Grant Project Page
Palace SG et al.
Yersinia pestis escapes entrapment in thrombi by targeting platelet function.
J Thromb Haemost (2020) 18:3236-3248.
Grant TR000921 Grant HL126495
Srinivasan S et al.
Discovery and verification of extracellular miRNA biomarkers for non-invasive prediction of pre-eclampsia in asymptomatic women.
Cell Rep Med (2020) 1:100013.
Biomarkers Grant TR000906 Grant TR000921 Grant HL126494
Fazzalari A et al.
A translational model for venous thromboembolism: microRNA expression in hibernating black bears.
J Surg Res (2021) 257:203-212.
exRNA and EV Biology exRNA Biology Grant TR000921
Vaze A et al.
Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study.
PLoS ONE (2020) 15:e0236960.
Biomarkers Grant TR000943 Grant TR000921
Chiu LS et al.
The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study.
Liver Int (2020) 40:2445-2454.
Grant TR000921
Koupenova M & Freedman JE.
Platelets and immunity: Going viral.
Arterioscler Thromb Vasc Biol (2020) 40:1605-1607.
Review exRNA and EV Biology EV Biology Grant TR000921 Grant HL126495
Ding EY et al.
Accuracy and usability of a novel algorithm for detection of irregular pulse using a smartwatch among older adults: Observational study.
JMIR Cardio (2019) 3:e13850.
Darling CE et al.
Bioimpedance-based heart failure deterioration prediction using a prototype fluid accumulation vest-mobile phone dyad: an observational study.
JMIR Cardio (2017) 1:e1.
Spartano NL et al.
Comparison of on-site versus remote mobile device support in the Framingham Heart Study using the health eHeart study for digital follow-up: Randomized pilot study set within an observational study design.
JMIR Mhealth Uhealth (2019) 7:e13238.
Koupenova M et al.
The role of platelets in mediating a response to human influenza infection.
Nat Commun (2019) 10:1780.
Shah R, Murthy V & Freedman JE.
Nuts, cardiovascular health, and diabetes.
Circ Res (2019) 124:825-826.
Ko D et al.
Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study.
J Am Heart Assoc (2019) 8:e010976.
Shah RV et al.
Proteins altered by surgical weight loss highlight biomarkers of insulin resistance in the community.
Arterioscler Thromb Vasc Biol (2019) 39:107-115.
Narla V et al.
Unique circulating microRNA profiles in HIV infection.
J Acquir Immune Defic Syndr (2018) 79:644-650.
Biomarkers Grant TR000921 Grant HL126495
Associations of circulating extracellular RNAs with myocardial remodeling and heart failure.
JAMA Cardiol (2018) 3:871-876.
Biomarkers Grant TR000901 Grant TR000921 Grant HL126495
Staerk L et al.
Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: Cohort study based on longitudinal data from the Framingham Heart Study.
BMJ (2018) 361:k1453.
Grant TR000888 Grant TR000921
Micro RNAs from DNA viruses are found widely in plasma in a large observational human population.
Sci Rep (2018) 8:6397.
exRNA and EV Biology exRNA Biology Biomarkers Grant TR000921 Grant TR000923
Sardana M et al.
Association of left atrial function index with atrial fibrillation and cardiovascular disease: the Framingham offspring study.
J Am Heart Assoc (2018) 7:7.
Viswanath P et al.
2-Hydroxyglutarate-mediated autophagy of the Endoplasmic Reticulum leads to an unusual downregulation of phospholipid biosynthesis in mutant IDH1 gliomas.
Cancer Res (2018) 78:2290-2304.
Grant CA179512 Grant TR000921
Circulating platelets as mediators of immunity, inflammation, and thrombosis.
Circ Res (2018) 122:337-351.
Related Pathway
Soni A et al.
Study protocol for Smartphone Monitoring for Atrial fibrillation in Real-Time in India (SMART-India): a community-based screening and referral programme.
BMJ Open (2017) 7:e017668.
Grant TR000943 Grant TR000921
Willinger CM et al.
MicroRNA signature of cigarette smoking and evidence for a putative causal role of microRNAs in smoking-related inflammation and target organ damage.
Circ Cardiovasc Genet (2017) 10:5.
Clinical and echocardiographic correlates of Left Atrial Function Index: the Framingham offspring study.
J Am Soc Echocardiogr (2017) 30:904-912.e2.
Aldrugh S et al.
Atrial fibrillation, cognition and dementia: A review.
J Cardiovasc Electrophysiol (2017) 28:958-965.
Grant TR000901 Grant TR000921
RAHI-SATHI Indo-U.S. collaboration: The evolution of a trainee-led twinning model in global health into a multidisciplinary collaborative program.
Glob Health Sci Pract (2017) 5:152-163.
Mick E et al.
Stroke and circulating extracellular RNAs.
Stroke (2017) 48:828-834.
Review Biomarkers Grant TR000921 Grant HL126495
Clancy L et al.
The role of RNA uptake in platelet heterogeneity.
Thromb Haemost (2017) 117:948-961.
exRNA and EV Biology EV Biology Grant TR000875 Grant TR000921 Grant HL126495
McManus DD et al.
Messenger RNA and microRNA transcriptomic signatures of cardiometabolic risk factors.
BMC Genomics (2017) 18:139.
Biomarkers Grant TR000921
Shah R, Pico AR & Freedman JE.
Translational epidemiology: Entering a brave new world of team science.
Circ Res (2016) 119:1060-1062.
High burden of unrecognized atrial fibrillation in rural india: An innovative community-based cross-sectional screening program.
JMIR Public Health Surveill (2016) 2:e159.
Association of left atrial function index with late atrial fibrillation recurrence after catheter ablation.
J Cardiovasc Electrophysiol (2016) 27:1411-1419.
Walkey AJ et al.
Practice patterns and outcomes associated with use of anticoagulation among patients with atrial fibrillation during sepsis.
JAMA Cardiol (2016) 1:682-90.
Freedman JE et al.
Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma.
Nat Commun (2016) 7:11902.
Resources and Technology Grant TR000901 Grant TR000921
Henninger N et al.
Atrial fibrillation is associated with a worse 90-day outcome than other cardioembolic stroke subtypes.
Stroke (2016) 47:1486-92.
Grant TR000921 Grant HL126496
Wen S et al.
Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.
Leukemia (2016) 30:2221-2231.
Therapeutics Grant TR000880 Grant TR000921
Shah R et al.
Discordant expression of circulating microRNA from cellular and extracellular sources.
PLoS ONE (2016) 11:e0153691.
Resources and Technology Grant CA179514 Grant TR000921 Grant HL126495
McKenzie AJ et al.
KRAS-MEK signaling controls Ago2 sorting into exosomes.
Cell Rep (2016) 15:978-87.
exRNA and EV Biology EV Biology Grant CA179514 Grant TR000921
Diverse human extracellular RNAs are widely detected in human plasma.
Nat Commun (2016) 7:11106.
Resources and Technology Grant TR000921 Grant TR000884 Grant HL126495
Almeida MI & Calin GA.
The miR-143/miR-145 cluster and the tumor microenvironment: Unexpected roles.
Genome Med (2016) 8:29.
Review exRNA and EV Biology Grant TR000943 Grant TR000921
Tanriverdi K et al.
Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative Polymerase Chain Reaction.
Anal Biochem (2016) 501:66-74.
Resources and Technology Grant TR000943 Grant TR000921 Grant HL126495
Kundu A et al.
Relation of atrial fibrillation in acute myocardial infarction to in-hospital complications and early hospital readmission.
Am J Cardiol (2016) 117:1213-8.
Gleber-Netto FO et al.
Salivary biomarkers for detection of oral squamous cell carcinoma in a Taiwanese population.
Clin Cancer Res (2016) 22:3340-7.
Biomarkers Grant TR000921 Grant TR000923
Clancy L & Freedman JE.
Blood-derived extracellular RNA and platelet pathobiology: Adding pieces to a complex circulating puzzle.
Circ Res (2016) 118:374-6.
Review exRNA and EV Biology EV Biology Grant TR000921 Grant DA036134 Grant HL126495
Reliability of predicting early hospital readmission after discharge for an acute coronary syndrome using claims-based data.
Am J Cardiol (2016) 117:501-7.
Shaikh AY et al.
Addition of B-type natriuretic peptide to existing clinical risk scores enhances identification of patients at risk for atrial fibrillation recurrence after pulmonary vein isolation.
Crit Pathw Cardiol (2015) 14:157-65.
Huan T et al.
Genome-wide identification of microRNA expression Quantitative Trait Loci.
Nat Commun (2015) 6:6601.
Grant TR000901 Grant TR000921 Grant HL126495
Wei X, Liu X & Rosenzweig A.
What do we know about the cardiac benefits of exercise?
Trends Cardiovasc Med (2015) 25:529-36.
Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors.
Arterioscler Thromb Vasc Biol (2015) 35:1030-7.
Grant TR000921 Grant TR000923 Grant HL126495
Lotvall J et al.
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles.
J Extracell Vesicles (2014) 3:26913.
Review Resources and Technology Grant TR000880 Grant TR000921
Yao C et al.
Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.
Circulation (2015) 131:536-49.
Grant TR000943 Grant TR000921 Grant HL126495
Platelets: the unsung hero of the immune response.
J Thromb Haemost (2015) 13:268-70.
Bottsford-Miller J et al.
Differential platelet levels affect response to taxane-based therapy in ovarian cancer.
Clin Cancer Res (2015) 21:602-10.
Quesenberry PJ et al.
Marrow hematopoietic stem cells revisited: They exist in a continuum and are not defined by standard purification approaches; Then there are the microvesicles.
Front Oncol (2014) 4:56.
Review exRNA and EV Biology EV Biology Grant TR000880 Grant TR000921
Freedman JE.
Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease.
Circ Res (2014) 114:1372-3.
Takahashi K et al.
Modulation of hypoxia-signaling pathways by extracellular linc-RoR.
J Cell Sci (2014) 127:1585-94.
exRNA and EV Biology exRNA Biology Grant TR000921 Grant TR000884
Beaulieu LM et al.
Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans.
Arterioscler Thromb Vasc Biol (2014) 34:552-64.
Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study.
Heart Rhythm (2014) 11:663-9.
Pusic AD et al.
IFNgamma-stimulated dendritic cell exosomes as a potential therapeutic for remyelination.
J Neuroimmunol (2014) 266:12-23.
Therapeutics Grant TR000918 Grant TR000921
Sex- and age-interacting eQTLs in human complex diseases.
Hum Mol Genet (2014) 23:1947-56.
Grant TR000931 Grant TR000921
New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.
J Thromb Thrombolysis (2014) 37:12-6.
Review exRNA and EV Biology exRNA Biology Grant CA179564 Grant TR000921