(UG3/UH3) RFA-RM-18-027

ERCC2: Improved isolation and analysis of exRNA carrier subclasses

High-throughput electrokinetic fractionation and analysis of extracellular RNA nano-carriers

Hsueh-Chia Chang
Notre Dame University
Lab webpage

Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasma

Robert J. Coffey
Vanderbilt University Medical Center
Lab webpage

Novel separation methods for exRNA carriers: Extracellular vesicles, lipoprotein particles, and protein aggregates

Kenneth W. Witwer
Johns Hopkins University
Lab webpage

P.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using Microfluidics

Robert Raffai
Northern California Institute for Research and Education
Lab webpage

Development and application of a scalable workflow for immunomagnetic separation of exRNA carrier subclasses and molecular analysis of their cargo

Louise C. Laurent
University of California San Diego
Lab webpage

(UG3/UH3) RFA-RM-18-028

ERCC2: Towards single extracellular vesicle (EV) sorting, isolation, and analysis of cargo

Single extracellular vesicle sorting and analysis

Daniel T. Chiu
University of Washington
Lab webpage

Enabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signatures

David Routenberg
Mesoscale Diagnostics, LLC
Lab webpage

Acoustofluidic Separation (AFS), purification, and Raman spectral fingerprinting of single EVs: from cell of origin to target cell and biofluids

David T. Wong
University of California Los Angeles
Lab webpage

Molecular dissection and imaging of extracellular vesicles to define their origin and targets

Saumya Das
Massachusetts General Hospital
Lab webpage

Microfluidics-array-based sorting, isolation, and RNA analysis in single extracellular vesicles

Eduardo Reategui
The Ohio State University
Lab webpage

Integrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometry

Ionita C. Ghiran
Beth Israel Deaconess Medical Center
Lab webpage

(u19) rfa-rm-12-012

ERCC1: Extracellular RNA Biogenesis, Biodistribution, Uptake, and Effector Function

In Vivo Regulated Release and Function of Extracellular Small RNAs

Robert H. Blelloch
University of California, San Francisco

ExRNA Released by Glioblastoma Alters Brain Microenvironment

Xandra Owens Breakefield
Massachusetts General Hospital

Secreted RNA During CRC Progression: Biogenesis, Function, and Clinical Markers

Robert J. Coffey
Vanderbilt University Medical Center

Genetic Models for exRNA Communication

Michael T. Mcmanus
University of California, San Francisco

Definition of Serum Ribonucleoprotein Composition and Its Regulation and Function

Thomas Tuschl
Rockefeller University

(uh2/uh3) rfa-rm-12-013

ERCC1: Clinical Utility of Extracellular RNA for Biomarker Development

exRNA Biomarkers for Human Glioma

Bob S. Carter
University Of California, San Diego

Plasma miRNA Predictors of Adverse Mechanical and Electrical Remodeling After Myocardial Infarction

Saumya Das
Beth Israel Deaconess Medical Center

Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease

Jane E. Freedman
University of Massachusetts Medical School, Worcester

exRNA Signatures Predict Outcomes After Brain Injury

Matthew Huentelman
Translational Genomics Research Institute

exRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction

Louise C. Laurent
University Of California, San Diego

Extracellular Non-coding RNA Biomarkers Of Hepatocellular Cancer

Tushar Patel
Mayo Clinic, Jacksonville

Clinical Utility of MicroRNAs as Diagnostic Biomarkers of Alzheimer's Disease

Julie Anne Saugstad
Oregon Health & Science University

Clinical Utility of Extracellular RNA as Marker of Kidney Disease Progression

Thomas Tuschl
Rockefeller University

Circulating MicroRNAs as Disease Biomarkers in Multiple Sclerosis

Howard L. Weiner
Brigham And Women's Hospital

Clinical Utility Of Salivary exRNA Biomarkers For Gastric Cancer Detection

David T. Wong
University Of California, Los Angeles

(UH2/UH3) RFA-RM-12-014

ERCC1: Clinical Utility of Extracellular RNA for Therapy Development

Targeting Tumor-derived exRNA-containing Microvesicles by High Throughput Screening

Asim B. Abdel-Mageed
Tulane University Of Louisiana

Exosome Based Therapeutics in Huntington's Disease

Neil Aronin
University of Massachusetts Medical School, Worcester

Exosome RNA-therapeutics to Promote CNS Myelination

Richard P. Kraig
University Of Chicago

HER2-targeted Exosomal Delivery of Therapeutic mRNA for Enzyme Pro-drug Therapy

AC Matin
Stanford University

Regulation of Renal and Bone Marrow Injury by Extracellular Vesicle Non-coding RNA

Peter J. Quesenberry
Rhode Island Hospital

Targeted Delivery of MicroRNA-loaded Microvesicle for Cancer Therapy

Thomas D. Schmittgen
Ohio State University

Novel Extracellular-RNA-based Combinatorial RNA Inhibition Therapy

Anil K. Sood
UT MD Anderson Cancer Center

Fruit Exosome-like Particles for Therapeutic Delivery of Extracellular miRNAs

Huang-ge Zhang
University Of Louisville

(u54) rfa-rm-12-010

ERCC1 & ERCC2: Data Management and Resource Repository (DMRR) on Extracellular RNA

Data Coordination Component of the Data Management and Resource Repository for the exRNA atlas (DMRR DCC)

Aleksandar Milosavljevic
Baylor College of Medicine

Data Integration and Analysis Component of the Data Management and Resource Repository for the exRNA atlas (DMRR DIAC)

Mark Bender Gerstein
Yale University

Scientific Outreach Component of the Data Management and Resource Repository for the exRNA atlas (DMRR SOC)

DAVID GALAS
Pacific Northwest Diabetes Research Institute

Administrative Core of the Data Management and Resource Repository for the exRNA Atlas (DMRR AC)

Aleksandar Milosavljevic
Baylor College of Medicine