Extracellular RNA Biogenesis, Biodistribution, Uptake, and Effector Function


Robert H. Blelloch
University of California, San Francisco

In Vivo Regulated Release and Function of Extracellular Small RNAs

There is a desperate need for new means to diagnose and treat most human diseases. Extracellular small RNAs provide great promise. In particular, recent findings provide strong evidence for their utility as biomarkers. More

Xandra Owens Breakefield
Massachusetts General Hospital

ExRNA Released by Glioblastoma Alters Brain Microenvironment

Our broad term objective is two-fold: to understand how extracellular RNA (exRNA) modulates the phenotype of normal cells in the tumor environment and to generate new experimental modalities that can elucidate mechanisms underlying this form of communication among cells. More

Robert J. Coffey
Vanderbilt University Medical Center

Secreted RNA During CRC Progression: Biogenesis, Function, and Clinical Markers

A major premise of this proposal is that RNAs present in biofluids represent a window into various cellular processes that exist in multiple tissues that release such RNAs. More

Michael T. Mcmanus
University of California, San Francisco

Genetic Models for exRNA Communication

Accumulating evidence indicates that some of the many RNAs identified in body fluids and cell culture medium may be functional. Although proof-of-principle and validation projects have demonstrated cell-to-cell RNA transfer, not a single mammalian extracellular RNA has been demonstrated to enter and function in a target cell, at least in a biologically relevant and robust manner. More

Thomas Tuschl
Rockefeller University

Definition of Serum Ribonucleoprotein Composition and Its Regulation and Function

Extracellular RNA (exRNA) from pathogens plays a key role as activator of innate immunity in mammals. However, the presence of host exRNA in serum and other body fluids challenges the current models of RNA based immune recognition. More