Bob S. Carter
University Of California, San Diego

exRNA Biomarkers for Human Glioma

The non-invasive diagnosis of human glioma could improve the quality of life of patients with this disease by allowing patients to be directly diagnosed or stratified for treatment without the need of an invasive brain biopsy. More

Saumya Das
Beth Israel Deaconess Medical Center

Plasma miRNA Predictors of Adverse Mechanical and Electrical Remodeling After Myocardial Infarction

The complications of myocardial infarction contribute to 550,000 cases of heart failure (HF) and 300,000 cases of sudden cardiac arrest (SCA) annually. HF and SCA are mechanistically linked to the closely related processes of mechanical and electrical remodeling of the heart following infarction. More

Jane E. Freedman
University of Massachusetts Medical School, Worcester

Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease

Cardiovascular disease (CVD) and stroke are two of the leading causes of morbidity and mortality among adults in North America and are strongly determined by levels of common CVD risk factors including hypertension, diabetes, obesity, cigarette smoking, and dyslipidemia. More

Matthew Huentelman
Translational Genomics Research Institute

exRNA Signatures Predict Outcomes After Brain Injury

Traumatic brain injury, both from direct trauma to the brain and as a sequela of ischemic or hemorrhagic infarction are associated with a significant rate of morbidity, mortality and cost to both patients and the healthcare system. More

Louise C. Laurent
University Of California, San Diego

ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction

Placental dysfunction, most commonly manifested as preeclampsia or intrauterine growth restriction, is an important cause of maternal and fetal morbidity and mortality in both the developing and developed world. More

Tushar Patel
Mayo Clinic, Jacksonville

Extracellular Non-coding RNA Biomarkers of Hepatocellular Cancer

The overall goal of this application is to identify and qualify exosomal non-coding RNA based biomarkers in the circulation to detect early stage disease in patients at risk, to predict recurrence after surgery and to monitor response to therapy in patients with hepatocellular cancer (HCC). More

Julie Anne Saugstad
Oregon Health & Science University

Clinical Utility of MicroRNAs as Diagnostic Biomarkers of Alzheimer's Disease

Alzheimer’s disease (AD) is the most common form of dementia and is the sixth leading cause of death in the United States. The greatest known risk factor for AD is increasing age; the majority of people with AD are age 65 and older. More

Thomas Tuschl
Rockefeller University

Clinical Utility of Extracellular RNA as Marker of Kidney Disease Progression

Chronic kidney disease (CKD) is responsible for premature death from cardiovascular disease, infections and cancer, considerable human suffering and social costs. A large proportion of CKD patients develop end stage renal disease and require dialysis or kidney transplantation. More

Howard L. Weiner
Brigham And Women's Hospital

Circulating MicroRNAs as Disease Biomarkers in Multiple Sclerosis

This application is in response to an NIH FOA inviting applications for projects to identify and qualify extracellular RNA (exRNA)-based biomarkers derived from human body fluids to diagnose and monitor disease progression and response to therapy. More

David T. Wong
University Of California, Los Angeles

Clinical Utility Of Salivary exRNA Biomarkers For Gastric Cancer Detection

Extracellular RNA (exRNA) is an emerging paradigm as endocrine signals in cellular communication, biomarker development, therapeutic applications and systemic physiology. More