Data Management And Resource Repository (DMRR) on Extracellular RNA

Projects

Aleksandar Milosavljevic
Baylor College of Medicine

Data Coordination Component of the Data Management and Resource Repository for the exRNA atlas (DMRR DCC)

The Data Coordination Component (DCC) will develop data and metadata standards, establish data flow into the exRNA Atlas database; develop tools for download, visualization and analysis of exRNA data; and integrate exRNA Atlas database with other relevant resources. More

Mark Bender Gerstein
Yale University

Data Integration and Analysis Component of the Data Management and Resource Repository for the exRNA atlas (DMRR DIAC)

The last decade has seen the discovery of miRNAs in body fluids including plasma and serum. This lead to the hypothesis that RNAs play roles as extracellular signaling molecules. It is now clear that these RNAs exist not only in exosomes or other vesicles, but also outside vesicles bound to carrier proteins, such as Argonaute (Ago) proteins In vesicle-mediated RNA signaling, the vesicles are secreted by a large variety of cells, and contain RNAs (e.g. mRNA, miRNA and other ncRNA) that can be taken up by other cells. More

David Galas
Pacific Northwest Diabetes Research Institute

Scientific Outreach Component of the Data Management and Resource Repository for the exRNA atlas (DMRR SOC)

Advanced genetic and genomic technologies promise to transform our understanding and approach to human health and disease. Such genomic analyses are now common in Western populations of European descent. Studies of host genetic factors underlying long-term non-progressors of HIV infection have led to new therapies through the identification of loci that are important to in vivo control of virus pathogenicity. More

Aleksandar Milosavljevic
Baylor College of Medicine

Administrative Core of the Data Management and Resource Repository for the exRNA Atlas (DMRR AC)

Extra-cellular RNAs (exRNAs) are emitted into the human bloodstream and other body fluids by different types of cells in the human body and may be uptaken by other cells. More