The Extracellular RNA Communication Consortium has published 800+ research articles since its inception in 2013. Articles in the category “Reviews” are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.
Jeppesen DK et al.
Extracellular vesicles and nanoparticles: Emerging complexities.
Trends Cell Biol AOP 2023-02-01.
Halushka MK & Witwer KW.
Letter by Halushka and Witwer regarding article, “Circulating microRNA-122-5p is associated with a lack of improvement in left ventricular function after transcatheter aortic valve replacement and regulates viability of cardiomyocytes through extracellular vesicles”.
Circulation (2023) 147:e64-e65.
Witwer KW & Wolfram J.
Extracellular vesicles versus synthetic nanoparticles for drug delivery.
Nat Rev Mater (2021) 6:103-106.
Mateescu B et al.
Phase 2 of Extracellular RNA Communication Consortium charts next-generation approaches for extracellular RNA research.
iScience (2022) 25:104653.
Arifin DR, Witwer KW & Bulte JWM.
Non-invasive imaging of extracellular vesicles: Quo vaditis in vivo?
J Extracell Vesicles (2022) 11:e12241.
Glass SE & Coffey RJ.
Recent advances in the study of extracellular vesicles in colorectal cancer.
Gastroenterology (2022) 163:1188-1197.
Rufo J et al.
A sound approach to advancing healthcare systems: the future of biomedical acoustics.
Nat Commun (2022) 13:3459.
Morris KV & Witwer KW.
The evolving paradigm of extracellular vesicles in intercellular signaling and delivery of therapeutic RNAs.
Mol Ther (2022) 30:2393-2394.
Gomes DE & Witwer KW.
L1CAM-associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization.
J Extracell Biol (2022) 1.
Chen B et al.
Targeting non-coding RNAs to overcome cancer therapy resistance.
Signal Transduct Target Ther (2022) 7:121.
Alexander RP et al.
Open problems in extracellular RNA data analysis: Insights from an ERCC online workshop.
Front Genet (2021) 12:778416.
Couch Y et al.
A brief history of nearly EV-erything – The rise and rise of extracellular vesicles.
J Extracell Vesicles (2021) 10:e12144.
Dragomir MP, Knutsen E & Calin GA.
Classical and noncanonical functions of miRNAs in cancers.
Trends Genet (2022) 38:379-394.
Verweij FJ et al.
The power of imaging to understand extracellular vesicle biology in vivo.
Nat Methods (2021) 18:1013-1026.
Pusic KM et al.
Environmental enrichment and its benefits for migraine: Dendritic cell extracellular vesicles as an effective mimetic.
J Cell Immunol (2021) 3:215-225.
Winkle M et al.
Noncoding RNA therapeutics – challenges and potential solutions.
Nat Rev Drug Discov (2021) 20:629-651.
Witwer KW.
On your MARCKS, get set, deliver: Engineering extracellular vesicles.
Mol Ther (2021) 29:1664-1665.
Gruner HN & McManus MT.
Examining the evidence for extracellular RNA function in mammals.
Nat Rev Genet (2021) 22:448-458.
Tallon C et al.
Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.
Drug Discov Today (2021) 26:1656-1668.
Noren Hooten N et al.
Hitting the bullseye: Are extracellular vesicles on target?
J Extracell Vesicles (2020) 10:e12032.
Nguyen VVT et al.
Functional assays to assess the therapeutic potential of extracellular vesicles.
J Extracell Vesicles (2020) 10:e12033.
Saheera S et al.
Extracellular vesicle interplay in cardiovascular pathophysiology.
Am J Physiol Heart Circ Physiol (2021) 320:H1749-H1761.
Tosar JP, Witwer K & Cayota A.
Revisiting extracellular RNA release, processing, and function.
Trends Biochem Sci (2021) 46:438-445.
Silverman DA et al.
Cancer-associated neurogenesis and nerve-cancer cross-talk.
Cancer Res (2021) 81:1431-1440.
Xie Y et al.
Microfluidic isolation and enrichment of nanoparticles.
ACS Nano (2020) 14:16220–16240.
Nieland L et al.
Extracellular vesicle-mediated bilateral communication between glioblastoma and astrocytes.
Trends Neurosci (2021) 44:215-226.
Anfossi S & Calin GA.
Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy.
Cancer Drug Resist (2020) 3:356-370.
Kaczor-Urbanowicz KE et al.
Reviews on current liquid biopsy for detection and management of pancreatic cancers.
Pancreas (2020) 49:1141-1152.
Xiao Y et al.
How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger.
J Extracell Vesicles (2020) 9:1793515.
Suea-Ngam A et al.
Enzyme-assisted nucleic acid detection for infectious disease diagnostics: Moving toward the point-of-care.
ACS Sens (2020) 5:2701-2723.
Charest A.
Experimental and biological insights from proteomic analyses of extracellular vesicle cargos in normalcy and disease.
Adv Biosyst (2020) 4:e2000069.
Drula R et al.
MicroRNAs from liquid biopsy derived extracellular vesicles: Recent advances in detection and characterization methods.
Cancers (Basel) (2020) 12:2009.
Koupenova M & Freedman JE.
Platelets and immunity: Going viral.
Arterioscler Thromb Vasc Biol (2020) 40:1605-1607.
Yekula A et al.
Liquid biopsy strategies to distinguish progression from pseudoprogression and radiation necrosis in glioblastomas.
Adv Biosyst (2020) 4:e2000029.
O’Brien K et al.
RNA delivery by extracellular vesicles in mammalian cells and its applications.
Nat Rev Mol Cell Biol (2020) 21:585-606.
Tran AM et al.
A new world of biomarkers and therapeutics for female reproductive system and breast cancers: Circular RNAs.
Front Cell Dev Biol (2020) 8:50.
Wang C, Senapati S & Chang HC.
Liquid biopsy technologies based on membrane microfluidics: High-yield purification and selective quantification of biomarkers in nanocarriers.
Electrophoresis (2020) 41:1878-1892.
Yekula A et al.
Extracellular vesicles in glioblastoma tumor microenvironment.
Front Immunol (2019) 10:3137.
De Los Santos MC, Dragomir MP & Calin GA.
The role of exosomal long non-coding RNAs in cancer drug resistance.
Cancer Drug Resist (2019) 2:1178-1192.
Weaver AM & Patton JG.
Argonautes in extracellular vesicles: Artifact or selected cargo?
Cancer Res (2020) 80:379-381.
Kaczor-Urbanowicz KE et al.
Clinical validity of saliva and novel technology for cancer detection.
Biochim Biophys Acta Rev Cancer (2019) 1872:49-59.
Petrescu GED et al.
MicroRNA based theranostics for brain cancer: Basic principles.
J Exp Clin Cancer Res (2019) 38:231.
Wiklander OPB et al.
Advances in therapeutic applications of extracellular vesicles.
Sci Transl Med (2019) 11:eaav8521.
Bruno S et al.
Role of extracellular vesicles in stem cell biology.
Am J Physiol Cell Physiol (2019) 317:C303-C313.
Watts JK, Brown RH & Khvorova A.
Nucleic acid therapeutics for neurological diseases.
Neurotherapeutics (2019) 16:245-247.
Das S et al.
The Extracellular RNA Communication Consortium: Establishing foundational knowledge and technologies for extracellular RNA research.
Cell (2019) 177:231-242.
Schmittgen TD.
Exosomal miRNA cargo as mediator of immune escape mechanisms in neuroblastoma.
Cancer Res (2019) 79:1293-1294.
Liu B et al.
Interplay between miRNAs and host genes and their role in cancer.
Brief Funct Genomics (2018) 18:255-266.
Krichevsky AM & Uhlmann EJ.
Oligonucleotide therapeutics as a new class of drugs for malignant brain tumors: Targeting mRNAs, regulatory RNAs, mutations, combinations, and beyond.
Neurotherapeutics (2019) 16:319-347.
Gulei D et al.
CRISPR-based RNA editing: Diagnostic applications and therapeutic options.
Expert Rev Mol Diagn (2019) 19:83-88.
Axtell MJ.
Second to none: Plant secondary siRNAs as defensive agents against phytophthora.
Cell Host Microbe (2019) 25:7-9.
LaFargue CJ et al.
Exploring and comparing adverse events between PARP inhibitors.
Lancet Oncol (2019) 20:e15-e28.
Shah R, Patel T & Freedman JE.
Circulating extracellular vesicles in human disease.
N Engl J Med (2018) 379:2180-2181.
Bei Y et al.
Circular RNAs as potential theranostics in the cardiovascular system.
Mol Ther Nucleic Acids (2018) 13:407-418.
Moirangthem A & Patel T.
Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.
Biotarget (2017) 1:12.
Dragomir M, Chen B & Calin GA.
Exosomal lncRNAs as new players in cell-to-cell communication.
Transl Cancer Res (2018) 7:S243-S252.
Raffai RL.
MicroRNA-146a and hematopoiesis: Friend or foe in atherosclerosis.
Noncoding RNA Investig (2018) 2:43.
Sung BH & Weaver AM.
Directed migration: Cells navigate by extracellular vesicles.
J Cell Biol (2018) 217:2613-2614.
Dragomir M & Calin GA.
Circular RNAs in cancer – Lessons learned from microRNAs.
Front Oncol (2018) 8:179.
Haemmerle M et al.
The platelet lifeline to cancer: Challenges and opportunities.
Cancer Cell (2018) 33:965-983.
Nonaka T & Wong DTW.
Liquid biopsy in head and neck cancer: Promises and challenges.
J Dent Res (2018) 97:701-708.
Roy S, Hochberg FH & Jones PS.
Extracellular vesicles: the growth as diagnostics and therapeutics; a survey.
J Extracell Vesicles (2018) 7:1438720.
Baecher-Allan C, Kaskow BJ & Weiner HL.
Multiple Sclerosis: Mechanisms and immunotherapy.
Neuron (2018) 97:742-768.
Bei Y et al.
Extracellular vesicles in cardiovascular theranostics.
Theranostics (2017) 7:4168-4182.
Bayraktar R, Van Roosbroeck K & Calin GA.
Cell-to-cell communication: microRNAs as hormones.
Mol Oncol (2017) 11:1673-1686.
Wu X et al.
The many faces of long noncoding RNAs in cancer.
Antioxid Redox Signal (2018) 29:922-935.
Ochocinska MJ et al.
NIH workshop report on the trans-agency Blood-Brain Interface Workshop 2016: Exploring key challenges and opportunities associated with the blood, brain and their interface.
Fluids Barriers CNS (2017) 14:12.
Camarda R, Williams J & Goga A.
In vivo reprogramming of cancer metabolism by MYC.
Front Cell Dev Biol (2017) 5:35.
Klingenberg M et al.
Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.
J Hepatol (2017) 67:603-618.
Mateescu B et al.
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper.
J Extracell Vesicles (2017) 6:1286095.
Sutaria DS et al.
Achieving the promise of therapeutic extracellular vesicles: The devil is in details of therapeutic loading.
Pharm Res (2017) 34:1053-1066.
Grossman RL et al.
Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.
Clin Pharmacol Ther (2017) 101:589-592.
Maji S et al.
Extracellular vesicles in liver diseases.
Am J Physiol Gastrointest Liver Physiol (2017) 312:G194-G200.
Lee I et al.
The importance of standardization on analyzing circulating RNA.
Mol Diagn Ther (2017) 21:259-268.
Maas SL, Breakefield XO & Weaver AM.
Extracellular vesicles: Unique intercellular delivery vehicles.
Trends Cell Biol (2017) 27:172-188.
Wang X, Kaczor-Urbanowicz KE & Wong DT.
Salivary biomarkers in cancer detection.
Med Oncol (2017) 34:7.
Matsuda A et al.
MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.
Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.
Kaczor-Urbanowicz KE et al.
Saliva diagnostics – Current views and directions.
Exp Biol Med (Maywood) (2017) 242:459-472.
Kaczor-Urbanowicz KE et al.
Emerging technologies for salivaomics in cancer detection.
J Cell Mol Med (2017) 21:640-647.
Nazimek K, Bryniarski K & Askenase PW.
Functions of exosomes and microbial extracellular vesicles in allergy and contact and delayed-type hypersensitivity.
Int Arch Allergy Immunol (2016) 171:1-26.
Ghai V & Wang K.
Recent progress toward the use of circulating microRNAs as clinical biomarkers.
Arch Toxicol (2016) 90:2959-2978.
Paladini L et al.
Targeting microRNAs as key modulators of tumor immune response.
J Exp Clin Cancer Res (2016) 35:103.
Srivastava A et al.
Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer.
J Biomed Nanotechnol (2016) 12:1159-73.
Fritz JV et al.
Sources and functions of extracellular small RNAs in human circulation.
Annu Rev Nutr (2016) 36:301-36.
Abels ER & Breakefield XO.
Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.
Cell Mol Neurobiol (2016) 36:301-12.
Zappulli V et al.
Extracellular vesicles and intercellular communication within the nervous system.
J Clin Invest (2016) 126:1198-207.
Hall J et al.
Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson’s disease, glioma, and schwannoma.
Cell Mol Neurobiol (2016) 36:417-27.
Parasramka MA et al.
Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.
Pharmacol Ther (2016) 161:67-78.
Byron SA et al.
Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.
Nat Rev Genet (2016) 17:257-71. Related blog post
Rennert RC, Hochberg FH & Carter BS.
ExRNA in biofluids as biomarkers for brain tumors.
Cell Mol Neurobiol (2016) 36:353-60.
Almeida MI & Calin GA.
The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.
Genome Med (2016) 8:29.
Zaborowski MP et al.
Extracellular vesicles: Composition, biological relevance, and methods of study.
Bioscience (2015) 65:783-797.
Zhang X et al.
Potential transfer of polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington’s disease: Background and evaluation in cell culture.
Cell Mol Neurobiol (2016) 36:459-70.
Rupaimoole R et al.
miRNA deregulation in cancer cells and the tumor microenvironment.
Cancer Discov (2016) 6:235-46.
Melman YF et al.
Response to letter regarding article, “Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study”
Circulation (2016) 133:e389-90.
Clancy L & Freedman JE.
Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.
Circ Res (2016) 118:374-6.
Fabris L et al.
The potential of microRNAs as prostate cancer biomarkers.
Eur Urol (2016) 70:312-22.
Lener T et al.
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper.
J Extracell Vesicles (2015) 4:30087.
Machtinger R, Laurent LC & Baccarelli AA.
Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation.
Hum Reprod Update (2016) 22:182-93.
Mohankumar S & Patel T.
Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.
Brief Funct Genomics (2016) 15:249-56.
Monroig-Bosque Pdel C, Rivera CA & Calin GA.
MicroRNAs in cancer therapeutics: “From the bench to the bedside”.
Expert Opin Biol Ther (2015) 15:1381-5.
Ainsztein AM et al.
The NIH Extracellular RNA Communication Consortium.
J Extracell Vesicles (2015) 4:27493.
Quesenberry PJ et al.
Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.
J Extracell Vesicles (2015) 4:27575.
Patton JG et al.
Biogenesis, delivery, and function of extracellular RNA.
J Extracell Vesicles (2015) 4:27494.
Laurent LC et al.
Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.
J Extracell Vesicles (2015) 4:26533.
Quinn JF et al.
Extracellular RNAs: Development as biomarkers of human disease.
J Extracell Vesicles (2015) 4:27495.
Pua HH & Ansel KM.
MicroRNA regulation of allergic inflammation and asthma.
Curr Opin Immunol (2015) 36:101-8.
Pichler M & Calin GA.
MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.
Br J Cancer (2015) 113:569-73.
Simpson LJ & Ansel KM.
MicroRNA regulation of lymphocyte tolerance and autoimmunity.
J Clin Invest (2015) 125:2242-9.
Camussi G & Quesenberry PJ.
Perspectives on the potential therapeutic uses of vesicles.
Exosomes Microvesicles (2013) 1:6.
Lin X et al.
Noncoding RNAs in human saliva as potential disease biomarkers.
Front Genet (2015) 6:175.
Majem B et al.
Non-coding RNAs in saliva: Emerging biomarkers for molecular diagnostics.
Int J Mol Sci (2015) 16:8676-98.
Nouraee N, Mowla SJ & Calin GA.
Tracking miRNAs’ footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy.
Genes Chromosomes Cancer (2015) 54:335-52.
Simonson B & Das S.
MicroRNA therapeutics: the next magic bullet?
Mini Rev Med Chem (2015) 15:467-74.
Wong DT.
Salivary extracellular noncoding RNA: Emerging biomarkers for molecular diagnostics.
Clin Ther (2015) 37:540-51.
Xiao J et al.
A snapshot of genetic and epigenetic basis of arrhythmia and heart failure.
Front Genet (2015) 6:74.
Gardiner C et al.
Extracellular vesicles, tissue factor, cancer and thrombosis – Discussion themes of the ISEV 2014 Educational Day.
J Extracell Vesicles (2015) 4:26901.
Ciccone M, Calin GA & Perrotti D.
From the biology of PP2A to the PADs for therapy of hematologic malignancies.
Front Oncol (2015) 5:21.
Tewari M.
A functional extracellular transcriptome in animals? Implications for biology, disease and medicine.
Genome Biol (2015) 16:47.
Boukouris S & Mathivanan S.
Exosomes in bodily fluids are a highly stable resource of disease biomarkers.
Proteomics Clin Appl (2015) 9:358-67.
George J & Patel T.
Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
Semin Liver Dis (2015) 35:63-74.
Srivastava A et al.
Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.
Curr Gene Ther (2015) 15:182-92.
Lotvall J et al.
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles.
J Extracell Vesicles (2014) 3:26913.
Berindan-Neagoe I & Calin GA.
Molecular pathways: microRNAs, cancer cells, and microenvironment.
Clin Cancer Res (2014) 20:6247-53.
Danielson KM & Das S.
Extracellular vesicles in heart disease: Excitement for the future?
Exosomes Microvesicles (2014) 2:1.
Fuentes L, Yakob M & Wong DT.
Emerging horizons of salivary diagnostics for periodontal disease.
Br Dent J (2014) 217:567-73.
Rajendran L et al.
Emerging roles of extracellular vesicles in the nervous system.
J Neurosci (2014) 34:15482-9.
Sato-Kuwabara Y et al.
The fusion of two worlds: Non-coding RNAs and extracellular vesicles–Diagnostic and therapeutic implications.
Int J Oncol (2015) 46:17-27.
Gangoda L et al.
Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?
Proteomics (2015) 15:260-71.
Kawikova I & Askenase PW.
Diagnostic and therapeutic potentials of exosomes in CNS diseases.
Brain Res (2015) 1617:63-71.
Godlewski J et al.
Belonging to a network–microRNAs, extracellular vesicles, and the glioblastoma microenvironment.
Neuro Oncol (2015) 17:652-62.
Gyorgy B et al.
Therapeutic applications of extracellular vesicles: Clinical promise and open questions.
Annu Rev Pharmacol Toxicol (2015) 55:439-64.
Haga H & Patel T.
Molecular diagnosis of intrahepatic cholangiocarcinoma.
J Hepatobiliary Pancreat Sci (2015) 22:114-23.
Braicu C et al.
Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?
Cell Death Differ (2015) 22:34-45.
Thomas MF, L’Etoile ND & Ansel KM.
Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.
Trends Genet (2014) 30:298-307.
Yakob M et al.
Salivary biomarkers for detection of oral squamous cell carcinoma – Current state and recent advances.
Curr Oral Health Rep (2014) 1:133-141.
Redzic JS et al.
Extracellular RNA mediates and marks cancer progression.
Semin Cancer Biol (2014) 28:14-23.
Quesenberry PJ et al.
Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.
Front Oncol (2014) 4:56.
Patel T.
Extracellular vesicle noncoding RNA: New players in the diagnosis and pathogenesis of cholangiocarcinoma.
Hepatology (2014) 60:782-4.
Hochberg FH et al.
Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.
Expert Rev Mol Diagn (2014) 14:439-52.
Vader P, Breakefield XO & Wood MJ.
Extracellular vesicles: Emerging targets for cancer therapy.
Trends Mol Med (2014) 20:385-393.
Quesenberry PJ et al.
Cellular phenotype and extracellular vesicles: Basic and clinical considerations.
Stem Cells Dev (2014) 23:1429-36.
Pusic AD, Pusic KM & Kraig RP.
What are exosomes and how can they be used in Multiple Sclerosis therapy?
Expert Rev Neurother (2014) 14:353-5.
Takahashi K et al.
Long noncoding RNA in liver diseases.
Hepatology (2014) 60:744-53.
Clancy L & Freedman JE.
New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.
J Thromb Thrombolysis (2014) 37:12-6.
Akers JC et al.
Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.
J Neurooncol (2013) 113:1-11.
