Grant Project Page
Forterre AV et al.
Extracellular vesicle-mediated in vitro transcribed mRNA delivery for treatment of HER2(+) breast cancer xenografts in mice by prodrug CB1954 without general toxicity.
Mol Cancer Ther (2020) 19:858-867.
Therapeutics Grant TR000902
Kanada M et al.
Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy.
Mol Cancer Ther (2019) 18:2331-2342.
exRNA and EV Biology EV Biology Grant TR000902
Roy S, Hochberg FH & Jones PS.
Extracellular vesicles: the growth as diagnostics and therapeutics; a survey.
J Extracell Vesicles (2018) 7:1438720.
Review exRNA and EV Biology EV Biology Grant TR000931 Grant TR000902
Wang JH et al.
Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation.
Mol Cancer Ther (2018) 17 :1133-1142.
Miranda F et al.
Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche.
Cancer Cell (2016) 30:273-289.
Grant TR000902 Grant TR000943
Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug.
BMC Cancer (2016) 16:524.
Grant TR000902 Grant TR000875
Guzman N et al.
Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes “microRNA-like” tRNA Fragments.
Mol Cancer Res (2015) 13:891-901.
Biomarkers Grant TR000902 Grant TR000914
Differential fates of biomolecules delivered to target cells via extracellular vesicles.
Proc Natl Acad Sci U S A (2015) 112:E1433-42.
exRNA and EV Biology EV Biology Grant TR000902 Grant TR000943
Zhang H et al.
Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.
Breast Cancer Res (2014) 16:R36.
Grant CA179563 Grant TR000902