell Mol Neurobiol (2016) 36:301-12.

Bahn JH et al.

The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva.

Clin Chem (2015) 61:221-30.

Khvorova A & Watts JK.

The chemical evolution of oligonucleotide therapies of clinical utility.

Nat Biotechnol (2017) 35:238-248.

Slenter DN et al.

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research.

Nucleic Acids Res (2018) 46:D661-D667.

Lai CP et al.

Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.

ACS Nano (2014) 8:483-94.

Berindan-Neagoe I et al.

MicroRNAome genome: a treasure for cancer diagnosis and therapy.

CA Cancer J Clin (2014) 64:311-36.

Mateescu B et al.

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper.

J Extracell Vesicles (2017) 6:1286095.

Byron SA et al.

Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.

Nat Rev Genet (2016) 17:257-71. Related blog post

Shao H et al.

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Nat Commun (2015) 6:6999.

Gyorgy B et al.

Therapeutic applications of extracellular vesicles: Clinical promise and open questions.

Annu Rev Pharmacol Toxicol (2015) 55:439-64.

Boettcher M & McManus MT.

Choosing the right tool for the job: RNAi, TALEN, or CRISPR.

Mol Cell (2015) 58:575-85.

Pecot CV et al.

Tumour angiogenesis regulation by the miR-200 family.

Nat Commun (2013) 4:2427.

Krzeszinski JY et al.

MiR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.

Nature (2014) 512:431-5.
Related Pathway


Sung BH et al.

Directional cell movement through tissues is controlled by exosome secretion.

Nat Commun (2015) 6:7164.

Vader P, Breakefield XO & Wood MJ.

Extracellular vesicles: Emerging targets for cancer therapy.

Trends Mol Med (2014) 20:385-393.