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New pathways for the exRNA portal at WikiPathways

We continue to curate relevant pathways for the exRNA portal at WikiPathways, highlighting the mechanisms of exRNA signaling and regulation. The latest set of pathways represent a range of topics, including microRNAs in osteoclastogenesis (WP2866) and new findings in RNA interference (WP2805). Several pathways describe results from studies conducted using exRNA as a research tool, including 1) the effects of a high fat diet on megakaryocyte and platelet function (WP2865), 2) extracellular vesicles as mediators of signal transduction (WP2870), and 3) the effects of tumor nutrient utilization on ovarian cancer progression (WP2868). Additionally, one study provided a network view of its findings on Notch3 apoptosis-related changes in ovarian cancer (WP2864). This pathway represents a great candidate for further curation.

The curation process involves transferring findings represented as a figure by creating a new pathway in gpml format, using the WikiPathways plugin for PathVisio. After upload to WikiPathways, the content is tagged with appropriate curation and ontology tags, to increase its utility and exposure.

The goal of the Wikipathways exRNA portal is to build a collection of pathway models for exRNA researchers to use for illustration, data visualization, and analysis. Each pathway is a self-contained data model that connects to identifier and annotation databases. In addition to providing static images for figures and presentations, these pathways can also be used by bioinformatics and network analysis packages such as Cytoscape and PathVisio. Furthermore, as a wiki, anyone can sign up to improve and grow the content. We invite you all to edit, fix, and add to the pathway models in the exRNA portal at WikiPathways.

The Wikipathways exRNA portal was developed by the Data Management and Resource Repository group, serving the data coordination and scientific outreach needs of the consortium. If you have questions and/or feedback on ways to improve the exRNA portal at WikiPathways, please contact or Alex Pico at

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