The Extracellular RNA Communication Consortium has published 700+ research articles since its inception in 2013. Articles in the category “Reviews” are listed here in reverse chronological order. Each article is tagged by category; you can browse different categories using the drop-down menu at the top of the page or by clicking on the tags of multi-category articles.



Couch Y et al.

A brief history of nearly EV-erything – The rise and rise of extracellular vesicles.

J Extracell Vesicles (2021) 10:e12144.

Johansson K, Woodruff PG & Ansel KM.

Regulation of airway immunity by epithelial miRNAs.

Immunol Rev AOP 2021-09-21.

Verweij FJ et al.

The power of imaging to understand extracellular vesicle biology in vivo.

Nat Methods (2021) 18:1013-1026.

Pusic KM et al.

Environmental enrichment and its benefits for migraine: Dendritic cell extracellular vesicles as an effective mimetic.

J Cell Immunol (2021) 3:215-225.

Mohapatra S & Calin G.

JAM-ming miR-21.

Cell Death Differ (2021) 28:2837-2839.

Winkle M et al.

Noncoding RNA therapeutics – challenges and potential solutions.

Nat Rev Drug Discov (2021) 20:629-651.

Witwer KW.

On your MARCKS, get set, deliver: Engineering extracellular vesicles.

Mol Ther (2021) 29:1664-1665.

Gruner HN & McManus MT.

Examining the evidence for extracellular RNA function in mammals.

Nat Rev Genet (2021) 22:448-458.

Tallon C et al.

Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.

Drug Discov Today (2021) 26:1656-1668.

Nguyen VVT et al.

Functional assays to assess the therapeutic potential of extracellular vesicles.

J Extracell Vesicles (2020) 10:e12033.

Noren Hooten N et al.

Hitting the bullseye: Are extracellular vesicles on target?

J Extracell Vesicles (2020) 10:e12032.

Saheera S et al.

Extracellular vesicle interplay in cardiovascular pathophysiology.

Am J Physiol Heart Circ Physiol AOP 2021-03-05.

Tosar JP, Witwer K & Cayota A.

Revisiting extracellular RNA release, processing, and function.

Trends Biochem Sci (2021) 46:438-445.


Silverman DA et al.

Cancer-associated neurogenesis and nerve-cancer cross-talk.

Cancer Res (2021) 81:1431-1440.

Xie Y et al.

Microfluidic isolation and enrichment of nanoparticles.

ACS Nano (2020) 14:16220–16240.

Nieland L et al.

Extracellular vesicle-mediated bilateral communication between glioblastoma and astrocytes.

Trends Neurosci (2021) 44:215-226.

Anfossi S & Calin GA.

Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy.

Cancer Drug Resist (2020) 3:356-370.

Kaczor-Urbanowicz KE et al.

Reviews on current liquid biopsy for detection and management of pancreatic cancers.

Pancreas (2020) 49:1141-1152.

Xiao Y et al.

How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger.

J Extracell Vesicles (2020) 9:1793515.

Suea-Ngam A et al.

Enzyme-assisted nucleic acid detection for infectious disease diagnostics: Moving toward the point-of-care.

ACS Sens (2020) 5:2701-2723.

Charest A.

Experimental and biological insights from proteomic analyses of extracellular vesicle cargos in normalcy and disease.

Adv Biosyst (2020) 4:e2000069.

Drula R et al.

MicroRNAs from liquid biopsy derived extracellular vesicles: Recent advances in detection and characterization methods.

Cancers (Basel) (2020) 12:2009.

Koupenova M & Freedman JE.

Platelets and immunity: Going viral.

Arterioscler Thromb Vasc Biol (2020) 40:1605-1607.

Zhang P et al.

Acoustic microfluidics.

Annu Rev Anal Chem (Palo Alto Calif) (2020) 13:17-43.

Yekula A et al.

Liquid biopsy strategies to distinguish progression from pseudoprogression and radiation necrosis in glioblastomas.

Adv Biosyst (2020) 4:e2000029.

O’Brien K et al.

RNA delivery by extracellular vesicles in mammalian cells and its applications.

Nat Rev Mol Cell Biol (2020) 21:585-606.

Tran AM et al.

A new world of biomarkers and therapeutics for female reproductive system and breast cancers: Circular RNAs.

Front Cell Dev Biol (2020) 8:50.

Wang C, Senapati S & Chang HC.

Liquid biopsy technologies based on membrane microfluidics: High-yield purification and selective quantification of biomarkers in nanocarriers.

Electrophoresis (2020) 41:1878-1892.

Tosar JP & Cayota A.

Extracellular tRNAs and tRNA-derived fragments.

RNA Biol (2020) 17:1149-1167.

Yekula A et al.

Extracellular vesicles in glioblastoma tumor microenvironment.

Front Immunol (2019) 10:3137.


De Los Santos MC, Dragomir MP & Calin GA.

The role of exosomal long non-coding RNAs in cancer drug resistance.

Cancer Drug Resist (2019) 2:1178-1192.

Weaver AM & Patton JG.

Argonautes in extracellular vesicles: Artifact or selected cargo?

Cancer Res (2020) 80:379-381.

Pegtel DM & Gould SJ.


Annu Rev Biochem (2019) 88:487-514.

Kaczor-Urbanowicz KE et al.

Clinical validity of saliva and novel technology for cancer detection.

Biochim Biophys Acta Rev Cancer (2019) 1872:49-59.

Petrescu GED et al.

MicroRNA based theranostics for brain cancer: Basic principles.

J Exp Clin Cancer Res (2019) 38:231.

Wiklander OPB et al.

Advances in therapeutic applications of extracellular vesicles.

Sci Transl Med (2019) 11:eaav8521.

Bruno S et al.

Role of extracellular vesicles in stem cell biology.

Am J Physiol Cell Physiol (2019) 317:C303-C313.

Watts JK, Brown RH & Khvorova A.

Nucleic acid therapeutics for neurological diseases.

Neurotherapeutics (2019) 16:245-247.

Das S et al.

The Extracellular RNA Communication Consortium: Establishing foundational knowledge and technologies for extracellular RNA research.

Cell (2019) 177:231-242.

Schmittgen TD.

Exosomal miRNA cargo as mediator of immune escape mechanisms in neuroblastoma.

Cancer Res (2019) 79:1293-1294.

Bach DH, Lee SK & Sood AK.

Circular RNAs in Cancer.

Mol Ther Nucleic Acids (2019) 16:118-129.

Liu B et al.

Interplay between miRNAs and host genes and their role in cancer.

Brief Funct Genomics (2018) 18:255-266.

Krichevsky AM & Uhlmann EJ.

Oligonucleotide therapeutics as a new class of drugs for malignant brain tumors: Targeting mRNAs, regulatory RNAs, mutations, combinations, and beyond.

Neurotherapeutics (2019) 16:319-347.

Gulei D et al.

CRISPR-based RNA editing: Diagnostic applications and therapeutic options.

Expert Rev Mol Diagn (2019) 19:83-88.

Axtell MJ.

Second to none: Plant secondary siRNAs as defensive agents against phytophthora.

Cell Host Microbe (2019) 25:7-9.

LaFargue CJ et al.

Exploring and comparing adverse events between PARP inhibitors.

Lancet Oncol (2019) 20:e15-e28.


Shah R, Patel T & Freedman JE.

Circulating extracellular vesicles in human disease.

N Engl J Med (2018) 379:2180-2181.

Bei Y et al.

Circular RNAs as potential theranostics in the cardiovascular system.

Mol Ther Nucleic Acids (2018) 13:407-418.

Moirangthem A & Patel T.

Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.

Biotarget (2017) 1:12.

Dragomir M, Chen B & Calin GA.

Exosomal lncRNAs as new players in cell-to-cell communication.

Transl Cancer Res (2018) 7:S243-S252.

Raffai RL.

MicroRNA-146a and hematopoiesis: Friend or foe in atherosclerosis.

Noncoding RNA Investig (2018) 2:43.

Sung BH & Weaver AM.

Directed migration: Cells navigate by extracellular vesicles.

J Cell Biol (2018) 217:2613-2614.

Dragomir M & Calin GA.

Circular RNAs in cancer – Lessons learned from microRNAs.

Front Oncol (2018) 8:179.

Haemmerle M et al.

The platelet lifeline to cancer: Challenges and opportunities.

Cancer Cell (2018) 33:965-983.

Nonaka T & Wong DTW.

Liquid biopsy in head and neck cancer: Promises and challenges.

J Dent Res (2018) 97:701-708.

Roy S, Hochberg FH & Jones PS.

Extracellular vesicles: the growth as diagnostics and therapeutics; a survey.

J Extracell Vesicles (2018) 7:1438720.

Baecher-Allan C, Kaskow BJ & Weiner HL.

Multiple Sclerosis: Mechanisms and immunotherapy.

Neuron (2018) 97:742-768.


Bei Y et al.

Extracellular vesicles in cardiovascular theranostics.

Theranostics (2017) 7:4168-4182.
Related Pathway


Bayraktar R, Van Roosbroeck K & Calin GA.

Cell-to-cell communication: microRNAs as hormones.

Mol Oncol (2017) 11:1673-1686.

Shankar GM et al.

Liquid biopsy for brain tumors.

Expert Rev Mol Diagn (2017) 17:943-947.

Wu X et al.

The many faces of long noncoding RNAs in cancer.

Antioxid Redox Signal (2018) 29:922-935.

Ochocinska MJ et al.

NIH workshop report on the trans-agency Blood-Brain Interface Workshop 2016: Exploring key challenges and opportunities associated with the blood, brain and their interface.

Fluids Barriers CNS (2017) 14:12.

Camarda R, Williams J & Goga A.

In vivo reprogramming of cancer metabolism by MYC.

Front Cell Dev Biol (2017) 5:35.

Klingenberg M et al.

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.

J Hepatol (2017) 67:603-618.
Related Pathways: 1, 2


Mateescu B et al.

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper.

J Extracell Vesicles (2017) 6:1286095.

Sutaria DS et al.

Achieving the promise of therapeutic extracellular vesicles: The devil is in details of therapeutic loading.

Pharm Res (2017) 34:1053-1066.

Mick E et al.

Stroke and circulating extracellular RNAs.

Stroke (2017) 48:828-834.

Nolan JP & Jones JC.

Detection of platelet vesicles by flow cytometry.

Platelets (2017) 28:256-262.

Grossman RL et al.

Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium.

Clin Pharmacol Ther (2017) 101:589-592.

Maji S et al.

Extracellular vesicles in liver diseases.

Am J Physiol Gastrointest Liver Physiol (2017) 312:G194-G200.

Lee I et al.

The importance of standardization on analyzing circulating RNA.

Mol Diagn Ther (2017) 21:259-268.


Maas SL, Breakefield XO & Weaver AM.

Extracellular vesicles: Unique intercellular delivery vehicles.

Trends Cell Biol (2017) 27:172-188.

Wang X, Kaczor-Urbanowicz KE & Wong DT.

Salivary biomarkers in cancer detection.

Med Oncol (2017) 34:7.

Matsuda A et al.

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases.

Best Pract Res Clin Endocrinol Metab (2016) 30:577-590.

Kaczor-Urbanowicz KE et al.

Saliva diagnostics – Current views and directions.

Exp Biol Med (Maywood) (2017) 242:459-472.

Kaczor-Urbanowicz KE et al.

Emerging technologies for salivaomics in cancer detection.

J Cell Mol Med (2017) 21:640-647.

Nazimek K, Bryniarski K & Askenase PW.

Functions of exosomes and microbial extracellular vesicles in allergy and contact and delayed-type hypersensitivity.

Int Arch Allergy Immunol (2016) 171:1-26.

Shah MY et al.

microRNA therapeutics in cancer – an emerging concept.

EBioMedicine (2016) 12:34-42.

Ghai V & Wang K.

Recent progress toward the use of circulating microRNAs as clinical biomarkers.

Arch Toxicol (2016) 90:2959-2978.

Paladini L et al.

Targeting microRNAs as key modulators of tumor immune response.

J Exp Clin Cancer Res (2016) 35:103.

Srivastava A et al.

Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer.

J Biomed Nanotechnol (2016) 12:1159-73.

Fritz JV et al.

Sources and functions of extracellular small RNAs in human circulation.

Annu Rev Nutr (2016) 36:301-36.

Abels ER & Breakefield XO.

Introduction to extracellular vesicles: Biogenesis, RNA cargo selection, content, release, and uptake.

Cell Mol Neurobiol (2016) 36:301-12.

Zappulli V et al.

Extracellular vesicles and intercellular communication within the nervous system.

J Clin Invest (2016) 126:1198-207.

Hall J et al.

Delivery of therapeutic proteins via extracellular vesicles: Review and potential treatments for Parkinson’s disease, glioma, and schwannoma.

Cell Mol Neurobiol (2016) 36:417-27.

Parasramka MA et al.

Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.

Pharmacol Ther (2016) 161:67-78.
Related Pathway


Byron SA et al.

Translating RNA sequencing into clinical diagnostics: Opportunities and challenges.

Nat Rev Genet (2016) 17:257-71. Related blog post

Rennert RC, Hochberg FH & Carter BS.

ExRNA in biofluids as biomarkers for brain tumors.

Cell Mol Neurobiol (2016) 36:353-60.

Almeida MI & Calin GA.

The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.

Genome Med (2016) 8:29.

Zhang X et al.

Potential transfer of polyglutamine and CAG-repeat RNA in extracellular vesicles in Huntington’s disease: Background and evaluation in cell culture.

Cell Mol Neurobiol (2016) 36:459-70.

Zaborowski MP et al.

Extracellular vesicles: Composition, biological relevance, and methods of study.

Bioscience (2015) 65:783-797.

Rupaimoole R et al.

miRNA deregulation in cancer cells and the tumor microenvironment.

Cancer Discov (2016) 6:235-46.

Melman YF et al.

Response to letter regarding article, “Circulating microRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis: A translational pilot study”

Circulation (2016) 133:e389-90.

Clancy L & Freedman JE.

Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.

Circ Res (2016) 118:374-6.

Fabris L et al.

The potential of microRNAs as prostate cancer biomarkers.

Eur Urol (2016) 70:312-22.

Lener T et al.

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper.

J Extracell Vesicles (2015) 4:30087.


Giza DE & Calin GA

microRNA and Chronic Lymphocytic Leukemia.

Adv Exp Med Biol (2015) 889:23-40.

Machtinger R, Laurent LC & Baccarelli AA.

Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation.

Hum Reprod Update (2016) 22:182-93.

Mohankumar S & Patel T.

Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.

Brief Funct Genomics (2016) 15:249-56.

Monroig-Bosque Pdel C, Rivera CA & Calin GA.

MicroRNAs in cancer therapeutics: “From the bench to the bedside”.

Expert Opin Biol Ther (2015) 15:1381-5.

Patton JG et al.

Biogenesis, delivery, and function of extracellular RNA.

J Extracell Vesicles (2015) 4:27494.

Ainsztein AM et al.

The NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27493.

Quesenberry PJ et al.

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:27575.

Laurent LC et al.

Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.

J Extracell Vesicles (2015) 4:26533.

Quinn JF et al.

Extracellular RNAs: Development as biomarkers of human disease.

J Extracell Vesicles (2015) 4:27495.

Pua HH & Ansel KM.

MicroRNA regulation of allergic inflammation and asthma.

Curr Opin Immunol (2015) 36:101-8.

Pichler M & Calin GA.

MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.

Br J Cancer (2015) 113:569-73.

Simpson LJ & Ansel KM.

MicroRNA regulation of lymphocyte tolerance and autoimmunity.

J Clin Invest (2015) 125:2242-9.

Camussi G & Quesenberry PJ.

Perspectives on the potential therapeutic uses of vesicles.

Exosomes Microvesicles (2013) 1:6.

Lin X et al.

Noncoding RNAs in human saliva as potential disease biomarkers.

Front Genet (2015) 6:175.

Majem B et al.

Non-coding RNAs in saliva: Emerging biomarkers for molecular diagnostics.

Int J Mol Sci (2015) 16:8676-98.

Nouraee N, Mowla SJ & Calin GA.

Tracking miRNAs’ footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy.

Genes Chromosomes Cancer (2015) 54:335-52.

Saugstad JA.

Non-coding RNAs in stroke and neuroprotection.

Front Neurol (2015) 6:50.

Simonson B & Das S.

MicroRNA therapeutics: the next magic bullet?

Mini Rev Med Chem (2015) 15:467-74.

Wong DT.

Salivary extracellular noncoding RNA: Emerging biomarkers for molecular diagnostics.

Clin Ther (2015) 37:540-51.

Xiao J et al.

A snapshot of genetic and epigenetic basis of arrhythmia and heart failure.

Front Genet (2015) 6:74.

Gardiner C et al.

Extracellular vesicles, tissue factor, cancer and thrombosis – Discussion themes of the ISEV 2014 Educational Day.

J Extracell Vesicles (2015) 4:26901.

Ciccone M, Calin GA & Perrotti D.

From the biology of PP2A to the PADs for therapy of hematologic malignancies.

Front Oncol (2015) 5:21.

Tewari M.

A functional extracellular transcriptome in animals? Implications for biology, disease and medicine.

Genome Biol (2015) 16:47.

Boukouris S & Mathivanan S.

Exosomes in bodily fluids are a highly stable resource of disease biomarkers.

Proteomics Clin Appl (2015) 9:358-67.

George J & Patel T.

Noncoding RNA as therapeutic targets for hepatocellular carcinoma.

Semin Liver Dis (2015) 35:63-74.


Lotvall J et al.

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles.

J Extracell Vesicles (2014) 3:26913.

Srivastava A et al.

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment.

Curr Gene Ther (2015) 15:182-92.

Berindan-Neagoe I & Calin GA.

Molecular pathways: microRNAs, cancer cells, and microenvironment.

Clin Cancer Res (2014) 20:6247-53.

Danielson KM & Das S.

Extracellular vesicles in heart disease: Excitement for the future?

Exosomes Microvesicles (2014) 2:1.
Related Pathway


Fuentes L, Yakob M & Wong DT.

Emerging horizons of salivary diagnostics for periodontal disease.

Br Dent J (2014) 217:567-73.

Rajendran L et al.

Emerging roles of extracellular vesicles in the nervous system.

J Neurosci (2014) 34:15482-9.

Sato-Kuwabara Y et al.

The fusion of two worlds: Non-coding RNAs and extracellular vesicles–Diagnostic and therapeutic implications.

Int J Oncol (2015) 46:17-27.

Gangoda L et al.

Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?

Proteomics (2015) 15:260-71.
Related Pathway


Kawikova I & Askenase PW.

Diagnostic and therapeutic potentials of exosomes in CNS diseases.

Brain Res (2015) 1617:63-71.

Godlewski J et al.

Belonging to a network–microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

Neuro Oncol (2015) 17:652-62.

Gyorgy B et al.

Therapeutic applications of extracellular vesicles: Clinical promise and open questions.

Annu Rev Pharmacol Toxicol (2015) 55:439-64.

Haga H & Patel T.

Molecular diagnosis of intrahepatic cholangiocarcinoma.

J Hepatobiliary Pancreat Sci (2015) 22:114-23.

Braicu C et al.

Exosomes as divine messengers: Are they the Hermes of modern molecular oncology?

Cell Death Differ (2015) 22:34-45.

Thomas MF, L’Etoile ND & Ansel KM.

Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.

Trends Genet (2014) 30:298-307.
Related Pathway


Yakob M et al.

Salivary biomarkers for detection of oral squamous cell carcinoma – Current state and recent advances.

Curr Oral Health Rep (2014) 1:133-141.

Redzic JS et al.

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol (2014) 28:14-23.

Quesenberry PJ et al.

Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.

Front Oncol (2014) 4:56.

Patel T.

Extracellular vesicle noncoding RNA: New players in the diagnosis and pathogenesis of cholangiocarcinoma.

Hepatology (2014) 60:782-4.

Hochberg FH et al.

Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science.

Expert Rev Mol Diagn (2014) 14:439-52.

Vader P, Breakefield XO & Wood MJ.

Extracellular vesicles: Emerging targets for cancer therapy.

Trends Mol Med (2014) 20:385-393.

Quesenberry PJ et al.

Cellular phenotype and extracellular vesicles: Basic and clinical considerations.

Stem Cells Dev (2014) 23:1429-36.

Pusic AD, Pusic KM & Kraig RP.

What are exosomes and how can they be used in Multiple Sclerosis therapy?

Expert Rev Neurother (2014) 14:353-5.

Takahashi K et al.

Long noncoding RNA in liver diseases.

Hepatology (2014) 60:744-53.
Related Pathway



Clancy L & Freedman JE.

New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.

J Thromb Thrombolysis (2014) 37:12-6.

Akers JC et al.

Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.

J Neurooncol (2013) 113:1-11.

Quesenberry PJ et al.

A new stem cell biology: the continuum and microvesicles.

Trans Am Clin Climatol Assoc (2012) 123:152-66.

Gonda DD et al.

Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.

Neurosurgery (2013) 72:501-10.