Grant Project Page
Fordjour FK et al.
A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes.
J Biol Chem (2022) 298:102394.
exRNA and EV Biology EV Biology Grant CA179563 Grant CA241687
Thompson L et al.
Quantification of cellular densities and antigenic properties using magnetic levitation.
J Vis Exp AOP 2021-05-17.
Resources and Technology Grant CA179563 Grant TR002881
Guo C et al.
Choice of selectable marker affects recombinant protein expression in cells and exosomes.
J Biol Chem (2021) 297:100838.
exRNA and EV Biology EV Biology Resources and Technology Grant CA179563 Grant TR002878
Xie Y et al.
Microfluidic isolation and enrichment of nanoparticles.
ACS Nano (2020) 14:16220–16240.
Review Resources and Technology Grant CA179563 Grant TR002978
Nieland L et al.
Extracellular vesicle-mediated bilateral communication between glioblastoma and astrocytes.
Trends Neurosci (2021) 44:215-226.
Review exRNA and EV Biology EV Biology Grant CA179563 Grant TR002881
Abels ER et al.
GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma.
Sci Rep (2020) 10:9898.
exRNA and EV Biology exRNA Biology Resources and Technology Grant CA179563
Maas SLN et al.
Glioblastoma hijacks microglial gene expression to support tumor growth.
J Neuroinflammation (2020) 17:120.
exRNA and EV Biology Resources and Technology Grant CA179563
Lucero R et al.
Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells.
Cell Rep (2020) 30:2065-2074.e4.
exRNA and EV Biology Grant CA179563 Grant TR000931 Grant DA036134
Zaborowski MP et al.
Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles.
Sci Rep (2019) 9:17387.
exRNA and EV Biology EV Biology Resources and Technology Grant CA179563 Grant CA179514
Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21.
Cell Rep (2019) 28:3105-3119.e7.
exRNA and EV Biology Grant CA179563
Gyuris A et al.
Physical and molecular landscapes of mouse glioma extracellular vesicles define heterogeneity.
Cell Rep (2019) 27:3972-3987.e6.
ERCC1 in Cell Press exRNA and EV Biology exRNA Biology EV Biology Resources and Technology Grant CA179563
Pegtel DM & Gould SJ.
Exosomes.
Annu Rev Biochem (2019) 88:487-514.
Review exRNA and EV Biology EV Biology Grant CA179563
Wiklander OPB et al.
Advances in therapeutic applications of extracellular vesicles.
Sci Transl Med (2019) 11:eaav8521.
Review Therapeutics Grant CA179563
Wei Z et al.
Co-cultures of glioma stem cells and primary neurons, astrocytes, microglia, and endothelial cells for investigation of intercellular communication in the brain.
Front Neurosci (2019) 13:361.
Krichevsky AM & Uhlmann EJ.
Oligonucleotide therapeutics as a new class of drugs for malignant brain tumors: Targeting mRNAs, regulatory RNAs, mutations, combinations, and beyond.
Neurotherapeutics (2019) 16:319-347.
Usmani SM et al.
HIV-1 balances the fitness costs and benefits of disrupting the host cell actin cytoskeleton early after mucosal transmission.
Cell Host Microbe (2019) 25:73-86.e5.
Grant CA179563 Grant TR000875
Zhou S et al.
Chronic Platelet-derived Growth Factor Receptor signaling exerts control over initiation of protein translation in glioma.
Life Sci Alliance (2018) 1:e201800029.
Grant CA179563
Related Pathway
Gustafsson G et al.
Secretion and uptake of alpha-synuclein via extracellular vesicles in cultured cells.
Cell Mol Neurobiol (2018) 38:1539-1550.
exRNA and EV Biology EV Biology Grant CA179563
Silva AM et al.
Profiling the circulating miRnome reveals a temporal regulation of the bone injury response.
Theranostics (2018) 8:3902-3917.
Biomarkers Grant CA179563 Grant TR000943
Jun HJ et al.
A PDGFRalpha-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.
Nat Commun (2018) 9:3116.
Giraldez MD et al.
Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
Nat Biotechnol (2018) 36:746-757.
Resources and Technology Grant CA179563 Grant TR000891 Grant HL126493 Grant HL126494 Grant HL126495 Grant HL126496 Grant HL126497 Grant HL126499
Broekman ML et al.
Multidimensional communication in the microenvirons of glioblastoma.
Nat Rev Neurol (2018) 14:482-495.
Yeung TL et al.
Systematic identification of druggable epithelial-stromal crosstalk signaling networks in ovarian cancer.
J Natl Cancer Inst (2019) 111:272-282.
Grant CA179563 Grant TR000943
Gyorgy B et al.
CRISPR/Cas9 mediated disruption of the Swedish APP allele as a therapeutic approach for early-onset Alzheimer”s disease.
Mol Ther Nucleic Acids (2018) 11:429-440.
Grant CA179563 Grant HL126496
Marangoni F et al.
Tumor tolerance-promoting function of regulatory T cells is optimized by CD28, but strictly dependent on calcineurin.
J Immunol (2018) 200:3647-3661.
Ricklefs FL et al.
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Sci Adv (2018) 4:eaar2766.
exRNA and EV Biology EV Biology Grant CA179563 Grant TR000931 Grant HL126496
Shao H et al.
New technologies for analysis of extracellular vesicles.
Chem Rev (2018) 118:1917-1950.
Resources and Technology Grant CA179563
Hulsmans M et al.
Cardiac macrophages promote diastolic dysfunction.
J Exp Med (2018) 215:423-440.
Grant CA179563 Grant TR000901
Reategui E et al.
Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.
Nat Commun (2018) 9:175.
Biomarkers Grant CA179563 Grant DA036134
Chen X et al.
RNA interference-based therapy and its delivery systems.
Cancer Metastasis Rev (2018) 37:107-124.
Therapeutics Grant CA179563 Grant TR000943
Boussiotis VA & Charest A.
Immunotherapies for malignant glioma.
Oncogene (2018) 37:1121-1141.
Zheng L et al.
Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.
Nat Commun (2017) 8:1180.
Grant CA179563 Grant CA179564
Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.
Nat Commun (2017) 8:1145.
Biomarkers Resources and Technology Grant CA179563 Grant TR000931
Wu AY & Lai CP.
Tracking extracellular vesicles delivery and RNA translation using multiplexed reporters.
Methods Mol Biol (2017) 1660:255-265.
Resources and Technology Grant CA179563 Grant TR000943
Khvorova A & Watts JK.
The chemical evolution of oligonucleotide therapies of clinical utility.
Nat Biotechnol (2017) 35:238-248.
Highly Cited (400+) Grant TR000888 Grant CA179563
Yeo AT & Charest A.
Immune checkpoint blockade biology in mouse models of glioblastoma.
J Cell Biochem (2017) 118:2516-2527.
Grant CA179512 Grant CA179563
Baldwin S et al.
Analyzing the miRNA content of extracellular vesicles by fluorescence nanoparticle tracking.
Nanomedicine (2017) 13:765-770.
Resources and Technology Grant CA179563 Grant TR000914
Maas SL, Breakefield XO & Weaver AM.
Extracellular vesicles: Unique intercellular delivery vehicles.
Trends Cell Biol (2017) 27:172-188.
Review exRNA and EV Biology EV Biology Therapeutics Grant CA179563 Grant CA179514 Grant TR000943
Didiot MC et al.
Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing.
Mol Ther (2016) 24:1836-1847.
Therapeutics Grant TR000888 Grant CA179563
Fetal bovine serum RNA interferes with the cell culture derived extracellular RNA.
Sci Rep (2016) 6:31175.
Fritz JV et al.
Sources and functions of extracellular small RNAs in human circulation.
Annu Rev Nutr (2016) 36:301-36.
Review exRNA and EV Biology exRNA Biology Grant CA179563 Grant HL126496
Soares VY et al.
Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.
Neuro Oncol (2016) 18:1498-1507.
exRNA and EV Biology EV Biology Grant CA179563 Grant TR000891
Akers JC et al.
Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid.
Cancer Biomark (2016) 17:125-32.
Resources and Technology Grant CA179563 Grant TR000931
Abels ER & Breakefield XO.
Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.
Cell Mol Neurobiol (2016) 36:301-12.
Highly Cited (550+) Review exRNA and EV Biology EV Biology Grant CA179563 Grant DA036134
Zappulli V et al.
Extracellular vesicles and intercellular communication within the nervous system.
J Clin Invest (2016) 126:1198-207.
Review exRNA and EV Biology EV Biology Grant CA179563 Grant TR000875
Putman TE et al.
Centralizing content and distributing labor: a community model for curating the very long tail of microbial genomes.
Database (Oxford) (2016) 2016:baw028.
Grant CA179563 Grant DA036134
Hall J et al.
Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson”s disease, glioma, and schwannoma.
Cell Mol Neurobiol (2016) 36:417-27.
Review Therapeutics Grant CA179563 Grant TR000884
Pucci F et al.
SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.
Science (2016) 352:242-6.
Rytelewski M et al.
Reciprocal positive selection for weakness – preventing olaparib resistance by inhibiting BRCA2.
Oncotarget (2016) 7:20825-39.
Extracellular vesicles: Composition, biological relevance, and methods of study.
Bioscience (2015) 65:783-797.
Review exRNA and EV Biology Resources and Technology Grant CA179563 Grant TR000943
van der Vos KE et al.
Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.
Neuro Oncol (2016) 18:58-69.
Lai CP et al.
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Nat Commun (2015) 6:7029.
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.
Nat Commun (2015) 6:6999.
Highly Cited (350+) Resources and Technology Grant CA179563
Wong HK et al.
The Cancer Genome Atlas analysis predicts microRNA for targeting cancer growth and vascularization in glioblastoma.
Mol Ther (2015) 23:1234-47.
Grant CA179563 Grant TR000880
miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients.
J Neurooncol (2015) 123:205-16.
Biomarkers Grant CA179563 Grant TR000931
Boukouris S & Mathivanan S.
Exosomes in bodily fluids are a highly stable resource of disease biomarkers.
Proteomics Clin Appl (2015) 9:358-67.
Review Biomarkers Grant CA179563 Grant DA036134
Martinez GJ et al.
The transcription factor NFAT promotes exhaustion of activated CD8(+) T cells.
Immunity (2015) 42:265-78.
Ren A et al.
In-line alignment and Mg(2)(+) coordination at the cleavage site of the env22 twister ribozyme.
Nat Commun (2014) 5:5534.
Rajendran L et al.
Emerging roles of extracellular vesicles in the nervous system.
J Neurosci (2014) 34:15482-9.
Kawikova I & Askenase PW.
Diagnostic and therapeutic potentials of exosomes in CNS diseases.
Brain Res (2015) 1617:63-71.
Review EV Biology Biomarkers Therapeutics Grant CA179563 Grant DA036134
Godlewski J et al.
Belonging to a network–microRNAs, extracellular vesicles, and the glioblastoma microenvironment.
Neuro Oncol (2015) 17:652-62.
Therapeutic applications of extracellular vesicles: Clinical promise and open questions.
Annu Rev Pharmacol Toxicol (2015) 55:439-64.
Highly Cited (300+) Review Therapeutics Grant CA179563 Grant TR000943
Han C et al.
The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.
Cell Rep (2014) 8:1447-60.
Maguire CA et al.
Gene therapy for the nervous system: Challenges and new strategies.
Neurotherapeutics (2014) 11:817-39.
Grant TR000928 Grant CA179563
Yakob M et al.
Salivary biomarkers for detection of oral squamous cell carcinoma – Current state and recent advances.
Curr Oral Health Rep (2014) 1:133-141.
Review Biomarkers Grant CA179563 Grant TR000923
Nery FC et al.
Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia.
J Neurosci Methods (2014) 232:181-8.
Grant CA179563 Grant TR000884
Mu J et al.
Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.
Mol Nutr Food Res (2014) 58:1561-73.
exRNA and EV Biology EV Biology Grant CA179563 Grant TR000875
Bauer CA et al.
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
J Clin Invest (2014) 124:2425-40.
Yang L et al.
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.
Mol Syst Biol (2014) 10:728.
Redzic JS et al.
Extracellular RNA mediates and marks cancer progression.
Semin Cancer Biol (2014) 28:14-23.
Review exRNA and EV Biology EV Biology Biomarkers Grant CA179563 Grant TR000880
Zhang H et al.
Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.
Breast Cancer Res (2014) 16:R36.
Grant CA179563 Grant TR000902
Vader P, Breakefield XO & Wood MJ.
Extracellular vesicles: Emerging targets for cancer therapy.
Trends Mol Med (2014) 20:385-393.
Highly Cited (250+) Review Therapeutics Grant CA179563 Grant TR000875
Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.
ACS Nano (2014) 8:483-94.
Highly Cited (400+) exRNA and EV Biology EV Biology Resources and Technology Grant CA179563 Grant TR000884
Jun HJ, Bronson RT & Charest A.
Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.
Stem Cells (2014) 32:338-48.
Gonda DD et al.
Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.
Neurosurgery (2013) 72:501-10.
Review exRNA and EV Biology EV Biology Biomarkers Therapeutics Grant CA179563 Grant TR000931
