(u54) rfa-rm-12-010
Projects
The Data Coordination Component (DCC) will develop data and metadata standards, establish data flow into the exRNA Atlas database; develop tools for download, visualization and analysis of exRNA data; and integrate exRNA Atlas database with other relevant resources. More
The last decade has seen the discovery of miRNAs in body fluids including plasma and serum. This lead to the hypothesis that RNAs play roles as extracellular signaling molecules. It is now clear that these RNAs exist not only in exosomes or other vesicles, but also outside vesicles bound to carrier proteins, such as Argonaute (Ago) proteins In vesicle-mediated RNA signaling, the vesicles are secreted by a large variety of cells, and contain RNAs (e.g. mRNA, miRNA and other ncRNA) that can be taken up by other cells. More
Advanced genetic and genomic technologies promise to transform our understanding and approach to human health and disease. Such genomic analyses are now common in Western populations of European descent. Studies of host genetic factors underlying long-term non-progressors of HIV infection have led to new therapies through the identification of loci that are important to in vivo control of virus pathogenicity. More
Extra-cellular RNAs (exRNAs) are emitted into the human bloodstream and other body fluids by different types of cells in the human body and may be uptaken by other cells. More
