Grant Project Page
Haraszti RA et al.
Serum deprivation of Mesenchymal Stem Cells improves exosome activity and alters lipid and protein composition.
iScience (2019) 16:230-241.
ERCC1 in Cell Press exRNA and EV Biology EV Biology Grant TR000888
Watts JK, Brown RH & Khvorova A.
Nucleic acid therapeutics for neurological diseases.
Neurotherapeutics (2019) 16:245-247.
Review Therapeutics Grant TR000888
Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles.
Mol Ther (2018) 26:1973-1982.
ERCC1 in Cell Press Therapeutics Grant TR000888
Biscans A et al.
Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles.
Mol Ther (2018) 26:1520-1528.
Staerk L et al.
Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: Cohort study based on longitudinal data from the Framingham Heart Study.
BMJ (2018) 361:k1453.
Grant TR000888 Grant TR000921
Didiot MC et al.
Loading of extracellular vesicles with hydrophobically modified siRNAs.
Methods Mol Biol (2018) 1740:199-214.
Resources and Technology Grant TR000888 Grant TR000884
Loading of extracellular vesicles with chemically stabilized hydrophobic siRNAs for the treatment of disease in the central nervous system.
Bio Protoc (2017) 7:20.
Therapeutics Grant TR000888
Nikan M et al.
Synthesis and evaluation of parenchymal retention and efficacy of a metabolically stable O-phosphocholine-N-docosahexaenoyl-l-serine siRNA conjugate in mouse brain.
Bioconjug Chem (2017) 28:1758-1766.
Grant TR000888
Shi J et al.
miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury.
Theranostics (2017) 7:664-676.
Grant TR000888 Grant TR000901
Khvorova A & Watts JK.
The chemical evolution of oligonucleotide therapies of clinical utility.
Nat Biotechnol (2017) 35:238-248.
Highly Cited (400+) Grant TR000888 Grant CA179563
Pi F et al.
RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery.
Nanomedicine (2017) 13:1183-1193.
Grant TR000888 Grant TR000943
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.
J Extracell Vesicles (2016) 5:32570.
EV Biology Resources and Technology Grant TR000888 Grant TR000923
Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing.
Mol Ther (2016) 24:1836-1847.
Therapeutics Grant TR000888 Grant CA179563
Mohankumar S & Patel T.
Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.
Brief Funct Genomics (2016) 15:249-56.
Review Biomarkers Grant TR000888 Grant TR000884
Alterman JF et al.
Hydrophobically modified siRNAs silence Huntingtin mRNA in primary neurons and mouse brain.
Mol Ther Nucleic Acids (2015) 4:e266.
Kalani MY et al.
Rare variants in cardiomyopathy genes associated with stress-induced cardiomyopathy.
Neurosurgery (2016) 78:835-43.
Grant TR000888 Grant TR000891