Grant Project Page
Wei S et al.
Rapid nanopore sequencing-based screen for aneuploidy in reproductive care.
N Engl J Med (2022) 387:658-660.
Grant CA179564
Gomes DE & Witwer KW.
L1CAM-associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization.
J Extracell Biol (2022) 1.
Review exRNA and EV Biology EV Biology Resources and Technology Grant CA179564 Grant CA241694
Suryawanshi H et al.
Dynamic genome-wide gene expression and immune cell composition in the developing human placenta.
J Reprod Immunol (2022) 151:103624.
Max KEA et al.
Plasma microRNA interindividual variability in healthy individuals, pregnant women, and an individual with a stably altered neuroendocrine phenotype.
Clin Chem (2021) 67:1676-1688.
Biomarkers Grant CA179564
Rao SL et al.
Altered level of salivary placental growth factor is associated with preeclampsia.
Placenta (2020) 90:118-120.
Biomarkers Grant CA179564 Grant TR000923
A rapid and simple bead-bashing-based method for genomic DNA extraction from mammalian tissue.
Biotechniques (2020) 68:240-244.
Resources and Technology Grant TR000931 Grant CA179564
Meyer C et al.
The G3BP1-Family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.
Mol Cell (2020) 77:1193-1205.e5.
exRNA and EV Biology exRNA Biology Grant CA179564
Fabbri M et al.
Decrypting noncoding RNA interactions, structures, and functional networks.
Genome Res (2019) 29:1377-1388.
exRNA and EV Biology exRNA Biology Grant TR000943 Grant CA179564
Batki J et al.
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
Nat Struct Mol Biol (2019) 26:720-731.
Xie W et al.
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc Natl Acad Sci U S A (2019) 116:11946-11955.
Zheng L et al.
Hatchet ribozyme structure and implications for cleavage mechanism.
Proc Natl Acad Sci U S A (2019) 116:10783-10791.
Mazzu YZ et al.
miR-193b regulates tumorigenesis in liposarcoma cells via PDGFR, TGFbeta, and Wnt signaling.
Sci Rep (2019) 9:3197.
Jia N et al.
Type III-A CRISPR-Cas Csm complexes: Assembly, periodic RNA cleavage, DNase activity regulation, and autoimmunity.
Mol Cell (2019) 73:264-277.e5.
Grant CA179512 Grant CA179564
A single-cell survey of the human first-trimester placenta and decidua.
Sci Adv (2018) 4:eaau4788.
Smith EMD et al.
A Markov Multi-State model of lupus nephritis urine biomarker panel dynamics in children: Predicting changes in disease activity.
Clin Immunol (2019) 198:71-78.
Biomarkers Grant CA179564 Grant TR000933
Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer.
Fertil Steril (2018) 110:910-916.e2.
Wei S, Weiss ZR & Williams Z.
Rapid multiplex small DNA sequencing on the MinION Nanopore sequencing platform.
G3 (Bethesda) (2018) 8:1649-1657.
Singh PB et al.
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
J Exp Med (2017) 214:3627-3643.
Ren A, Micura R & Patel DJ.
Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes.
Curr Opin Chem Biol (2017) 41:71-83.
Grant TR000943 Grant CA179564
Amorim MG et al.
A total transcriptome profiling method for plasma-derived extracellular vesicles: Applications for liquid biopsies.
Sci Rep (2017) 7:14395.
Resources and Technology Grant TR000943 Grant CA179564
Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.
Nat Commun (2017) 8:1180.
Grant CA179563 Grant CA179564
Piao X et al.
Assessment and comparison of thermal stability of phosphorothioate-DNA, DNA, RNA, 2”-F RNA, and LNA in the context of Phi29 pRNA 3WJ.
RNA (2018) 24:67-76.
Grant CA179564 Grant TR000875
Gerstberger S et al.
The conserved RNA exonuclease Rexo5 is required for 3” end maturation of 28S rRNA, 5S rRNA, and snoRNAs.
Cell Rep (2017) 21:758-772.
Grant CA179514 Grant CA179564
Gogakos T et al.
Characterizing expression and processing of precursor and mature human tRNAs by hydro-tRNAseq and PAR-CLIP.
Cell Rep (2017) 20:1463-1475.
Resources and Technology Grant TR000943 Grant CA179564 Grant TR000933
Regev K et al.
Comprehensive evaluation of serum microRNAs as biomarkers in Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm (2016) 3:e267.
Biomarkers Grant CA179564 Grant TR000890
Smith EM et al.
International validation of a urinary biomarker panel for identification of active lupus nephritis in children.
Pediatr Nephrol (2017) 32:283-295.
Biomarkers Grant CA179564 Grant HL126496
Anfossi S & Calin GA.
Hodgkin lymphoma cells have a specific long noncoding RNA expression pattern.
Am J Pathol (2016) 186:2251-3.
Gao P et al.
Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.
Cell Res (2016) 26:901-13.
Grant CA179564 Grant TR000884
Wu S et al.
Circulating microRNAs and life expectancy among identical twins.
Ann Hum Genet (2016) 80:247-56.
Ren A et al.
Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
Nat Chem Biol (2016) 12:702-8.
Structural and dynamic basis for low-affinity, high-selectivity binding of L-glutamine by the glutamine riboswitch.
Cell Rep (2015) 13:1800-13.
Giza DE & Calin GA
microRNA and Chronic Lymphocytic Leukemia.
Adv Exp Med Biol (2015) 889:23-40.
Review exRNA and EV Biology exRNA Biology Grant TR000943 Grant CA179564
Wei S & Williams Z.
Rapid short-read sequencing and aneuploidy detection using MinION nanopore technology.
Genetics (2016) 202:37-44.
Pradeep S et al.
Erythropoietin stimulates tumor growth via EphB4.
Cancer Cell (2015) 28:610-22.
Kosutic M et al.
A mini-twister variant and impact of residues/cations on the phosphodiester cleavage of this ribozyme class.
Angew Chem Int Ed Engl (2015) 54:15128-33.
Li X, Mauro M & Williams Z.
Comparison of plasma extracellular RNA isolation kits reveals kit-dependent biases.
Biotechniques (2015) 59:13-7.
Resources and Technology Grant CA179564
Pichler M & Calin GA.
MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients.
Br J Cancer (2015) 113:569-73.
Cha DJ et al.
KRAS-dependent sorting of miRNA to exosomes.
Elife (2015) 4:e07197.
exRNA and EV Biology EV Biology Grant CA179514 Grant CA179564
Ren A, Rajashankar KR & Patel DJ.
Global RNA fold and molecular recognition for a pfl riboswitch bound to ZMP, a master regulator of one-carbon metabolism.
Structure (2015) 23:1375-81.
Li X et al.
Lowering the quantification limit of the QubitTM RNA HS assay using RNA spike-in.
BMC Mol Biol (2015) 16:9.
Saugstad JA.
Non-coding RNAs in stroke and neuroprotection.
Front Neurol (2015) 6:50.
Review exRNA and EV Biology Biomarkers Grant CA179564 Grant TR000903
Structural basis for molecular discrimination by a 3”,3”-cGAMP sensing riboswitch.
Cell Rep (2015) 11:1-12.
Grant TR000901 Grant CA179564
Ho GY et al.
Differential expression of circulating microRNAs according to severity of colorectal neoplasia.
Transl Res (2015) 166:225-32.
Biomarkers Grant TR000943 Grant CA179564
In-line alignment and Mg(2)(+) coordination at the cleavage site of the env22 twister ribozyme.
Nat Commun (2014) 5:5534.
Berindan-Neagoe I et al.
MicroRNAome genome: a treasure for cancer diagnosis and therapy.
CA Cancer J Clin (2014) 64:311-36.
Highly Cited (350+) Grant TR000943 Grant CA179564
Ren A & Patel DJ.
c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets.
Nat Chem Biol (2014) 10:780-6.
Akat KM et al.
Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.
Proc Natl Acad Sci U S A (2014) 111:11151-6.
Clancy L & Freedman JE.
New paradigms in thrombosis: Novel mediators and biomarkers platelet RNA transfer.
J Thromb Thrombolysis (2014) 37:12-6.
Review exRNA and EV Biology exRNA Biology Grant CA179564 Grant TR000921